[Hub]/) : Traits : Leg fat-free mass (left) :

chr2:171,478,402-173,555,880

Best TWAS P=1.25e-30 · Best GWAS P=3.77e-33 conditioned to 0.65

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CYBRD1 0.33 0.18 lasso 7 0.27 5.2e-33 6.1 9.8 7.9e-23 -0.69 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex METTL8 0.07 0.05 lasso 4 0.06 1.0e-07 6.1 -6.7 2.1e-11 0.29 0.99 0.00 FALSE
3 GTEx Adipose Subcutaneous CYBRD1 0.35 0.19 lasso 6 0.24 7.3e-20 -8.8 10.0 1.9e-23 -0.77 0.00 1.00 FALSE
4 GTEx Adipose Subcutaneous DYNC1I2 0.13 0.11 enet 13 0.11 4.1e-09 -6.5 6.5 9.0e-11 -0.29 1.00 0.00 FALSE
5 GTEx Adipose Visceral Omentum CYBRD1 0.33 0.10 lasso 10 0.26 4.6e-14 -8.0 10.6 2.1e-26 -0.71 0.03 0.97 FALSE
6 GTEx Artery Aorta CYBRD1 0.52 0.30 lasso 10 0.41 6.0e-24 6.1 9.5 1.6e-21 -0.66 0.95 0.05 FALSE
7 GTEx Artery Aorta SLC25A12 0.13 0.03 lasso 16 0.01 1.2e-01 -6.4 -6.1 1.3e-09 0.27 0.57 0.02 FALSE
8 GTEx Artery Coronary CYBRD1 0.29 0.01 enet 44 0.11 2.0e-04 -8.0 10.4 1.8e-25 -0.68 0.04 0.61 FALSE
9 GTEx Artery Tibial CYBRD1 0.37 0.08 lasso 9 0.21 3.0e-16 -7.9 10.0 1.2e-23 -0.75 0.00 1.00 FALSE
10 GTEx Artery Tibial DYNC1I2 0.10 0.06 enet 17 0.06 2.2e-05 -7.0 6.0 1.7e-09 -0.23 0.94 0.01 FALSE
11 GTEx Artery Tibial SLC25A12 0.11 0.09 lasso 8 0.06 8.4e-06 -6.3 -6.5 8.1e-11 0.28 1.00 0.00 FALSE
12 GTEx Brain Cerebellar Hemisphere DYNC1I2 0.32 0.24 lasso 7 0.26 2.0e-07 -5.7 6.0 2.2e-09 -0.27 0.90 0.01 FALSE
13 GTEx Brain Cerebellum SLC25A12 0.24 0.22 lasso 7 0.17 1.3e-05 -6.8 -6.2 7.4e-10 0.28 0.90 0.01 FALSE
14 GTEx Brain Hypothalamus SLC25A12 0.29 -0.01 lasso 4 0.01 1.8e-01 -5.8 -5.7 1.1e-08 0.18 0.09 0.05 TRUE
15 GTEx Breast Mammary Tissue CYBRD1 0.32 0.21 enet 16 0.27 2.0e-14 -8.8 10.4 2.8e-25 -0.74 0.00 1.00 FALSE
16 GTEx Breast Mammary Tissue (Male) CYBRD1 0.35 0.24 lasso 6 0.20 2.4e-05 -8.8 9.7 2.8e-22 -0.72 0.00 0.98 FALSE
17 GTEx Breast Mammary Tissue (Female) CYBRD1 0.20 0.07 lasso 2 0.14 4.5e-05 -8.8 10.2 1.7e-24 -0.78 0.00 0.98 FALSE
18 GTEx Cells Transformed fibroblasts CYBRD1 0.34 0.16 enet 27 0.26 6.3e-20 -8.0 9.7 3.5e-22 -0.57 0.33 0.67 FALSE
19 GTEx Cells Transformed fibroblasts DYNC1I2 0.12 0.14 lasso 3 0.14 1.4e-10 -6.9 6.9 5.4e-12 -0.29 1.00 0.00 FALSE
20 GTEx Esophagus Muscularis CYBRD1 0.33 0.07 lasso 9 0.22 1.3e-13 -7.9 10.9 1.0e-27 -0.75 0.06 0.94 FALSE
21 GTEx Lung CYBRD1 0.14 0.05 enet 8 0.10 5.6e-08 5.0 8.2 3.8e-16 -0.45 0.98 0.01 FALSE
22 GTEx Muscle Skeletal CYBRD1 0.10 0.00 enet 9 0.01 1.5e-02 -8.8 8.8 1.9e-18 -0.71 0.00 0.99 FALSE
23 GTEx Muscle Skeletal DYNC1I2 0.11 0.12 lasso 2 0.12 6.5e-12 -7.0 7.1 1.1e-12 -0.30 1.00 0.00 FALSE
