Hub : Genes

FAM184B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1450	0.0280	0.0000	0.246	0.175	0.236	0.229	0.234	1.3e-29	8.4e-21	2.0e-28	1.7e-27	3.9e-28
2	ROSMAP	Brain Pre-frontal Cortex	0.1736	0.0341	0.0000	0.138	0.175	0.184	0.169	0.166	2.5e-17	6.5e-22	5.1e-23	3.3e-21	8.0e-21
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0211	0.0145	0.0037	0.027	0.015	0.019	NA	0.019	4.8e-04	6.7e-03	2.8e-03	NA	2.6e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.2	0.4	0.4	0.6	-0.6	-0.6
Bipolar Disorder or Schizophrenia	1.4	3.4	4.3	2.1	-1.6	-1.9
Depressed Affect (Nagel 2018)	0.1	0.3	0.7	-0.3	0.8	0.3
Depression (Nagel 2018)	0.9	1.3	2.4	-1.6	0.9	0.9
Intelligence (Savage-Jansen 2018)	2.6	8.0	12.0	2.3	-3.5	-2.6
Neuroticism (Nagel 2018)	0.1	0.2	0.7	0.1	0.1	-0.8
Schizophrenia (2018)	1.7	3.6	4.7	2.2	-1.5	-1.9
Schizophrenia vs Biploar Disorder	2.6	3.5	4.4	2.0	-1.4	-2.1
Worry (Nagel 2018)	0.6	1.3	2.4	0.7	-1.1	-1.5
Alzheimer’s Disease (in mother)	1.3	1.5	1.9	-1.3	1.4	0.9
Alzheimer’s Disease (in father)	0.7	0.7	1.2	-1.1	0.9	0.4
Alzheimer’s Disease (including proxy)	1.6	2.4	3.7	-1.6	1.9	1.0
Crohns Disease (2017)	0.4	0.8	1.0	-0.8	1.0	0.9
Irritable Bowel Disease (IBD)	1.5	3.6	4.9	-1.5	2.2	1.9
Ulcerative Colitis (UC)	2.1	4.0	4.5	-1.8	2.1	2.1
Major Depression (MDD)	0.1	0.2	0.5	0.0	-0.1	-0.7
Reaction Time	0.5	1.0	1.1	-1.0	1.0	1.0
Verbal and Numeric Reasoning (VNR)	1.7	4.0	7.4	1.6	-2.7	-1.4
Breast Cancer	0.1	0.1	0.2	0.4	0.2	-0.4
Ovarian Cancer	0.8	1.1	1.3	-1.0	0.9	1.1
Prostate Cancer	0.1	0.1	0.2	-0.1	-0.5	0.3
Age at First Birth	0.3	0.4	0.7	0.2	-0.7	-0.8
Bipolar Disorder (2011)	3.2	3.1	4.8	1.6	-2.2	-1.4
Body Mass Index (BMI) (2010)	0.2	0.2	0.5	0.5	0.1	-0.7
Coronary Artery Disease (CAD)	1.5	1.8	2.1	-1.4	1.4	1.2
Crohns Disease (2012)	1.4	2.2	3.4	-1.5	1.8	1.0
Mean Putamen Volume	0.3	0.3	0.4	-0.6	0.6	0.4
Fasting Glucose	0.8	1.0	1.6	-0.3	1.3	1.1
HbA1C	0.1	0.1	0.1	-0.3	0.1	0.3
HDL Cholesterol	0.1	0.2	0.3	0.4	-0.5	-0.4
LDL Cholesterol	0.1	0.2	0.3	0.4	-0.5	-0.3
Lupus	1.9	2.9	4.1	2.0	-1.7	-1.3
Neuroticism (2016)	0.1	0.2	0.5	-0.3	0.1	-0.7
Primary Biliary Cirrhosis	1.7	2.4	4.0	-1.5	1.0	2.0
Rheumatoid Arthritis	1.0	1.4	1.8	1.3	-1.2	-1.0
Schizophrenia (2014)	2.1	4.7	6.1	2.5	-1.7	-2.2
Triglycerides	0.1	0.2	0.6	-0.0	-0.1	-0.8
Type 2 Diabetes (T2D) (2012)	2.9	3.4	4.7	-1.8	2.2	1.5
Ulcerative Colitis	5.4	7.9	8.9	-2.5	3.0	2.9
Blood Eosinophil Count	0.3	2.0	3.7	1.3	-1.9	-0.8
Blood Platelet Count	6.1	71.2	88.5	-8.0	9.4	7.8
Blood Red Count	0.1	0.6	1.4	0.6	0.2	-1.2
Blood White Count	0.1	0.6	1.6	0.5	1.3	-0.1
Heel T-Score	0.2	1.3	2.2	-0.4	1.5	1.2
BMI	0.1	0.5	0.8	0.9	0.4	-0.7
Height	10.5	201.9	285.6	12.4	-16.9	-12.9
Waist Hip Ratio (WHR)	0.2	1.0	1.4	0.7	-1.0	-1.2
Systolic Blood Pressure	4.4	21.8	23.8	-4.7	4.9	4.4
