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chr19:1,127,720-5,153,606

Best TWAS P=3.88e-13 · Best GWAS P=2.79e-13 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
41	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	UBXN6	0.05	0.01	blup	57	0.04	6.6e-05	5.6	-7.3	3.9e-13	0.10	0.01	0.97	TRUE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DOT1L	0.08	0.12	enet	8	0.10	2.5e-11	6.6	6.9	4.2e-12	0.84	0.03	0.97	TRUE
1	CommonMind	Brain Pre-frontal Cortex	REXO1	0.07	0.01	bslmm	391	0.01	1.7e-02	-2.9	6.9	7.0e-12	0.16	0.28	0.02	TRUE
47	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	DOT1L	0.09	0.08	blup	60	0.07	4.1e-04	-5.6	6.3	2.6e-10	0.68	0.10	0.78	TRUE
4	GTEx	Adipose Visceral Omentum	NFIC	0.20	0.00	lasso	5	0.02	2.2e-02	5.8	-6.2	4.6e-10	-0.04	0.07	0.22	TRUE
8	GTEx	Artery Tibial	DOT1L	0.09	0.06	lasso	5	0.05	7.3e-05	6.6	6.0	1.7e-09	0.78	0.09	0.88	TRUE
39	ROSMAP	Brain Pre-frontal Cortex	KLF16	0.12	0.08	bslmm	372	0.08	1.0e-10	-5.4	-5.8	6.1e-09	-0.01	1.00	0.00	TRUE
49	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	JSRP1	0.03	0.00	blup	33	0.02	2.1e-03	-3.8	-5.7	1.1e-08	-0.52	0.01	0.26	TRUE
11	GTEx	Artery Tibial	AC005306.3	0.25	0.12	enet	59	0.11	3.9e-09	-3.5	-5.3	1.3e-07	-0.11	1.00	0.00	TRUE
19	GTEx	Brain Nucleus accumbens basal ganglia	CTB-50L17.9	0.45	0.25	lasso	8	0.23	8.6e-07	5.6	-6.6	3.1e-11	0.09	0.02	0.97	FALSE
10	GTEx	Artery Tibial	UBXN6	0.18	0.07	lasso	3	0.14	6.3e-11	5.6	-6.4	2.0e-10	0.11	0.01	0.99	FALSE
28	GTEx	Muscle Skeletal	UBXN6	0.19	0.14	lasso	5	0.18	4.1e-17	-5.3	-6.3	2.8e-10	0.08	0.05	0.95	FALSE
5	GTEx	Artery Aorta	UBXN6	0.13	0.02	lasso	5	0.03	5.7e-03	-5.2	-6.3	3.2e-10	0.09	0.03	0.94	FALSE
23	GTEx	Heart Atrial Appendage	UBXN6	0.34	0.12	lasso	6	0.21	6.5e-10	5.6	-6.2	6.9e-10	0.09	0.02	0.98	FALSE
52	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	UBXN6	0.23	0.11	lasso	5	0.12	2.5e-05	5.0	-6.1	1.2e-09	0.12	0.02	0.61	FALSE
9	GTEx	Artery Tibial	NFIC	0.14	0.13	enet	11	0.12	7.6e-10	5.8	-6.1	1.3e-09	-0.02	0.25	0.75	FALSE
26	GTEx	Heart Left Ventricle	UBXN6	0.21	0.14	lasso	6	0.16	5.6e-09	-5.3	-6.0	1.7e-09	0.08	0.02	0.98	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	UBXN6	0.13	0.10	lasso	2	0.10	1.3e-10	5.6	-5.9	3.1e-09	0.09	0.01	0.99	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	UBXN6	0.16	0.12	lasso	2	0.12	5.4e-12	5.6	-5.8	7.0e-09	0.09	0.01	0.99	FALSE
51	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CHAF1A	0.20	0.11	lasso	2	0.11	5.6e-05	5.6	-5.8	7.1e-09	0.11	0.01	0.96	FALSE
2	CommonMind	Brain Pre-frontal Cortex	UBXN6	0.27	0.25	enet	28	0.29	4.6e-36	4.7	-5.8	8.0e-09	0.11	0.09	0.91	FALSE
33	GTEx	Stomach	AC007292.4	0.27	0.09	lasso	5	0.04	4.0e-03	-5.6	5.8	8.7e-09	-0.05	0.01	0.94	FALSE
29	GTEx	Nerve Tibial	UBXN6	0.17	0.08	enet	20	0.09	4.4e-07	5.0	-5.7	9.3e-09	0.13	0.04	0.96	FALSE
54	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DOT1L	0.40	-0.01	enet	20	0.03	3.6e-02	-4.0	5.7	1.3e-08	0.50	0.01	0.22	FALSE
15	GTEx	Brain Cerebellum	CTB-50L17.9	0.53	0.41	lasso	2	0.50	3.6e-17	5.0	-5.6	2.1e-08	0.10	0.02	0.98	FALSE
25	GTEx	Heart Left Ventricle	CHAF1A	0.17	0.12	lasso	2	0.11	1.9e-06	5.6	-5.6	2.4e-08	0.09	0.01	0.99	FALSE
