TWAS hub - PLCL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0640	0.0270	6.5e-04	0.005	0.025	0.021	0.024	0.009	6.9e-02	4.9e-04	1.3e-03	5.5e-04	2.7e-02
2	GTEx	Artery Aorta	0.1090	0.0520	2.6e-03	0.102	NA	0.042	NA	0.064	2.9e-06	NA	2.3e-03	NA	2.0e-04
3	GTEx	Lung	0.1287	0.0524	8.7e-04	-0.001	NA	0.035	NA	0.001	4.1e-01	NA	9.5e-04	NA	2.6e-01
4	GTEx	Nerve Tibial	0.0731	0.0414	1.0e-02	0.005	NA	0.014	NA	0.012	1.3e-01	NA	3.1e-02	NA	4.4e-02
5	GTEx	Thyroid	0.0380	0.0190	4.5e-03	0.014	NA	0.000	NA	0.001	2.7e-02	NA	2.9e-01	NA	2.6e-01
6	GTEx	Whole Blood	0.0750	0.0290	3.9e-05	0.077	NA	0.046	NA	0.018	1.5e-07	NA	4.1e-05	NA	7.4e-03
7	METSIM	Adipose	0.0570	0.0205	1.1e-06	0.014	0.051	0.038	0.050	0.031	3.0e-03	3.6e-08	2.1e-06	4.7e-08	1.4e-05
8	NTR	Blood	0.0233	0.0111	4.6e-04	0.009	0.010	0.017	0.012	0.017	5.2e-04	3.4e-04	1.9e-06	8.0e-05	2.4e-06
9	YFS	Blood	0.1028	0.0223	0.0e+00	0.101	0.118	0.139	0.136	0.140	3.0e-31	1.1e-36	3.1e-43	2.7e-42	1.5e-43
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0395	0.0212	2.4e-03	0.000	0.017	0.005	NA	0.004	3.3e-01	4.0e-03	8.9e-02	NA	9.5e-02
11	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1830	0.0750	1.2e-03	0.110	0.064	0.118	NA	0.111	7.5e-07	1.5e-04	3.1e-07	NA	6.4e-07
12	TCGA	Prostate Adenocarcinoma	0.0705	0.0315	1.3e-06	0.057	0.066	0.052	NA	0.054	1.4e-06	1.8e-07	3.7e-06	NA	2.2e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Allergy or Eczema	12.3	32.5	86.1	3.6	0.6	1.7	0.6	9.3	8.5	5.0	6.4	8.6	5.8	2.3	-6.0
Impedance of arm (right)	12.1	56.4	141.6	6.4	2.4	0.1	2.6	11.9	10.9	7.4	8.4	9.8	9.4	4.2	-6.0
Impedance of arm (left)	11.6	53.8	136.9	6.5	2.4	-0.5	2.3	11.7	10.6	7.2	8.4	9.8	8.8	3.5	-5.9
Impedance of whole body	10.7	54.4	121.0	5.9	4.0	0.7	3.8	11.0	11.0	8.1	8.5	9.7	9.4	2.8	-4.2
Hayfever, allergic rhinitis or eczema	10.5	22.8	59.0	3.1	0.3	1.5	0.2	7.7	7.1	4.3	5.6	7.2	4.8	1.7	-4.8
Hayfever/allergic rhinitis (self-reported)	8.6	11.3	26.9	2.0	2.5	2.2	1.5	5.1	5.2	4.3	3.8	4.4	3.5	0.3	-0.9
