Hub : Genes

PIP4K2B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1490	0.0540	5.0e-03	0.072	NA	0.044	NA	0.070	1.7e-06	NA	1.7e-04	NA	2.1e-06
2	GTEx	Artery Aorta	0.3130	0.0840	4.7e-04	0.032	NA	0.103	NA	0.103	7.3e-03	NA	2.6e-06	NA	2.8e-06
3	GTEx	Artery Tibial	0.3737	0.0633	7.9e-09	0.163	NA	0.223	NA	0.167	8.7e-13	NA	2.0e-17	NA	4.7e-13
4	GTEx	Cells Transformed fibroblasts	0.1840	0.0640	6.2e-03	0.082	NA	0.026	NA	0.051	9.4e-07	NA	4.6e-03	NA	1.1e-04
5	GTEx	Lung	0.1604	0.0567	2.4e-03	0.066	NA	0.030	NA	0.050	8.3e-06	NA	2.2e-03	NA	1.1e-04
6	GTEx	Testis	0.2190	0.0860	7.2e-03	0.003	NA	0.029	NA	-0.005	2.2e-01	NA	1.9e-02	NA	6.3e-01
7	METSIM	Adipose	0.0637	0.0227	2.8e-04	0.006	0.019	0.011	0.015	0.014	3.4e-02	7.0e-04	7.1e-03	0.0024	2.6e-03
8	NTR	Blood	0.0217	0.0093	6.7e-03	0.007	0.007	0.007	0.007	0.009	1.4e-03	1.8e-03	2.2e-03	0.0018	6.4e-04
9	YFS	Blood	0.0263	0.0115	2.8e-03	0.002	0.003	0.002	0.005	0.001	6.0e-02	2.7e-02	4.4e-02	0.0065	1.6e-01
10	TCGA	Bladder Urothelial Carcinoma	0.0660	0.0320	1.1e-03	0.010	0.040	0.039	NA	0.023	4.3e-02	2.5e-04	2.9e-04	NA	4.1e-03
11	TCGA	Head and Neck Squamous Cell Carcinoma	0.0393	0.0211	2.8e-03	0.013	0.026	0.015	NA	0.014	1.3e-02	6.3e-04	6.7e-03	NA	9.3e-03
12	TCGA	Kidney Renal Clear Cell Carcinoma	0.0681	0.0334	6.2e-03	0.006	0.013	0.017	NA	0.009	6.3e-02	1.2e-02	4.3e-03	NA	3.1e-02
13	TCGA	Prostate Adenocarcinoma	0.0502	0.0219	8.1e-05	0.041	0.050	0.047	NA	0.032	3.5e-05	5.3e-06	1.1e-05	NA	2.4e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.4	0.6	2.2	-0.5	0.8	-0.8	-0.4	-0.1	-1.5	0.4	1.1	0.0	1.4	0.1	0.2	0.1
Bipolar Disorder or Schizophrenia	0.4	1.0	2.2	-1.4	-0.7	-1.5	-1.3	-0.7	0.6	0.6	1.5	1.3	-0.6	-0.2	-0.6	-0.0
Depressed Affect (Nagel 2018)	0.5	1.2	3.8	-1.0	-0.3	-0.2	-1.4	-1.3	-0.8	-0.7	0.8	1.4	-0.5	-1.9	0.5	-1.4
Depression (Nagel 2018)	1.0	1.5	3.4	-1.6	-1.4	-0.8	-1.9	-1.8	-0.2	0.1	1.4	1.0	1.0	-1.3	-0.9	-1.3
Intelligence (Savage-Jansen 2018)	0.4	1.3	3.8	-0.2	-0.9	-2.0	-1.1	-0.8	-0.0	1.2	0.0	-1.2	1.6	0.8	-1.9	0.3
Neuroticism (Nagel 2018)	1.5	3.5	8.0	-2.2	-1.1	-1.6	-2.2	-2.5	-0.5	-2.4	1.6	1.6	-0.2	-2.8	-0.0	-2.5
Schizophrenia (2018)	0.8	1.7	3.7	-1.4	-1.8	-1.3	-1.3	-1.2	1.9	0.5	1.0	1.6	-1.9	-0.3	-0.8	-0.0
Schizophrenia vs Biploar Disorder	0.7	0.9	4.4	-1.0	-1.1	-0.6	-0.2	-0.7	1.5	0.7	0.7	0.5	-2.1	0.6	-0.2	0.1
Worry (Nagel 2018)	0.9	1.8	3.9	-1.6	-1.0	-1.6	-1.2	-1.4	0.5	-1.7	0.9	1.7	0.3	-2.0	-0.0	-1.7
Alzheimer’s Disease (in mother)	0.5	0.6	2.3	-0.2	0.8	-0.5	-0.2	0.3	-0.5	-1.3	0.4	-1.4	-1.5	-0.6	0.2	-0.3
Alzheimer’s Disease (in father)	1.3	1.5	4.6	-0.1	0.6	0.1	1.7	1.8	1.2	-1.7	0.4	2.1	-0.8	-1.6	0.0	-0.6
Alzheimer’s Disease (including proxy)	1.1	1.6	6.4	-0.6	1.0	-0.8	0.9	1.4	1.2	-2.5	1.0	0.3	-1.9	-1.5	-0.4	-0.9
Crohns Disease (2017)	0.3	0.8	2.0	0.8	-0.1	0.5	-0.7	-0.6	-1.0	0.7	-1.4	-1.3	1.3	0.9	-0.0	0.4
Irritable Bowel Disease (IBD)	0.5	1.2	3.3	1.2	0.3	0.7	-0.6	-0.5	-1.4	1.8	-1.5	-0.4	1.6	0.9	0.5	1.0
Ulcerative Colitis (UC)	0.7	1.2	5.1	1.1	0.7	1.1	-0.2	-0.1	-1.3	2.3	-1.1	0.4	1.5	0.9	0.6	1.3
Major Depression (MDD)	1.0	1.2	5.2	-1.9	-0.7	-1.6	-0.1	-0.3	0.4	0.0	2.3	1.1	-0.5	-1.0	-0.4	-1.2
Reaction Time	0.6	1.1	4.2	1.2	1.9	1.0	0.1	0.2	-0.6	0.2	-1.3	-2.1	-0.3	0.8	0.1	1.1
Verbal and Numeric Reasoning (VNR)	0.8	2.0	9.2	1.2	-0.3	0.1	-0.7	-0.5	-1.3	2.3	-1.1	-1.1	3.0	1.7	-0.7	1.0
Breast Cancer	0.3	0.7	1.7	-0.9	-1.2	-0.7	0.1	-0.5	0.7	-0.4	1.1	0.4	-0.2	-1.3	-0.9	-1.2
Ovarian Cancer	0.3	0.4	2.0	-0.1	-0.3	0.5	-0.7	-0.8	-1.4	0.2	-0.0	1.1	-0.1	-0.5	0.7	-0.2
Prostate Cancer	0.6	0.8	2.8	-0.8	-0.4	-0.3	-1.7	-1.5	-0.8	-0.6	0.4	-0.4	0.3	-1.5	-0.1	-1.1
Age at First Birth	0.4	0.6	2.9	-0.1	1.2	0.2	0.4	0.7	-0.4	-0.7	0.1	-1.2	-1.7	0.2	0.7	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.2	1.3	0.4	1.1	-0.1	0.1	0.1	-0.4	-0.1	-0.3	-0.4	0.5	0.1	0.4	0.2
Coronary Artery Disease (CAD)	1.8	2.1	7.7	1.4	1.9	1.2	-0.2	0.7	-1.7	2.8	-1.2	1.6	0.3	0.9	1.2	1.7
Crohns Disease (2012)	1.4	2.2	6.6	1.4	-1.1	1.2	-0.7	-0.9	-1.5	2.6	-1.8	-1.5	2.2	1.5	-0.1	1.0
Mean Putamen Volume	1.0	1.2	4.6	0.2	1.7	0.3	0.9	1.6	-0.4	0.3	1.1	2.2	-1.0	-0.4	1.3	-0.0
Fasting Glucose	0.7	0.8	4.0	-0.1	-0.7	-0.4	-2.0	-1.7	-1.1	-0.8	-0.7	0.6	0.7	-0.3	0.2	-0.1
HbA1C	0.8	0.9	4.0	1.1	0.4	0.6	0.3	0.1	-0.6	-1.3	-1.5	-0.2	2.0	0.4	-1.2	0.5
HDL Cholesterol	0.9	1.5	7.8	0.5	-0.1	0.5	-1.0	-1.3	-1.5	-0.5	-1.7	-2.8	0.3	0.8	-1.1	0.6
LDL Cholesterol	0.1	0.2	0.7	0.1	-0.7	0.1	-0.3	-0.4	0.2	0.7	-0.5	0.2	-0.8	0.3	-0.6	0.2
Lupus	4.0	6.0	14.6	-3.4	-2.4	-2.7	-1.4	-1.6	1.3	-2.6	2.7	-0.1	-2.2	-3.2	-1.9	-3.8
