Hub : Genes

HSPD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0750 0.0250 2.2e-10 0.090 0.088 0.086 0.087 0.093 4.5e-11 7.6e-11 1.3e-10 9.8e-11 2.2e-11
2 GTEx Cells EBV-transformed lymphocytes 0.1520 0.0680 8.0e-04 0.043 NA 0.034 NA 0.039 1.5e-02 NA 2.7e-02 NA 2.0e-02
3 GTEx Pituitary 0.0990 0.0570 9.2e-03 0.028 NA 0.059 NA -0.001 6.7e-02 NA 1.4e-02 NA 3.5e-01
4 METSIM Adipose 0.0178 0.0115 9.8e-03 0.002 0.008 0.001 0.008 0.006 1.4e-01 1.8e-02 2.0e-01 1.9e-02 3.4e-02
5 TCGA Thyroid Carcinoma 0.0270 0.0210 5.5e-03 0.032 0.020 0.019 NA 0.023 4.2e-04 4.4e-03 4.9e-03 NA 2.5e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 6.6 10.5 14.2 -3.7 3.1 2.5 3.8 3.0
Bipolar Disorder or Schizophrenia 6.5 15.8 45.4 -2.5 1.2 6.7 4.8 1.8
Depressed Affect (Nagel 2018) 0.8 1.7 3.6 -1.0 1.1 1.5 1.9 0.6
Depression (Nagel 2018) 0.5 0.8 1.5 -1.0 1.2 -0.8 0.8 0.6
Intelligence (Savage-Jansen 2018) 0.6 1.9 4.6 0.4 -1.9 2.1 0.8 -0.5
Neuroticism (Nagel 2018) 0.7 1.6 2.4 -1.3 1.2 1.3 1.6 0.8
Schizophrenia (2018) 5.1 10.7 42.6 -0.3 -1.0 6.5 3.1 -0.1
Schizophrenia vs Biploar Disorder 7.8 10.3 16.2 3.8 -4.0 2.2 -1.9 -3.6
Worry (Nagel 2018) 1.0 2.1 2.8 -1.5 1.3 1.7 1.6 1.1
Alzheimer’s Disease (in mother) 0.0 0.1 0.2 0.3 -0.0 -0.1 -0.1 -0.4
Alzheimer’s Disease (in father) 0.6 0.6 1.1 -0.9 0.9 -1.1 0.7 0.4
Alzheimer’s Disease (including proxy) 0.1 0.2 0.7 0.3 0.1 -0.8 -0.3 -0.4
Crohns Disease (2017) 1.3 2.9 6.5 0.4 -2.2 2.5 1.7 0.1
Irritable Bowel Disease (IBD) 1.6 3.9 8.1 -1.7 0.5 2.2 2.9 1.8
Ulcerative Colitis (UC) 3.2 6.0 8.5 -2.9 2.8 0.3 2.5 2.7
Major Depression (MDD) 0.9 1.1 3.9 -0.7 -0.1 2.0 0.8 -0.7
Reaction Time 0.8 1.6 2.9 1.3 -1.0 -0.7 -1.3 -1.7
Verbal and Numeric Reasoning (VNR) 0.7 1.7 3.7 0.7 -1.9 1.8 0.8 -0.7
Breast Cancer 2.2 5.4 7.4 2.7 -2.5 -0.7 -2.5 -2.5
Ovarian Cancer 0.3 0.4 1.5 0.3 0.0 -1.2 -0.5 -0.4
Prostate Cancer 0.3 0.4 1.9 0.0 -0.4 1.4 -0.2 0.2
Age at First Birth 0.8 1.2 1.6 1.0 -1.2 -1.2 -1.3 -0.6
Bipolar Disorder (2011) 1.7 1.7 5.2 -0.8 0.7 2.3 1.4 0.2
Body Mass Index (BMI) (2010) 2.7 3.7 5.2 -2.1 2.0 1.0 2.3 1.9
Coronary Artery Disease (CAD) 0.1 0.1 0.3 -0.1 -0.1 0.4 0.5 -0.2
Crohns Disease (2012) 2.3 3.7 11.6 0.6 -2.1 3.4 1.3 -0.7
Mean Putamen Volume 1.2 1.4 2.1 0.9 -1.4 1.4 0.0 -1.4
Fasting Glucose 1.2 1.5 2.4 -1.5 1.5 0.5 1.2 1.1
HbA1C 0.6 0.7 2.6 0.2 -0.5 -1.6 -0.5 0.4
HDL Cholesterol 1.4 2.4 3.4 1.5 -1.4 -1.4 -1.8 -1.5
LDL Cholesterol 0.2 0.4 0.7 -0.7 0.4 0.2 0.8 0.8
Lupus 0.3 0.5 1.3 -0.3 1.1 -0.6 -0.7 0.2
Neuroticism (2016) 0.1 0.1 0.3 -0.5 -0.0 0.5 0.2 0.3
Primary Biliary Cirrhosis 1.1 1.6 5.3 -1.1 2.3 -0.9 -0.2 0.7
Rheumatoid Arthritis 1.5 2.1 5.1 -0.7 2.2 -2.2 -0.4 -0.3
Schizophrenia (2014) 5.4 11.9 44.9 -0.8 -0.8 6.7 3.7 0.3
Triglycerides 2.1 3.4 4.6 -1.6 2.1 2.1 2.1 1.1
Type 2 Diabetes (T2D) (2012) 0.4 0.4 0.9 0.5 -0.2 -0.3 -1.0 -0.9
