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chr17:15,149,905-16,908,991

Best TWAS P=9.6e-11 · Best GWAS P=3.46e-09 conditioned to 0.533

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADORA2B	0.06	0.07	blup	304	0.07	5.0e-09	-5.6	-5.9	3.7e-09	0.92	0.06	0.94	FALSE
2	GTEx	Adipose Subcutaneous	ADORA2B	0.16	0.23	lasso	4	0.26	1.7e-21	-4.9	-5.3	1.2e-07	0.98	0.11	0.89	FALSE
3	GTEx	Adipose Visceral Omentum	TTC19	0.11	0.12	lasso	4	0.11	3.0e-06	-5.6	5.6	2.5e-08	-0.92	0.10	0.90	FALSE
4	GTEx	Adipose Visceral Omentum	ADORA2B	0.13	0.16	lasso	3	0.16	1.8e-08	-5.4	-5.4	7.5e-08	0.98	0.07	0.93	FALSE
5	GTEx	Adrenal Gland	TTC19	0.07	0.09	enet	11	0.09	5.0e-04	-5.2	5.5	4.9e-08	-0.92	0.09	0.82	FALSE
6	GTEx	Artery Aorta	TTC19	0.06	0.00	lasso	3	0.00	7.1e-01	-5.6	6.5	9.6e-11	-0.86	0.07	0.40	TRUE
7	GTEx	Artery Aorta	PIGL	0.09	0.03	lasso	5	0.04	1.8e-03	-4.5	-5.7	1.5e-08	0.78	0.09	0.82	FALSE
8	GTEx	Artery Coronary	TTC19	0.19	0.07	enet	2	0.03	3.9e-02	-5.7	5.7	1.1e-08	-0.93	0.07	0.67	FALSE
9	GTEx	Artery Tibial	ADORA2B	0.23	0.42	lasso	3	0.42	1.2e-35	-4.9	-5.1	2.8e-07	0.97	0.40	0.60	FALSE
10	GTEx	Brain Cerebellar Hemisphere	ADORA2B	0.16	0.00	lasso	9	-0.01	5.6e-01	-5.8	-5.4	6.5e-08	0.96	0.04	0.62	FALSE
11	GTEx	Brain Cerebellar Hemisphere	ZSWIM7	0.32	0.26	lasso	5	0.15	9.8e-05	-4.9	5.3	8.8e-08	-0.98	0.06	0.94	FALSE
12	GTEx	Brain Cerebellum	ZSWIM7	0.25	0.13	lasso	4	0.12	2.6e-04	-5.4	5.6	2.1e-08	-0.98	0.06	0.92	FALSE
13	GTEx	Brain Cortex	ZSWIM7	0.16	0.22	lasso	2	0.22	7.5e-07	-5.3	-5.2	1.5e-07	0.95	0.08	0.91	FALSE
14	GTEx	Brain Frontal Cortex BA9	ZSWIM7	0.15	0.21	lasso	3	0.20	6.3e-06	-5.8	-5.6	1.8e-08	0.99	0.05	0.94	FALSE
15	GTEx	Brain Hypothalamus	ZSWIM7	0.13	0.18	lasso	2	0.14	3.8e-04	-5.9	-5.5	4.1e-08	0.99	0.05	0.84	FALSE
16	GTEx	Breast Mammary Tissue	TTC19	0.07	0.05	enet	6	0.05	2.0e-03	-5.6	5.6	2.6e-08	-0.97	0.09	0.87	FALSE
17	GTEx	Breast Mammary Tissue (Male)	TTC19	0.13	0.08	lasso	3	0.01	1.6e-01	-5.8	5.5	4.6e-08	-0.99	0.05	0.69	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	TTC19	0.15	0.05	lasso	4	0.08	1.6e-03	-5.9	5.6	2.1e-08	-0.99	0.04	0.92	FALSE
19	GTEx	Cells Transformed fibroblasts	TTC19	0.13	0.21	lasso	5	0.24	9.6e-18	-5.6	5.6	2.0e-08	-0.94	0.10	0.90	FALSE
20	GTEx	Colon Transverse	TTC19	0.09	0.10	lasso	5	0.11	5.4e-06	-5.6	5.4	5.6e-08	-0.91	0.12	0.88	FALSE
21	GTEx	Esophagus Mucosa	ADORA2B	0.07	0.04	enet	17	0.07	1.9e-05	-5.9	-5.7	1.1e-08	0.86	0.05	0.95	FALSE
22	GTEx	Heart Atrial Appendage	ADORA2B	0.19	0.14	lasso	10	0.13	2.4e-06	-5.9	-5.3	9.9e-08	0.98	0.04	0.96	FALSE
23	GTEx	Heart Left Ventricle	ADORA2B	0.14	0.11	lasso	7	0.10	6.0e-06	-5.9	-5.4	5.6e-08	0.96	0.05	0.95	FALSE
24	GTEx	Heart Left Ventricle	ZSWIM7	0.12	0.22	lasso	2	0.22	4.4e-12	-4.9	-5.1	2.9e-07	0.96	0.14	0.86	FALSE
