Best TWAS P=3.17e-14 · Best GWAS P=1.14e-12 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | NOSTRIN | 0.14 | 0.13 | lasso | 4 | 0.12 | 1.9e-14 | -7.1 | 7.6 | 3.2e-14 | -0.97 | 0.00 | 1.00 | TRUE |
2 | GTEx | Adrenal Gland | NOSTRIN | 0.21 | 0.09 | lasso | 4 | 0.09 | 4.1e-04 | 5.4 | 5.5 | 3.8e-08 | -0.40 | 0.34 | 0.38 | FALSE |
3 | GTEx | Lung | NOSTRIN | 0.09 | 0.06 | lasso | 4 | 0.07 | 7.1e-06 | 6.5 | 5.9 | 3.7e-09 | -0.39 | 0.08 | 0.90 | FALSE |
4 | GTEx | Stomach | NOSTRIN | 0.15 | 0.04 | enet | 9 | 0.09 | 6.8e-05 | 6.6 | 6.9 | 4.5e-12 | -0.58 | 0.09 | 0.89 | FALSE |
5 | GTEx | Testis | NOSTRIN | 0.43 | 0.17 | enet | 17 | 0.32 | 1.0e-14 | -4.6 | 5.9 | 3.2e-09 | -0.68 | 0.07 | 0.93 | FALSE |
6 | METSIM | Adipose | NOSTRIN | 0.07 | 0.09 | lasso | 6 | 0.08 | 1.6e-12 | 6.6 | 6.5 | 8.6e-11 | -0.59 | 0.09 | 0.91 | FALSE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NOSTRIN | 0.03 | 0.01 | blup | 55 | 0.02 | 9.5e-05 | -5.0 | 5.5 | 3.6e-08 | -0.37 | 0.02 | 0.96 | FALSE |
8 | The Cancer Genome Atlas | Colon Adenocarcinoma | G6PC2 | 0.32 | 0.07 | blup | 29 | 0.06 | 3.8e-04 | -4.7 | -6.1 | 9.7e-10 | 0.79 | 0.01 | 0.80 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | G6PC2 | 0.47 | 0.23 | enet | 8 | 0.28 | 4.4e-32 | -4.7 | -5.4 | 5.4e-08 | 0.79 | 0.02 | 0.96 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NOSTRIN | 0.12 | 0.13 | lasso | 7 | 0.14 | 4.5e-15 | -5.0 | 5.8 | 7.3e-09 | -0.43 | 0.02 | 0.98 | FALSE |
11 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | G6PC2 | 0.56 | 0.13 | blup | 29 | 0.16 | 2.1e-09 | -4.7 | -5.9 | 4.0e-09 | 0.75 | 0.02 | 0.97 | FALSE |
12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NOSTRIN | 0.08 | 0.01 | enet | 6 | 0.04 | 2.1e-05 | 5.0 | 5.8 | 7.5e-09 | -0.32 | 0.01 | 0.96 | FALSE |
13 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NOSTRIN | 0.05 | 0.00 | blup | 55 | 0.01 | 1.1e-02 | -5.0 | 5.4 | 7.7e-08 | -0.38 | 0.01 | 0.66 | FALSE |
14 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | NOSTRIN | 0.17 | 0.07 | lasso | 2 | 0.08 | 4.3e-04 | 4.6 | 5.2 | 2.0e-07 | -0.44 | 0.01 | 0.93 | FALSE |