Ulcerative Colitis 5.4 7.9 10.6 -3.3 3.0 0.7 3.2 3.1
Blood Eosinophil Count 0.3 2.0 5.3 0.2 -1.3 1.6 2.3 -0.2
Blood Platelet Count 2.6 29.7 50.3 4.8 -2.5 -7.1 -7.1 -4.3
Blood Red Count 0.6 5.5 12.4 -1.5 2.9 -3.5 -1.0 1.7
Blood White Count 3.1 23.3 31.2 -5.6 5.4 1.2 5.4 5.0
Heel T-Score 0.6 4.6 6.5 -2.4 2.1 0.2 2.5 2.5
BMI 5.8 33.4 58.5 -6.9 7.7 -1.8 5.1 5.7
Height 1.1 20.6 27.9 5.2 -4.9 -1.7 -4.7 -5.3
Waist Hip Ratio (WHR) 0.6 2.8 8.5 0.7 -2.0 2.9 0.8 -0.7
Systolic Blood Pressure 1.1 5.7 8.1 2.6 -2.5 1.2 -2.4 -2.9
Smoking Status 2.2 5.3 8.6 -2.5 2.4 0.7 2.9 2.4
Allergy or Eczema 6.8 17.9 60.7 0.9 -4.0 7.8 3.5 -0.6
Cardiovascular Disease 1.3 4.2 11.1 -2.4 3.3 0.9 1.0 1.5
Hypothyroidism (self reported) 0.8 1.8 4.7 -1.5 2.2 -0.8 1.0 0.6
Respiratory disease 1.5 3.3 7.1 1.4 -2.4 2.7 0.3 -1.3
Type 2 Diabetes (T2D) (2018) 1.9 3.6 7.0 -2.4 2.6 -0.4 1.5 1.7
Lung FEV1/FVC ratio 3.7 18.7 25.6 -5.1 4.8 1.7 4.6 4.6
Lung FVC 0.1 0.6 1.8 -0.7 0.6 1.4 0.1 0.5
Neuroticism 0.9 2.2 4.4 -1.1 0.6 1.9 2.1 1.1
Chronotype (morning person) 2.3 5.3 12.5 -2.1 3.5 -2.5 -0.0 1.8
Hair Pigment 0.1 3.9 5.7 2.4 -2.3 0.4 -2.2 -1.8
Tanning 0.2 2.4 5.8 0.9 -0.0 -2.4 -2.3 -0.5
Hand grip strength (left) 1.0 2.5 5.7 0.7 0.0 -2.4 -2.0 -1.5
Number of treatments/medications taken 0.8 1.4 2.6 -1.3 1.6 0.8 1.4 -0.0
Average weekly spirits intake 0.9 1.1 3.2 0.1 0.6 -1.8 -1.4 0.1
Sensitivity / hurt feelings 0.6 1.0 2.2 -0.7 0.2 1.1 1.5 1.1
Frequency of depressed mood in last 2 weeks 0.9 1.2 2.0 -1.2 1.4 -0.3 0.7 1.4
Hearing difficulty/problems: Yes 2.2 3.3 5.3 -2.0 2.3 -1.2 1.5 1.8
Relative age of first facial hair 0.4 0.8 1.8 -1.0 0.2 0.6 1.0 1.3
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.2 -0.5 0.8 -1.1 -0.3 0.4
Ever used hormone-replacement therapy (HRT) 2.4 3.0 6.5 -2.2 2.5 -0.3 0.9 1.7
Ever had hysterectomy (womb removed) 1.2 1.3 2.7 -1.1 1.6 -1.2 0.2 1.1
Systolic blood pressure, automated reading 0.5 1.4 2.4 1.0 -1.2 1.4 -0.5 -1.5
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 0.9 -0.2 0.7 -0.7 -0.9 -0.1
Angina 6.9 9.0 13.2 -3.6 3.1 0.8 2.9 3.6
Medication for hormone replacement therapy 1.4 1.5 4.3 0.7 -0.7 -2.1 -1.4 -0.7
Vitamin and mineral supplements 3.3 4.5 9.7 1.6 -0.6 -3.1 -2.7 -1.4
Supplements: Zinc 2.4 2.6 3.8 -1.7 1.5 1.9 1.7 1.1
Medication: Co-codamol 0.8 0.9 1.4 -1.1 1.2 0.9 0.9 0.5
Medication: Metformin 3.4 4.8 9.9 -2.7 3.1 0.1 1.8 1.9
Diabetes (father) 1.2 1.5 2.4 -1.1 1.4 -1.6 0.4 1.2
Diabetes (mother) 2.6 3.3 6.7 -2.2 2.6 -0.6 1.3 1.7
Severe depression (siblings) 0.1 0.1 0.1 0.2 0.1 -0.2 -0.3 -0.3
Pack years adult smoking proportion 1.7 2.7 3.9 -1.9 2.0 0.5 1.6 1.7
Impedance of leg (right) 5.4 26.0 59.9 5.5 -7.7 3.4 -2.2 -4.8
Leg fat-free mass (left) 2.1 11.3 25.8 -3.8 5.1 -2.1 1.9 2.8
Trunk fat percentage 3.5 13.9 30.9 -3.7 2.3 3.5 5.6 2.6