25	GTEx	Liver	ADORA2B	0.15	0.15	lasso	6	0.10	8.2e-04	-4.9	-5.1	3.1e-07	0.97	0.07	0.82	FALSE
26	GTEx	Lung	TTC19	0.07	0.10	lasso	3	0.10	4.0e-08	-5.7	5.6	2.5e-08	-0.96	0.08	0.92	FALSE
27	GTEx	Lung	ADORA2B	0.19	0.09	lasso	4	0.07	3.2e-06	-4.9	-5.2	2.2e-07	0.96	0.06	0.94	FALSE
28	GTEx	Muscle Skeletal	TTC19	0.03	0.04	lasso	3	0.02	2.9e-03	-5.7	5.2	2.0e-07	-0.87	0.10	0.86	FALSE
29	GTEx	Muscle Skeletal	ADORA2B	0.27	0.44	lasso	3	0.45	5.3e-48	-4.9	-5.3	1.2e-07	0.98	0.70	0.30	FALSE
30	GTEx	Muscle Skeletal	ZSWIM7	0.22	0.42	enet	15	0.42	9.6e-45	-4.9	-5.3	9.2e-08	0.98	0.30	0.70	FALSE
31	GTEx	Nerve Tibial	TTC19	0.09	0.11	lasso	3	0.11	2.3e-08	-5.7	5.4	6.3e-08	-0.89	0.07	0.93	FALSE
32	GTEx	Pancreas	TTC19	0.12	0.09	enet	9	0.07	8.5e-04	-5.3	5.9	3.5e-09	-0.85	0.09	0.75	FALSE
33	GTEx	Pancreas	ADORA2B	0.12	0.16	enet	9	0.14	1.5e-06	-5.8	-5.7	1.5e-08	0.98	0.06	0.94	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	TTC19	0.21	0.18	lasso	5	0.18	6.3e-10	-5.6	5.4	5.6e-08	-0.92	0.10	0.90	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	ADORA2B	0.15	0.13	lasso	3	0.12	3.8e-07	-5.9	-5.9	3.5e-09	1.00	0.04	0.96	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	ZSWIM7	0.17	0.17	lasso	4	0.19	1.1e-10	-5.4	5.5	3.9e-08	-0.98	0.06	0.94	FALSE
37	GTEx	Skin Sun Exposed Lower leg	TTC19	0.08	0.18	lasso	3	0.17	6.9e-14	-5.7	5.6	2.4e-08	-0.94	0.07	0.93	FALSE
38	GTEx	Skin Sun Exposed Lower leg	ADORA2B	0.12	0.17	lasso	4	0.17	3.1e-14	-5.8	-5.7	1.6e-08	0.99	0.04	0.96	FALSE
39	GTEx	Skin Sun Exposed Lower leg	ZSWIM7	0.12	0.08	enet	16	0.10	2.1e-08	-5.4	5.3	1.5e-07	-0.91	0.11	0.89	FALSE
40	GTEx	Spleen	TTC19	0.28	0.06	enet	12	0.03	7.0e-02	-5.7	5.6	2.3e-08	-0.88	0.07	0.78	FALSE
41	GTEx	Spleen	ADORA2B	0.23	0.27	enet	10	0.24	7.4e-07	-5.7	-6.1	1.3e-09	0.96	0.05	0.95	FALSE
42	GTEx	Spleen	ZSWIM7	0.37	0.39	lasso	7	0.40	2.8e-11	-5.6	5.5	4.7e-08	-0.98	0.11	0.89	FALSE
43	GTEx	Stomach	TTC19	0.14	0.12	enet	13	0.09	2.8e-05	-5.6	5.2	2.4e-07	-0.83	0.11	0.88	FALSE
44	GTEx	Whole Blood	ADORA2B	0.08	0.00	lasso	5	0.00	2.5e-01	-4.7	-5.9	3.4e-09	0.84	0.04	0.64	FALSE
45	METSIM	Adipose	ADORA2B	0.10	0.20	lasso	3	0.20	4.2e-29	-5.4	-5.5	3.8e-08	0.98	0.08	0.92	FALSE
46	METSIM	Adipose	TTC19	0.09	0.21	lasso	4	0.21	4.1e-30	-5.6	5.6	1.7e-08	-0.92	0.09	0.91	FALSE
47	NTR	Blood	NCOR1	0.02	0.01	blup	321	0.01	7.2e-04	4.3	-5.2	2.2e-07	0.70	0.32	0.40	FALSE
48	NTR	Blood	ZSWIM7	0.02	0.03	lasso	5	0.03	9.3e-10	-5.2	5.1	3.1e-07	-0.96	0.05	0.95	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	TTC19	0.14	0.24	lasso	10	0.27	1.2e-34	-5.8	-5.2	1.8e-07	0.95	0.03	0.97	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	ADORA2B	0.09	0.11	lasso	5	0.10	5.7e-13	-5.6	-5.4	5.5e-08	0.98	0.05	0.95	FALSE