Smoking Status	0.2	0.5	0.8	-0.7	0.5	0.9
Allergy or Eczema	0.2	0.6	0.9	0.5	-0.8	-1.0
Cardiovascular Disease	1.3	4.3	5.3	-2.3	2.2	1.7
Hypothyroidism (self reported)	2.7	6.1	6.4	2.5	-2.4	-2.5
Respiratory disease	0.0	0.1	0.1	-0.0	-0.4	-0.4
Type 2 Diabetes (T2D) (2018)	0.8	1.6	2.6	-1.4	0.3	1.6
Lung FEV1/FVC ratio	0.4	2.1	4.1	0.4	2.0	1.4
Lung FVC	0.9	4.6	10.3	1.2	-3.2	-1.4
Neuroticism	0.2	0.6	1.1	0.3	-1.0	-0.8
Chronotype (morning person)	1.7	3.8	4.8	2.1	-1.4	-2.2
Hair Pigment	0.1	1.6	3.8	-0.3	2.0	0.9
Tanning	0.0	0.2	0.3	-0.5	0.3	0.6
Hand grip strength (left)	2.1	5.4	11.5	2.0	-3.4	-1.0
Number of treatments/medications taken	1.1	2.0	2.7	-1.7	1.2	1.3
Average weekly spirits intake	0.2	0.2	0.7	0.0	0.9	-0.0
Sensitivity / hurt feelings	0.3	0.5	1.3	-1.1	0.5	-0.2
Frequency of depressed mood in last 2 weeks	0.9	1.3	2.3	-1.5	0.9	0.9
Hearing difficulty/problems: Yes	0.5	0.8	1.8	-0.6	1.3	0.4
Relative age of first facial hair	0.0	0.1	0.1	-0.4	-0.2	-0.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	0.7	0.7	-0.8	-0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.5	-0.6	0.2	0.7
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.3	0.3	-0.5
Systolic blood pressure, automated reading	3.0	8.7	9.7	-3.0	3.1	2.7
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.8	-0.6	1.3	0.3
Angina	0.5	0.7	1.4	-0.7	0.4	1.2
Medication for hormone replacement therapy	2.0	2.2	2.6	-1.6	1.3	1.5
Vitamin and mineral supplements	0.6	0.9	1.1	0.9	-0.9	-1.1
Supplements: Zinc	1.2	1.3	2.1	-1.0	1.4	0.9
Medication: Co-codamol	1.4	1.6	2.1	-1.1	1.2	1.4
Medication: Metformin	0.8	1.1	1.8	-1.0	0.8	1.4
Diabetes (father)	0.7	0.9	2.0	1.4	-0.3	-0.7
Diabetes (mother)	1.4	1.7	3.5	1.9	-1.0	-0.9
Severe depression (siblings)	0.7	0.8	1.2	1.1	-0.8	-0.6
Pack years adult smoking proportion	0.2	0.3	0.4	-0.6	0.6	0.1
Impedance of leg (right)	0.2	1.0	1.1	-1.1	1.0	1.0
Leg fat-free mass (left)	4.3	22.5	30.9	4.2	-5.6	-4.4
Trunk fat percentage	0.0	0.1	0.2	-0.1	0.4	-0.3
Hand grip strength (right)	3.4	9.2	16.0	2.7	-4.0	-2.1
Townsend deprivation index at recruitment	0.6	0.9	1.3	1.0	-0.6	-1.1
Current tobacco smoking	0.3	0.5	0.9	0.7	-0.0	-1.0
Average weekly fortified wine intake	1.2	1.4	1.6	1.2	-1.0	-1.3
Maternal smoking around birth	2.9	4.2	6.0	-1.5	2.1	2.4
Fed-up feelings	1.5	2.7	3.2	-1.7	1.8	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.0	-1.4	0.3	0.6
Relative age voice broke	0.3	0.4	0.6	0.4	-0.8	-0.7
Taking other prescription medications	0.2	0.4	0.6	0.5	-0.8	-0.5
Age when periods started (menarche)	0.2	0.4	1.2	-0.2	-0.0	1.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	0.3	-0.2	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	0.4	-0.1	0.7
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.2	1.1	-0.5	-0.5