Hand grip strength (right) 0.6 1.6 3.8 0.5 0.2 -1.9 -1.6 -1.1
Townsend deprivation index at recruitment 0.2 0.3 0.7 0.2 0.4 0.8 -0.2 -0.6
Current tobacco smoking 0.3 0.6 1.3 -0.5 1.0 -1.1 0.4 0.3
Average weekly fortified wine intake 0.4 0.4 1.3 -0.1 0.0 1.1 0.6 0.7
Maternal smoking around birth 0.3 0.4 0.7 -0.6 0.8 0.2 0.5 0.7
Fed-up feelings 0.1 0.2 0.4 0.2 -0.1 0.6 0.4 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.8 2.4 5.0 -1.7 2.2 -0.9 1.3 1.4
Relative age voice broke 0.4 0.7 1.7 0.9 -1.3 0.5 -0.8 -0.2
Taking other prescription medications 0.4 0.6 1.6 -0.0 -0.1 1.3 0.8 -0.8
Age when periods started (menarche) 0.0 0.1 0.3 0.5 -0.2 0.0 -0.3 -0.5
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 1.7 -1.2 1.2 0.6 1.3 1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.1 0.2 -0.2 0.1 0.3 0.4 0.3
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.7 -0.5 0.2 -0.9 0.6 0.6
Qualifications: CSEs or equivalent 0.3 0.3 0.9 -0.3 0.6 -0.9 -0.3 0.5
Serious illness, injury or assault to yourself 0.3 0.4 1.1 -0.5 0.3 -0.6 0.5 1.1
High blood pressure 1.0 2.7 6.7 -1.9 2.6 0.6 1.3 1.0
Hayfever, allergic rhinitis or eczema 6.3 13.6 46.0 1.1 -3.6 6.8 2.7 -0.4
Multivitamins +/- minerals 0.5 0.6 1.4 -0.5 0.1 1.0 1.2 0.5
Stomach or abdominal pain in last month 0.3 0.3 0.8 -0.0 0.1 -0.9 -0.7 0.4
Supplements: Glucosamine 0.8 1.1 2.4 0.9 -1.5 1.3 -0.0 -0.7
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 0.9 -0.8 0.7 0.6 0.9 0.2
Medication: Atenolol 0.6 0.7 2.3 -0.6 0.5 0.9 1.5 0.1
Medication: Levothyroxine sodium 1.1 1.9 4.2 -1.7 2.1 -0.2 0.8 1.2
Sitting height 0.1 0.5 1.5 -0.2 -0.2 1.2 0.9 -0.5
Chronic bronchitis/emphysema (father) 0.2 0.2 0.7 -0.4 0.8 -0.2 0.6 0.0
High blood pressure (mother) 1.9 2.7 6.9 -1.4 0.7 2.6 1.7 1.2
Body mass index (BMI) 5.9 25.3 45.7 -6.0 6.8 -0.6 4.6 4.8
Impedance of leg (left) 4.9 23.7 54.6 5.4 -7.4 2.7 -2.1 -4.8
Leg predicted mass (left) 2.2 11.6 26.3 -3.9 5.1 -2.1 1.9 2.9
Trunk fat mass 2.4 10.4 20.8 -3.6 2.9 2.1 4.6 2.4
Waist circumference 3.5 12.8 17.9 -4.1 4.1 1.4 4.2 3.2
Number of incorrect matches in round 0.4 0.6 1.3 -0.5 0.1 1.1 1.0 0.8
Past tobacco smoking 1.6 2.9 5.5 1.8 -1.4 -1.5 -2.3 -1.3
Alcohol usually taken with meals 1.0 1.7 5.8 -0.3 -0.9 2.4 1.2 0.3
Nervous feelings 1.0 1.8 4.1 -1.1 0.7 1.3 1.3 2.0
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 2.6 -0.5 0.7 -1.6 -0.6 1.3
Hearing difficulty/problems with background noise 2.1 3.4 5.2 -2.1 2.3 -0.3 2.0 1.8
Hair/balding pattern: Pattern 2 0.4 0.5 1.2 0.5 -1.1 0.6 0.6 0.4
Had menopause 1.2 1.5 2.3 -1.5 1.2 0.7 1.4 1.1
Had other major operations 1.2 1.5 5.9 -0.3 -0.4 2.4 0.9 0.7
Forced vital capacity (FVC) 1.1 4.2 5.9 2.3 -2.4 -0.1 -2.4 -2.0
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.9 -0.4 -0.0 0.8 0.9 0.5
