[Hub]/) : Traits : Leg fat-free mass (left) : ← →

chr3:8,706,520-11,999,795

Best TWAS P=1.19e-12 · Best GWAS P=7.23e-12 conditioned to 8.97e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
19	GTEx	Testis	CRELD1	0.22	0.22	lasso	8	0.26	1.1e-11	5.4	-7.1	1.2e-12	0.00	0.14	0.86	TRUE
12	GTEx	Cells Transformed fibroblasts	HRH1	0.20	0.00	lasso	3	0.01	1.1e-01	6.9	-5.8	7.4e-09	-0.77	0.01	0.92	TRUE
20	GTEx	Thyroid	THUMPD3	0.24	0.10	lasso	7	0.10	4.6e-08	4.3	-5.3	1.3e-07	0.02	0.02	0.90	TRUE
6	GTEx	Artery Aorta	RP11-1020A11.1	0.15	0.01	lasso	3	0.00	4.0e-01	-6.0	-6.7	1.6e-11	-0.03	0.03	0.58	FALSE
10	GTEx	Cells Transformed fibroblasts	CRELD1	0.39	0.19	enet	39	0.28	4.5e-21	-6.0	-6.3	2.9e-10	0.04	0.02	0.98	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	AC022007.5	0.05	0.02	blup	515	0.03	2.8e-04	6.0	6.0	1.6e-09	0.02	0.04	0.96	FALSE
15	GTEx	Esophagus Muscularis	CRELD1	0.21	0.10	lasso	1	0.08	1.7e-05	-6.0	-6.0	1.9e-09	-0.02	0.02	0.96	FALSE
31	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC401052	0.06	0.07	enet	6	0.06	3.5e-07	6.0	-6.0	2.2e-09	-0.05	0.01	0.99	FALSE
13	GTEx	Cells Transformed fibroblasts	RP11-1020A11.1	0.20	0.10	enet	67	0.09	1.9e-07	-6.0	-6.0	2.6e-09	0.01	0.02	0.98	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	CIDECP	0.04	0.02	blup	33	0.03	3.8e-04	5.4	5.9	3.7e-09	0.00	0.04	0.90	FALSE
25	YFS	Blood	FANCD2	0.04	0.04	lasso	1	0.04	7.7e-13	5.9	-5.9	4.8e-09	-0.06	0.04	0.96	FALSE
23	METSIM	Adipose	BRK1	0.04	0.02	bslmm	559	0.01	8.9e-03	5.0	-5.8	5.9e-09	-0.04	0.15	0.68	FALSE
3	GTEx	Adipose Visceral Omentum	CRELD1	0.19	0.12	lasso	4	0.10	4.1e-06	-6.0	-5.8	7.2e-09	-0.02	0.02	0.92	FALSE
8	GTEx	Breast Mammary Tissue	CRELD1	0.25	0.19	lasso	6	0.18	2.2e-09	-6.0	-5.8	7.4e-09	-0.02	0.02	0.98	FALSE
1	GTEx	Adipose Subcutaneous	CRELD1	0.46	0.16	enet	51	0.27	2.2e-22	-6.0	-5.7	1.0e-08	0.07	0.02	0.98	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	AC034193.5	0.15	0.09	enet	11	0.08	3.3e-05	5.4	5.7	1.0e-08	0.02	0.41	0.48	FALSE
22	GTEx	Thyroid	BRK1	0.08	0.05	lasso	3	0.04	6.8e-04	5.4	-5.6	2.5e-08	0.01	0.31	0.68	FALSE
5	GTEx	Artery Aorta	AC034193.5	0.12	0.01	lasso	3	0.00	1.6e-01	5.5	5.5	4.8e-08	-0.01	0.17	0.38	FALSE
2	GTEx	Adipose Subcutaneous	AC034193.5	0.08	0.07	lasso	4	0.07	2.2e-06	5.2	5.4	5.2e-08	0.00	0.53	0.44	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	CYCSP10	0.19	0.01	lasso	5	-0.01	6.6e-01	5.4	-5.4	5.6e-08	0.01	0.07	0.15	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	C3orf10	0.05	0.02	blup	49	0.04	9.3e-05	5.0	-5.4	6.0e-08	-0.03	0.11	0.87	FALSE
14	GTEx	Esophagus Mucosa	VHL	0.14	0.00	lasso	1	0.00	2.9e-01	5.4	-5.4	7.1e-08	0.02	0.08	0.34	FALSE
7	GTEx	Artery Tibial	AC034193.5	0.10	0.08	lasso	1	0.06	1.2e-05	5.4	5.4	7.3e-08	-0.02	0.40	0.58	FALSE
28	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C3orf10	0.03	0.05	lasso	5	0.04	3.4e-05	5.3	-5.4	7.4e-08	-0.01	0.08	0.90	FALSE
11	GTEx	Cells Transformed fibroblasts	AC034193.5	0.12	0.05	lasso	3	0.05	1.2e-04	5.4	5.4	7.7e-08	-0.03	0.43	0.55	FALSE
18	GTEx	Skin Sun Exposed Lower leg	AC034193.5	0.09	0.11	lasso	2	0.09	8.7e-08	5.4	5.4	7.8e-08	-0.02	0.44	0.56	FALSE
4	GTEx	Artery Aorta	CRELD1	0.30	0.07	lasso	7	0.12	2.4e-07	-6.0	-5.4	8.2e-08	0.03	0.02	0.98	FALSE
26	YFS	Blood	PRRT3	0.08	0.02	bslmm	469	0.04	7.4e-13	-6.0	-5.3	1.1e-07	-0.03	0.02	0.98	FALSE
21	GTEx	Thyroid	CIDECP	0.11	0.12	lasso	2	0.11	1.1e-08	5.2	5.3	1.3e-07	0.00	0.52	0.48	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	C3orf10	0.01	0.01	blup	49	0.01	9.4e-03	4.9	-5.3	1.3e-07	0.02	0.07	0.33	FALSE
32	The Cancer Genome Atlas	Prostate Adenocarcinoma	VHL	0.03	0.00	blup	61	0.01	8.2e-02	5.0	-5.2	2.3e-07	-0.04	0.04	0.24	FALSE
29	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C3orf10	0.05	0.04	lasso	3	0.04	1.4e-03	5.0	-5.1	2.7e-07	0.02	0.14	0.54	FALSE
16	GTEx	Pancreas	BRK1	0.22	0.20	lasso	9	0.15	6.3e-07	5.0	-5.1	2.9e-07	0.01	0.80	0.20	FALSE