[Hub]/) : Traits : Leg predicted mass (left) :

chr6:124,741,508-127,355,237

Best TWAS P=3.87e-24 · Best GWAS P=1.5e-25 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CENPW 0.04 0.06 lasso 10 0.06 2.4e-07 10.12 -10.1 3.9e-24 -0.99 0.02 0.98 TRUE
2 CommonMind Brain Pre-frontal Cortex HEY2 0.15 0.20 lasso 10 0.21 6.7e-25 -8.46 -8.4 5.1e-17 -0.07 0.01 0.99 FALSE
3 GTEx Artery Coronary TPD52L1 0.31 -0.01 enet 19 0.05 7.0e-03 0.27 -5.9 3.8e-09 -0.15 0.03 0.54 FALSE
4 GTEx Esophagus Muscularis HINT3 0.08 0.00 enet 14 0.00 2.9e-01 8.07 -6.6 3.3e-11 -0.11 0.07 0.04 FALSE
5 GTEx Pancreas HEY2 0.28 0.11 lasso 3 0.10 3.5e-05 -5.96 -6.7 1.6e-11 -0.05 0.09 0.91 FALSE
6 GTEx Testis HEY2 0.31 0.17 lasso 5 0.19 7.4e-09 -8.43 -8.5 2.5e-17 -0.08 0.01 0.99 FALSE
7 GTEx Thyroid HEY2 0.22 0.24 lasso 6 0.23 1.0e-17 -8.43 -8.5 1.6e-17 -0.08 0.00 1.00 TRUE
8 GTEx Vagina CENPW 0.24 -0.01 lasso 8 -0.01 7.9e-01 5.01 5.5 3.1e-08 0.41 0.04 0.07 FALSE
9 METSIM Adipose CENPW 0.02 0.02 blup 189 0.01 8.3e-03 10.38 -7.4 1.1e-13 -0.74 0.02 0.80 FALSE
10 METSIM Adipose HEY2 0.02 0.04 lasso 1 0.02 1.6e-04 -6.10 -6.1 1.1e-09 -0.05 0.02 0.97 FALSE
11 METSIM Adipose NCOA7 0.05 0.05 enet 5 0.05 1.9e-07 6.54 8.1 4.8e-16 0.24 0.95 0.02 FALSE
12 ROSMAP Brain Pre-frontal Cortex HEY2 0.10 0.12 enet 15 0.13 9.8e-17 8.00 -7.7 1.3e-14 -0.06 0.01 0.99 FALSE
13 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CENPW 0.04 0.05 lasso 5 0.05 2.6e-06 10.42 -10.0 1.7e-23 -0.98 0.01 0.98 FALSE
14 The Cancer Genome Atlas Brain Lower Grade Glioma CENPW 0.04 0.06 blup 35 0.05 9.2e-07 10.20 -10.1 4.9e-24 -0.98 0.01 0.99 FALSE
15 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma HEY2 0.09 0.06 lasso 8 0.06 2.3e-03 -5.96 -5.9 4.1e-09 -0.03 0.03 0.76 FALSE
16 The Cancer Genome Atlas Thyroid Carcinoma HEY2 0.03 0.04 lasso 3 0.02 3.8e-03 7.44 -7.7 1.7e-14 -0.07 0.01 0.98 FALSE