[Hub]/) : Traits : Leg fat-free mass (left) : ← →

chr2:241,563,169-243,048,760

Best TWAS P=1.97e-12 · Best GWAS P=1.13e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
17	GTEx	Esophagus Gastroesophageal Junction	SEPT2	0.66	0.38	enet	29	0.50	7.1e-21	5.2	7.0	2.0e-12	-0.08	0.68	0.32	TRUE
4	GTEx	Adipose Visceral Omentum	BOK	0.20	0.12	lasso	4	0.12	1.4e-06	-6.4	-6.7	1.6e-11	0.97	0.00	1.00	TRUE
2	GTEx	Adipose Subcutaneous	SEPT2	0.45	0.36	enet	32	0.43	3.0e-38	5.2	6.7	2.2e-11	-0.08	0.68	0.32	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	AC005104.3	0.27	0.06	enet	24	0.20	5.6e-11	4.1	6.6	4.1e-11	-0.21	0.57	0.08	FALSE
11	GTEx	Brain Frontal Cortex BA9	SEPT2	0.30	-0.01	enet	32	0.02	1.1e-01	5.2	6.5	8.5e-11	-0.13	0.07	0.06	FALSE
35	NTR	Blood	SEPT2	0.18	0.10	enet	34	0.14	1.0e-43	5.2	6.4	1.2e-10	-0.13	0.68	0.32	FALSE
3	GTEx	Adipose Subcutaneous	AC005104.3	0.12	0.03	lasso	5	0.06	1.5e-05	5.2	6.4	1.3e-10	-0.06	0.43	0.21	FALSE
40	The Cancer Genome Atlas	Lung Adenocarcinoma	SEPT2	0.24	0.04	blup	45	0.08	1.6e-09	2.9	6.3	2.6e-10	-0.12	0.01	0.07	FALSE
33	METSIM	Adipose	BOK	0.06	0.03	lasso	6	0.03	7.8e-06	-6.4	-6.2	4.2e-10	0.95	0.00	1.00	FALSE
14	GTEx	Cells Transformed fibroblasts	SEPT2	0.34	0.14	lasso	6	0.32	5.5e-25	5.2	6.2	5.0e-10	-0.09	0.68	0.32	FALSE
12	GTEx	Breast Mammary Tissue	SEPT2	0.46	0.33	enet	37	0.35	5.2e-19	5.2	6.2	6.7e-10	-0.08	0.68	0.32	FALSE
19	GTEx	Esophagus Muscularis	SEPT2	0.57	0.34	enet	34	0.48	1.7e-32	5.2	6.1	8.3e-10	-0.11	0.68	0.31	FALSE
21	GTEx	Heart Atrial Appendage	AC114730.11	0.16	0.07	enet	11	0.16	1.2e-07	-3.4	-6.1	1.1e-09	0.28	0.31	0.21	FALSE
32	GTEx	Whole Blood	SEPT2	0.26	0.10	lasso	5	0.12	1.8e-11	5.2	6.1	1.3e-09	-0.08	0.68	0.32	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SEPT2	0.19	0.06	enet	9	0.08	1.0e-09	2.9	6.0	1.7e-09	-0.10	0.01	0.07	FALSE
25	GTEx	Nerve Tibial	AC005104.3	0.28	0.21	enet	19	0.24	4.6e-17	5.2	6.0	1.8e-09	-0.06	0.68	0.32	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	SEPT2	0.63	0.38	enet	29	0.42	1.1e-24	5.2	6.0	2.1e-09	-0.08	0.68	0.32	FALSE
18	GTEx	Esophagus Mucosa	SEPT2	0.59	0.50	enet	37	0.56	2.7e-44	5.2	6.0	2.2e-09	-0.06	0.68	0.32	FALSE
42	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SEPT2	0.42	0.11	enet	14	0.18	5.2e-08	2.9	6.0	2.4e-09	-0.07	0.00	0.03	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	BOK	0.07	0.04	lasso	5	0.03	1.8e-04	6.1	-5.9	2.9e-09	0.76	0.01	0.98	FALSE
26	GTEx	Ovary	SEPT2	0.56	0.29	lasso	5	0.23	2.4e-06	5.2	5.9	3.0e-09	-0.06	0.39	0.20	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SEPT2	0.52	0.29	bslmm	377	0.44	2.0e-59	5.3	5.9	3.3e-09	-0.12	0.67	0.32	FALSE
