[Hub]/) : Traits : Leg fat-free mass (left) : ← →

chr4:16,922,182-18,507,692

Best TWAS P=1.93e-37 · Best GWAS P=5.14e-34 conditioned to 0.002

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Artery Aorta	DCAF16	0.10	0.01	enet	6	0.02	4.7e-02	-11.4	12.8	1.9e-37	-0.81	0.06	0.77	TRUE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	DCAF16	0.09	0.02	lasso	3	0.04	5.2e-05	8.3	11.9	1.5e-32	-0.64	0.08	0.81	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	DCAF16	0.07	0.04	blup	31	0.07	4.9e-07	8.1	11.4	6.2e-30	-0.65	0.14	0.79	FALSE
14	GTEx	Spleen	DCAF16	0.35	0.02	lasso	5	0.11	8.5e-04	6.9	11.2	7.1e-29	-0.66	0.05	0.58	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	NCAPG	0.02	0.03	lasso	1	0.02	9.0e-04	-11.1	-11.1	1.7e-28	0.88	0.02	0.66	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NCAPG	0.14	0.07	lasso	3	0.07	5.2e-08	-10.9	-10.7	9.9e-27	0.84	0.20	0.79	FALSE
6	GTEx	Breast Mammary Tissue (Male)	DCAF16	0.24	0.03	enet	18	-0.01	4.4e-01	-10.9	10.5	9.1e-26	-0.76	0.04	0.60	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	DCAF16	0.04	0.04	blup	31	0.04	2.2e-05	6.9	10.4	1.5e-25	-0.58	0.28	0.22	FALSE
16	GTEx	Thyroid	DCAF16	0.11	0.02	lasso	5	0.03	2.3e-03	6.9	10.4	1.7e-25	-0.54	0.17	0.70	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	DCAF16	0.04	0.02	bslmm	379	0.01	3.9e-02	-10.9	10.4	1.8e-25	-0.83	0.03	0.89	FALSE
21	The Cancer Genome Atlas	Colon Adenocarcinoma	NCAPG	0.08	0.04	blup	34	0.09	1.1e-05	-11.1	-9.8	9.7e-23	0.84	0.01	0.99	FALSE
5	GTEx	Breast Mammary Tissue	DCAF16	0.12	0.08	lasso	4	0.10	6.4e-06	7.0	9.5	3.1e-21	-0.52	0.13	0.68	FALSE
4	GTEx	Artery Tibial	DCAF16	0.16	0.16	lasso	5	0.13	1.5e-10	8.3	9.3	1.9e-20	-0.36	1.00	0.00	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	NCAPG	0.02	0.02	blup	34	0.02	3.4e-03	-9.9	-9.1	8.4e-20	0.76	0.03	0.51	FALSE
15	GTEx	Stomach	DCAF16	0.21	0.04	lasso	6	0.02	5.6e-02	8.1	9.1	1.3e-19	-0.26	0.19	0.05	FALSE
12	GTEx	Skin Not Sun Exposed Suprapubic	DCAF16	0.16	0.08	lasso	5	0.12	4.4e-07	8.1	8.9	6.7e-19	-0.35	0.64	0.04	FALSE
20	YFS	Blood	DCAF16	0.02	0.02	lasso	1	0.01	1.1e-04	8.3	8.3	9.9e-17	-0.25	0.84	0.04	FALSE
10	GTEx	Nerve Tibial	DCAF16	0.16	0.14	lasso	3	0.14	2.8e-10	6.9	8.0	9.1e-16	-0.37	0.99	0.01	FALSE
13	GTEx	Skin Sun Exposed Lower leg	DCAF16	0.14	0.12	enet	14	0.12	5.4e-10	7.0	7.9	2.6e-15	-0.28	1.00	0.00	FALSE
2	GTEx	Adipose Visceral Omentum	DCAF16	0.19	0.06	enet	10	0.11	3.9e-06	6.9	7.8	5.2e-15	-0.35	0.30	0.45	FALSE
8	GTEx	Esophagus Mucosa	DCAF16	0.10	0.02	lasso	4	0.02	8.3e-03	7.0	7.4	9.8e-14	-0.37	0.13	0.40	FALSE
25	The Cancer Genome Atlas	Lung Adenocarcinoma	NCAPG	0.06	0.02	blup	34	0.04	1.0e-05	-11.1	-7.3	2.9e-13	0.68	0.02	0.84	FALSE
11	GTEx	Pituitary	DCAF16	0.27	0.20	enet	15	0.19	1.3e-05	6.9	7.2	8.6e-13	-0.38	0.07	0.32	FALSE
7	GTEx	Breast Mammary Tissue (Female)	DCAF16	0.16	0.13	lasso	2	0.06	7.8e-03	6.9	7.0	3.2e-12	-0.27	0.06	0.09	FALSE
9	GTEx	Esophagus Muscularis	DCAF16	0.16	0.14	lasso	3	0.14	9.3e-09	6.9	6.8	1.4e-11	-0.27	0.99	0.00	FALSE
1	GTEx	Adipose Subcutaneous	DCAF16	0.21	0.15	lasso	3	0.17	5.1e-14	6.9	6.6	4.0e-11	-0.24	1.00	0.00	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	FAM184B	0.17	0.14	enet	31	0.18	5.1e-23	-4.3	-5.6	2.7e-08	0.26	1.00	0.00	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	MED28	0.02	0.01	bslmm	411	0.00	1.9e-01	-4.1	5.3	1.4e-07	-0.30	0.22	0.03	FALSE