Neuroticism (2016)	1.8	2.7	8.3	-2.2	-1.1	-1.2	-1.4	-1.4	-0.4	-1.6	2.1	1.8	-0.7	-2.9	-0.3	-1.9
Primary Biliary Cirrhosis	1.9	2.7	5.2	1.7	0.5	1.6	-0.3	-0.4	-1.8	2.3	-1.8	-2.3	0.5	2.0	2.1	1.7
Rheumatoid Arthritis	1.4	2.0	5.9	1.7	0.6	1.0	1.7	1.3	0.5	1.6	-1.8	-2.4	0.2	1.6	-0.5	1.4
Schizophrenia (2014)	0.4	0.8	1.7	-0.5	-1.0	-0.4	-1.1	-1.2	1.1	1.2	-0.2	0.9	-1.3	0.7	-0.5	0.7
Triglycerides	0.2	0.3	0.8	0.2	-0.2	0.6	-0.8	-0.4	-0.3	0.8	-0.6	0.1	0.7	0.6	0.9	-0.1
Type 2 Diabetes (T2D) (2012)	2.7	3.1	7.8	1.7	2.8	0.7	2.3	2.5	-0.1	1.4	-0.7	0.8	1.8	1.8	1.7	2.2
Ulcerative Colitis	1.6	2.3	5.1	1.6	1.0	1.3	-0.2	0.2	-2.3	2.2	-1.8	0.9	1.4	1.0	2.1	1.7
Blood Eosinophil Count	0.3	2.3	9.7	1.5	1.2	0.8	3.1	1.9	2.1	-1.6	-1.3	-1.2	0.4	0.6	0.1	1.1
Blood Platelet Count	0.2	2.2	5.9	0.4	-2.0	-0.8	0.6	-0.5	0.2	2.3	-1.3	-2.1	1.4	1.6	-2.4	0.6
Blood Red Count	0.2	1.8	14.4	0.2	1.0	1.6	-0.7	-0.3	-1.6	0.6	0.7	3.8	-0.0	0.8	-0.6	0.7
Blood White Count	0.1	0.8	3.3	0.7	1.4	-0.8	-0.0	-0.2	0.2	-0.4	-1.6	-0.0	-1.8	0.7	0.6	0.7
Heel T-Score	3.6	28.8	62.4	7.7	3.7	6.3	1.6	1.7	-3.0	5.2	-7.2	-4.2	4.3	7.9	3.6	7.4
BMI	0.2	1.2	4.0	0.8	2.0	1.3	1.2	1.3	-0.5	0.7	0.0	0.8	-2.0	-0.4	1.0	0.5
Height	5.1	98.6	201.6	-14.2	-8.0	-12.3	-1.6	-2.2	8.8	-8.9	14.0	3.5	-6.8	-12.0	-10.3	-14.0
Waist Hip Ratio (WHR)	3.4	15.1	30.5	5.5	3.0	5.1	2.1	1.3	-1.7	4.1	-5.2	-0.1	3.4	5.4	3.8	4.7
Systolic Blood Pressure	1.0	5.1	16.6	2.4	3.7	2.1	-0.1	0.8	-1.9	1.1	-1.6	2.1	-2.6	1.3	4.1	2.2
Smoking Status	0.2	0.4	1.0	0.1	0.7	-0.1	0.9	0.5	0.6	0.0	0.6	0.5	-0.9	0.3	-1.0	-0.4
Allergy or Eczema	0.5	1.3	4.0	1.0	0.0	1.2	0.5	-0.3	-0.5	1.6	-0.6	1.8	2.0	0.9	0.9	1.3
Cardiovascular Disease	2.0	6.6	18.6	2.7	4.3	2.5	0.8	1.6	-3.3	2.6	-1.8	2.0	-1.3	1.1	4.0	2.7
Hypothyroidism (self reported)	0.6	1.5	4.6	-0.4	-1.2	-1.5	-1.0	-1.7	1.2	-1.2	-0.1	-0.5	0.0	-0.9	-2.1	-1.6
Respiratory disease	1.6	3.6	8.4	-1.9	-0.8	-1.5	-1.7	-1.8	-0.2	-2.3	1.8	2.7	-2.4	-2.9	-0.4	-1.9
Type 2 Diabetes (T2D) (2018)	1.7	3.1	7.3	2.2	2.7	1.3	1.9	2.2	-1.8	0.7	-1.2	0.7	-0.7	1.8	2.1	2.1
Lung FEV1/FVC ratio	5.6	28.3	80.1	7.3	4.7	6.1	2.6	2.7	-2.9	5.2	-6.7	-5.7	1.1	8.9	2.6	6.5
Lung FVC	0.7	3.3	14.8	-1.8	-3.9	-2.5	-0.6	-1.0	1.8	-0.8	0.9	-2.5	0.7	-0.1	-1.6	-1.7
Neuroticism	2.0	4.8	12.5	-2.5	-1.1	-1.7	-1.9	-2.1	0.9	-2.8	2.1	2.6	-1.4	-3.5	0.6	-3.0
Chronotype (morning person)	0.7	1.5	4.3	-0.9	2.0	-1.7	-0.7	0.2	-0.4	-0.2	1.4	1.0	-2.1	-0.9	1.7	-0.8
Hair Pigment	0.3	7.2	15.5	3.3	1.9	2.8	0.4	0.6	-1.9	1.9	-3.9	-3.7	0.8	3.9	2.8	3.1
Tanning	0.0	0.2	0.6	-0.2	0.2	-0.3	0.8	0.5	0.7	-0.1	0.2	0.0	-0.6	0.4	0.2	0.2
Hand grip strength (left)	10.2	26.9	56.0	-7.3	-4.3	-7.5	-1.8	-1.3	2.8	-5.6	7.2	1.2	-5.0	-5.8	-3.1	-7.4
Number of treatments/medications taken	0.4	0.7	1.7	-0.2	1.2	-0.3	0.4	0.6	-0.2	-1.1	0.8	1.3	-1.3	-1.2	0.2	-0.3
Average weekly spirits intake	1.1	1.4	4.0	-0.9	-1.5	-0.6	-1.7	-2.0	-0.7	-0.8	0.1	0.4	0.6	-1.6	-0.9	-1.6
Sensitivity / hurt feelings	2.0	3.4	9.4	-2.4	-0.6	-1.9	-0.7	-0.9	1.3	-2.6	2.4	1.1	-1.4	-3.1	-0.3	-2.6
Frequency of depressed mood in last 2 weeks	1.9	2.7	5.0	-2.2	-1.8	-1.3	-1.5	-1.8	1.0	1.1	2.1	1.5	0.2	-2.1	-1.9	-2.0
Hearing difficulty/problems: Yes	0.9	1.3	3.4	-1.1	0.1	-0.7	-1.7	-1.8	0.4	-1.6	0.5	1.8	-0.0	-1.4	-0.7	-0.9
Relative age of first facial hair	0.9	1.8	6.4	2.1	0.7	1.3	0.2	0.4	-2.5	0.8	-1.8	-0.5	1.0	1.2	1.2	1.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	2.2	-0.1	0.2	0.9	0.1	0.0	0.8	-0.6	-0.1	0.4	-0.4	-0.3	1.5	-0.1
Ever used hormone-replacement therapy (HRT)	1.2	1.6	4.8	0.0	1.2	-0.7	2.2	1.9	1.3	-0.6	0.4	2.0	-1.8	-0.5	0.1	-0.1
Ever had hysterectomy (womb removed)	0.7	0.8	3.0	0.2	-1.7	-0.4	0.8	-0.2	1.6	-0.6	-0.7	0.0	0.4	0.1	-1.5	-0.5
Systolic blood pressure, automated reading	0.9	2.5	6.3	2.0	2.4	1.6	1.2	1.6	-0.8	0.2	-1.4	-0.3	-1.4	1.3	2.5	1.9
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.9	0.7	0.4	0.4	1.7	1.7	0.1	0.7	-0.4	1.0	0.7	0.6	0.2	1.0
Angina	1.6	2.1	4.6	-2.0	-1.1	-0.0	-1.2	-1.0	1.3	-1.8	2.2	2.1	0.3	-1.8	0.3	-1.6
Medication for hormone replacement therapy	1.9	2.1	6.7	-1.3	-1.9	-2.6	0.1	-0.9	0.8	-2.0	0.8	0.2	0.4	-1.1	-2.2	-1.8
Vitamin and mineral supplements	1.0	1.4	6.9	0.4	0.1	0.7	-2.6	-1.9	-1.7	-0.2	-0.9	-1.2	0.4	0.5	0.9	-0.1
Supplements: Zinc	0.8	0.8	3.1	-0.3	0.4	0.6	1.0	0.9	0.4	1.8	0.6	1.5	-0.9	0.4	1.1	0.7
Medication: Co-codamol	0.9	1.1	3.5	-0.0	0.3	1.9	1.3	1.0	0.8	1.4	-0.2	1.5	-1.4	0.2	-0.9	-0.1
Medication: Metformin	1.5	2.1	6.0	1.9	2.5	0.1	1.2	1.6	-2.1	-0.4	-1.5	0.4	-0.4	1.3	1.7	1.5
Diabetes (father)	0.5	0.6	3.4	-0.6	-0.3	-1.8	-0.7	-0.1	0.3	-0.1	0.5	0.1	-1.4	-0.2	1.0	0.0
Diabetes (mother)	0.3	0.4	1.0	-0.1	-0.7	-0.5	0.7	0.9	0.8	-0.0	0.5	0.3	-1.0	-0.2	0.6	-0.4