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.7 -0.9 1.3 -0.3 0.3 0.6
Qualifications: None of the above 1.0 2.1 5.1 -1.7 2.2 0.7 1.0 1.0
Financial difficulties in last 2 years 0.3 0.4 0.8 -0.7 0.8 -0.2 0.9 0.1
Mouth/teeth dental problems 1.0 1.5 3.0 1.3 -1.0 -1.1 -1.7 -0.8
Heart attack 3.3 4.2 6.2 -2.4 2.5 -0.6 2.2 2.0
Allergy 4.1 9.5 34.2 0.1 2.3 -5.8 -2.8 -0.5
Pain all over the body in last month 0.6 0.6 2.1 -0.5 0.9 -1.4 0.1 -0.2
Diabetes (self-reported) 0.8 1.2 3.1 -1.3 1.8 0.4 1.0 0.6
Hayfever/allergic rhinitis (self-reported) 5.6 7.4 13.8 2.5 -3.7 3.2 -0.3 -2.5
Medication: Ramipril 0.3 0.4 1.6 -0.6 1.3 -0.1 -0.4 0.0
Medication: Simvastatin 1.0 1.5 2.4 -1.6 1.5 0.6 1.3 0.9
Fluid intelligence score 0.9 1.8 4.1 1.4 -2.0 1.1 -0.1 -1.4
Illnesses of siblings 0.4 0.5 0.9 0.9 -0.9 0.5 -0.8 -0.1
Neuroticism score 0.9 1.8 3.4 -1.1 0.5 1.9 1.7 1.1
Weight 2.4 11.7 22.9 -4.1 4.8 -0.9 3.1 2.9
Impedance of arm (right) 5.2 24.2 50.0 3.4 -7.1 7.1 1.8 -2.5
Arm fat percentage (right) 5.3 20.7 38.1 -5.0 3.9 3.1 6.2 4.0
Trunk fat-free mass 1.3 7.6 18.3 -1.8 3.8 -4.3 -0.9 0.9
Hip circumference 2.3 10.0 13.9 -3.6 3.6 1.1 3.7 2.9
Time employed in main current job 3.4 4.0 6.2 -2.4 2.5 -0.5 2.0 2.0
Alcohol intake versus 10 years previously 0.3 0.5 1.0 0.7 -0.3 0.6 -0.8 -1.0
Father’s age at death 0.3 0.4 1.4 -0.3 -0.3 1.2 0.6 0.3
Worrier / anxious feelings 0.1 0.3 1.0 -0.0 -0.3 1.0 0.2 -0.3
Frequency of tiredness / lethargy in last 2 weeks 2.4 4.0 7.5 -2.3 2.7 -1.3 1.3 1.9
Falls in the last year 0.7 0.9 1.7 -0.6 1.0 -1.1 0.1 1.3
Hair/balding pattern: Pattern 3 0.6 1.0 1.7 -1.1 1.1 0.3 0.6 1.3
Number of live births 0.1 0.2 0.4 0.5 -0.6 0.6 -0.2 -0.3
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 0.6 0.6 -0.8 0.7 -0.7 -0.3
Pulse rate 0.4 0.6 2.0 -0.1 -0.2 1.4 1.0 0.2
Happiness 1.3 1.5 3.8 -1.1 2.0 -0.6 0.1 1.5
Noisy workplace 0.2 0.2 0.6 0.2 -0.1 -0.8 -0.5 -0.4
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.3 -0.6 0.4 -0.2 0.6 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.8 1.0 2.8 0.5 -1.0 1.7 0.4 -0.8
Mouth/teeth dental problems: Dentures 1.4 2.3 7.1 -0.5 -0.1 2.7 2.1 0.0
Asthma 2.1 4.0 11.0 1.3 -2.5 3.3 0.4 -1.2
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 0.8 -0.8 0.8 -0.3 0.9 0.2
Medication: Cholesterol lowering 0.6 1.0 2.3 -1.2 1.5 0.1 0.9 0.7
Depression (self-reported) 0.7 0.8 1.5 -1.0 1.0 -0.6 1.2 0.6
Medication: Lansoprazole 1.7 1.9 3.0 -1.7 1.6 -0.8 1.4 1.1
Prospective memory result 0.2 0.2 0.6 -0.2 0.3 -0.5 -0.8 0.1
Lung cancer (father) 3.1 3.6 6.9 -2.4 2.6 -0.1 1.7 1.6
Illnesses of mother 1.6 2.0 3.0 1.7 -1.3 -0.3 -1.5 -1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.9 0.5 -0.5 -0.1 -0.9 -0.3
Pulse wave Arterial Stiffness index 4.4 5.2 6.8 -2.4 2.1 2.6 2.6 1.5
Impedance of arm (left) 5.0 23.2 48.4 3.4 -7.0 6.8 1.6 -2.5