Qualifications: CSEs or equivalent	1.3	1.7	2.8	-1.0	1.7	1.1
Serious illness, injury or assault to yourself	0.0	0.0	0.0	0.2	0.2	-0.2
High blood pressure	0.2	0.5	0.7	-0.6	0.8	0.6
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	0.3	-0.6	-0.7
Multivitamins +/- minerals	0.3	0.3	0.6	-0.6	0.1	0.8
Stomach or abdominal pain in last month	1.3	1.6	2.0	-1.2	1.2	1.4
Supplements: Glucosamine	0.1	0.1	0.3	0.0	0.3	0.6
Diverticular disease/diverticulitis (self-reported)	3.5	4.1	5.8	-2.4	0.9	2.4
Medication: Atenolol	0.1	0.1	0.2	0.4	-0.3	0.4
Medication: Levothyroxine sodium	2.6	4.3	6.1	2.5	-1.6	-2.0
Sitting height	4.6	32.4	52.4	4.3	-7.2	-5.1
Chronic bronchitis/emphysema (father)	0.8	0.9	2.0	-0.8	1.4	0.0
High blood pressure (mother)	0.0	0.1	0.2	0.2	0.4	0.1
Body mass index (BMI)	0.0	0.2	0.6	-0.1	0.8	0.1
Impedance of leg (left)	0.2	1.1	1.3	-1.2	0.9	1.1
Leg predicted mass (left)	4.2	22.2	30.6	4.1	-5.5	-4.3
Trunk fat mass	0.6	2.7	3.2	1.3	-1.8	-1.8
Waist circumference	0.4	1.6	1.9	1.0	-1.4	-1.4
Number of incorrect matches in round	0.1	0.1	0.1	0.4	-0.1	-0.3
Past tobacco smoking	1.6	2.9	5.5	1.7	-0.5	-2.3
Alcohol usually taken with meals	0.9	1.5	2.4	-1.5	1.3	0.6
Nervous feelings	0.9	1.6	2.4	-1.6	1.2	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.1	-1.1	0.3	0.8
Hearing difficulty/problems with background noise	1.6	2.6	3.6	-1.9	1.5	1.4
Hair/balding pattern: Pattern 2	0.1	0.2	0.4	-0.6	0.3	0.4
Had menopause	1.2	1.5	2.4	-1.2	1.5	0.7
Had other major operations	0.6	0.7	1.7	-0.3	1.3	0.5
Forced vital capacity (FVC)	3.2	12.3	24.3	2.3	-4.9	-2.7
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.3	0.5	-0.1	-0.0
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.9	0.2	-0.0	-0.9
Qualifications: None of the above	0.2	0.5	0.8	-0.6	0.5	0.9
Financial difficulties in last 2 years	0.9	1.2	2.2	-1.5	0.6	1.0
Mouth/teeth dental problems	1.9	2.9	4.3	-1.9	2.1	0.8
Heart attack	2.0	2.5	3.2	-1.8	1.4	1.6
Allergy	0.0	0.1	0.1	0.4	-0.1	0.0
Pain all over the body in last month	0.4	0.4	0.8	-0.3	0.9	0.5
Diabetes (self-reported)	0.1	0.1	0.3	-0.3	0.1	0.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.9	-0.7	1.0	-0.2
Medication: Ramipril	1.3	1.7	2.3	-1.4	0.8	1.5
Medication: Simvastatin	0.3	0.4	0.5	-0.6	0.7	0.6
Fluid intelligence score	1.2	2.6	3.6	1.3	-1.9	-1.5
Illnesses of siblings	0.9	1.3	1.8	1.1	-1.3	-1.0
Neuroticism score	0.4	0.9	1.3	0.6	-1.0	-1.2
Weight	2.5	12.1	16.4	3.0	-4.0	-3.3
Impedance of arm (right)	0.0	0.1	0.4	-0.2	0.6	0.0
Arm fat percentage (right)	0.2	0.6	1.7	-0.4	1.3	0.2
Trunk fat-free mass	7.0	40.3	61.2	5.3	-7.8	-5.6
Hip circumference	0.7	3.2	4.1	1.5	-2.0	-1.8
Time employed in main current job	0.3	0.3	0.5	0.4	0.7	-0.5
Alcohol intake versus 10 years previously	0.1	0.2	0.3	0.5	-0.5	-0.1
Father’s age at death	0.1	0.1	0.2	-0.4	0.0	0.5