Severe depression (siblings)	1.1	1.3	4.8	-0.5	0.1	-0.7	-0.5	-1.1	-0.9	-1.8	0.5	2.2	-0.1	-1.8	-0.3	-1.4
Pack years adult smoking proportion	0.6	0.9	2.6	-0.3	-1.0	-0.1	-1.2	-1.2	-1.3	1.5	0.6	1.6	-0.4	-0.7	-0.6	-0.4
Impedance of leg (right)	1.0	4.7	10.5	3.0	2.9	2.2	0.9	1.1	-0.2	-0.4	-3.1	-0.2	2.5	3.2	1.5	2.8
Leg fat-free mass (left)	2.9	15.4	38.4	-5.8	-3.2	-4.5	-0.8	-1.1	2.6	-2.3	6.2	2.5	-3.3	-5.2	-3.0	-5.6
Trunk fat percentage	0.2	0.9	4.0	0.3	1.8	2.0	-0.8	-0.4	-0.5	-0.6	-0.2	0.7	-1.4	-0.4	0.5	-0.1
Hand grip strength (right)	9.9	26.8	70.4	-7.3	-4.8	-8.4	-1.9	-1.7	3.5	-4.6	7.1	0.7	-4.3	-4.8	-4.3	-7.1
Townsend deprivation index at recruitment	0.7	1.0	3.3	0.3	1.3	1.2	0.1	0.5	-1.4	0.3	0.5	1.8	-1.4	-0.6	1.2	0.5
Current tobacco smoking	0.4	0.6	2.0	0.2	1.1	0.6	0.9	0.8	-0.2	0.8	0.8	0.9	-0.9	0.2	-1.4	0.2
Average weekly fortified wine intake	0.5	0.6	2.2	0.7	-0.5	0.8	-0.8	-0.9	-0.3	1.5	-0.5	0.3	0.5	0.6	1.2	0.5
Maternal smoking around birth	2.4	3.5	12.0	-1.9	-1.9	-1.7	-1.8	-2.0	-1.6	0.3	2.4	3.5	-0.7	-1.9	0.8	-1.9
Fed-up feelings	1.1	2.1	5.3	-1.9	-0.5	-0.4	-1.4	-1.6	-0.2	-1.1	1.5	1.7	-1.8	-2.3	0.6	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.2	5.2	-1.5	-1.5	-0.8	-2.0	-2.3	-0.9	-0.6	1.2	1.8	0.1	-2.3	0.1	-1.8
Relative age voice broke	0.6	0.9	3.4	-0.1	-0.0	-0.6	-1.6	-1.5	-1.1	-1.8	0.1	-0.1	0.0	-0.5	0.8	-0.7
Taking other prescription medications	0.7	1.0	2.7	-0.9	-0.1	-1.0	-0.7	-0.4	0.8	-1.1	0.9	1.6	-1.6	-1.4	-0.2	-1.0
Age when periods started (menarche)	0.2	0.4	1.5	-0.3	-0.8	-1.2	0.5	0.8	0.7	0.1	0.5	-0.5	-0.7	1.0	-0.1	-0.5
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.4	0.7	0.9	0.3	1.5	1.6	0.8	1.2	-0.2	1.3	-0.5	1.0	0.9	1.0
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	8.4	2.5	0.7	2.3	0.9	0.3	-0.8	1.0	-1.9	-2.1	1.4	2.9	2.1	2.5
Tinnitus: Yes, but not now, but have in the past	2.1	2.3	4.9	1.8	0.4	0.7	1.6	2.0	0.6	1.6	-1.3	-0.5	1.6	1.8	1.9	2.2
Qualifications: CSEs or equivalent	0.5	0.6	2.1	-0.5	0.4	-0.0	-0.6	-0.1	-0.2	0.8	0.5	1.3	-1.4	-1.3	1.1	-0.5
Serious illness, injury or assault to yourself	0.8	0.9	3.1	1.0	1.8	1.4	0.4	0.4	-0.7	1.0	-0.8	0.9	-0.4	0.5	1.4	0.8
High blood pressure	1.5	4.1	13.4	1.8	3.7	1.8	0.1	1.0	-2.9	1.8	-1.1	0.8	-1.5	0.6	3.6	1.8
Hayfever, allergic rhinitis or eczema	0.6	1.3	4.5	0.8	0.4	0.9	0.9	0.2	-0.6	2.1	-0.2	1.9	1.6	1.0	0.3	1.5
Multivitamins +/- minerals	0.8	1.0	3.9	-0.6	0.2	-0.5	1.9	1.4	0.3	0.2	1.0	2.0	-0.4	-1.0	0.3	0.1
Stomach or abdominal pain in last month	0.9	1.1	3.3	-0.7	-1.8	-0.1	-1.0	-1.3	-1.4	0.5	0.8	0.8	1.3	-1.6	-0.1	-0.9
Supplements: Glucosamine	3.1	4.0	11.3	2.6	1.9	2.3	1.3	1.2	0.1	3.4	-2.9	-0.9	1.6	2.1	0.5	2.2
Diverticular disease/diverticulitis (self-reported)	4.4	5.2	12.3	-2.7	-1.1	-2.4	-0.3	-0.8	2.2	-3.5	2.7	1.3	-2.2	-2.2	-2.8	-3.0
Medication: Atenolol	1.0	1.3	4.2	-0.6	0.0	0.4	-1.9	-1.5	-2.0	0.7	0.5	1.2	0.3	-1.4	1.4	-0.4
Medication: Levothyroxine sodium	0.4	0.6	2.4	0.2	-0.6	-0.7	-1.5	-1.5	0.2	-0.6	-0.5	-0.8	0.7	-0.3	-0.8	-0.5
Sitting height	5.7	40.6	84.1	-9.1	-5.9	-8.8	-1.8	-2.3	4.7	-5.5	9.2	2.8	-2.9	-6.8	-6.4	-9.1
Chronic bronchitis/emphysema (father)	1.0	1.2	3.4	-1.0	-0.1	-0.4	0.3	0.2	1.1	-1.4	1.5	1.3	-1.9	-1.3	0.2	-1.1
High blood pressure (mother)	0.6	0.9	1.9	1.4	1.3	0.8	0.8	1.0	0.1	-0.2	-1.4	-0.1	1.1	0.6	0.9	1.1
Body mass index (BMI)	0.2	0.9	3.1	0.5	1.4	1.8	0.2	0.5	-0.9	0.9	-0.1	0.6	-1.6	-0.1	1.3	0.5
Impedance of leg (left)	1.2	5.6	14.1	3.5	2.6	2.6	0.4	0.6	-0.5	0.2	-3.7	-1.2	2.2	3.8	1.4	3.1
Leg predicted mass (left)	2.9	15.3	38.6	-5.8	-3.2	-4.5	-0.7	-1.1	2.7	-2.2	6.2	2.5	-3.3	-5.1	-3.0	-5.5
Trunk fat mass	0.4	1.6	4.5	-1.4	0.6	0.4	-0.6	-0.4	0.6	-1.0	1.7	1.5	-2.1	-1.7	-0.7	-1.7
Waist circumference	0.1	0.4	1.4	0.2	0.8	1.2	0.1	0.1	-0.2	0.5	0.3	1.1	-0.9	-0.5	0.7	-0.1
Number of incorrect matches in round	0.8	1.3	6.3	1.2	2.5	1.4	0.7	1.1	0.0	0.3	-0.4	-1.6	-0.8	0.5	0.5	1.3
Past tobacco smoking	0.4	0.7	2.3	0.8	0.2	0.5	-0.6	-0.1	-1.2	0.4	-1.0	-1.5	1.1	0.3	0.4	1.0
Alcohol usually taken with meals	0.4	0.7	4.3	-0.7	0.8	-2.1	0.3	0.6	0.7	-1.5	0.7	-0.2	-0.1	-0.5	-0.3	-0.5
Nervous feelings	0.7	1.4	5.1	-1.2	-0.5	-2.0	0.4	0.2	0.4	-1.6	1.1	0.7	0.7	-2.3	0.7	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	3.9	-1.5	-2.0	-1.2	-1.7	-1.9	-0.3	-0.7	0.9	-0.7	0.2	-0.5	-0.5	-1.0
Hearing difficulty/problems with background noise	0.5	0.7	2.9	0.1	0.7	0.3	-1.4	-1.7	-0.4	-1.4	-0.4	-0.5	1.1	0.1	0.4	0.1
Hair/balding pattern: Pattern 2	1.1	1.4	5.5	-1.3	-0.0	-1.8	0.1	0.3	0.4	-1.3	1.6	2.3	0.4	-1.1	-0.1	-1.5