Impedance of leg (right)	7.5	36.5	85.9	4.2	4.7	2.7	4.2	8.0	9.3	7.5	6.8	7.7	7.7	0.7	-1.9
Chronotype (morning person)	7.0	16.3	35.4	-2.0	-1.7	-2.0	-2.2	-5.1	-5.8	-4.9	-4.0	-4.9	-6.0	-3.6	2.6
Impedance of leg (left)	6.9	33.5	76.6	3.5	4.7	2.1	4.2	7.5	8.8	7.3	6.7	7.4	7.5	1.2	-1.4
Schizophrenia vs Biploar Disorder	6.5	8.6	14.6	3.3	3.6	3.3	2.3	3.4	3.8	3.8	2.2	2.7	3.2	-0.1	0.6
Overall health rating	6.5	14.0	29.3	-3.9	-1.7	-2.9	-1.8	-5.3	-5.4	-4.9	-3.2	-4.1	-4.8	-1.5	2.2
Allergy	6.4	14.8	35.5	-2.4	0.4	-1.1	-0.7	-5.7	-6.0	-2.6	-4.9	-5.9	-3.7	-1.7	4.4
Exposure to tobacco smoke outside home	5.5	7.3	16.0	-2.2	-3.1	-1.7	-0.9	-3.3	-3.3	-4.0	-2.8	-3.0	-3.7	-1.3	0.1
Crohns Disease (2012)	5.4	8.8	20.7	1.4	0.6	0.8	0.2	4.2	4.5	3.7	3.6	4.4	2.9	0.3	-2.9
Arm fat-free mass (right)	4.9	25.0	58.4	-5.7	-1.6	-1.1	-3.2	-7.6	-7.5	-3.1	-5.1	-6.2	-6.6	-3.0	3.2
Arm predicted mass (left)	4.9	25.0	58.7	-5.8	-1.9	-1.5	-3.6	-7.2	-7.7	-3.0	-5.3	-6.4	-6.7	-2.9	2.6
BMI	4.8	27.8	74.5	-5.2	-5.6	-2.9	-5.3	-4.0	-7.3	-6.4	-4.2	-4.7	-8.6	-3.5	-1.1
Body mass index (BMI)	4.8	20.4	49.4	-4.5	-4.7	-2.6	-4.0	-3.8	-6.3	-5.6	-4.5	-4.4	-7.0	-2.2	-1.2
Arm predicted mass (right)	4.7	24.0	56.1	-5.7	-1.6	-1.4	-3.3	-7.4	-7.5	-3.1	-4.9	-6.0	-6.6	-2.9	2.8
Crohns Disease (2017)	4.6	10.0	29.4	-0.2	-0.1	-0.2	-0.5	4.2	4.9	4.1	3.9	5.4	2.9	0.2	-3.0
Schizophrenia (2014)	4.5	9.9	30.5	2.6	-0.4	-0.8	-1.1	5.5	4.7	0.9	2.9	4.4	2.0	1.4	-4.9
Arm fat-free mass (left)	4.4	22.1	54.1	-5.4	-1.7	-1.6	-3.4	-6.9	-7.4	-2.8	-4.9	-6.1	-6.2	-2.3	2.3
Schizophrenia (2018)	4.2	8.6	24.4	2.4	0.1	-0.9	-0.5	4.9	4.4	1.3	2.8	4.1	2.5	1.9	-4.2
Unable to work because of sickness or disability	4.0	5.1	18.5	-2.7	0.7	0.4	1.4	-4.3	-3.0	-1.1	-0.9	-2.0	-2.2	-1.4	3.4
Seen doctor (GP) for nerves, anxiety, tension or depression	3.9	6.0	20.1	-2.8	-3.9	-4.5	-2.9	0.1	-1.2	-1.9	0.6	0.3	-2.0	0.2	-3.4
Leg pain on walking	3.9	4.9	17.0	-2.8	-1.7	-2.4	-2.7	-1.5	-1.9	-2.1	-0.0	-0.3	-4.1	-2.9	-0.5
Mother’s age at death	3.8	4.7	11.8	0.4	0.3	-0.2	0.3	2.8	3.4	2.7	3.4	3.4	2.0	0.2	-1.5