Worrier / anxious feelings	0.2	0.3	0.7	-0.8	-0.3	-0.3
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	4.4	-2.1	1.4	1.5
Falls in the last year	2.6	3.5	4.0	-1.9	2.0	1.7
Hair/balding pattern: Pattern 3	3.4	5.1	6.0	-2.4	2.0	2.3
Number of live births	0.0	0.1	0.2	-0.4	0.1	0.2
Forced expiratory volume in 1-second (FEV1)	2.1	7.1	13.3	2.1	-3.6	-1.9
Pulse rate	1.4	2.4	2.7	-1.7	1.5	1.5
Happiness	0.1	0.2	0.3	-0.1	-0.6	-0.4
Noisy workplace	2.5	3.0	3.7	-1.7	1.9	1.5
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.0	0.3	-1.0	-0.4
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.8	2.6	1.0	-1.6	-1.3
Mouth/teeth dental problems: Dentures	3.3	5.6	7.5	2.7	-2.3	-2.0
Asthma	0.4	0.7	1.5	0.5	-1.2	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.2	-0.4	0.5	0.5
Medication: Cholesterol lowering	3.0	4.7	5.8	-2.2	1.8	2.4
Depression (self-reported)	0.6	0.8	1.1	-1.1	1.0	0.5
Medication: Lansoprazole	0.2	0.3	0.4	-0.7	0.4	0.5
Prospective memory result	1.3	1.5	1.9	-1.0	1.4	1.3
Lung cancer (father)	1.0	1.2	1.8	0.6	-1.4	-1.2
Illnesses of mother	0.1	0.2	0.2	-0.4	-0.3	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.8	9.1	13.9	2.8	-3.7	-2.3
Pulse wave Arterial Stiffness index	5.9	6.9	8.6	-2.9	2.2	2.6
Impedance of arm (left)	0.0	0.2	0.4	-0.4	0.7	0.2
Arm fat mass (right)	0.2	1.0	1.6	0.9	-0.7	-1.3
Trunk predicted mass	6.9	39.2	59.9	5.2	-7.7	-5.5
Standing height	7.8	77.0	118.8	7.2	-10.9	-7.8
Length of working week for main job	0.1	0.1	0.3	-0.3	0.1	0.5
Exposure to tobacco smoke at home	0.4	0.4	1.1	-0.3	-1.1	0.3
Breastfed as a baby	0.2	0.3	0.5	-0.6	0.1	0.7
Tense / ‘highly strung’	1.2	1.9	3.5	0.8	-1.9	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	3.5	-0.5	1.9	0.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	0.7	-0.1	-0.4
Birth weight of first child	4.7	8.6	10.8	2.5	-3.3	-3.0
Peak expiratory flow (PEF)	0.4	0.8	2.3	0.5	-1.5	-0.2
Pulse wave reflection index	1.4	1.8	2.9	-1.7	0.6	1.4
Ever highly irritable/argumentative for 2 days	0.6	0.8	1.4	0.6	-0.8	-1.2
Loud music exposure frequency	0.1	0.1	0.1	0.4	0.4	-0.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.0	0.6	-0.9	-1.4
Mouth/teeth dental problems: Bleeding gums	2.5	3.2	4.0	-1.8	1.6	2.0
Blood clot in the leg (DVT)	0.3	0.4	0.8	0.5	0.9	-0.5
Medication: Paracetamol	0.1	0.1	0.2	-0.4	-0.3	-0.4
Headache pain in last month	1.1	1.9	2.8	1.0	-1.7	-1.4
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	1.8	1.3	-1.1	-1.3
Glaucoma (self-reported)	0.6	0.7	1.0	-0.8	0.8	1.0
Gout (self-reported)	0.5	0.7	1.3	-0.7	-0.4	1.2
Hypothyroidism/myxoedema (self-reported)	3.1	6.0	7.1	2.7	-2.1	-2.5
Medication: Amlodipine	0.1	0.2	0.3	0.4	-0.0	-0.6
Medication: Ventolin 100micrograms inhaler	0.9	1.1	1.4	-1.1	1.2	0.8
Birth weight	6.6	14.3	18.7	3.7	-4.3	-3.2