24 GTEx Nerve Tibial CYBRD1 0.36 0.07 lasso 10 0.20 2.3e-14 -8.8 10.2 1.2e-24 -0.73 0.00 1.00 FALSE
25 GTEx Skin Sun Exposed Lower leg DYNC1I2 0.11 0.16 lasso 1 0.15 8.9e-13 -6.9 6.9 6.2e-12 -0.29 1.00 0.00 FALSE
26 GTEx Spleen METTL8 0.39 0.34 lasso 2 0.29 4.4e-08 6.3 -6.3 2.5e-10 0.25 0.89 0.01 FALSE
27 GTEx Testis DYNC1I2 0.13 0.02 lasso 4 0.01 1.1e-01 -6.9 6.9 5.6e-12 -0.29 0.17 0.09 FALSE
28 GTEx Thyroid CYBRD1 0.26 0.08 enet 26 0.12 1.4e-09 -8.8 8.7 2.4e-18 -0.72 0.00 1.00 FALSE
29 GTEx Uterus CYBRD1 0.54 0.04 lasso 6 0.19 1.1e-04 7.6 8.4 4.3e-17 -0.49 0.05 0.44 FALSE
30 GTEx Whole Blood CYBRD1 0.25 0.14 enet 19 0.15 1.4e-13 5.5 7.0 2.0e-12 -0.52 1.00 0.00 FALSE
31 METSIM Adipose CYBRD1 0.08 0.06 lasso 6 0.06 8.0e-09 5.6 7.3 2.8e-13 -0.48 0.92 0.08 FALSE
32 METSIM Adipose SLC25A12 0.05 0.03 blup 544 0.04 8.2e-07 -7.0 -6.6 5.4e-11 0.33 1.00 0.00 FALSE
33 NTR Blood METTL8 0.03 0.02 lasso 7 0.02 1.7e-08 6.1 -7.5 8.9e-14 0.37 1.00 0.00 FALSE
34 ROSMAP Brain Pre-frontal Cortex CYBRD1 0.37 0.16 lasso 9 0.30 3.0e-39 -7.8 10.4 2.0e-25 -0.77 0.30 0.70 FALSE
35 ROSMAP Brain Pre-frontal Cortex SLC25A12 0.13 0.08 lasso 6 0.11 1.8e-13 -6.8 -6.6 3.5e-11 0.28 1.00 0.00 FALSE
36 ROSMAP Brain Pre-frontal Cortex AC068039.4 0.43 0.64 enet 35 0.65 1.6e-110 -6.9 -7.0 1.8e-12 0.29 1.00 0.00 FALSE
37 YFS Blood METTL8 0.04 0.03 lasso 9 0.03 4.4e-11 6.3 -6.3 3.7e-10 0.27 1.00 0.00 FALSE
38 YFS Blood SLC25A12 0.09 0.15 lasso 7 0.15 1.3e-45 -6.9 -6.9 4.4e-12 0.29 1.00 0.00 FALSE
39 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CYBRD1 0.14 0.04 enet 12 0.09 2.2e-05 -12.0 -10.7 1.0e-26 0.78 0.00 0.96 FALSE
40 The Cancer Genome Atlas Colon Adenocarcinoma CYBRD1 0.14 0.06 blup 69 0.05 6.4e-04 5.0 -5.3 1.5e-07 0.52 0.16 0.48 FALSE
41 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma DYNC1I2 0.05 0.06 lasso 4 0.05 6.3e-06 -7.1 6.8 7.4e-12 -0.26 0.02 0.98 FALSE
42 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma METTL8 0.06 0.01 enet 15 0.04 4.4e-05 6.4 -5.2 1.7e-07 0.17 0.20 0.63 TRUE
43 The Cancer Genome Atlas Brain Lower Grade Glioma CYBRD1 0.03 0.02 lasso 3 0.03 4.5e-04 6.1 7.5 5.9e-14 -0.46 0.18 0.21 FALSE
44 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MAP1D 0.03 0.03 lasso 2 0.02 1.5e-03 -5.5 5.6 2.6e-08 -0.21 0.04 0.76 FALSE
45 The Cancer Genome Atlas Prostate Adenocarcinoma CYBRD1 0.08 0.06 blup 68 0.08 1.5e-08 -7.8 7.4 1.5e-13 -0.51 0.94 0.06 FALSE
46 The Cancer Genome Atlas Thyroid Carcinoma CYBRD1 0.10 0.06 lasso 4 0.06 6.2e-07 -8.8 11.5 1.2e-30 -0.86 0.00 1.00 TRUE