Had menopause	1.0	1.3	3.6	1.4	0.1	1.0	0.9	0.7	-0.8	1.6	-1.5	0.1	1.9	1.2	0.5	1.4
Had other major operations	0.8	1.0	3.1	-0.7	-1.7	0.3	-1.4	-1.8	-0.8	-0.3	0.3	0.8	0.7	-1.3	-0.3	-0.9
Forced vital capacity (FVC)	2.8	11.0	31.8	-4.7	-3.9	-5.6	-0.8	-1.1	2.8	-2.7	4.2	0.1	-0.9	-2.8	-2.9	-4.7
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.1	10.8	2.7	1.2	2.7	1.7	1.0	-0.4	2.0	-1.9	-1.6	1.3	3.3	2.0	2.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	3.8	0.1	0.6	-0.6	0.8	0.7	0.0	0.8	0.2	2.0	0.1	0.1	0.6	-0.1
Qualifications: None of the above	0.4	0.8	2.1	-1.1	-1.1	0.2	-0.7	-1.1	0.5	-0.6	0.7	1.2	-1.4	-0.7	-0.9	-0.5
Financial difficulties in last 2 years	0.6	0.8	2.9	0.2	0.3	1.3	-1.7	-1.0	-1.4	0.5	-0.5	1.2	0.1	0.6	0.7	0.3
Mouth/teeth dental problems	2.1	3.2	6.6	2.6	1.7	2.1	1.2	1.3	-0.9	0.7	-2.6	-2.5	-0.2	2.1	1.8	2.0
Heart attack	1.1	1.4	4.2	0.3	0.3	1.8	-2.0	-1.6	-1.9	-0.1	-0.3	0.9	-0.7	-0.4	1.8	0.3
Allergy	0.4	1.0	7.6	0.6	0.2	-0.1	0.3	0.9	0.7	-1.0	-1.0	-2.8	0.1	0.7	0.7	0.2
Pain all over the body in last month	0.2	0.2	1.5	-0.1	-0.2	0.5	-0.0	-0.5	0.9	-0.0	-0.0	1.2	0.1	0.3	-0.4	0.2
Diabetes (self-reported)	0.9	1.4	4.2	1.4	1.6	1.3	0.6	1.1	-1.6	0.6	-1.0	0.4	-0.6	0.9	2.0	1.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.2	-0.7	-0.6	-0.1	-1.1	-1.0	-0.6	0.6	1.0	-0.2	0.9	-0.5	-0.6	-0.4
Medication: Ramipril	1.0	1.3	5.9	-0.6	0.3	-0.7	-0.5	0.2	-1.4	0.3	1.1	1.6	-2.4	-1.7	0.4	-0.7
Medication: Simvastatin	0.4	0.6	2.4	-0.2	-0.6	0.1	-1.6	-1.2	-1.2	-1.0	-0.0	-0.8	0.0	-0.4	0.9	0.0
Fluid intelligence score	1.0	2.1	9.5	1.0	0.6	0.4	-1.3	-0.8	-1.8	2.6	-0.9	-0.3	3.1	1.3	-0.8	0.7
Illnesses of siblings	0.5	0.7	2.4	0.2	-0.5	0.1	0.3	0.2	0.6	1.3	-0.2	-0.7	1.5	1.5	-0.9	0.4
Neuroticism score	1.4	2.9	9.1	-2.2	-0.6	-1.5	-1.2	-1.4	0.2	-1.8	2.1	1.8	-1.1	-3.0	0.9	-2.1
Weight	1.4	7.1	18.6	-3.8	-1.1	-2.4	-0.2	-0.1	2.1	-1.7	4.3	2.2	-3.3	-3.5	-1.9	-3.7
Impedance of arm (right)	0.2	1.1	2.9	1.2	1.7	1.0	-0.3	-0.0	0.3	-1.6	-1.7	-0.5	1.0	1.0	0.6	1.1
Arm fat percentage (right)	0.3	1.3	5.3	0.9	2.3	2.3	-0.2	0.4	-0.7	0.3	-0.6	0.7	-1.6	0.1	1.2	0.8
Trunk fat-free mass	3.7	21.1	55.4	-6.6	-3.5	-6.1	0.5	0.1	4.1	-2.1	7.4	3.0	-3.5	-5.4	-4.0	-6.1
Hip circumference	0.7	2.9	8.2	-2.3	-0.5	-1.0	-1.1	-0.7	0.1	-1.0	2.6	1.6	-2.0	-2.9	-0.9	-2.3
Time employed in main current job	0.7	0.8	2.2	-0.1	1.3	-0.2	1.4	1.2	-0.3	-1.3	0.4	-0.7	0.0	-1.5	0.3	-0.3
Alcohol intake versus 10 years previously	0.4	0.5	2.0	-0.1	-1.4	0.3	-1.2	-1.1	-1.1	0.7	-0.0	0.3	0.4	0.1	0.1	-0.2
Father’s age at death	0.7	1.0	3.9	0.4	0.3	0.4	-1.2	-1.2	-0.8	-1.4	-1.6	-2.0	-0.0	0.5	0.4	-0.2
Worrier / anxious feelings	0.3	0.6	2.1	-0.7	-0.8	-1.0	-0.3	-0.9	1.4	-0.7	0.4	0.0	-0.7	-0.8	0.3	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	4.6	-0.5	-0.2	-0.3	-2.0	-2.1	-0.9	-0.1	0.0	0.5	0.0	-0.9	0.9	-0.4
Falls in the last year	0.3	0.5	2.2	-0.2	0.2	-0.8	-0.3	-0.4	-0.7	-0.5	-0.4	-0.1	1.5	-0.6	-1.2	-0.2
Hair/balding pattern: Pattern 3	0.3	0.5	4.4	-0.4	-0.3	0.1	-0.2	-0.1	-0.0	0.1	0.4	-0.7	-2.1	-1.0	-0.5	-0.3
Number of live births	0.3	0.4	1.5	-0.4	-0.4	-0.2	-0.6	-0.8	0.2	-1.2	0.1	0.8	-0.4	-0.5	-1.1	-0.9
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	12.6	-2.4	-2.6	-3.5	-0.6	-0.7	1.3	-1.2	2.0	-1.1	-0.6	-0.4	-1.4	-2.7
Pulse rate	0.6	1.1	4.5	-0.8	0.3	-0.3	-0.4	-0.5	-0.5	-1.9	1.0	0.8	-0.2	-2.1	-1.0	-1.3
Happiness	1.5	1.8	8.2	-1.5	-0.7	-1.5	-1.0	-1.6	-0.1	0.9	1.9	2.9	-0.5	-1.1	0.3	-0.9
Noisy workplace	0.5	0.6	2.4	-0.5	0.5	-0.3	-0.2	-0.8	0.3	-1.5	0.1	1.0	-0.8	-0.8	-1.1	-0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.4	-0.2	-0.5	-0.3	0.4	0.4	0.1	-0.5	0.1	-0.3	0.6	-0.4	0.1	-0.5
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	2.9	0.6	0.0	1.2	-1.1	-1.3	-0.7	0.1	-1.4	-1.7	0.9	1.4	-1.4	1.0
Mouth/teeth dental problems: Dentures	4.2	7.0	22.3	-4.0	-1.5	-2.9	-0.8	-0.9	1.4	-1.9	4.7	3.2	-2.7	-2.9	-1.6	-2.7
Asthma	1.2	2.4	6.0	-1.4	-0.6	-1.3	-1.2	-1.4	0.1	-1.6	1.2	2.4	-2.4	-2.3	-1.0	-1.5
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.4	1.6	-0.4	-0.6	-1.3	-0.9	-1.0	-0.9	-0.3	-0.2	0.5	-0.3	0.3	0.8	-0.1
Medication: Cholesterol lowering	0.3	0.5	1.9	0.2	-0.2	0.3	-1.3	-0.7	-1.1	0.2	0.1	1.0	0.2	0.1	1.4	0.2
Depression (self-reported)	0.6	0.7	2.5	-0.3	0.4	-0.4	1.0	1.0	1.1	-0.7	0.8	0.8	-0.6	-1.6	-0.4	-0.8
Medication: Lansoprazole	1.3	1.5	4.8	0.9	-0.1	2.2	-1.2	-0.8	-1.8	1.5	-1.5	-0.2	-0.4	0.1	1.9	0.7
Prospective memory result	0.6	0.7	2.9	-0.1	-0.2	0.4	0.1	-0.0	0.8	-1.7	-0.1	-1.3	-1.4	-0.4	1.4	-0.1
Lung cancer (father)	0.4	0.5	3.0	0.4	-0.3	0.6	1.0	1.0	-0.4	0.6	-0.3	0.3	-0.4	-0.0	1.7	0.2