Arm fat mass (right) 4.7 19.4 27.5 -5.2 5.1 1.0 5.1 4.1
Trunk predicted mass 1.3 7.7 18.1 -1.8 3.9 -4.3 -0.9 0.9
Standing height 0.9 9.0 12.6 3.5 -3.5 -0.7 -2.8 -3.5
Length of working week for main job 0.2 0.2 0.6 -0.1 0.3 -0.7 -0.5 0.2
Exposure to tobacco smoke at home 0.4 0.4 0.9 -0.6 0.9 1.0 0.1 0.2
Breastfed as a baby 1.0 1.2 3.1 -0.9 0.9 1.8 1.1 0.4
Tense / ‘highly strung’ 0.5 0.9 2.4 -0.6 0.2 1.5 0.9 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 8.2 12.6 19.2 -4.1 3.2 1.2 4.4 3.8
Hair/balding pattern: Pattern 4 0.4 0.9 2.1 0.4 -0.4 1.5 -0.0 -1.4
Birth weight of first child 2.2 4.0 5.5 -2.1 2.3 -0.2 2.1 2.3
Peak expiratory flow (PEF) 0.5 1.1 3.8 -0.5 0.0 2.0 1.0 0.5
Pulse wave reflection index 1.4 1.7 4.8 -1.7 2.2 0.1 0.8 0.6
Ever highly irritable/argumentative for 2 days 0.4 0.5 0.9 -1.0 0.5 0.1 0.7 0.8
Loud music exposure frequency 0.7 0.8 1.2 1.0 -1.1 0.4 -0.9 -0.8
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.4 -0.4 0.1 -0.6 0.6 0.2
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.8 -0.7 0.9 -0.5 0.6 0.5
Blood clot in the leg (DVT) 0.6 0.8 1.6 -1.1 1.3 -0.3 -0.1 1.0
Medication: Paracetamol 0.2 0.4 0.9 -0.2 -0.3 1.0 0.9 0.1
Headache pain in last month 0.4 0.6 1.3 -0.8 1.1 -0.5 0.7 0.7
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 4.1 1.6 -2.0 -0.1 -1.3 -0.8
Glaucoma (self-reported) 1.2 1.4 3.6 0.7 -0.1 -1.9 -1.2 -1.3
Gout (self-reported) 0.9 1.2 3.4 -0.8 1.1 -1.9 -0.3 0.6
Hypothyroidism/myxoedema (self-reported) 0.7 1.5 3.2 -1.4 1.8 -0.9 0.7 0.8
Medication: Amlodipine 1.8 2.5 3.6 -1.9 1.9 -0.5 1.4 1.8
Medication: Ventolin 100micrograms inhaler 1.2 1.5 2.6 1.4 -1.6 0.9 -0.2 -1.5
Birth weight 1.0 2.1 4.6 -1.6 2.1 -1.5 0.5 1.0
Chronic bronchitis/emphysema (mother) 0.4 0.4 0.7 -0.8 0.7 0.1 0.6 0.8
High blood pressure (siblings) 1.1 1.6 2.3 -1.5 1.1 0.9 1.5 1.1
Forced vital capacity (FVC), Best measure 1.4 5.1 8.5 2.4 -2.1 -1.4 -2.9 -2.1
Body fat percentage 3.5 13.8 28.5 -3.9 2.8 3.0 5.3 2.8
Leg fat percentage (right) 2.0 7.1 12.2 -3.1 2.7 1.4 3.5 2.1
Arm fat-free mass (right) 2.2 11.4 25.0 -2.6 5.0 -4.7 -0.5 1.7
Exposure to tobacco smoke outside home 5.7 7.5 13.2 -3.2 3.6 -0.4 2.1 3.1
Comparative body size at age 10 2.5 6.8 13.8 -2.9 3.7 -1.5 1.1 2.9
Number of full brothers 0.1 0.2 0.6 -0.1 -0.0 0.7 -0.1 0.4
Worry too long after embarrassment 0.0 0.0 0.1 -0.2 -0.0 0.2 0.1 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 4.3 5.5 8.0 -2.7 2.8 0.5 2.5 2.4
Wheeze or whistling in the chest in last year 0.3 0.5 1.2 -0.6 0.7 0.6 1.1 -0.2
Number of children fathered 0.4 0.4 1.3 -0.1 -0.0 1.1 0.9 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 2.1 2.4 3.7 1.9 -1.7 -0.3 -1.9 -1.3
Age at first live birth 1.6 2.8 4.9 1.9 -2.0 0.6 -0.9 -2.2
Pulse wave peak to peak time 5.2 6.1 7.8 2.7 -2.5 -2.5 -2.8 -1.8
