Best TWAS P=1.07e-09 · Best GWAS P=1.72e-11 conditioned to 0.00443
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RFTN2 | 0.14 | 0.10 | enet | 11 | 0.13 | 5.3e-11 | -5.4 | -5.7 | 1.1e-08 | 0.86 | 0.42 | 0.58 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | HSPD1 | 0.15 | 0.04 | lasso | 7 | 0.04 | 2.0e-02 | -4.3 | 5.1 | 2.9e-07 | -0.64 | 0.12 | 0.52 | FALSE |
| 3 | GTEx | Lung | RFTN2 | 0.06 | 0.08 | lasso | 8 | 0.06 | 2.7e-05 | -5.9 | -5.7 | 1.4e-08 | 0.86 | 0.22 | 0.77 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | MARS2 | 0.04 | 0.05 | enet | 8 | 0.03 | 1.2e-03 | -6.1 | 6.0 | 2.4e-09 | -0.86 | 0.16 | 0.83 | FALSE |
| 5 | GTEx | Spleen | RFTN2 | 0.11 | 0.03 | enet | 26 | 0.05 | 2.4e-02 | -6.1 | -5.4 | 6.0e-08 | 0.84 | 0.10 | 0.27 | FALSE |
| 6 | GTEx | Spleen | MARS2 | 0.12 | 0.04 | lasso | 5 | 0.00 | 3.4e-01 | -6.1 | 5.5 | 3.9e-08 | -0.82 | 0.08 | 0.28 | FALSE |
| 7 | GTEx | Thyroid | RFTN2 | 0.04 | 0.01 | enet | 11 | 0.01 | 9.5e-02 | -6.0 | -5.8 | 7.4e-09 | 0.80 | 0.11 | 0.66 | FALSE |
| 8 | GTEx | Whole Blood | PLCL1 | 0.08 | 0.08 | enet | 15 | 0.05 | 4.1e-05 | -5.6 | -6.1 | 1.1e-09 | 0.92 | 0.13 | 0.87 | TRUE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PLCL1 | 0.04 | 0.00 | blup | 130 | 0.02 | 4.0e-03 | 1.1 | -5.4 | 7.6e-08 | 0.65 | 0.05 | 0.38 | FALSE |