Illnesses of mother	2.6	3.2	6.1	-2.5	-2.3	-2.3	-1.9	-2.2	-0.3	-0.7	1.9	-0.5	0.0	-1.6	-1.7	-2.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	11.7	-2.1	-1.7	-3.4	-0.1	0.2	1.4	-1.1	1.9	-0.8	-0.9	-0.1	-1.0	-2.2
Pulse wave Arterial Stiffness index	0.7	0.8	2.9	-0.6	0.4	-0.5	0.6	0.6	-0.5	1.7	1.5	1.3	0.0	-0.0	-1.2	0.5
Impedance of arm (left)	0.2	1.0	3.3	0.8	0.8	0.5	-1.3	-1.1	0.1	-1.8	-1.6	-0.5	1.4	0.7	0.4	0.5
Arm fat mass (right)	0.3	1.2	6.0	-0.9	1.0	0.5	-0.2	0.2	0.4	-0.2	1.5	1.6	-2.4	-1.3	0.1	-1.0
Trunk predicted mass	3.6	20.4	53.7	-6.5	-3.5	-5.9	0.5	0.0	4.0	-2.1	7.3	2.9	-3.3	-5.4	-3.9	-6.0
Standing height	4.3	42.6	92.2	-9.2	-5.0	-8.9	-0.2	-0.6	6.6	-5.5	9.6	3.5	-3.8	-7.2	-6.3	-8.9
Length of working week for main job	1.8	2.0	6.5	1.4	1.8	-0.3	1.0	0.9	-1.8	-0.1	-1.4	-2.5	1.0	1.9	0.5	1.5
Exposure to tobacco smoke at home	0.3	0.3	0.9	-0.6	-0.7	0.6	0.6	0.1	0.9	-0.3	1.0	0.1	-0.3	-0.4	-0.4	-0.7
Breastfed as a baby	0.6	0.7	2.2	-0.1	0.2	-0.8	1.4	1.1	0.1	-1.5	0.4	1.0	1.1	-0.8	-0.2	-0.2
Tense / ‘highly strung’	0.3	0.6	1.7	-0.6	-0.4	-0.6	-1.1	-1.1	-1.3	-0.1	0.1	-0.3	-0.2	-0.7	1.2	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	4.9	-1.9	-1.4	-1.4	-0.0	-0.5	2.2	0.5	1.6	1.4	0.1	-1.4	-0.9	-1.7
Hair/balding pattern: Pattern 4	0.9	2.3	8.1	-1.4	-1.9	-1.4	0.4	0.1	1.8	-2.9	1.4	-0.9	-0.1	-1.4	-1.8	-1.7
Birth weight of first child	2.8	5.0	9.1	-2.7	-1.7	-3.0	0.2	-0.0	2.8	-3.0	2.6	1.1	0.2	-2.2	-2.8	-3.0
Peak expiratory flow (PEF)	1.2	2.9	9.2	-1.8	-2.1	-2.4	-0.7	-0.8	1.3	-3.0	1.0	-0.7	-2.0	-0.2	-0.3	-2.5
Pulse wave reflection index	5.0	6.1	22.1	2.5	0.7	2.6	-0.2	-0.1	-1.3	4.7	-2.5	-1.9	2.6	3.7	0.9	3.4
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.8	1.3	1.5	-0.3	1.5	0.9	0.6	1.7	-0.7	0.9	0.0	1.6	-0.1	1.2
Loud music exposure frequency	1.0	1.1	4.4	1.2	-0.2	1.0	-0.2	-0.0	0.5	2.1	-1.5	-0.2	-0.1	1.2	1.5	1.0
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	4.0	1.5	1.1	0.9	1.2	1.5	-0.8	0.3	-0.9	-0.1	2.0	0.4	1.2	1.1
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	4.9	1.0	-0.2	1.6	-0.7	-1.2	-1.1	1.5	-1.4	0.7	2.2	0.4	0.2	0.4
Blood clot in the leg (DVT)	0.7	0.9	3.2	0.4	-0.1	1.2	-1.8	-1.7	-0.5	0.3	-0.9	-0.8	0.9	0.8	0.5	0.2
Medication: Paracetamol	0.1	0.2	0.7	0.2	-0.1	0.8	0.2	-0.6	0.4	-0.0	-0.6	-0.1	0.6	0.4	-0.6	0.5
Headache pain in last month	1.0	1.8	8.1	-1.4	-1.7	-1.3	-0.1	-0.6	0.8	-0.8	1.0	-1.1	0.6	-1.3	-2.9	-1.6
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	4.0	-1.5	-1.2	-0.9	0.5	-0.1	1.6	-0.6	1.2	0.3	-1.0	-1.2	-2.0	-1.5
Glaucoma (self-reported)	1.3	1.6	3.2	1.8	0.8	1.3	-0.5	-0.7	-1.3	0.6	-1.7	-1.4	1.1	1.5	1.0	1.6
Gout (self-reported)	3.7	5.1	9.8	2.7	2.7	2.8	2.7	2.7	-1.3	2.4	-2.1	-0.8	-0.8	2.2	1.3	3.1
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	5.5	-0.2	-1.1	-0.7	-2.1	-2.4	0.2	-0.7	-0.1	-0.2	0.5	-1.2	-1.6	-1.5
Medication: Amlodipine	1.1	1.6	6.2	1.0	2.5	0.4	1.2	1.6	-1.6	0.3	-0.4	0.9	-0.5	0.5	1.5	1.6
Medication: Ventolin 100micrograms inhaler	0.5	0.7	3.8	-0.6	-0.2	0.1	0.3	-0.3	0.6	-0.7	0.9	1.3	-1.9	-0.9	-0.8	-0.1
Birth weight	1.1	2.4	9.1	-2.4	-1.0	-1.1	-0.7	-0.8	1.6	-0.2	3.0	0.7	-0.8	-0.6	-2.5	-1.5
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.8	-0.7	-0.7	-1.7	0.6	0.1	1.1	1.1	0.7	0.8	0.2	-0.4	-1.5	-0.3
High blood pressure (siblings)	0.7	1.0	3.1	-0.0	0.3	0.2	-1.3	-1.2	-1.6	-0.9	-0.6	0.2	-1.8	-1.0	0.8	-0.7
Forced vital capacity (FVC), Best measure	2.8	10.3	32.8	-4.5	-3.2	-5.7	-0.7	-0.7	2.5	-2.7	4.3	0.8	-1.2	-2.9	-2.6	-4.5
Body fat percentage	0.4	1.5	7.4	1.1	2.3	2.7	-0.5	-0.1	-1.0	0.1	-0.9	0.7	-1.1	0.3	1.1	0.7
Leg fat percentage (right)	0.6	2.2	8.6	1.6	2.9	2.9	0.3	0.6	-0.9	0.5	-1.1	1.0	-0.5	1.0	1.5	1.4
Arm fat-free mass (right)	2.3	12.0	30.8	-5.0	-3.1	-4.2	0.3	-0.3	3.2	-1.4	5.5	1.9	-2.5	-3.9	-3.5	-4.8
Exposure to tobacco smoke outside home	0.6	0.7	3.3	-0.5	-1.0	0.1	0.5	-0.1	1.8	-0.6	0.2	-0.5	-0.8	-0.8	-1.2	-1.2
Comparative body size at age 10	0.6	1.7	4.5	-1.6	-0.5	-1.9	0.5	0.4	1.6	-0.4	1.8	0.7	-2.1	-0.5	-1.6	-1.0
Number of full brothers	0.9	1.1	3.5	-0.8	-1.4	-0.2	-0.8	-1.1	1.5	-0.8	0.5	0.9	-1.0	-0.4	-1.9	-1.2
Worry too long after embarrassment	0.9	1.6	4.3	-1.2	-0.3	-0.4	-1.7	-1.8	-0.6	-1.9	0.8	-0.2	1.1	-2.1	-0.1	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	5.9	-1.6	-1.2	-0.7	-1.5	-1.4	-1.0	0.3	1.2	1.3	0.2	-2.4	0.7	-2.0
Wheeze or whistling in the chest in last year	0.2	0.3	1.1	0.2	-0.4	0.6	0.6	0.0	1.0	0.1	-0.5	0.6	-0.8	-0.8	-0.0	-0.1
Number of children fathered	0.8	0.9	3.7	-0.6	0.6	-0.2	0.2	-0.1	1.2	-0.4	0.8	1.7	-0.3	-0.3	-1.9	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	3.8	1.1	0.7	0.0	-0.3	0.4	-2.0	0.9	-1.2	-1.5	0.7	0.2	1.0	0.9
