[Hub]/) : Traits : Leg predicted mass (left) :

chr16:52,772,129-54,846,383

Best TWAS P=1.38e-41 · Best GWAS P=1.53e-147 conditioned to 4.55e-68

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex AKTIP 0.12 0.09 enet 10 0.08 1.9e-10 6.06 -5.4 6.9e-08 0.07 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex FTO 0.11 0.00 bslmm 739 0.02 1.6e-03 -0.99 12.6 2.3e-36 0.38 0.09 0.55 TRUE
3 CommonMind Brain Pre-frontal Cortex RBL2 0.22 0.24 enet 15 0.26 1.8e-31 6.04 -7.8 4.9e-15 0.02 1.00 0.00 FALSE
4 GTEx Adipose Subcutaneous RBL2 0.34 0.28 enet 18 0.30 1.0e-24 6.10 -7.1 1.1e-12 0.02 1.00 0.00 FALSE
5 GTEx Adipose Visceral Omentum RBL2 0.30 0.27 lasso 2 0.27 4.3e-14 6.10 -6.1 1.1e-09 0.04 1.00 0.00 FALSE
6 GTEx Adrenal Gland RBL2 0.35 0.27 enet 22 0.25 2.3e-09 6.10 -5.8 6.7e-09 0.04 1.00 0.00 FALSE
7 GTEx Artery Aorta RBL2 0.27 0.21 enet 14 0.19 1.5e-10 6.03 -6.2 7.7e-10 0.04 1.00 0.00 FALSE
8 GTEx Artery Coronary RBL2 0.36 0.33 enet 14 0.27 1.4e-09 6.11 -5.9 3.6e-09 0.05 1.00 0.00 FALSE
9 GTEx Artery Tibial RBL2 0.16 0.17 enet 11 0.20 2.1e-15 6.15 -7.7 2.1e-14 0.02 1.00 0.00 FALSE
10 GTEx Brain Cerebellar Hemisphere RBL2 0.55 0.55 enet 20 0.46 2.1e-13 6.10 -6.6 4.7e-11 0.04 1.00 0.00 FALSE
11 GTEx Brain Cerebellum RBL2 0.66 0.72 enet 16 0.70 5.7e-28 6.11 -6.4 1.9e-10 0.05 1.00 0.00 FALSE
12 GTEx Brain Cortex RBL2 0.51 0.45 enet 12 0.46 3.5e-14 5.62 -7.8 7.0e-15 0.02 1.00 0.00 FALSE
13 GTEx Breast Mammary Tissue RBL2 0.36 0.35 lasso 3 0.36 3.0e-19 6.05 -6.0 1.5e-09 0.04 1.00 0.00 FALSE
14 GTEx Breast Mammary Tissue (Male) RBL2 0.40 0.29 lasso 2 0.25 1.4e-06 6.05 -6.1 1.4e-09 0.04 0.60 0.02 FALSE
15 GTEx Breast Mammary Tissue (Female) RBL2 0.47 0.27 lasso 7 0.20 1.1e-06 5.62 -5.8 6.7e-09 0.04 0.97 0.00 FALSE
16 GTEx Colon Sigmoid RBL2 0.38 0.37 lasso 12 0.29 8.4e-11 6.10 -7.1 1.5e-12 0.03 1.00 0.00 FALSE
17 GTEx Colon Transverse RBL2 0.59 0.44 enet 13 0.52 4.4e-28 6.10 -5.8 5.9e-09 0.05 1.00 0.00 FALSE
18 GTEx Esophagus Gastroesophageal Junction RBL2 0.38 0.40 enet 17 0.38 1.1e-14 6.11 -5.9 3.3e-09 0.05 1.00 0.00 FALSE
19 GTEx Esophagus Mucosa RBL2 0.36 0.36 enet 37 0.37 2.9e-26 6.10 -7.1 9.6e-13 0.00 1.00 0.00 FALSE
20 GTEx Esophagus Muscularis RBL2 0.36 0.38 enet 10 0.41 6.8e-27 6.06 -6.0 1.9e-09 0.05 1.00 0.00 FALSE
21 GTEx Heart Atrial Appendage RBL2 0.28 0.14 enet 25 0.23 8.6e-11 6.04 -6.5 1.1e-10 0.03 1.00 0.00 FALSE