Basal cell carcinoma (self-reported)	3.8	4.5	10.1	-0.0	2.5	1.0	1.6	0.8	2.7	2.7	2.6	2.8	3.2	1.8	1.2
Bipolar Disorder or Schizophrenia	3.6	8.7	37.5	2.1	-1.8	-2.9	-2.5	4.2	3.0	-0.7	1.9	3.2	0.7	1.4	-6.1
Medication: Metformin	3.6	5.1	10.6	-1.2	-1.8	-2.1	-2.9	-2.0	-3.3	-2.6	-2.8	-2.6	-2.6	0.7	-0.4
Health satisfaction	3.6	4.6	16.1	-4.0	-1.0	-2.0	-0.1	-3.1	-2.6	-2.2	-0.1	-1.3	-2.9	-0.9	1.6
Bipolar Disorder (2018)	3.5	5.5	20.4	0.5	-3.0	-3.5	-3.5	0.6	-0.6	-2.8	-0.4	0.1	-2.0	-0.0	-4.5
Comparative body size at age 10	3.5	9.7	17.6	-1.9	-2.8	-0.9	-2.2	-3.9	-4.1	-4.0	-4.2	-4.2	-3.8	-1.2	0.2
Time employed in main current job	3.4	3.9	8.7	-0.5	-2.0	-0.7	-2.4	-0.9	-2.1	-2.7	-3.0	-2.4	-2.5	-1.5	-0.6
Asthma	3.4	6.8	15.5	2.4	1.2	1.2	2.2	3.4	3.9	2.7	3.2	3.0	3.3	1.2	-1.4
Osteoporosis (self-reported)	3.4	4.2	12.2	2.1	-0.8	0.8	-2.0	3.5	2.3	0.7	2.0	2.8	0.3	-0.9	-3.2
Whole body fat-free mass	3.3	18.7	45.3	-4.9	-1.7	-1.5	-3.1	-6.5	-6.7	-2.5	-4.5	-5.6	-5.6	-1.9	2.2
Whole body water mass	3.3	18.7	45.4	-4.8	-1.7	-1.6	-3.2	-6.4	-6.7	-2.6	-4.4	-5.6	-5.7	-2.0	2.2
Angina (self-reported)	3.2	4.2	14.7	-2.9	-3.8	-2.8	-1.9	-0.4	-1.6	-1.9	-0.6	-0.9	-1.5	1.1	-2.2
Leg fat-free mass (right)	3.2	16.9	41.3	-4.5	-2.8	-2.7	-3.7	-5.4	-6.4	-3.2	-4.1	-5.0	-5.5	-0.9	0.7
Leg predicted mass (right)	3.2	17.1	41.6	-4.5	-2.9	-2.7	-3.8	-5.4	-6.5	-3.3	-4.2	-5.0	-5.5	-0.9	0.7
Primary Biliary Cirrhosis	3.1	4.4	11.3	-0.8	-0.8	-0.6	-1.4	-3.1	-3.4	-2.3	-2.5	-2.9	-2.6	-1.1	0.5
Basal metabolic rate	3.1	17.1	41.0	-4.9	-2.2	-2.0	-3.5	-5.6	-6.4	-2.6	-4.2	-5.1	-5.7	-1.9	1.3
Rheumatoid Arthritis	3.0	4.2	12.5	-1.4	0.4	-0.1	0.3	-2.8	-3.5	-1.8	-1.9	-2.7	-2.6	-1.1	2.4
Angina	3.0	3.9	13.4	-2.9	-3.7	-2.7	-1.8	-0.4	-1.6	-1.8	-0.5	-0.9	-1.4	1.1	-2.1
Trunk predicted mass	3.0	17.0	43.3	-4.6	-0.8	-0.7	-2.6	-6.6	-6.4	-1.7	-4.2	-5.5	-5.2	-2.2	2.9
Leg predicted mass (left)	2.9	15.5	37.2	-4.3	-2.8	-2.6	-3.8	-4.8	-6.1	-3.0	-4.0	-4.7	-5.4	-1.2	0.3