Age at first live birth	0.4	0.7	2.7	0.2	1.4	0.9	0.5	1.0	-0.4	-0.7	-0.2	-1.0	0.4	0.3	1.7	0.7
Pulse wave peak to peak time	0.6	0.7	3.6	-0.1	-0.7	-0.1	-0.6	-0.7	0.8	-1.9	-0.6	-1.1	-0.2	-0.5	0.8	-1.2
Health satisfaction	0.8	1.0	2.6	-0.5	1.2	-1.4	0.4	0.1	-0.9	-1.0	1.0	1.6	-0.7	-1.6	0.8	-0.4
Shortness of breath walking on level ground	0.5	0.6	1.5	-0.6	0.6	-0.2	0.6	0.4	0.6	-1.2	0.7	1.2	-1.1	-1.0	-0.6	-0.4
Qualifications: College or University degree	0.5	1.6	7.6	1.1	0.5	-0.3	0.4	0.3	-1.0	0.6	-1.3	-2.6	2.8	1.2	-0.2	0.9
Eye problems/disorders: None of the above	0.5	0.6	2.4	-0.7	-0.3	-0.5	-1.5	-1.1	0.3	-0.4	0.6	0.3	-0.8	-0.6	-0.3	-1.3
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.5	0.2	-0.6	-0.5	0.4	0.1	0.2	1.1	-0.0	0.9	1.2	0.3	-0.5	0.3
Emphysema/chronic bronchitis	1.2	1.3	4.2	-1.0	-0.8	0.1	-1.2	-1.5	-0.2	-1.1	0.9	1.1	-1.0	-2.0	-1.2	-1.4
Medication for pain relief, constipation, heartburn	0.6	1.0	4.1	0.4	-0.3	-0.3	0.5	0.7	0.7	1.9	-0.1	-2.0	0.9	1.5	-0.8	0.6
Neck or shoulder pain in last month	0.2	0.2	0.8	-0.5	-0.7	-0.6	-0.4	-0.5	-0.6	0.1	0.3	-0.1	0.4	-0.5	0.9	-0.0
Medication: Blood pressure	0.9	1.5	5.2	1.4	1.8	1.2	-0.4	0.2	-2.0	1.0	-0.8	0.4	-0.2	0.7	2.3	1.4
Angina (self-reported)	1.5	2.0	4.6	-2.0	-0.9	-0.2	-1.1	-0.9	1.3	-1.6	2.1	2.1	0.0	-1.8	0.2	-1.6
Migraine (self-reported)	1.6	2.0	4.7	-1.8	-1.0	-1.7	-0.7	-1.0	1.7	-1.5	1.1	0.5	-0.3	-1.1	-2.2	-2.2
Medication: Ibuprofen	0.4	0.4	1.6	0.2	-0.1	-1.1	-0.8	-0.9	-1.3	-0.1	-0.7	-0.2	-0.4	0.7	0.6	0.3
Medication: Allopurinol	1.1	1.5	3.5	1.2	1.9	1.9	1.5	1.4	-0.6	1.3	-1.0	-0.1	-1.1	0.7	0.4	1.5
Medication: Omeprazole	1.6	1.9	3.3	-1.7	-0.1	-1.8	0.1	0.1	1.5	-1.8	1.8	1.1	-1.6	-1.6	-1.1	-1.5
Medication: Seretide 50 evohaler	0.5	0.6	2.4	-1.0	-0.2	-0.2	-1.6	-1.5	-0.5	-0.1	0.4	0.4	-0.6	-0.5	-0.6	-0.6
Mean time to correctly identify matches	0.7	1.3	4.8	1.3	2.0	1.1	0.2	0.1	-1.0	0.1	-1.4	-2.2	-0.2	0.8	-0.5	1.2
Heart disease (mother)	2.5	3.1	6.2	2.4	2.0	2.5	1.7	1.7	-0.7	1.6	-1.9	0.6	1.2	1.0	1.8	2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	6.0	0.2	0.1	0.4	-1.1	-0.4	-1.0	-0.2	-0.2	0.1	0.1	-0.7	2.5	-0.6
Whole body fat mass	0.2	1.0	3.6	-0.8	1.0	0.8	-0.4	-0.2	0.2	-0.5	1.2	1.5	-1.9	-1.2	0.0	-1.1
Leg fat mass (right)	0.2	0.7	2.1	-0.4	1.2	1.1	0.2	0.3	0.3	-0.2	1.0	1.4	-1.4	-0.5	0.2	-0.5
Arm predicted mass (right)	2.4	12.1	31.2	-5.1	-3.1	-4.1	0.2	-0.3	3.0	-1.3	5.6	2.1	-2.6	-4.0	-3.5	-4.8
Pulse rate, automated reading	0.6	2.1	9.5	-1.4	0.4	-0.6	0.4	0.6	-0.1	-1.6	2.1	3.1	-0.4	-2.7	-0.1	-0.8
Alcohol intake frequency.	1.8	4.1	13.9	-2.0	-0.8	-0.1	-3.7	-3.4	-1.4	-1.6	1.5	1.9	-2.3	-1.7	0.1	-2.0
Comparative height size at age 10	4.5	24.6	49.0	-6.7	-3.8	-6.2	-0.5	-0.7	4.6	-4.0	7.0	4.0	-3.9	-5.9	-5.0	-6.6
Number of full sisters	0.3	0.4	1.4	-0.0	0.0	0.6	1.2	1.0	-0.9	0.2	0.4	0.8	0.2	-0.3	0.5	0.3
Suffer from ‘nerves’	0.6	1.0	2.9	-0.5	-1.0	-1.1	-1.4	-1.3	-1.2	-0.5	-0.4	0.2	1.7	-1.0	1.1	-0.4
Overall health rating	0.7	1.6	12.7	-0.7	0.6	-0.1	0.1	0.0	-0.3	1.1	1.2	3.6	-0.6	-1.5	1.2	-0.1
Chest pain or discomfort	2.9	4.1	9.2	-2.2	-2.1	-1.5	-2.6	-2.7	0.2	-3.0	1.3	1.1	-1.0	-3.0	-0.0	-2.4
Had major operations	1.1	1.3	3.2	-1.0	0.1	-1.5	1.1	1.0	1.8	-0.3	1.4	1.4	-0.6	-1.2	-1.1	-0.9
Age at last live birth	0.8	1.2	4.8	1.0	0.8	1.1	-0.1	0.1	-2.2	-0.0	-1.5	-0.8	1.7	0.2	0.7	1.1
Family relationship satisfaction	0.5	0.7	3.6	-0.3	0.2	-0.0	-0.2	-0.2	-0.5	1.9	0.8	1.1	0.1	-0.4	1.6	0.3
Leg pain on walking	0.5	0.6	2.5	-0.0	-0.7	0.3	0.5	-0.1	1.6	0.2	-0.5	-0.9	-1.2	0.0	-1.2	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.5	-0.4	0.6	0.7	0.8	0.8	1.5	-0.4	0.9	1.6	-0.7	-0.8	-0.4	-0.9
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.0	-0.9	-1.0	-0.9	0.0	-0.3	-0.6	-0.4	1.2	0.3	-0.4	-0.7	-0.8	-1.4
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	2.2	-0.0	0.5	-1.2	1.5	1.2	0.1	-0.8	0.8	-0.5	-0.3	-1.0	0.8	-0.3
Medication: Aspirin	0.7	0.9	3.2	0.0	0.9	0.5	-0.2	0.1	-1.4	-0.8	0.2	1.8	0.2	-1.7	1.3	-0.3
Supplements: Vitamin C	0.3	0.3	1.7	-0.4	-0.5	0.6	-0.1	-0.2	1.3	0.5	0.6	-0.3	0.2	0.1	-0.8	-0.0
Knee pain experienced in last month	0.6	0.9	3.8	-0.5	-1.4	-0.8	1.0	0.1	1.2	1.1	0.1	0.2	0.8	0.3	-1.9	-0.5
Hypertension (Self-reported)	1.7	4.7	15.8	1.8	3.9	2.2	0.4	1.3	-2.9	2.0	-1.0	0.8	-1.5	0.6	4.0	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.4	0.8	-0.1	0.7	-0.1	0.3	0.7	-0.3	-1.1	-0.6	0.2	0.5	1.2	0.9
Illnesses of father: Heart disease	0.6	0.8	3.3	0.6	0.4	-0.0	-0.6	-0.1	-1.8	0.7	-0.2	-0.2	0.3	0.8	1.8	1.4