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	-0.0	0.6	-0.1
High blood pressure (siblings)	1.0	1.4	1.5	-1.2	1.2	1.1
Forced vital capacity (FVC), Best measure	4.0	14.5	25.9	2.9	-5.1	-3.0
Body fat percentage	0.1	0.2	0.6	-0.3	0.8	-0.1
Leg fat percentage (right)	0.3	1.0	2.0	-0.7	1.4	0.7
Arm fat-free mass (right)	5.7	29.2	44.3	4.4	-6.7	-4.9
Exposure to tobacco smoke outside home	0.4	0.6	0.8	-0.9	0.8	0.6
Comparative body size at age 10	0.2	0.6	0.9	0.8	-0.9	-0.5
Number of full brothers	0.0	0.0	0.0	0.0	-0.1	-0.0
Worry too long after embarrassment	0.8	1.3	2.1	0.9	-1.1	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.1	-0.5	0.2	1.1
Wheeze or whistling in the chest in last year	0.0	0.1	0.2	0.2	-0.5	-0.0
Number of children fathered	0.9	1.0	1.4	-1.2	0.6	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	-0.2	-0.3	-0.1
Age at first live birth	1.1	2.0	2.2	1.5	-1.4	-1.3
Pulse wave peak to peak time	8.9	10.5	12.2	3.5	-3.0	-3.2
Health satisfaction	4.0	5.2	8.2	-2.4	2.9	1.4
Shortness of breath walking on level ground	1.1	1.3	2.9	-0.7	1.7	0.6
Qualifications: College or University degree	2.8	8.8	11.6	2.2	-3.4	-3.1
Eye problems/disorders: None of the above	0.0	0.0	0.1	-0.1	-0.2	0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.0	-0.4	-0.5
Emphysema/chronic bronchitis	5.1	5.7	9.1	-2.0	3.0	2.0
Medication for pain relief, constipation, heartburn	0.0	0.0	0.1	0.0	0.3	0.1
Neck or shoulder pain in last month	1.1	1.5	2.5	-1.3	1.6	0.7
Medication: Blood pressure	0.4	0.7	0.9	-0.8	0.9	0.8
Angina (self-reported)	0.4	0.5	1.0	-0.7	0.3	1.0
Migraine (self-reported)	0.2	0.2	0.4	-0.6	-0.3	0.5
Medication: Ibuprofen	0.4	0.5	0.6	-0.6	0.7	0.8
Medication: Allopurinol	0.1	0.2	0.5	-0.1	-0.7	0.3
Medication: Omeprazole	0.1	0.2	0.2	0.5	-0.5	0.1
Medication: Seretide 50 evohaler	0.1	0.1	0.1	0.2	-0.2	0.3
Mean time to correctly identify matches	0.7	1.4	1.8	-1.3	0.9	1.2
Heart disease (mother)	0.2	0.2	0.5	-0.7	0.3	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.2	-1.5	0.2	1.0
Whole body fat mass	0.4	1.8	2.2	1.1	-1.4	-1.5
Leg fat mass (right)	0.1	0.5	0.6	0.6	-0.8	-0.8
Arm predicted mass (right)	5.9	30.0	44.5	4.6	-6.7	-5.0
Pulse rate, automated reading	1.5	4.8	8.6	-1.7	2.9	1.8
Alcohol intake frequency.	0.1	0.3	0.5	0.5	-0.0	-0.7
Comparative height size at age 10	6.3	34.9	54.5	5.0	-7.4	-5.0
Number of full sisters	0.1	0.1	0.2	-0.4	0.2	0.3
Suffer from ‘nerves’	0.6	1.0	1.3	1.0	-0.9	-1.1
Overall health rating	0.3	0.6	1.0	-1.0	0.9	0.2
Chest pain or discomfort	0.1	0.1	0.2	-0.3	0.4	0.3
Had major operations	0.2	0.2	0.4	-0.5	-0.1	0.6
Age at last live birth	0.1	0.2	0.3	0.4	-0.6	-0.4
Family relationship satisfaction	0.2	0.2	0.6	-0.8	-0.1	0.1
Leg pain on walking	0.8	1.0	2.0	-1.0	1.4	0.4
Qualifications: NVQ or HND or HNC or equivalent	3.0	3.7	5.6	-1.3	2.4	1.9