51	YFS	Blood	NCOR1	0.02	0.04	lasso	5	0.04	2.6e-13	-5.6	-5.2	1.9e-07	0.91	0.09	0.91	FALSE
52	YFS	Blood	PIGL	0.02	0.02	blup	279	0.02	1.5e-06	-3.8	-6.4	1.6e-10	0.88	0.20	0.80	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	PIGL	0.02	0.01	blup	71	0.02	3.5e-04	-4.6	-5.1	2.8e-07	0.90	0.08	0.84	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZSWIM7	0.06	0.10	lasso	2	0.09	1.4e-17	-5.5	-5.5	3.8e-08	0.98	0.04	0.96	FALSE
55	The Cancer Genome Atlas	Colon Adenocarcinoma	ZSWIM7	0.04	0.02	blup	44	0.03	5.0e-03	-5.7	-5.5	3.2e-08	0.99	0.02	0.77	FALSE
56	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TTC19	0.03	0.04	enet	11	0.04	1.0e-05	-5.0	5.4	6.3e-08	-0.90	0.03	0.96	FALSE
57	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TTC19	0.04	0.06	lasso	2	0.06	7.7e-07	-5.2	5.2	1.5e-07	-0.91	0.04	0.96	FALSE
58	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ADORA2B	0.28	0.24	enet	14	0.27	7.3e-16	-4.9	-5.6	2.1e-08	0.94	0.04	0.96	FALSE
59	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TTC19	0.07	0.08	lasso	2	0.07	5.2e-05	-5.3	5.3	1.4e-07	-0.91	0.05	0.91	FALSE
60	The Cancer Genome Atlas	Brain Lower Grade Glioma	NCOR1	0.03	0.04	blup	97	0.04	8.1e-06	-5.6	-5.5	3.2e-08	0.99	0.05	0.94	FALSE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZSWIM7	0.19	0.32	lasso	4	0.32	5.9e-37	-4.9	-5.1	3.0e-07	0.97	0.09	0.91	FALSE
62	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ADORA2B	0.13	0.17	blup	37	0.16	8.2e-08	-5.4	-5.8	7.9e-09	0.95	0.02	0.98	FALSE
63	The Cancer Genome Atlas	Lung Adenocarcinoma	ZSWIM7	0.05	0.05	blup	48	0.05	3.3e-06	-4.9	-5.6	2.2e-08	0.98	0.03	0.97	FALSE
64	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TTC19	0.03	0.03	enet	8	0.03	2.0e-04	-5.5	5.5	3.7e-08	-0.96	0.04	0.95	FALSE
65	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ADORA2B	0.10	0.07	enet	9	0.08	5.0e-06	-5.6	-5.7	1.1e-08	0.94	0.01	0.98	FALSE
66	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TTC19	0.10	0.11	lasso	1	0.09	9.6e-05	-5.4	5.4	5.3e-08	-0.98	0.04	0.95	FALSE
67	The Cancer Genome Atlas	Prostate Adenocarcinoma	ADORA2B	0.14	0.19	lasso	3	0.20	8.0e-21	-4.9	-5.2	2.0e-07	0.96	0.04	0.96	FALSE
68	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZSWIM7	0.15	0.25	enet	13	0.26	2.0e-27	-5.4	-5.5	3.1e-08	0.99	0.03	0.97	FALSE
69	The Cancer Genome Atlas	Skin Cutaneous Melanoma	ZSWIM7	0.27	0.26	blup	44	0.30	1.2e-08	-5.5	-5.1	3.0e-07	0.96	0.03	0.97	FALSE
70	The Cancer Genome Atlas	Thyroid Carcinoma	ADORA2B	0.12	0.23	lasso	7	0.24	1.5e-23	-4.9	-5.2	1.6e-07	0.97	0.02	0.97	FALSE
71	The Cancer Genome Atlas	Thyroid Carcinoma	TTC19	0.16	0.21	lasso	5	0.20	1.4e-19	-5.7	5.7	1.4e-08	-0.92	0.03	0.97	FALSE