Illnesses of siblings: Diabetes	0.2	0.3	1.0	0.7	0.5	-0.1	-0.0	-0.2	0.6	-0.7	-0.4	1.0	-0.2	-0.3	0.6	0.5
Smoking status: Previous	0.3	0.4	1.6	-0.3	-0.2	-0.3	0.5	0.2	1.3	-1.0	0.1	0.5	-1.0	0.2	0.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	3.6	7.5	18.9	-3.5	-0.8	-4.3	-0.3	-0.4	2.0	-3.2	3.5	0.9	-1.9	-3.2	-3.1	-3.7
Whole body fat-free mass	3.3	18.9	48.9	-6.4	-3.5	-5.3	-0.1	-0.6	3.6	-2.1	7.0	2.7	-3.5	-5.3	-3.7	-6.0
Leg fat-free mass (right)	3.1	16.5	39.2	-6.0	-3.5	-4.7	-1.0	-1.3	2.7	-2.2	6.3	2.0	-3.6	-5.3	-3.3	-5.7
Arm fat percentage (left)	0.3	1.3	6.1	1.0	2.1	2.5	-0.5	-0.1	-1.0	0.5	-0.9	0.6	-1.1	0.1	1.1	0.7
Average weekly red wine intake	0.4	0.6	1.9	-0.2	0.8	-0.2	0.5	1.0	0.4	-1.1	0.8	-0.5	-0.7	-0.6	1.4	-0.7
Handedness (chirality/laterality): Left-handed	1.8	2.2	6.6	0.9	0.4	2.0	-1.9	-1.1	-2.2	2.6	-1.0	0.3	-0.8	1.1	1.5	1.4
Mood swings	0.7	1.2	4.0	-0.8	-0.8	0.4	-1.9	-2.0	-1.2	0.8	0.5	0.0	-0.2	-1.6	0.5	-1.0
Loneliness, isolation	1.1	1.6	7.1	-0.7	-0.2	0.3	-1.5	-1.1	-2.7	1.4	1.2	1.6	0.8	-1.1	1.2	-0.3
Long-standing illness, disability or infirmity	0.3	0.5	2.9	-0.1	1.0	0.4	0.3	0.3	0.1	-0.5	0.2	1.0	-1.7	-0.5	0.7	0.1
Ever had bowel cancer screening	0.7	0.9	6.1	-0.6	-0.3	-0.8	0.2	0.0	0.6	-2.5	0.4	0.3	0.9	-1.1	-0.3	-1.1
Diabetes diagnosed by doctor	0.9	1.4	4.7	1.3	1.8	0.8	0.6	1.1	-2.2	0.5	-0.7	0.3	-0.4	0.8	1.8	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	2.3	0.5	0.8	0.8	1.4	1.5	-0.0	0.1	-0.4	0.2	0.8	-0.0	-0.4	0.4
Friendships satisfaction	3.1	3.8	13.3	2.0	1.9	2.4	0.4	0.3	-2.0	2.7	-1.3	1.2	1.7	1.0	3.6	2.1
Qualifications: nursing, teaching	1.3	2.0	5.1	1.6	0.3	1.2	0.6	0.7	-0.7	2.0	-1.3	-1.3	2.1	2.2	0.6	1.8
Commuting to job workplace: Walk	0.6	0.7	3.8	0.4	0.7	0.2	0.9	1.0	1.9	0.1	-0.5	1.4	-0.1	-0.1	-0.0	0.2
Eye problems/disorders: Cataract	1.5	1.7	4.2	-1.4	-0.3	-1.7	1.5	1.5	1.6	-1.2	1.9	-0.2	-2.0	-1.1	-0.4	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	4.0	-0.6	-1.4	-0.6	-0.9	-0.9	-0.1	0.1	-0.0	-1.2	1.0	-0.4	-2.0	-0.4
Medication for cholesterol	0.4	0.7	2.2	0.3	-0.4	1.1	-0.4	-0.0	0.9	1.5	-0.4	-0.8	0.8	1.4	-0.1	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.1	4.8	12.9	-2.5	-1.7	-2.3	-1.2	-1.8	1.1	-2.8	2.1	1.6	-0.6	-2.9	-2.4	-3.6
Back pain experienced in last month	0.9	1.3	5.6	1.1	1.3	1.0	0.4	1.4	-1.2	0.1	-1.1	0.0	-1.1	0.4	2.4	0.9
Mineral and other dietary supplements	2.2	3.0	7.3	-1.9	-1.5	-1.2	-2.7	-1.8	-1.7	-2.2	1.3	1.6	-1.6	-1.5	0.2	-1.9
Breast cancer (self-reported)	0.4	0.5	2.8	0.2	0.0	0.4	0.4	0.2	1.7	1.2	-0.3	-0.9	0.9	0.5	0.1	0.3
Asthma (self-reported)	1.4	2.9	6.8	-1.6	-0.7	-1.7	-1.0	-1.3	0.2	-1.9	1.5	2.6	-2.4	-2.5	-1.1	-1.7
Osteoporosis (self-reported)	1.3	1.6	4.1	-1.2	-2.0	0.3	-0.1	-0.5	2.0	-0.7	0.7	-0.0	1.6	-1.3	-2.0	-1.1
Osteoarthritis (self-reported)	1.0	1.3	5.6	1.0	0.8	0.7	1.1	0.5	1.2	0.8	-1.4	-0.5	1.2	2.4	-1.1	1.2
Medication: Aspirin	0.6	0.8	2.9	0.4	1.2	0.9	-0.2	0.3	-1.5	-0.1	-0.2	1.7	-0.1	-1.2	1.1	0.3
Medication: Gliclazide	0.4	0.5	1.5	0.5	0.3	0.6	-1.2	-1.2	-1.1	-0.2	-0.8	0.5	0.0	0.3	0.7	0.4
Illnesses of father: None of the above (group 1)	0.8	0.9	6.3	-0.4	-0.6	-0.1	-0.1	-0.5	0.1	-1.1	-0.2	-1.4	0.5	-0.6	-2.5	-1.0
Smoking status: Current	0.3	0.5	1.5	0.1	0.8	0.4	0.7	0.7	-0.2	1.0	1.0	1.1	-0.7	-0.2	-1.2	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	7.6	1.7	0.7	0.7	0.1	1.0	-1.6	1.6	-2.1	-2.5	0.1	2.8	1.7	1.4
Whole body water mass	3.4	19.3	49.3	-6.5	-3.6	-5.5	-0.2	-0.6	3.7	-2.0	7.0	2.6	-3.6	-5.3	-3.7	-6.0
Leg predicted mass (right)	3.2	16.9	40.3	-6.1	-3.6	-4.7	-1.0	-1.3	2.8	-2.2	6.3	2.1	-3.6	-5.4	-3.3	-5.8
Arm fat mass (left)	0.3	1.1	4.8	-1.0	0.6	0.3	-0.3	-0.0	0.4	-0.3	1.4	1.4	-2.2	-1.4	0.0	-1.2
Number of self-reported non-cancer illnesses	0.3	0.5	1.8	-0.3	0.7	-0.2	-1.0	-0.6	-1.3	0.1	0.5	0.5	-0.6	-0.7	0.9	-0.2
Average weekly champagne plus white wine intake	0.3	0.4	1.9	-0.7	-0.5	-0.2	0.3	-0.0	1.2	0.1	0.5	0.8	0.6	-0.0	-1.4	-0.1
Miserableness	0.3	0.6	3.0	0.7	1.0	0.5	0.4	0.7	-0.5	0.8	-0.7	0.4	0.4	-0.0	1.7	0.5
Guilty feelings	0.7	1.0	2.8	-0.8	0.6	-0.4	-1.6	-1.4	-1.7	-0.6	0.8	0.4	-0.0	-1.1	1.4	-0.7
Wears glasses or contact lenses	0.7	0.9	3.5	-0.7	-0.0	-1.2	0.6	0.7	1.0	-1.1	0.9	0.2	-1.9	-1.2	0.1	-0.7
Ever taken oral contraceptive pill	0.5	0.6	2.3	0.7	0.7	-0.6	1.5	1.2	1.1	0.1	-0.2	0.4	-0.8	0.6	-0.3	0.4
Hearing aid user	0.5	0.5	1.6	0.8	0.1	0.4	0.2	0.2	0.1	0.3	-1.0	-1.3	0.6	0.9	1.0	0.9
Mother’s age at death	0.9	1.1	4.5	-0.3	-0.3	0.0	0.8	0.5	1.9	-1.2	-0.4	-1.0	-1.0	-0.4	-2.1	-0.9
