Best TWAS P=2.53e-10 · Best GWAS P=4.1e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PIP4K2B | 0.15 | 0.07 | lasso | 5 | 0.07 | 2.2e-06 | -6.2 | -5.8 | 5.2e-09 | 0.92 | 0 | 1.00 | FALSE |
| 2 | GTEx | Artery Aorta | PSMB3 | 0.23 | 0.17 | enet | 26 | 0.22 | 2.1e-12 | -6.2 | -5.8 | 5.8e-09 | 0.83 | 0 | 1.00 | FALSE |
| 3 | GTEx | Artery Tibial | PSMB3 | 0.10 | 0.02 | enet | 12 | 0.03 | 1.2e-03 | -6.2 | -5.8 | 7.6e-09 | 0.73 | 0 | 0.99 | FALSE |
| 4 | GTEx | Testis | PSMB3 | 0.30 | 0.24 | lasso | 4 | 0.21 | 8.9e-10 | -6.2 | -6.3 | 2.5e-10 | 0.97 | 0 | 1.00 | TRUE |
| 5 | NTR | Blood | PIP4K2B | 0.02 | 0.01 | lasso | 3 | 0.01 | 6.4e-04 | -6.2 | 6.2 | 5.2e-10 | -0.94 | 0 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PIP4K2B | 0.05 | 0.04 | blup | 56 | 0.05 | 5.3e-06 | -4.4 | -5.5 | 3.3e-08 | 0.85 | 0 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PSMB3 | 0.12 | 0.09 | lasso | 3 | 0.06 | 3.0e-03 | -6.2 | -6.3 | 3.3e-10 | 0.99 | 0 | 0.94 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | PSMB3 | 0.05 | 0.06 | lasso | 1 | 0.05 | 2.4e-05 | -6.2 | -6.2 | 4.2e-10 | 0.97 | 0 | 1.00 | FALSE |