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	0.1	-0.1	0.2
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	3.3	-1.0	1.4	1.8
Medication: Aspirin	0.1	0.1	0.1	-0.2	0.2	0.4
Supplements: Vitamin C	0.6	0.7	1.2	-0.4	1.1	0.9
Knee pain experienced in last month	0.1	0.2	0.3	-0.5	0.3	0.6
Hypertension (Self-reported)	0.3	0.7	1.0	-0.7	1.0	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.3	-0.0	0.5	0.5
Illnesses of father: Heart disease	2.4	3.3	5.0	-1.6	2.2	1.6
Illnesses of siblings: Diabetes	0.6	0.8	2.2	-0.3	1.5	0.1
Smoking status: Previous	3.4	5.1	8.5	-2.4	1.1	2.9
Forced expiratory volume in 1-second (FEV1), predicted	5.0	10.4	19.0	2.8	-4.4	-2.1
Whole body fat-free mass	5.8	33.4	49.6	4.9	-7.0	-5.2
Leg fat-free mass (right)	4.4	23.5	32.9	4.2	-5.7	-4.4
Arm fat percentage (left)	0.2	0.7	1.8	-0.5	1.3	0.2
Average weekly red wine intake	0.1	0.1	0.3	0.1	0.6	0.0
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.8	-0.9	0.5	0.4
Mood swings	0.5	0.9	1.5	1.2	0.1	-1.1
Loneliness, isolation	0.3	0.5	0.7	-0.8	0.8	0.0
Long-standing illness, disability or infirmity	1.4	2.1	2.4	-1.6	1.2	1.6
Ever had bowel cancer screening	0.5	0.6	1.7	-0.0	-1.3	0.3
Diabetes diagnosed by doctor	0.4	0.7	1.0	-0.9	0.5	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.4	0.9	-1.2	-0.7
Friendships satisfaction	0.3	0.3	0.8	-0.9	0.3	-0.2
Qualifications: nursing, teaching	0.1	0.2	0.6	-0.2	0.8	-0.1
Commuting to job workplace: Walk	0.2	0.2	0.3	-0.5	0.4	0.3
Eye problems/disorders: Cataract	2.2	2.5	4.3	-1.5	2.1	1.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.1	-0.3	0.5	1.0
Medication for cholesterol	0.9	1.4	1.7	1.2	-1.3	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.1	0.3	1.0	0.6
Back pain experienced in last month	0.0	0.0	0.0	0.1	0.2	-0.1
Mineral and other dietary supplements	0.3	0.4	1.0	-1.0	0.6	0.1
Breast cancer (self-reported)	0.1	0.1	0.1	-0.2	-0.3	0.4
Asthma (self-reported)	0.7	1.4	2.2	0.8	-1.5	-1.1
Osteoporosis (self-reported)	1.8	2.2	4.4	-2.1	1.2	0.9
Osteoarthritis (self-reported)	0.2	0.2	0.4	0.6	-0.2	-0.5
Medication: Aspirin	0.5	0.6	0.9	-0.8	0.7	0.9
Medication: Gliclazide	0.0	0.0	0.1	-0.3	-0.1	0.2
Illnesses of father: None of the above (group 1)	2.6	3.2	5.8	1.3	-2.4	-1.4
Smoking status: Current	0.2	0.3	0.6	0.6	0.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	0.6	-0.4	-0.1
Whole body water mass	6.0	34.0	50.0	4.9	-7.1	-5.3
Leg predicted mass (right)	4.5	23.9	33.4	4.2	-5.8	-4.5
Arm fat mass (left)	0.2	1.0	1.5	0.9	-0.8	-1.2
Number of self-reported non-cancer illnesses	0.4	0.6	0.9	-1.0	0.8	0.7
Average weekly champagne plus white wine intake	2.7	3.7	4.9	1.4	-2.2	-2.1
Miserableness	0.1	0.3	0.7	0.2	-0.8	-0.2
Guilty feelings	1.6	2.4	3.2	1.4	-1.4	-1.8