Financial situation satisfaction	0.3	0.4	1.5	-0.7	-0.5	-0.9	0.3	-0.0	1.2	1.1	0.5	0.9	0.1	0.3	-0.5	0.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.7	-0.6	0.5	-0.6	-0.4	-0.5	0.2	-0.6	0.5	1.3	-1.6	-0.7	-0.3	-0.9
Commuting to job workplace: Public transport	1.7	2.0	3.9	1.8	1.4	0.8	0.3	0.9	0.1	1.8	-1.8	-0.8	1.4	2.0	1.5	1.9
Eye problems/disorders: Glaucoma	1.9	2.2	4.5	2.0	0.6	1.4	-0.3	-0.6	-1.3	0.4	-2.1	-1.6	1.6	2.1	1.3	2.0
Medication: Blood pressure	0.5	1.0	3.4	0.1	1.3	0.4	-0.3	0.0	-1.9	0.6	0.4	1.3	-1.4	-1.1	1.7	0.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	2.0	0.4	0.6	0.5	-0.6	-0.7	0.0	-1.4	-0.7	-0.4	-0.0	-0.3	0.7	-0.2
Supplements: Fish oil (including cod liver oil)	0.8	1.0	3.6	0.9	0.4	0.6	1.3	0.6	1.9	1.2	-0.4	-1.3	1.3	0.7	-0.0	1.0
High cholesterol (Self-reported)	0.5	0.8	2.9	1.0	0.4	0.6	-0.3	-0.0	-1.7	1.3	-0.8	0.5	0.7	0.5	1.4	1.0
Medication: Bendroflumethiazide	0.8	1.1	4.9	0.9	1.7	0.6	-0.4	0.2	-1.8	0.7	-0.5	0.2	0.9	0.3	2.2	1.0
Medication: Paracetamol	0.3	0.4	1.9	0.4	0.3	0.7	0.7	-0.2	0.1	-0.3	-0.5	-0.9	0.6	0.5	-1.4	0.6
Medication: Lisinopril	0.4	0.5	1.5	0.6	0.8	0.2	-1.1	-0.6	-0.3	0.3	-0.7	-0.2	1.2	0.3	1.1	0.5
Medication: Atorvastatin	0.7	0.9	4.8	-0.2	0.3	-0.2	-1.0	-0.6	-1.6	0.6	0.6	2.2	-0.7	-0.9	0.7	-0.6
Illnesses of father: High blood pressure	0.6	0.7	2.1	-0.7	-1.1	-0.1	-1.1	-1.0	1.1	-0.6	0.1	1.4	-0.8	-0.1	0.5	-0.8
Alcohol drinker status: Never	1.0	1.2	4.9	0.0	0.1	0.7	-1.8	-1.6	-1.1	-0.1	-0.4	-2.2	0.8	1.2	0.7	0.5
Ever smoked	1.0	1.8	6.1	-1.1	0.2	-0.7	1.0	0.3	1.5	-1.0	1.7	2.5	-1.8	-1.1	-0.7	-1.6
Basal metabolic rate	3.0	16.4	42.4	-5.9	-3.0	-4.8	-0.2	-0.6	3.3	-2.1	6.5	2.6	-3.6	-5.0	-3.3	-5.6
Leg fat percentage (left)	0.7	2.4	10.2	1.8	2.7	3.2	-0.0	0.4	-1.1	0.9	-1.4	0.5	-0.8	1.2	1.5	1.5
Arm fat-free mass (left)	2.5	12.5	34.0	-5.2	-2.8	-4.1	0.1	-0.2	3.1	-1.4	5.8	2.6	-2.9	-4.2	-3.1	-4.8
Number of operations (self-reported)	2.3	3.3	7.0	-2.0	-1.3	-1.9	0.6	0.2	2.1	-2.3	1.8	2.0	-0.4	-2.6	-2.2	-2.2
Average weekly beer plus cider intake	0.9	1.3	3.7	1.0	0.8	0.9	1.7	1.9	-0.3	1.4	-0.9	0.3	0.6	0.7	1.2	1.5
Irritability	1.3	2.2	4.5	-1.9	-1.8	-1.5	-1.5	-2.0	-0.6	-0.6	1.7	1.1	-0.8	-2.1	0.3	-1.7
Risk taking	0.5	0.7	2.7	-0.1	0.8	-0.1	1.2	1.6	0.0	0.1	0.4	-0.0	-1.6	0.4	-0.8	0.2
Ever had prostate specific antigen (PSA) test	2.8	3.2	7.8	-2.6	-1.9	-2.4	-0.2	-0.1	1.6	-1.6	2.8	-0.9	-0.9	-2.0	-1.3	-2.3
Fractured/broken bones in last 5 years	0.6	0.8	2.6	-0.7	-0.5	-1.4	0.1	-0.2	0.9	0.5	0.8	0.8	0.2	-1.6	-1.1	-1.2
Age started oral contraceptive pill	0.7	0.9	2.8	0.9	0.6	1.0	1.5	1.1	1.2	-0.4	-0.9	-1.7	0.7	0.5	-0.3	0.7
Diastolic blood pressure, automated reading	1.1	3.3	10.1	1.9	3.2	1.4	0.9	1.5	-2.4	0.6	-1.2	-0.5	-0.0	1.2	3.2	2.2
Ever depressed for a whole week	2.1	2.5	7.5	-1.7	-1.0	-2.2	-1.2	-1.2	1.1	0.1	1.5	2.7	-2.0	-1.3	-1.1	-1.8
Unable to work because of sickness or disability	0.7	0.9	3.2	-0.1	-0.5	1.2	-1.8	-1.8	-0.7	-0.8	-0.5	1.4	0.0	-0.2	0.7	-0.3
Commuting to job workplace: Cycle	0.2	0.2	0.7	0.1	-0.2	-0.8	0.1	-0.5	-0.2	-0.8	-0.3	-0.5	0.6	-0.1	0.4	0.4
Myopia	0.8	1.1	3.6	-1.3	0.3	-1.9	-0.6	-0.1	0.9	-0.3	1.6	0.2	-1.4	-1.2	0.5	-1.1
Vascular/heart problems diagnosed by doctor	1.2	3.4	12.7	-1.7	-3.0	-1.9	0.2	-0.5	2.9	-1.3	1.0	-0.5	0.8	-0.4	-3.6	-1.6
Cholesterol lowering medication	0.4	0.6	2.5	0.8	1.0	0.5	0.3	0.4	-1.6	-0.2	-0.6	0.4	0.4	-0.4	1.1	0.7
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	5.6	-1.9	-0.1	-1.3	-0.9	-0.5	1.2	-2.4	1.7	0.8	-1.6	-1.9	-0.8	-2.0
Pain experienced in last month	0.4	0.7	3.2	-0.8	0.2	-0.3	-0.3	0.1	1.8	-0.5	1.1	0.0	-1.6	-0.2	0.3	-0.4
Supplements: Calcium	1.6	1.8	6.7	1.0	0.5	1.5	2.0	1.8	-0.6	2.6	-0.3	-0.1	1.1	0.1	1.4	1.5
Basal cell carcinoma (self-reported)	1.3	1.5	4.2	-1.3	-0.5	-1.5	-1.6	-1.1	-0.2	-1.4	0.7	0.3	-1.7	-2.0	-0.6	-1.6
Heart attack/myocardial infarction (self-reported)	1.3	1.6	5.2	0.1	0.2	1.6	-2.3	-1.8	-2.1	-0.1	-0.2	1.2	-0.8	-0.7	1.7	0.1
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	5.2	0.1	-0.3	1.0	-2.3	-2.1	-0.7	0.0	-0.8	-0.6	1.1	0.5	0.5	-0.1
Heart disease (siblings)	0.2	0.3	1.0	0.5	0.6	-0.5	0.4	1.0	0.5	0.1	-0.2	0.5	-0.4	-0.1	0.8	0.5
Alcohol drinker status: Previous	1.4	1.6	3.2	-1.5	-0.5	-1.1	-1.3	-1.2	-1.5	-0.2	1.6	1.4	-1.8	-1.3	-0.6	-1.5
Pack years of smoking	0.5	0.8	2.1	-0.5	-1.0	-0.3	-1.1	-1.1	-0.9	1.3	0.7	1.5	-0.3	-0.8	-0.6	-0.5
Impedance of whole body	0.7	3.6	10.7	2.6	2.0	2.1	-0.6	-0.4	-0.6	-0.9	-3.3	-1.3	2.4	2.6	1.1	2.1
Leg fat mass (left)	0.2	0.6	2.8	-0.4	1.2	1.2	0.0	0.2	0.2	-0.0	0.8	1.1	-1.7	-0.5	0.2	-0.5
Arm predicted mass (left)	2.5	12.7	34.0	-5.1	-2.7	-4.2	0.1	-0.2	3.2	-1.5	5.8	2.6	-2.9	-4.2	-3.2	-4.9