[Hub]/) : Traits : Leg predicted mass (left) :

chr10:123,438,113-124,889,817

Best TWAS P=3.88e-14 · Best GWAS P=2.1e-11 conditioned to 0.738

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous PLEKHA1 0.14 0.06 lasso 2 0.03 2.4e-03 6.6 -6.8 1.5e-11 -0.99 0.01 0.98 FALSE
2 GTEx Muscle Skeletal PLEKHA1 0.10 0.04 lasso 3 0.04 8.2e-05 -6.6 -5.8 8.4e-09 -0.68 0.04 0.95 FALSE
3 GTEx Nerve Tibial PLEKHA1 0.22 0.23 enet 17 0.19 1.1e-13 6.6 -6.2 4.5e-10 -0.97 0.01 0.99 FALSE
4 GTEx Skin Sun Exposed Lower leg PLEKHA1 0.16 0.02 lasso 5 0.01 4.0e-02 -6.3 -6.5 6.0e-11 -0.61 0.05 0.90 FALSE
5 METSIM Adipose PLEKHA1 0.05 0.03 lasso 4 0.04 3.6e-07 6.6 -7.6 3.9e-14 -0.86 0.01 0.99 TRUE
6 ROSMAP Brain Pre-frontal Cortex PLEKHA1 0.06 0.05 lasso 4 0.05 1.3e-06 -6.5 -6.5 6.3e-11 -0.77 0.02 0.98 FALSE
7 The Cancer Genome Atlas Brain Lower Grade Glioma PLEKHA1 0.04 0.05 lasso 2 0.04 4.3e-05 6.6 -6.6 3.7e-11 -1.00 0.01 0.99 FALSE
8 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma PLEKHA1 0.08 0.06 blup 103 0.02 4.0e-02 6.6 -5.8 6.7e-09 -0.93 0.01 0.86 FALSE
9 The Cancer Genome Atlas Prostate Adenocarcinoma ARMS2 0.06 0.04 blup 71 0.05 4.9e-06 -6.5 -5.7 1.1e-08 -0.75 0.01 0.99 FALSE
10 The Cancer Genome Atlas Thyroid Carcinoma PLEKHA1 0.08 0.10 lasso 1 0.09 3.5e-09 6.6 -6.6 3.5e-11 -0.99 0.01 0.99 FALSE