23	GTEx	Muscle Skeletal	SEPT2	0.39	0.22	enet	46	0.26	1.0e-25	5.2	5.8	6.1e-09	-0.13	0.68	0.32	FALSE
6	GTEx	Artery Aorta	SEPT2	0.60	0.38	lasso	9	0.46	5.8e-28	5.2	5.8	6.8e-09	-0.08	0.68	0.32	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	SEPT2	0.48	0.39	enet	49	0.42	6.0e-58	5.2	5.8	8.3e-09	-0.10	0.68	0.32	FALSE
22	GTEx	Lung	SEPT2	0.42	0.33	lasso	6	0.38	2.6e-30	5.2	5.7	9.7e-09	-0.04	0.68	0.32	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	SEPT2	0.40	0.06	enet	14	0.17	8.0e-18	2.9	5.7	1.0e-08	-0.10	0.01	0.07	FALSE
9	GTEx	Artery Tibial	SEPT2	0.58	0.50	lasso	13	0.58	1.4e-55	5.2	5.7	1.2e-08	-0.06	0.68	0.32	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	SEPT2	0.51	0.10	enet	14	0.20	2.4e-22	2.9	5.7	1.4e-08	-0.09	0.01	0.07	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	SEPT2	0.76	0.25	enet	14	0.47	1.8e-50	2.9	5.6	1.9e-08	-0.05	0.01	0.07	FALSE
24	GTEx	Nerve Tibial	SEPT2	0.70	0.52	lasso	11	0.58	1.4e-49	5.2	5.6	2.0e-08	-0.06	0.68	0.32	FALSE
34	METSIM	Adipose	SEPT2	0.29	0.21	bslmm	375	0.20	1.6e-29	5.2	5.6	2.1e-08	-0.04	0.68	0.32	FALSE
37	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEPT2	0.21	0.02	enet	11	0.07	4.9e-15	2.9	5.6	2.2e-08	-0.10	0.01	0.05	FALSE
29	GTEx	Skin Sun Exposed Lower leg	SEPT2	0.55	0.36	lasso	9	0.37	7.6e-32	5.2	5.6	2.5e-08	-0.04	0.68	0.32	FALSE
7	GTEx	Artery Aorta	AC005104.3	0.10	0.01	lasso	4	0.01	1.6e-01	-3.2	5.5	3.2e-08	-0.20	0.09	0.26	FALSE
15	GTEx	Colon Sigmoid	SEPT2	0.55	0.49	lasso	8	0.48	4.7e-19	5.2	5.5	3.7e-08	-0.05	0.68	0.32	FALSE
20	GTEx	Heart Atrial Appendage	SEPT2	0.26	0.21	lasso	5	0.20	1.7e-09	5.2	5.5	4.9e-08	-0.04	0.68	0.31	FALSE
10	GTEx	Artery Tibial	AC005104.3	0.18	0.14	lasso	5	0.12	6.7e-10	5.2	5.3	9.3e-08	-0.03	0.69	0.31	FALSE
5	GTEx	Adipose Visceral Omentum	AC005104.3	0.17	0.14	lasso	3	0.09	3.0e-05	5.2	5.3	1.1e-07	-0.04	0.68	0.31	FALSE
30	GTEx	Stomach	SEPT2	0.24	0.27	lasso	8	0.25	3.6e-12	5.2	5.3	1.2e-07	-0.03	0.68	0.32	FALSE
8	GTEx	Artery Coronary	SEPT2	0.38	0.18	enet	22	0.17	1.7e-06	5.2	5.2	1.7e-07	-0.05	0.31	0.15	FALSE
41	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SEPT2	0.14	0.00	enet	7	0.02	7.7e-04	2.0	5.2	1.7e-07	-0.09	0.00	0.04	FALSE
13	GTEx	Breast Mammary Tissue (Male)	SEPT2	0.18	0.31	lasso	2	0.29	1.6e-07	5.2	5.2	2.1e-07	-0.03	0.28	0.14	FALSE
16	GTEx	Colon Sigmoid	AC005104.3	0.26	0.21	lasso	3	0.20	1.9e-07	5.2	5.2	2.1e-07	-0.03	0.61	0.25	FALSE
31	GTEx	Thyroid	SEPT2	0.55	0.43	lasso	8	0.45	4.7e-38	5.2	5.2	2.7e-07	-0.05	0.68	0.32	FALSE