Health satisfaction 2.4 3.1 6.6 -1.8 2.6 -1.9 1.0 1.1
Shortness of breath walking on level ground 2.7 3.2 7.3 -2.0 2.7 -0.0 1.5 1.6
Qualifications: College or University degree 0.6 1.9 4.1 1.5 -1.3 0.1 -2.0 -1.2
Eye problems/disorders: None of the above 0.3 0.3 1.0 0.5 -1.0 0.6 -0.1 -0.2
Mouth/teeth dental problems: Loose teeth 1.8 2.1 2.8 -1.5 1.5 -0.9 1.5 1.7
Emphysema/chronic bronchitis 1.0 1.2 1.8 -1.3 1.3 -0.1 1.2 1.0
Medication for pain relief, constipation, heartburn 2.7 4.6 7.2 2.7 -2.7 -0.3 -2.5 -1.6
Neck or shoulder pain in last month 3.3 4.7 7.0 -2.6 2.6 0.2 1.9 2.4
Medication: Blood pressure 2.1 3.8 6.5 -2.3 2.6 0.4 2.2 1.5
Angina (self-reported) 7.5 9.8 14.7 -3.8 3.2 0.9 3.1 3.8
Migraine (self-reported) 0.4 0.5 0.9 0.5 -0.2 -0.9 -1.0 -0.6
Medication: Ibuprofen 0.5 0.6 1.0 -0.8 1.0 -0.4 0.9 0.3
Medication: Allopurinol 1.4 1.8 8.0 -0.1 0.6 -2.8 -0.9 -0.2
Medication: Omeprazole 0.3 0.4 0.9 -0.1 1.0 -0.5 0.0 -0.8
Medication: Seretide 50 evohaler 0.8 1.0 2.2 -0.7 0.4 1.5 1.4 0.1
Mean time to correctly identify matches 0.9 1.8 3.2 1.4 -1.3 -0.5 -1.3 -1.8
Heart disease (mother) 1.8 2.2 3.2 -1.8 1.4 -0.9 1.4 1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.1 1.0 -1.0 0.6 -1.0 -0.9
Whole body fat mass 2.8 11.6 19.7 -4.0 3.6 1.4 4.4 2.7
Leg fat mass (right) 2.5 9.6 15.2 -3.8 3.9 0.1 3.4 2.6
Arm predicted mass (right) 2.3 11.6 26.4 -2.9 5.1 -4.5 -0.2 1.7
Pulse rate, automated reading 0.1 0.4 1.5 -0.1 0.7 1.2 0.0 -0.3
Alcohol intake frequency. 0.2 0.5 1.5 -0.3 1.2 0.7 0.4 -0.5
Comparative height size at age 10 0.2 1.4 5.4 -0.1 0.8 -2.3 -0.9 -0.3
Number of full sisters 1.2 1.4 2.6 -1.3 1.6 -1.4 0.3 0.9
Suffer from ‘nerves’ 1.4 2.3 3.2 -1.8 1.5 1.3 1.7 1.1
Overall health rating 3.9 8.3 20.9 -3.0 4.6 -2.8 0.8 1.7
Chest pain or discomfort 0.1 0.2 0.5 -0.4 0.6 -0.7 0.3 -0.0
Had major operations 0.2 0.2 0.7 -0.2 0.3 -0.4 0.4 0.9
Age at last live birth 0.8 1.2 2.2 1.2 -1.3 0.0 -0.9 -1.5
Family relationship satisfaction 1.3 1.6 3.0 -1.5 1.7 0.2 1.0 1.2
Leg pain on walking 3.5 4.4 8.3 -2.6 2.9 0.4 1.9 1.7
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 4.4 0.2 -0.0 -2.1 -0.9 -0.3
Commuting to job workplace: Car/motor vehicle 1.6 1.9 3.2 -1.5 1.8 -1.4 0.8 1.1
Illness, injury, bereavement, stress in last 2 years 0.0 0.0 0.1 0.1 -0.1 -0.4 -0.0 0.2
Medication: Aspirin 2.7 3.5 5.1 -2.2 2.2 0.8 1.5 2.1
Supplements: Vitamin C 2.5 2.9 4.2 -2.0 1.6 0.7 1.9 1.9
Knee pain experienced in last month 1.7 2.6 4.9 -1.9 2.2 -1.0 1.1 1.4
Hypertension (Self-reported) 1.8 4.9 11.0 -2.7 3.3 0.7 1.8 1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 1.2 0.3 0.5 -1.1 -0.3 -0.7
Illnesses of father: Heart disease 0.2 0.2 0.7 0.0 0.2 0.8 0.2 -0.5
Illnesses of siblings: Diabetes 1.7 2.1 3.8 -1.6 1.7 0.6 1.9 0.9
Smoking status: Previous 1.6 2.4 3.5 -1.6 1.2 1.9 1.7 1.3