Trunk fat-free mass	2.9	16.5	42.8	-4.6	-0.8	-0.6	-2.5	-6.5	-6.3	-1.6	-4.1	-5.4	-5.0	-2.1	2.9
Happiness	2.9	3.6	7.6	-2.5	-1.5	-1.8	-1.2	-2.8	-2.4	-2.5	-0.6	-1.4	-2.4	-0.3	1.4
Shortness of breath walking on level ground	2.9	3.5	11.3	-1.5	-1.5	-1.3	-1.2	-1.9	-2.2	-2.7	-1.3	-1.6	-3.4	-1.5	0.5
Verbal and Numeric Reasoning (VNR)	2.8	6.8	14.4	1.0	0.7	0.0	1.4	3.4	3.7	2.3	2.8	3.5	3.8	2.7	-2.4
Leg fat-free mass (left)	2.8	15.1	36.4	-4.2	-2.8	-2.5	-3.7	-4.8	-6.0	-3.0	-4.0	-4.6	-5.3	-1.2	0.4
Fluid intelligence score	2.8	5.8	12.2	2.4	1.4	0.4	0.7	3.1	3.2	2.3	2.3	3.0	3.5	2.5	-2.1
Ulcerative Colitis	2.7	3.9	10.9	-0.7	-3.1	-2.6	-2.5	-0.1	-1.9	-2.4	-0.8	-1.0	-1.5	0.1	-3.3
Back pain experienced in last month	2.7	3.9	13.1	-3.6	-0.9	-2.3	0.3	-2.8	-2.7	-1.6	-0.7	-1.6	-2.0	0.3	1.8
Irritability	2.7	4.6	15.3	0.1	-0.3	-0.5	0.0	3.1	3.2	1.0	3.0	3.9	1.5	1.0	-2.5
Friendships satisfaction	2.6	3.3	7.9	-1.5	-2.5	-1.5	-2.1	-1.4	-1.6	-2.3	-1.0	-0.8	-2.8	-1.0	-1.9
Asthma (self-reported)	2.6	5.2	12.7	2.2	0.7	1.0	1.7	3.1	3.6	2.3	2.6	2.6	2.9	1.2	-1.7
Respiratory disease	2.5	5.5	11.0	1.4	1.3	0.9	1.9	3.0	3.3	2.5	3.1	3.2	3.1	1.5	-0.9
Lung cancer (father)	2.5	2.9	10.5	-2.5	-1.6	-3.2	-1.5	-1.4	-1.6	-1.7	0.8	0.2	-2.2	0.2	-0.7
Arm fat mass (right)	2.5	10.3	24.4	-3.8	-4.0	-3.1	-4.2	-0.7	-3.8	-2.9	-2.2	-1.8	-4.9	-1.4	-2.7
Commuting to job workplace: Car/motor vehicle	2.5	2.9	5.6	-2.4	-1.1	-0.5	-1.7	-1.8	-2.3	-1.7	-2.3	-1.8	-2.0	-0.7	0.6
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.9	12.8	-3.6	-1.8	-2.1	-1.8	-2.4	-2.4	-1.5	-0.6	-1.2	-2.6	-0.3	0.5
Falls in the last year	2.4	3.2	16.2	-4.0	-1.3	-2.2	-0.4	-1.8	-2.1	-0.4	0.4	-0.5	-1.6	-1.0	2.0
Arm fat mass (left)	2.4	9.7	24.8	-3.3	-3.8	-2.9	-4.1	-0.7	-3.6	-2.9	-2.1	-1.8	-5.0	-1.6	-2.8
Intelligence (Savage-Jansen 2018)	2.3	6.9	15.4	1.4	0.5	0.1	0.2	3.0	3.6	2.0	2.5	3.2	3.9	3.6	-3.2
Pulse wave peak to peak time	2.3	2.8	8.4	-0.1	1.8	-0.1	1.9	-0.6	0.1	2.3	0.1	-0.2	2.9	2.7	2.3
Neck or shoulder pain in last month	2.3	3.2	6.3	-2.5	-2.4	-0.7	-1.0	-2.2	-2.4	-2.5	-1.5	-1.5	-1.7	0.5	-0.7
