Best TWAS P=1.07e-11 · Best GWAS P=5.35e-13 conditioned to 0.000174
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CRIPAK | 0.31 | 0.15 | enet | 34 | 0.26 | 1.2e-31 | -3.10 | -5.3 | 9.9e-08 | 0.04 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Brain Cortex | CRIPAK | 0.34 | 0.10 | lasso | 6 | 0.18 | 9.5e-06 | -4.12 | -5.8 | 7.5e-09 | 0.03 | 0.19 | 0.10 | FALSE |
| 3 | GTEx | Brain Hippocampus | CRIPAK | 0.48 | 0.22 | lasso | 4 | 0.23 | 4.0e-06 | -3.46 | -5.9 | 3.9e-09 | 0.00 | 0.18 | 0.14 | FALSE |
| 4 | GTEx | Brain Putamen basal ganglia | CRIPAK | 0.30 | 0.00 | enet | 25 | 0.10 | 1.9e-03 | -3.03 | -5.1 | 2.9e-07 | 0.11 | 0.06 | 0.10 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Female) | CRIPAK | 0.32 | 0.17 | enet | 29 | 0.26 | 2.7e-08 | -3.05 | -5.6 | 1.8e-08 | 0.01 | 0.53 | 0.03 | FALSE |
| 6 | GTEx | Colon Transverse | TMEM129 | 0.23 | 0.05 | lasso | 4 | 0.03 | 1.8e-02 | -5.18 | 5.8 | 6.6e-09 | 0.51 | 0.09 | 0.09 | FALSE |
| 7 | GTEx | Lung | CRIPAK | 0.61 | 0.22 | enet | 46 | 0.41 | 1.1e-33 | -4.12 | -6.3 | 3.8e-10 | 0.02 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Muscle Skeletal | FGFRL1 | 0.14 | 0.08 | lasso | 4 | 0.06 | 3.7e-06 | -6.67 | 6.1 | 1.1e-09 | 0.01 | 0.00 | 1.00 | TRUE |
| 9 | GTEx | Muscle Skeletal | CRIPAK | 0.25 | 0.11 | enet | 32 | 0.18 | 7.6e-18 | -4.12 | -5.3 | 1.1e-07 | 0.03 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Nerve Tibial | CRIPAK | 0.50 | 0.11 | enet | 76 | 0.38 | 1.1e-28 | -3.46 | -6.2 | 7.8e-10 | -0.08 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Ovary | CRIPAK | 0.43 | 0.27 | enet | 19 | 0.32 | 9.0e-09 | -4.12 | -5.3 | 1.0e-07 | 0.03 | 0.46 | 0.06 | FALSE |
| 12 | GTEx | Whole Blood | CRIPAK | 0.38 | 0.17 | lasso | 9 | 0.28 | 3.4e-26 | -3.46 | -5.2 | 1.5e-07 | 0.02 | 1.00 | 0.00 | FALSE |
| 13 | METSIM | Adipose | CRIPAK | 0.28 | 0.16 | bslmm | 335 | 0.25 | 2.7e-37 | -3.24 | -6.2 | 4.7e-10 | -0.01 | 1.00 | 0.00 | FALSE |
| 14 | METSIM | Adipose | UVSSA | 0.26 | 0.04 | bslmm | 366 | 0.12 | 9.0e-18 | 0.86 | -5.5 | 3.5e-08 | 0.02 | 0.98 | 0.02 | FALSE |
| 15 | NTR | Blood | CRIPAK | 0.13 | 0.09 | enet | 31 | 0.15 | 1.5e-46 | -2.93 | -6.8 | 1.1e-11 | 0.00 | 1.00 | 0.00 | TRUE |
| 16 | NTR | Blood | KIAA1530 | 0.19 | 0.04 | blup | 345 | 0.10 | 9.1e-32 | -3.62 | -6.4 | 2.0e-10 | 0.08 | 1.00 | 0.00 | FALSE |
| 17 | NTR | Blood | SLBP | 0.04 | 0.02 | lasso | 5 | 0.02 | 2.8e-08 | -5.31 | 6.1 | 8.0e-10 | 0.82 | 0.03 | 0.97 | TRUE |
| 18 | NTR | Blood | TACC3 | 0.05 | 0.03 | lasso | 9 | 0.04 | 2.7e-13 | -5.12 | 6.1 | 1.2e-09 | 0.71 | 0.50 | 0.50 | FALSE |
| 19 | YFS | Blood | CRIPAK | 0.35 | 0.27 | bslmm | 301 | 0.33 | 6.0e-112 | -3.46 | -5.4 | 5.7e-08 | -0.03 | 1.00 | 0.00 | FALSE |
| 20 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CRIPAK | 0.22 | 0.11 | blup | 28 | 0.14 | 5.6e-28 | -3.46 | -5.5 | 3.9e-08 | 0.01 | 0.00 | 0.32 | FALSE |