[Hub]/) : Traits : Leg fat-free mass (left) : ← →

chr1:10,391,536-12,013,869

Best TWAS P=8.58e-19 · Best GWAS P=1.49e-16 conditioned to 0.268

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
17	ROSMAP	Brain Pre-frontal Cortex	MTOR	0.07	0.05	bslmm	423	0.04	2.0e-06	8.0	8.8	8.6e-19	0.87	0.09	0.91	TRUE
12	GTEx	Thyroid	RP4-635E18.7	0.07	0.02	lasso	2	0.01	5.5e-02	8.2	8.8	1.3e-18	0.93	0.02	0.91	FALSE
1	CommonMind	Brain Pre-frontal Cortex	EXOSC10	0.06	0.08	lasso	2	0.07	6.8e-09	8.3	8.3	8.6e-17	0.99	0.01	0.99	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	EXOSC10	0.06	0.06	lasso	2	0.06	4.9e-08	8.3	8.2	1.7e-16	1.00	0.01	0.99	FALSE
7	GTEx	Brain Cerebellum	EXOSC10	0.33	0.16	lasso	6	0.18	3.8e-06	8.2	8.2	2.5e-16	0.94	0.02	0.97	FALSE
10	GTEx	Lung	EXOSC10	0.11	0.07	lasso	4	0.05	1.2e-04	8.2	8.1	5.7e-16	0.97	0.01	0.98	FALSE
8	GTEx	Brain Cerebellum	RP4-635E18.7	0.17	0.17	lasso	5	0.09	1.3e-03	8.2	8.1	6.3e-16	0.96	0.02	0.94	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MTOR	0.02	0.02	blup	54	0.02	5.4e-03	7.8	8.0	1.3e-15	0.91	0.07	0.67	FALSE
9	GTEx	Brain Cortex	RP4-635E18.7	0.17	0.05	lasso	4	0.07	6.4e-03	8.0	8.0	1.4e-15	0.91	0.04	0.76	FALSE
15	METSIM	Adipose	MTOR	0.04	0.02	bslmm	434	0.02	1.5e-04	8.0	7.9	2.0e-15	0.89	0.03	0.97	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MTOR	0.13	0.15	lasso	4	0.15	5.6e-18	8.0	7.8	5.6e-15	0.88	0.06	0.94	FALSE
4	GTEx	Adipose Subcutaneous	EXOSC10	0.17	0.00	lasso	3	0.00	1.8e-01	8.1	7.8	6.2e-15	0.94	0.02	0.55	FALSE
6	GTEx	Brain Cerebellar Hemisphere	EXOSC10	0.23	0.10	lasso	3	0.12	6.4e-04	7.5	7.8	7.8e-15	0.90	0.05	0.74	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTOR	0.03	0.01	blup	54	0.02	5.9e-03	7.8	7.8	8.0e-15	0.88	0.03	0.74	FALSE
5	GTEx	Adipose Visceral Omentum	RP4-635E18.7	0.19	0.08	lasso	6	0.05	9.0e-04	8.2	7.7	1.3e-14	0.96	0.02	0.96	FALSE
21	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MASP2	0.05	0.03	blup	30	0.04	6.0e-03	2.6	-6.7	2.1e-11	-0.84	0.02	0.58	FALSE
14	METSIM	Adipose	EXOSC10	0.05	0.06	lasso	1	0.05	3.5e-08	6.4	6.4	1.3e-10	0.85	0.02	0.98	FALSE
13	GTEx	Whole Blood	MTOR	0.16	0.06	enet	18	0.07	5.1e-07	7.3	6.1	1.1e-09	0.66	0.76	0.23	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	RP4-635E18.7	0.23	0.09	enet	24	0.24	3.8e-30	5.7	6.0	1.8e-09	0.71	0.02	0.98	FALSE
3	GTEx	Adipose Subcutaneous	MASP2	0.10	0.06	lasso	2	0.03	8.8e-04	5.9	5.9	4.0e-09	0.69	0.51	0.28	FALSE
11	GTEx	Nerve Tibial	MASP2	0.14	0.07	lasso	5	0.09	1.2e-06	5.9	5.8	6.1e-09	0.68	0.36	0.55	FALSE