Ever used hormone-replacement therapy (HRT)	2.2	2.8	7.0	-1.5	-1.7	-1.1	-2.1	-2.7	-2.5	-1.7	-0.8	-1.6	-1.8	-0.1	-0.5
Vitamin and mineral supplements	2.2	3.0	9.5	-0.1	1.5	-0.5	1.9	-2.5	-2.1	-0.8	-1.7	-2.3	-0.0	0.6	3.1
Diabetes (mother)	2.2	2.8	7.9	-2.8	-1.7	-2.5	-1.0	-2.3	-1.5	-1.7	-0.3	-0.9	-2.2	-0.4	0.1
Weight	2.2	11.0	27.6	-4.3	-2.8	-2.6	-3.7	-2.9	-4.7	-2.5	-2.7	-3.0	-5.3	-1.8	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.8	6.4	-2.4	-2.4	-2.5	-1.4	-0.7	-2.4	-1.3	-0.2	-1.3	-1.6	0.3	-1.3
Age at first live birth	2.2	3.9	9.1	1.7	2.2	-1.0	1.4	1.9	2.7	1.8	2.3	1.9	3.0	2.1	-0.3
Ulcerative Colitis (UC)	2.1	3.9	8.0	-1.6	-2.7	-2.4	-2.5	-1.0	-2.2	-2.8	-1.2	-1.3	-1.4	0.7	-2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	7.6	-2.7	-1.4	-0.7	-1.6	-2.0	-2.2	-1.7	-1.0	-1.1	-2.5	-1.0	0.3
Mineral and other dietary supplements	2.1	2.8	8.5	-1.0	-1.3	-1.8	-1.2	-1.0	-2.9	-2.4	-1.7	-2.0	-1.6	0.9	-0.3
Osteoarthritis (self-reported)	2.1	2.8	12.3	-3.5	-0.6	-1.2	-0.5	-3.0	-1.8	-0.7	-0.5	-1.1	-1.6	-0.4	1.6
Cardiovascular Disease	2.0	6.5	16.7	-1.6	-1.5	-2.7	-2.1	-2.4	-3.8	-2.9	-2.2	-2.8	-4.1	-1.9	-0.1
Pulse wave Arterial Stiffness index	2.0	2.3	6.3	0.3	-1.5	0.1	-1.8	0.8	0.2	-1.7	0.3	0.5	-2.5	-2.5	-2.3
Birth weight	2.0	4.3	11.1	-2.3	-0.9	0.1	-0.1	-3.3	-3.2	-2.0	-2.6	-3.0	-1.7	0.5	1.1
Leg fat mass (left)	2.0	8.0	21.5	-4.2	-2.6	-2.5	-2.8	-1.6	-3.8	-2.4	-2.0	-2.0	-4.6	-1.8	-1.1
Lupus	1.9	2.9	10.8	0.2	-0.2	0.5	0.8	-1.5	-2.8	-1.2	-2.9	-3.3	-1.1	-0.6	1.1
Ever had hysterectomy (womb removed)	1.9	2.1	6.1	-1.6	-1.1	-1.0	-1.4	-2.5	-2.1	-1.4	-1.1	-1.5	-1.5	0.4	0.3
Supplements: Glucosamine	1.9	2.5	7.2	1.0	0.6	1.7	-0.2	1.9	2.7	2.5	1.0	1.6	1.9	0.3	-1.1
Alcohol usually taken with meals	1.9	3.0	8.0	1.1	-0.3	-0.1	-1.5	2.5	2.4	1.1	2.2	2.8	0.9	0.6	-2.3
Mouth/teeth dental problems: Dentures	1.9	3.2	12.1	1.4	-0.0	-1.9	0.1	3.5	2.1	1.5	2.0	1.9	0.8	-0.1	-2.4
Pulse wave reflection index	1.9	2.4	6.1	-2.5	-0.7	-0.7	-1.8	-1.9	-1.2	-1.6	-1.4	-1.1	-2.2	-1.5	-0.5
