Best TWAS P=7.21e-09 · Best GWAS P=1.21e-12 conditioned to 8.88e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | RPL9P25 | 0.26 | 0.02 | enet | 27 | 0.07 | 1.3e-04 | -2.4 | -5.6 | 2.1e-08 | 0.05 | 0.72 | 0.03 | TRUE |
| 2 | GTEx | Breast Mammary Tissue | MAP2K5 | 0.14 | 0.07 | lasso | 5 | 0.09 | 2.8e-05 | -5.8 | 5.7 | 1.3e-08 | -0.87 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Heart Atrial Appendage | MAP2K5 | 0.16 | 0.08 | lasso | 5 | 0.16 | 1.3e-07 | -4.4 | 5.3 | 1.1e-07 | -0.76 | 0.39 | 0.60 | FALSE |
| 4 | GTEx | Muscle Skeletal | MAP2K5 | 0.08 | 0.03 | lasso | 6 | 0.05 | 1.9e-05 | 4.5 | 5.8 | 7.2e-09 | -0.69 | 0.24 | 0.76 | TRUE |
| 5 | METSIM | Adipose | MAP2K5 | 0.07 | 0.05 | enet | 19 | 0.06 | 2.8e-09 | -5.7 | 5.3 | 8.9e-08 | -0.84 | 0.11 | 0.89 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MAP2K5 | 0.03 | 0.03 | blup | 142 | 0.02 | 1.6e-03 | -4.6 | 5.2 | 1.6e-07 | -0.90 | 0.05 | 0.93 | FALSE |