[Hub]/) : Traits : Leg fat-free mass (left) : ← →

chr2:171,478,402-173,555,880

Best TWAS P=1.25e-30 · Best GWAS P=3.77e-33 conditioned to 0.65

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
46	The Cancer Genome Atlas	Thyroid Carcinoma	CYBRD1	0.10	0.06	lasso	4	0.06	6.2e-07	-8.8	11.5	1.2e-30	-0.86	0.00	1.00	TRUE
14	GTEx	Brain Hypothalamus	SLC25A12	0.29	-0.01	lasso	4	0.01	1.8e-01	-5.8	-5.7	1.1e-08	0.18	0.09	0.05	TRUE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	METTL8	0.06	0.01	enet	15	0.04	4.4e-05	6.4	-5.2	1.7e-07	0.17	0.20	0.63	TRUE
20	GTEx	Esophagus Muscularis	CYBRD1	0.33	0.07	lasso	9	0.22	1.3e-13	-7.9	10.9	1.0e-27	-0.75	0.06	0.94	FALSE
39	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CYBRD1	0.14	0.04	enet	12	0.09	2.2e-05	-12.0	-10.7	1.0e-26	0.78	0.00	0.96	FALSE
5	GTEx	Adipose Visceral Omentum	CYBRD1	0.33	0.10	lasso	10	0.26	4.6e-14	-8.0	10.6	2.1e-26	-0.71	0.03	0.97	FALSE
8	GTEx	Artery Coronary	CYBRD1	0.29	0.01	enet	44	0.11	2.0e-04	-8.0	10.4	1.8e-25	-0.68	0.04	0.61	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	CYBRD1	0.37	0.16	lasso	9	0.30	3.0e-39	-7.8	10.4	2.0e-25	-0.77	0.30	0.70	FALSE
15	GTEx	Breast Mammary Tissue	CYBRD1	0.32	0.21	enet	16	0.27	2.0e-14	-8.8	10.4	2.8e-25	-0.74	0.00	1.00	FALSE
24	GTEx	Nerve Tibial	CYBRD1	0.36	0.07	lasso	10	0.20	2.3e-14	-8.8	10.2	1.2e-24	-0.73	0.00	1.00	FALSE
17	GTEx	Breast Mammary Tissue (Female)	CYBRD1	0.20	0.07	lasso	2	0.14	4.5e-05	-8.8	10.2	1.7e-24	-0.78	0.00	0.98	FALSE
9	GTEx	Artery Tibial	CYBRD1	0.37	0.08	lasso	9	0.21	3.0e-16	-7.9	10.0	1.2e-23	-0.75	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	CYBRD1	0.35	0.19	lasso	6	0.24	7.3e-20	-8.8	10.0	1.9e-23	-0.77	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CYBRD1	0.33	0.18	lasso	7	0.27	5.2e-33	6.1	9.8	7.9e-23	-0.69	1.00	0.00	FALSE
16	GTEx	Breast Mammary Tissue (Male)	CYBRD1	0.35	0.24	lasso	6	0.20	2.4e-05	-8.8	9.7	2.8e-22	-0.72	0.00	0.98	FALSE
18	GTEx	Cells Transformed fibroblasts	CYBRD1	0.34	0.16	enet	27	0.26	6.3e-20	-8.0	9.7	3.5e-22	-0.57	0.33	0.67	FALSE
6	GTEx	Artery Aorta	CYBRD1	0.52	0.30	lasso	10	0.41	6.0e-24	6.1	9.5	1.6e-21	-0.66	0.95	0.05	FALSE
22	GTEx	Muscle Skeletal	CYBRD1	0.10	0.00	enet	9	0.01	1.5e-02	-8.8	8.8	1.9e-18	-0.71	0.00	0.99	FALSE
28	GTEx	Thyroid	CYBRD1	0.26	0.08	enet	26	0.12	1.4e-09	-8.8	8.7	2.4e-18	-0.72	0.00	1.00	FALSE
29	GTEx	Uterus	CYBRD1	0.54	0.04	lasso	6	0.19	1.1e-04	7.6	8.4	4.3e-17	-0.49	0.05	0.44	FALSE
21	GTEx	Lung	CYBRD1	0.14	0.05	enet	8	0.10	5.6e-08	5.0	8.2	3.8e-16	-0.45	0.98	0.01	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	CYBRD1	0.03	0.02	lasso	3	0.03	4.5e-04	6.1	7.5	5.9e-14	-0.46	0.18	0.21	FALSE