Type 2 Diabetes (T2D) (2018)	1.8	3.4	7.8	-1.3	-1.6	-1.4	-2.5	-1.9	-2.4	-2.7	-1.1	-1.6	-2.8	-0.3	-0.1
Lung FEV1/FVC ratio	1.8	9.0	25.6	-1.9	-4.5	-3.1	-3.8	-0.2	-2.4	-3.6	-0.1	-0.2	-5.1	-2.7	-3.0
Diabetes (father)	1.8	2.2	6.1	-1.2	-1.2	-0.3	-0.4	-1.6	-2.5	-0.8	-2.2	-2.2	-1.7	-1.0	0.2
Waist circumference	1.8	6.5	14.2	-2.4	-3.2	-3.2	-3.6	-0.2	-2.8	-2.2	-1.6	-1.3	-3.8	-0.9	-2.6
Had other major operations	1.8	2.2	7.0	0.2	-0.7	-0.2	-0.5	1.4	1.8	1.1	2.5	2.6	0.7	-0.2	-2.2
Leg fat mass (right)	1.8	6.8	18.8	-3.9	-2.6	-2.2	-2.7	-1.3	-3.4	-2.2	-1.7	-1.7	-4.3	-1.8	-1.4
Arm fat percentage (left)	1.8	7.0	19.4	-1.5	-3.9	-3.1	-3.6	2.1	-1.5	-2.4	-0.6	0.2	-3.3	-0.6	-4.4
Eye problems/disorders: Glaucoma	1.8	2.2	5.2	-0.3	0.9	0.5	1.6	-1.7	-1.8	-1.6	-1.3	-2.0	-1.1	-1.2	2.3
Commuting to job workplace: Cycle	1.8	2.2	8.1	0.4	1.2	0.3	1.8	1.0	1.7	2.8	0.9	1.2	2.5	0.9	0.6
Myopia	1.8	2.6	7.9	0.3	-1.2	-0.1	-1.3	-1.9	-2.2	-1.5	-2.8	-2.8	-0.6	1.2	0.7
Pain experienced in last month	1.8	3.1	8.0	2.8	1.8	2.2	1.1	2.0	2.2	2.1	1.1	1.3	2.0	-0.3	0.0
Heart attack/myocardial infarction (self-reported)	1.8	2.4	4.8	-1.5	-2.1	-1.4	-1.4	-0.8	-1.7	-2.2	-1.5	-1.5	-1.9	0.2	-0.9
Major Depression (MDD)	1.7	2.1	7.9	-0.3	0.7	-0.6	-0.6	1.4	1.7	0.8	2.8	2.7	0.3	-0.7	-1.6
Hand grip strength (left)	1.7	4.5	14.2	-1.2	1.6	3.7	0.9	-2.9	-1.5	0.7	-0.2	-1.3	-1.9	-3.8	2.4
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	8.4	-2.8	-1.3	-0.6	-0.6	-2.9	-1.6	-1.7	-1.1	-1.3	-0.7	0.9	1.8
Heart attack	1.7	2.2	4.7	-1.6	-1.9	-1.4	-1.4	-0.8	-1.6	-2.2	-1.4	-1.4	-1.8	0.5	-0.7
Arm fat percentage (right)	1.7	6.7	19.3	-1.7	-4.0	-2.8	-3.5	2.2	-1.5	-2.2	-0.7	0.1	-3.0	-0.2	-4.4
Prospective memory result	1.7	2.0	8.0	-2.8	-0.1	0.5	1.1	-2.1	-1.2	-0.7	0.4	-0.3	-1.4	-1.6	2.0
Medication: Ventolin 100micrograms inhaler	1.7	2.2	3.8	1.1	1.6	1.1	1.7	1.7	1.7	1.4	2.0	1.9	1.7	0.8	0.6
Medication: Gliclazide	1.7	1.9	4.8	0.3	0.1	-2.0	-0.2	-0.6	-2.2	-1.2	-1.9	-2.1	-1.6	-0.5	1.1
