[Hub]/) : Traits : Leg predicted mass (left) :

chr12:53,025,391-54,539,005

Best TWAS P=1.56e-11 · Best GWAS P=3.24e-10 conditioned to 0.0687

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous PRR13 0.13 0.10 lasso 7 0.09 9.2e-08 5.2 -5.7 1.0e-08 0.35 0.67 0.33 FALSE
2 GTEx Artery Aorta SP1 0.14 0.14 lasso 8 0.14 2.2e-08 5.0 5.2 1.8e-07 -0.24 0.77 0.23 FALSE
3 GTEx Artery Aorta PRR13 0.23 0.28 enet 39 0.30 4.3e-17 5.2 -5.7 9.6e-09 0.32 0.54 0.46 FALSE
4 GTEx Artery Coronary SP1 0.17 0.12 lasso 4 0.12 8.6e-05 4.9 6.1 1.4e-09 -0.31 0.17 0.58 FALSE
5 GTEx Artery Tibial PRR13 0.15 0.18 enet 21 0.22 5.4e-17 5.2 -5.2 2.5e-07 0.31 0.48 0.52 FALSE
6 GTEx Breast Mammary Tissue SP1 0.12 0.13 lasso 5 0.08 9.5e-05 5.0 5.8 5.0e-09 -0.23 0.72 0.23 FALSE
7 GTEx Esophagus Gastroesophageal Junction PRR13 0.22 0.16 lasso 4 0.18 3.2e-07 5.2 -6.1 7.8e-10 0.29 0.25 0.17 FALSE
8 GTEx Esophagus Muscularis PRR13 0.13 0.15 lasso 2 0.14 9.2e-09 5.2 -5.3 1.1e-07 0.23 0.51 0.48 FALSE
9 GTEx Nerve Tibial PRR13 0.17 0.21 lasso 3 0.20 2.7e-14 5.2 -5.2 2.0e-07 0.22 0.49 0.51 FALSE
10 GTEx Skin Sun Exposed Lower leg PRR13 0.22 0.08 lasso 5 0.17 6.5e-14 4.8 -5.6 2.2e-08 0.30 0.72 0.28 FALSE
11 GTEx Thyroid SP1 0.11 0.05 lasso 7 0.04 8.2e-04 4.9 5.2 2.2e-07 -0.23 0.41 0.47 FALSE
12 GTEx Thyroid PRR13 0.22 0.18 lasso 9 0.24 4.8e-18 4.9 -5.6 2.3e-08 0.31 0.79 0.21 FALSE
13 METSIM Adipose SP7 0.03 0.02 lasso 2 0.01 6.1e-03 5.1 -5.5 2.9e-08 0.15 0.23 0.07 TRUE
14 YFS Blood SP1 0.22 0.17 bslmm 398 0.18 1.4e-56 5.0 5.2 1.9e-07 -0.16 0.53 0.46 FALSE
15 The Cancer Genome Atlas Bladder Urothelial Carcinoma PRR13 0.13 0.04 blup 28 0.07 3.3e-06 4.9 -6.2 6.7e-10 0.58 0.07 0.39 FALSE
16 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PRR13 0.03 0.03 blup 28 0.04 4.6e-05 4.9 -5.5 4.0e-08 0.37 0.39 0.18 FALSE
17 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PRR13 0.05 0.03 blup 28 0.04 4.1e-03 5.2 -6.2 5.0e-10 0.47 0.03 0.13 FALSE
18 The Cancer Genome Atlas Brain Lower Grade Glioma PRR13 0.07 0.04 blup 28 0.05 4.7e-06 5.2 -6.7 1.6e-11 0.60 0.34 0.33 TRUE
19 The Cancer Genome Atlas Rectum Adenocarcinoma PCBP2 0.25 0.04 blup 36 0.10 2.3e-03 -6.3 -6.3 2.9e-10 0.64 0.00 0.54 FALSE
20 The Cancer Genome Atlas Thyroid Carcinoma PCBP2 0.04 0.01 enet 6 0.02 4.8e-03 3.7 -6.4 1.4e-10 0.63 0.01 0.58 FALSE