33	NTR	Blood	METTL8	0.03	0.02	lasso	7	0.02	1.7e-08	6.1	-7.5	8.9e-14	0.37	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	CYBRD1	0.08	0.06	blup	68	0.08	1.5e-08	-7.8	7.4	1.5e-13	-0.51	0.94	0.06	FALSE
31	METSIM	Adipose	CYBRD1	0.08	0.06	lasso	6	0.06	8.0e-09	5.6	7.3	2.8e-13	-0.48	0.92	0.08	FALSE
23	GTEx	Muscle Skeletal	DYNC1I2	0.11	0.12	lasso	2	0.12	6.5e-12	-7.0	7.1	1.1e-12	-0.30	1.00	0.00	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	AC068039.4	0.43	0.64	enet	35	0.65	1.6e-110	-6.9	-7.0	1.8e-12	0.29	1.00	0.00	FALSE
30	GTEx	Whole Blood	CYBRD1	0.25	0.14	enet	19	0.15	1.4e-13	5.5	7.0	2.0e-12	-0.52	1.00	0.00	FALSE
38	YFS	Blood	SLC25A12	0.09	0.15	lasso	7	0.15	1.3e-45	-6.9	-6.9	4.4e-12	0.29	1.00	0.00	FALSE
19	GTEx	Cells Transformed fibroblasts	DYNC1I2	0.12	0.14	lasso	3	0.14	1.4e-10	-6.9	6.9	5.4e-12	-0.29	1.00	0.00	FALSE
27	GTEx	Testis	DYNC1I2	0.13	0.02	lasso	4	0.01	1.1e-01	-6.9	6.9	5.6e-12	-0.29	0.17	0.09	FALSE
25	GTEx	Skin Sun Exposed Lower leg	DYNC1I2	0.11	0.16	lasso	1	0.15	8.9e-13	-6.9	6.9	6.2e-12	-0.29	1.00	0.00	FALSE
41	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DYNC1I2	0.05	0.06	lasso	4	0.05	6.3e-06	-7.1	6.8	7.4e-12	-0.26	0.02	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	METTL8	0.07	0.05	lasso	4	0.06	1.0e-07	6.1	-6.7	2.1e-11	0.29	0.99	0.00	FALSE
35	ROSMAP	Brain Pre-frontal Cortex	SLC25A12	0.13	0.08	lasso	6	0.11	1.8e-13	-6.8	-6.6	3.5e-11	0.28	1.00	0.00	FALSE
32	METSIM	Adipose	SLC25A12	0.05	0.03	blup	544	0.04	8.2e-07	-7.0	-6.6	5.4e-11	0.33	1.00	0.00	FALSE
11	GTEx	Artery Tibial	SLC25A12	0.11	0.09	lasso	8	0.06	8.4e-06	-6.3	-6.5	8.1e-11	0.28	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	DYNC1I2	0.13	0.11	enet	13	0.11	4.1e-09	-6.5	6.5	9.0e-11	-0.29	1.00	0.00	FALSE
26	GTEx	Spleen	METTL8	0.39	0.34	lasso	2	0.29	4.4e-08	6.3	-6.3	2.5e-10	0.25	0.89	0.01	FALSE
37	YFS	Blood	METTL8	0.04	0.03	lasso	9	0.03	4.4e-11	6.3	-6.3	3.7e-10	0.27	1.00	0.00	FALSE
13	GTEx	Brain Cerebellum	SLC25A12	0.24	0.22	lasso	7	0.17	1.3e-05	-6.8	-6.2	7.4e-10	0.28	0.90	0.01	FALSE
7	GTEx	Artery Aorta	SLC25A12	0.13	0.03	lasso	16	0.01	1.2e-01	-6.4	-6.1	1.3e-09	0.27	0.57	0.02	FALSE
10	GTEx	Artery Tibial	DYNC1I2	0.10	0.06	enet	17	0.06	2.2e-05	-7.0	6.0	1.7e-09	-0.23	0.94	0.01	FALSE
12	GTEx	Brain Cerebellar Hemisphere	DYNC1I2	0.32	0.24	lasso	7	0.26	2.0e-07	-5.7	6.0	2.2e-09	-0.27	0.90	0.01	FALSE
44	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MAP1D	0.03	0.03	lasso	2	0.02	1.5e-03	-5.5	5.6	2.6e-08	-0.21	0.04	0.76	FALSE
40	The Cancer Genome Atlas	Colon Adenocarcinoma	CYBRD1	0.14	0.06	blup	69	0.05	6.4e-04	5.0	-5.3	1.5e-07	0.52	0.16	0.48	FALSE