Pain type(s) experienced in last month: Hip pain	1.7	2.1	10.2	-3.2	-1.5	-0.5	0.7	-2.3	-1.3	-1.1	0.5	-0.4	-1.5	-0.3	0.8
Medication: Bendroflumethiazide	1.7	2.6	6.9	-1.6	-0.8	-1.6	-0.2	-2.5	-2.2	-0.9	-1.6	-2.6	-1.4	0.4	-0.9
Irritable Bowel Disease (IBD)	1.6	3.8	14.3	-0.7	-1.9	-1.9	-2.4	2.3	1.4	1.0	1.6	2.5	0.9	0.6	-3.8
Trunk fat percentage	1.6	6.3	24.5	-1.2	-2.6	-3.5	-2.6	3.9	0.5	-0.3	1.2	2.1	-1.5	-0.1	-5.0
Hearing difficulty/problems with background noise	1.6	2.5	8.1	1.0	-1.7	-0.9	-2.9	-0.5	-0.8	-1.7	-2.0	-1.2	-2.1	-0.4	-1.7
Medication: Ramipril	1.6	2.0	5.6	-0.0	-0.0	-0.8	0.5	-1.8	-2.4	-1.8	-1.9	-2.3	-1.3	0.3	0.8
Glaucoma (self-reported)	1.6	1.9	5.5	-0.1	1.3	0.7	1.5	-1.5	-1.6	-0.9	-1.4	-1.9	-0.8	-1.2	2.4
Medication: Seretide 50 evohaler	1.6	1.8	5.1	-1.2	-0.1	-1.6	-0.6	1.3	0.7	1.0	2.3	2.0	0.6	1.4	-1.6
Alcohol drinker status: Never	1.6	2.0	3.9	-0.1	0.9	0.6	1.8	-2.0	-1.7	-0.8	-1.1	-1.8	-1.7	-1.4	1.6
Cholesterol lowering medication	1.6	2.3	7.4	-1.5	-1.8	-2.0	-2.7	-1.2	-1.6	-1.5	-1.1	-0.9	-1.7	0.1	-0.6
Supplements: Calcium	1.6	1.8	6.3	1.8	-0.7	0.2	-1.4	1.8	1.4	0.2	1.2	1.6	0.0	-0.5	-2.5
Blood Red Count	1.5	14.2	33.7	-4.1	-1.7	-1.5	0.6	-5.8	-5.2	-3.6	-5.1	-5.8	-3.0	0.3	2.4
Supplements: Zinc	1.5	1.7	6.3	0.1	-1.2	-0.4	-2.5	0.3	-0.4	-0.3	-0.5	0.3	-2.0	-2.2	-1.6
Hand grip strength (right)	1.5	4.0	17.1	-2.1	1.1	1.9	0.5	-2.4	-1.5	1.0	-0.1	-1.1	-2.3	-4.1	2.4
Medication: Amlodipine	1.5	2.1	7.3	-0.2	-1.8	-1.0	-0.5	-1.3	-1.4	-2.7	-1.0	-1.3	-2.3	-1.2	0.1
Heart disease (mother)	1.5	1.8	8.4	-2.9	-1.8	-2.0	-1.2	-0.7	-0.2	-0.6	0.7	0.8	-1.4	-0.7	-0.4
Number of full sisters	1.5	1.9	5.6	-0.8	-0.9	-1.7	0.6	-2.0	-2.4	-1.0	-1.7	-1.9	-0.9	0.3	0.6
Knee pain experienced in last month	1.5	2.4	8.2	-2.9	-1.3	-2.1	-0.7	-1.8	-1.5	-1.9	-0.1	-0.5	-2.0	0.0	-0.0
Hypertension (Self-reported)	1.5	4.1	12.6	-1.5	-1.7	-2.1	-2.0	-1.6	-3.0	-2.5	-1.3	-1.7	-3.6	-1.0	-1.1
Handedness (chirality/laterality): Left-handed	1.5	1.8	10.2	-0.3	-1.4	-1.1	-1.1	-0.1	0.2	-1.2	-0.4	-0.1	1.1	3.2	-2.0