Wears glasses or contact lenses	0.3	0.3	0.9	0.4	-0.1	-0.9
Ever taken oral contraceptive pill	1.9	2.1	2.7	-1.6	1.6	1.0
Hearing aid user	0.6	0.7	1.0	0.5	-0.9	-1.0
Mother’s age at death	0.1	0.1	0.2	-0.4	0.1	0.3
Financial situation satisfaction	0.0	0.0	0.0	-0.1	-0.0	-0.0
Tinnitus: Yes, now most or all of the time	2.3	2.6	3.7	-1.6	1.9	1.2
Commuting to job workplace: Public transport	0.1	0.1	0.4	-0.2	0.6	0.1
Eye problems/disorders: Glaucoma	0.6	0.7	1.5	-0.7	0.3	1.2
Medication: Blood pressure	0.1	0.3	0.5	0.7	-0.4	-0.4
Pain type(s) experienced in last month: Hip pain	6.3	7.9	9.4	-2.9	2.4	3.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.6	0.8	-0.7	0.3
High cholesterol (Self-reported)	4.7	8.3	10.2	-3.2	2.7	2.8
Medication: Bendroflumethiazide	0.4	0.6	0.8	-0.8	0.7	0.9
Medication: Paracetamol	0.1	0.2	0.3	-0.5	-0.4	-0.5
Medication: Lisinopril	0.5	0.6	1.7	-0.1	1.3	-0.4
Medication: Atorvastatin	2.5	3.1	4.0	-2.0	1.3	1.9
Illnesses of father: High blood pressure	0.3	0.4	1.1	-0.1	1.1	-0.1
Alcohol drinker status: Never	0.1	0.1	0.1	-0.4	-0.1	-0.4
Ever smoked	0.9	1.5	2.8	-1.3	0.2	1.7
Basal metabolic rate	5.2	28.8	41.7	4.6	-6.5	-4.9
Leg fat percentage (left)	0.3	0.9	1.8	-0.7	1.3	0.7
Arm fat-free mass (left)	5.2	26.5	39.1	4.3	-6.2	-4.7
Number of operations (self-reported)	0.1	0.1	0.2	-0.4	0.3	0.1
Average weekly beer plus cider intake	0.6	0.9	1.6	-0.6	0.9	1.3
Irritability	0.4	0.7	1.3	-1.2	-0.5	0.7
Risk taking	0.1	0.1	0.2	0.4	-0.3	-0.0
Ever had prostate specific antigen (PSA) test	1.7	1.9	3.9	0.8	-2.0	-1.1
Fractured/broken bones in last 5 years	0.2	0.2	0.4	-0.4	-0.6	0.2
Age started oral contraceptive pill	1.5	1.9	2.5	1.3	-1.6	-1.3
Diastolic blood pressure, automated reading	2.4	7.3	10.6	-2.6	3.3	2.2
Ever depressed for a whole week	0.1	0.2	0.3	-0.4	0.5	0.1
Unable to work because of sickness or disability	6.6	8.6	9.8	-2.9	3.1	2.8
Commuting to job workplace: Cycle	1.2	1.5	2.4	0.9	-1.5	-1.1
Myopia	0.4	0.6	1.2	0.8	-0.3	-1.1
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.0	0.6	-1.0	-0.7
Cholesterol lowering medication	0.6	0.8	1.1	-0.9	1.0	0.8
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.2	0.9	-1.1	-0.6
Pain experienced in last month	0.0	0.0	0.0	0.2	0.1	0.2
Supplements: Calcium	4.8	5.3	7.0	-2.2	2.7	2.0
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	0.4	-0.3	-0.2
Heart attack/myocardial infarction (self-reported)	1.4	1.8	2.5	-1.6	1.1	1.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	0.4	0.9	-0.4
Heart disease (siblings)	6.3	7.7	8.1	-2.7	2.8	2.8
Alcohol drinker status: Previous	0.0	0.0	0.0	-0.2	-0.2	0.1
Pack years of smoking	0.7	1.0	1.3	-1.1	1.1	0.7
Impedance of whole body	0.2	0.9	1.1	-0.9	1.1	0.8
Leg fat mass (left)	0.2	0.8	1.0	0.8	-1.0	-0.9
Arm predicted mass (left)	5.3	26.7	40.8	4.3	-6.4	-4.6