22 GTEx Heart Left Ventricle RBL2 0.12 0.11 enet 12 0.08 3.3e-05 6.03 -6.1 1.3e-09 -0.03 0.94 0.01 FALSE
23 GTEx Lung RBL2 0.29 0.37 enet 16 0.35 9.1e-28 6.10 -6.6 3.0e-11 0.03 1.00 0.00 FALSE
24 GTEx Muscle Skeletal RBL2 0.11 0.00 lasso 5 0.00 2.9e-01 8.84 -11.6 5.7e-31 -0.10 0.28 0.23 FALSE
25 GTEx Nerve Tibial RBL2 0.46 0.52 enet 19 0.53 1.6e-43 6.04 -6.6 3.4e-11 0.04 1.00 0.00 FALSE
26 GTEx Pancreas RBL2 0.36 0.36 enet 26 0.36 5.9e-16 6.06 -6.3 2.9e-10 0.08 1.00 0.00 FALSE
27 GTEx Pituitary RBL2 0.36 0.39 lasso 6 0.40 4.5e-11 6.11 6.2 6.9e-10 -0.04 0.98 0.00 FALSE
28 GTEx Prostate RBL2 0.55 0.45 lasso 4 0.45 1.0e-12 6.04 -6.2 6.0e-10 0.04 0.99 0.00 FALSE
29 GTEx Skin Not Sun Exposed Suprapubic RBL2 0.35 0.33 enet 16 0.34 2.6e-19 6.04 -6.7 1.6e-11 0.03 1.00 0.00 FALSE
30 GTEx Skin Sun Exposed Lower leg RBL2 0.35 0.39 enet 25 0.37 2.9e-32 6.04 -6.5 5.6e-11 0.03 1.00 0.00 FALSE
31 GTEx Spleen RBL2 0.59 0.47 enet 51 0.46 3.2e-13 6.11 -7.1 1.0e-12 -0.06 1.00 0.00 FALSE
32 GTEx Stomach RBL2 0.33 0.26 enet 20 0.26 8.7e-13 6.10 -6.3 2.2e-10 0.04 1.00 0.00 FALSE
33 GTEx Testis AKTIP 0.19 0.00 enet 26 0.00 1.9e-01 5.62 13.5 1.4e-41 0.51 0.03 0.40 TRUE
34 GTEx Thyroid RBL2 0.34 0.47 lasso 4 0.45 3.6e-38 6.10 -6.3 3.7e-10 0.04 1.00 0.00 FALSE
35 GTEx Vagina RBL2 0.41 0.37 enet 13 0.34 1.6e-08 6.29 -6.8 1.0e-11 0.03 0.89 0.01 FALSE
36 NTR Blood RBL2 0.09 0.11 bslmm 419 0.11 1.1e-33 6.10 -5.7 1.2e-08 0.06 1.00 0.00 FALSE
37 YFS Blood AKTIP 0.19 0.27 lasso 13 0.30 3.3e-99 9.50 8.5 1.4e-17 -0.01 1.00 0.00 FALSE
38 The Cancer Genome Atlas Esophageal Carcinoma RBL2 0.08 0.04 lasso 3 0.03 4.4e-02 9.50 7.7 1.4e-14 0.00 0.01 0.82 FALSE
39 The Cancer Genome Atlas Glioblastoma Multiforme FTO 0.27 0.16 enet 13 0.14 6.7e-05 -2.27 9.8 1.8e-22 0.33 0.11 0.32 TRUE
40 The Cancer Genome Atlas Brain Lower Grade Glioma AKTIP 0.04 0.03 blup 42 0.05 1.9e-06 6.04 -5.7 1.1e-08 0.04 0.98 0.01 FALSE
41 The Cancer Genome Atlas Brain Lower Grade Glioma RBL2 0.03 0.06 enet 5 0.05 8.2e-07 5.62 -7.0 2.4e-12 0.04 0.83 0.17 FALSE
42 The Cancer Genome Atlas Pancreatic Adenocarcinoma RBL2 0.11 0.08 blup 44 0.06 1.5e-03 8.81 -8.8 1.7e-18 -0.03 0.01 0.78 FALSE
43 The Cancer Genome Atlas Testicular Germ Cell Tumors AKTIP 0.18 -0.01 enet 10 0.08 6.9e-04 -2.44 -5.6 2.5e-08 -0.01 0.01 0.29 TRUE