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 3.5 0.5 -0.4 -1.9 -0.9 0.2
Whole body fat-free mass 1.7 9.5 22.3 -2.7 4.7 -3.8 0.1 1.8
Leg fat-free mass (right) 2.3 12.4 28.3 -3.8 5.3 -2.7 1.7 2.9
Arm fat percentage (left) 5.1 20.3 37.1 -4.9 3.9 3.1 6.1 4.0
Average weekly red wine intake 0.3 0.4 0.8 -0.6 -0.2 -0.4 0.8 0.9
Handedness (chirality/laterality): Left-handed 1.4 1.7 3.1 -1.5 1.1 0.3 1.8 1.4
Mood swings 1.2 2.2 4.0 -1.6 1.4 0.7 2.0 1.4
Loneliness, isolation 1.4 2.0 3.5 -1.2 0.9 1.9 1.4 1.3
Long-standing illness, disability or infirmity 0.2 0.3 1.1 -0.6 1.0 -0.4 0.1 0.3
Ever had bowel cancer screening 1.8 2.1 3.9 -2.0 1.5 -0.1 1.8 1.1
Diabetes diagnosed by doctor 1.3 2.1 4.2 -1.9 2.1 0.1 1.3 1.1
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.0 1.5 1.1 -1.1 1.2 -1.0 -0.6
Friendships satisfaction 4.8 6.0 8.9 -3.0 3.0 0.6 2.3 2.5
Qualifications: nursing, teaching 0.2 0.3 0.5 0.5 -0.5 -0.7 -0.2 -0.7
Commuting to job workplace: Walk 1.0 1.1 1.5 1.2 -1.2 -0.1 -1.2 -0.8
Eye problems/disorders: Cataract 1.5 1.8 2.7 -1.4 1.4 -0.4 1.4 1.6
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 3.1 0.2 0.2 -1.5 -1.8 0.0
Medication for cholesterol 1.5 2.2 3.8 1.9 -2.0 -0.4 -1.1 -1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 2.6 0.3 -0.0 -1.6 -0.8 -0.2
Back pain experienced in last month 2.2 3.2 9.1 -1.4 2.0 -3.0 0.1 1.0
Mineral and other dietary supplements 1.8 2.4 5.1 -1.7 2.3 -0.8 1.2 1.4
Breast cancer (self-reported) 0.2 0.2 0.7 -0.3 0.6 -0.9 0.1 0.2
Asthma (self-reported) 1.5 2.9 9.2 0.7 -1.9 3.0 0.9 -0.7
Osteoporosis (self-reported) 2.5 3.1 9.0 -0.8 -0.1 3.0 2.3 0.8
Osteoarthritis (self-reported) 0.9 1.1 3.3 -0.7 1.2 -1.8 -0.4 0.6
Medication: Aspirin 3.1 4.0 5.3 -2.3 2.3 1.2 1.8 2.3
Medication: Gliclazide 0.3 0.4 1.3 -0.4 1.2 -0.6 0.3 -0.1
Illnesses of father: None of the above (group 1) 0.3 0.4 0.8 0.4 -0.6 -0.4 -0.9 0.5
Smoking status: Current 0.5 0.8 1.5 -0.7 1.2 -1.2 0.5 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 0.9 0.3 -0.6 0.9 -0.5 0.4
Whole body water mass 1.7 9.6 22.9 -2.8 4.8 -3.8 0.2 1.8
Leg predicted mass (right) 2.3 12.5 28.4 -3.9 5.3 -2.7 1.8 2.9
Arm fat mass (left) 4.5 18.7 26.6 -5.2 5.0 1.0 5.0 3.9
Number of self-reported non-cancer illnesses 1.5 2.7 5.3 -1.7 1.1 1.6 2.3 1.2
Average weekly champagne plus white wine intake 0.4 0.5 1.8 -0.6 -0.1 0.4 0.7 1.3
Miserableness 0.4 0.8 2.0 -0.7 0.7 0.9 1.4 0.2
Guilty feelings 0.2 0.3 1.1 -0.1 0.1 -1.1 -0.2 0.4
Wears glasses or contact lenses 0.1 0.1 0.4 0.1 -0.3 0.4 -0.2 -0.6
Ever taken oral contraceptive pill 0.6 0.7 1.6 1.1 -1.3 0.2 -0.7 -0.5
Hearing aid user 0.5 0.5 1.3 -0.9 0.6 0.2 0.5 1.1
Mother’s age at death 1.2 1.5 4.0 0.9 -2.0 1.5 0.4 -0.3
Financial situation satisfaction 0.1 0.2 0.4 0.1 0.5 0.2 -0.7 -0.2
Tinnitus: Yes, now most or all of the time 3.0 3.5 5.1 -2.1 1.4 1.4 2.2 2.0
