[Hub]/) : Traits : Leg fat-free mass (left) :

chr1:10,391,536-12,013,869

Best TWAS P=8.58e-19 · Best GWAS P=1.49e-16 conditioned to 0.268

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex EXOSC10 0.06 0.08 lasso 2 0.07 6.8e-09 8.3 8.3 8.6e-17 0.99 0.01 0.99 FALSE
2 CommonMind Brain Pre-frontal Cortex MTOR 0.13 0.15 lasso 4 0.15 5.6e-18 8.0 7.8 5.6e-15 0.88 0.06 0.94 FALSE
3 GTEx Adipose Subcutaneous MASP2 0.10 0.06 lasso 2 0.03 8.8e-04 5.9 5.9 4.0e-09 0.69 0.51 0.28 FALSE
4 GTEx Adipose Subcutaneous EXOSC10 0.17 0.00 lasso 3 0.00 1.8e-01 8.1 7.8 6.2e-15 0.94 0.02 0.55 FALSE
5 GTEx Adipose Visceral Omentum RP4-635E18.7 0.19 0.08 lasso 6 0.05 9.0e-04 8.2 7.7 1.3e-14 0.96 0.02 0.96 FALSE
6 GTEx Brain Cerebellar Hemisphere EXOSC10 0.23 0.10 lasso 3 0.12 6.4e-04 7.5 7.8 7.8e-15 0.90 0.05 0.74 FALSE
7 GTEx Brain Cerebellum EXOSC10 0.33 0.16 lasso 6 0.18 3.8e-06 8.2 8.2 2.5e-16 0.94 0.02 0.97 FALSE
8 GTEx Brain Cerebellum RP4-635E18.7 0.17 0.17 lasso 5 0.09 1.3e-03 8.2 8.1 6.3e-16 0.96 0.02 0.94 FALSE
9 GTEx Brain Cortex RP4-635E18.7 0.17 0.05 lasso 4 0.07 6.4e-03 8.0 8.0 1.4e-15 0.91 0.04 0.76 FALSE
10 GTEx Lung EXOSC10 0.11 0.07 lasso 4 0.05 1.2e-04 8.2 8.1 5.7e-16 0.97 0.01 0.98 FALSE
11 GTEx Nerve Tibial MASP2 0.14 0.07 lasso 5 0.09 1.2e-06 5.9 5.8 6.1e-09 0.68 0.36 0.55 FALSE
12 GTEx Thyroid RP4-635E18.7 0.07 0.02 lasso 2 0.01 5.5e-02 8.2 8.8 1.3e-18 0.93 0.02 0.91 FALSE
13 GTEx Whole Blood MTOR 0.16 0.06 enet 18 0.07 5.1e-07 7.3 6.1 1.1e-09 0.66 0.76 0.23 FALSE
14 METSIM Adipose EXOSC10 0.05 0.06 lasso 1 0.05 3.5e-08 6.4 6.4 1.3e-10 0.85 0.02 0.98 FALSE
15 METSIM Adipose MTOR 0.04 0.02 bslmm 434 0.02 1.5e-04 8.0 7.9 2.0e-15 0.89 0.03 0.97 FALSE
16 ROSMAP Brain Pre-frontal Cortex EXOSC10 0.06 0.06 lasso 2 0.06 4.9e-08 8.3 8.2 1.7e-16 1.00 0.01 0.99 FALSE
17 ROSMAP Brain Pre-frontal Cortex MTOR 0.07 0.05 bslmm 423 0.04 2.0e-06 8.0 8.8 8.6e-19 0.87 0.09 0.91 TRUE
18 ROSMAP Brain Pre-frontal Cortex RP4-635E18.7 0.23 0.09 enet 24 0.24 3.8e-30 5.7 6.0 1.8e-09 0.71 0.02 0.98 FALSE
19 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MTOR 0.02 0.02 blup 54 0.02 5.4e-03 7.8 8.0 1.3e-15 0.91 0.07 0.67 FALSE
20 The Cancer Genome Atlas Brain Lower Grade Glioma MTOR 0.03 0.01 blup 54 0.02 5.9e-03 7.8 7.8 8.0e-15 0.88 0.03 0.74 FALSE
21 The Cancer Genome Atlas Liver Hepatocellular Carcinoma MASP2 0.05 0.03 blup 30 0.04 6.0e-03 2.6 -6.7 2.1e-11 -0.84 0.02 0.58 FALSE