37	GTEx	Thyroid	UBXN6	0.25	0.19	lasso	5	0.23	8.8e-18	5.6	-5.5	3.0e-08	0.11	0.02	0.98	FALSE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CHAF1A	0.12	0.11	lasso	3	0.12	7.9e-13	5.3	-5.5	3.1e-08	0.10	0.03	0.97	FALSE
36	GTEx	Testis	CTB-50L17.9	0.39	0.30	enet	36	0.34	9.4e-16	5.0	-5.5	3.4e-08	0.08	0.10	0.90	FALSE
27	GTEx	Muscle Skeletal	CHAF1A	0.18	0.21	lasso	2	0.20	9.7e-20	5.6	-5.5	3.6e-08	0.09	0.01	0.99	FALSE
17	GTEx	Brain Frontal Cortex BA9	CTB-50L17.9	0.27	0.21	lasso	3	0.19	7.9e-06	5.0	-5.5	3.8e-08	0.10	0.03	0.94	FALSE
21	GTEx	Colon Sigmoid	UBXN6	0.34	0.15	lasso	6	0.14	1.7e-05	5.0	-5.5	3.9e-08	0.09	0.04	0.95	FALSE
12	GTEx	Brain Caudate basal ganglia	CTB-50L17.9	0.27	0.25	lasso	2	0.24	1.8e-07	5.6	-5.5	4.3e-08	0.09	0.01	0.97	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	UBXN6	0.03	0.03	lasso	3	0.03	2.3e-06	-5.2	-5.5	4.7e-08	0.06	0.02	0.97	FALSE
6	GTEx	Artery Aorta	CTB-50L17.5	0.16	0.15	lasso	7	0.15	1.0e-08	5.6	-5.5	4.8e-08	0.09	0.02	0.98	FALSE
13	GTEx	Brain Cerebellar Hemisphere	CHAF1A	0.62	0.40	lasso	8	0.36	3.5e-10	5.6	-5.5	4.8e-08	0.09	0.01	0.98	FALSE
38	GTEx	Vagina	CTB-50L17.9	0.38	0.26	lasso	5	0.23	5.7e-06	5.6	-5.5	4.9e-08	0.11	0.02	0.94	FALSE
14	GTEx	Brain Cerebellum	CHAF1A	0.51	0.35	lasso	4	0.34	9.7e-11	5.6	-5.4	5.3e-08	0.09	0.02	0.98	FALSE
50	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UBXN6	0.04	0.03	lasso	2	0.02	1.6e-03	5.0	-5.4	6.8e-08	0.09	0.02	0.75	FALSE
30	GTEx	Nerve Tibial	CTB-50L17.5	0.11	0.08	enet	4	0.08	1.6e-06	5.3	-5.4	7.6e-08	0.09	0.02	0.98	FALSE
46	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FZR1	0.21	0.07	lasso	3	0.07	5.6e-05	-4.5	-5.3	9.0e-08	-0.03	0.00	0.39	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	AC007292.6	0.11	0.08	lasso	6	0.07	7.8e-05	5.6	-5.3	1.2e-07	0.10	0.02	0.95	FALSE
45	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CHAF1A	0.15	0.12	lasso	2	0.12	3.2e-07	5.3	-5.3	1.3e-07	0.09	0.06	0.94	FALSE
32	GTEx	Skin Sun Exposed Lower leg	CHAF1A	0.19	0.18	lasso	1	0.17	5.1e-14	5.3	-5.3	1.4e-07	0.09	0.02	0.98	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	CHAF1A	0.31	0.28	lasso	2	0.24	4.0e-07	5.3	-5.2	1.5e-07	0.09	0.02	0.96	FALSE
22	GTEx	Esophagus Muscularis	UBXN6	0.35	0.24	enet	20	0.29	3.7e-18	5.0	-5.2	1.8e-07	0.09	0.02	0.98	FALSE
34	GTEx	Testis	CHAF1A	0.18	0.09	lasso	2	0.07	4.0e-04	5.6	-5.2	1.8e-07	0.08	0.02	0.89	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UBXN6	0.18	0.17	enet	18	0.18	9.9e-20	5.6	-5.2	1.9e-07	0.09	0.01	0.99	FALSE
16	GTEx	Brain Frontal Cortex BA9	UBXN6	0.31	0.06	enet	5	0.12	3.5e-04	5.0	-5.2	2.0e-07	0.11	0.02	0.86	FALSE
24	GTEx	Heart Atrial Appendage	CTB-50L17.9	0.32	0.34	lasso	3	0.34	3.8e-16	5.0	-5.2	2.0e-07	0.09	0.16	0.84	FALSE
20	GTEx	Cells Transformed fibroblasts	UBXN6	0.09	0.10	lasso	1	0.08	1.5e-06	-5.2	-5.2	2.1e-07	0.05	0.05	0.95	FALSE
48	The Cancer Genome Atlas	Lung Adenocarcinoma	CHAF1A	0.05	0.04	lasso	4	0.03	2.3e-04	5.6	-5.2	2.3e-07	0.09	0.02	0.96	FALSE
3	GTEx	Adipose Subcutaneous	NFIC	0.14	0.00	enet	11	0.00	2.7e-01	-1.9	-5.1	2.9e-07	0.03	0.04	0.47	FALSE
7	GTEx	Artery Coronary	CTB-50L17.9	0.43	0.14	lasso	6	0.12	6.5e-05	5.0	-5.1	3.1e-07	0.07	0.06	0.71	FALSE
35	GTEx	Testis	UBXN6	0.20	0.10	lasso	3	0.10	2.9e-05	5.0	-5.1	3.1e-07	0.09	0.04	0.95	FALSE