Commuting to job workplace: Public transport 1.7 2.1 2.8 1.7 -1.4 0.9 -1.5 -1.6
Eye problems/disorders: Glaucoma 0.8 0.9 2.5 0.3 0.3 -1.6 -1.1 -0.9
Medication: Blood pressure 1.7 3.2 5.7 -2.2 2.4 0.6 1.6 1.6
Pain type(s) experienced in last month: Hip pain 1.7 2.2 2.8 -1.5 1.6 -1.7 0.7 1.6
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.0 1.1 -1.4 -0.1 -0.9 -0.3
High cholesterol (Self-reported) 0.3 0.6 2.5 -0.6 1.6 -0.2 -0.2 0.3
Medication: Bendroflumethiazide 1.4 2.1 5.1 -1.6 2.3 -1.4 0.6 0.8
Medication: Paracetamol 0.4 0.7 1.8 -0.5 -0.2 1.1 1.3 0.2
Medication: Lisinopril 0.4 0.6 1.4 -0.8 1.2 0.6 0.2 0.6
Medication: Atorvastatin 0.4 0.5 1.0 -0.7 0.8 1.0 0.2 0.7
Illnesses of father: High blood pressure 1.0 1.3 3.8 -0.3 -0.2 1.9 1.5 0.5
Alcohol drinker status: Never 0.6 0.7 1.7 0.1 0.6 -1.3 -0.9 -0.8
Ever smoked 0.9 1.6 3.6 -1.3 0.8 1.3 1.9 0.8
Basal metabolic rate 1.8 10.2 24.3 -3.3 4.9 -3.1 1.1 2.2
Leg fat percentage (left) 2.0 7.4 12.3 -3.2 3.0 0.9 3.5 2.1
Arm fat-free mass (left) 2.3 11.6 27.4 -3.1 5.2 -4.2 0.2 1.8
Number of operations (self-reported) 0.4 0.6 1.5 -0.4 0.3 1.2 0.8 0.8
Average weekly beer plus cider intake 0.7 1.0 2.5 0.5 0.3 -1.6 -1.5 -0.2
Irritability 1.3 2.2 7.3 -0.2 -0.7 2.7 1.8 0.2
Risk taking 0.1 0.2 0.7 0.1 0.0 -0.8 -0.2 -0.3
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.3 0.3 -1.1 0.4 0.5 -0.3
Fractured/broken bones in last 5 years 1.0 1.3 3.1 -0.7 0.2 1.8 1.5 0.8
Age started oral contraceptive pill 0.6 0.8 1.8 -0.9 0.5 -0.3 1.0 1.3
Diastolic blood pressure, automated reading 2.1 6.5 11.7 2.6 -1.7 -0.8 -3.4 -3.2
Ever depressed for a whole week 0.9 1.2 1.7 -1.0 0.5 1.3 1.3 1.1
Unable to work because of sickness or disability 2.6 3.3 9.9 0.4 1.0 -3.2 -2.2 -0.6
Commuting to job workplace: Cycle 2.0 2.5 5.2 1.8 -2.3 0.7 -1.4 -1.1
Myopia 0.6 0.8 1.5 -0.7 1.0 -1.1 0.0 1.2
Vascular/heart problems diagnosed by doctor 1.4 3.7 8.5 2.3 -2.9 -0.4 -1.6 -1.5
Cholesterol lowering medication 2.2 3.2 5.2 -2.2 2.3 0.7 1.4 1.9
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 2.2 -0.8 1.5 -0.7 0.5 -0.3
Pain experienced in last month 2.3 3.8 6.7 2.3 -2.6 1.2 -1.6 -1.8
Supplements: Calcium 1.5 1.6 3.6 -1.2 0.2 1.6 1.9 0.7
Basal cell carcinoma (self-reported) 5.1 6.1 8.8 2.9 -3.0 0.6 -2.5 -2.6
Heart attack/myocardial infarction (self-reported) 3.6 4.7 6.8 -2.5 2.6 -0.6 2.3 2.1
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.1 -1.0 1.1 0.1 0.1 1.0
Heart disease (siblings) 0.3 0.4 0.7 -0.6 0.8 -0.8 0.4 -0.0
Alcohol drinker status: Previous 0.4 0.5 1.0 0.6 0.2 -0.8 -1.0 -0.6
Pack years of smoking 1.8 2.6 3.4 -1.8 1.8 0.5 1.6 1.8
Impedance of whole body 5.5 27.8 66.3 5.0 -8.1 5.5 -0.3 -4.2
Leg fat mass (left) 2.6 10.3 17.4 -3.9 4.2 -0.2 3.4 2.7
Arm predicted mass (left) 2.4 12.4 29.6 -3.2 5.4 -4.3 0.2 2.0