Medication: Aspirin	1.5	2.0	5.7	-2.2	-2.2	-2.4	-1.0	-1.2	-0.7	-1.3	0.1	-0.4	-0.9	0.9	-1.2
Commuting to job workplace: Public transport	1.5	1.8	8.4	2.9	1.7	0.9	0.9	0.5	1.0	1.4	0.6	0.2	2.0	1.1	-0.1
Ever had prostate specific antigen (PSA) test	1.5	1.7	4.1	0.3	0.3	-1.1	-0.1	1.9	1.7	1.5	1.7	2.0	1.2	0.3	-1.3
Mean Putamen Volume	1.4	1.6	5.6	0.9	1.4	0.8	-0.0	1.5	2.4	1.0	1.2	2.2	0.9	-0.1	-0.5
Blood Platelet Count	1.4	15.9	74.8	-1.6	4.4	1.9	5.4	-5.7	-3.1	-0.1	-1.9	-3.4	-1.0	-2.1	8.7
Blood White Count	1.4	10.1	25.2	-3.7	-5.0	-2.8	-3.7	-0.5	-4.3	-2.7	-2.5	-2.7	-3.8	-0.3	-2.7
Hearing difficulty/problems: Yes	1.4	2.1	4.5	-0.1	-1.6	-0.3	-1.8	-1.7	-1.5	-1.9	-1.7	-1.5	-2.1	-0.8	-0.6
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.7	3.1	0.1	0.8	-0.0	1.2	1.6	1.7	1.5	1.8	1.7	1.7	0.9	-0.7
Supplements: Vitamin C	1.4	1.7	5.2	-1.2	-1.9	-1.0	-2.3	-0.1	-0.1	-0.6	0.6	0.8	-1.7	-1.2	-1.9
Fasting Glucose	1.3	1.5	3.5	-1.3	-1.1	-1.5	-0.7	-0.2	-1.9	-1.4	-1.5	-1.4	-1.6	-0.1	-0.2
Waist Hip Ratio (WHR)	1.3	5.7	13.9	2.5	0.6	-1.0	-1.2	3.7	3.5	2.5	1.6	2.9	2.8	0.6	-2.8
Average weekly spirits intake	1.3	1.6	7.4	-0.5	-0.1	0.9	-0.2	-2.7	-1.2	-1.0	-0.7	-0.9	-1.4	-1.5	1.4
Hip circumference	1.3	5.5	14.1	-2.8	-2.8	-2.9	-3.2	-0.2	-2.6	-1.8	-0.8	-0.9	-3.8	-1.1	-2.1
Body fat percentage	1.3	5.1	18.7	-1.8	-2.8	-3.0	-2.8	2.7	-0.4	-1.1	0.4	1.2	-2.2	-0.3	-4.3
Medication for pain relief, constipation, heartburn	1.3	2.2	6.9	0.8	1.6	1.4	1.9	0.6	1.5	2.6	0.7	0.8	1.9	-0.1	1.9
Medication: Blood pressure	1.3	2.3	6.8	-0.9	-1.5	-0.5	-1.5	-0.4	-2.1	-2.4	-1.1	-1.1	-2.6	-1.0	-1.3
Whole body fat mass	1.3	5.4	11.9	-3.1	-2.7	-3.0	-3.2	0.5	-2.1	-1.3	-0.7	-0.3	-3.5	-1.0	-2.9
Family relationship satisfaction	1.3	1.6	5.1	-0.7	-1.1	-1.0	-1.1	-1.4	-1.5	-1.8	-0.6	-0.9	-2.2	-1.3	-0.1
Medication: Aspirin	1.3	1.7	4.5	-1.7	-2.1	-1.9	-0.9	-1.3	-0.8	-1.7	-0.1	-0.4	-1.5	0.1	-0.9
Financial situation satisfaction	1.3	1.6	6.1	-2.5	0.3	-0.3	0.2	-1.6	-0.7	-0.1	1.0	0.4	-1.7	-1.8	1.3
High cholesterol (Self-reported)	1.3	2.3	6.1	0.6	-0.2	-0.9	-1.6	-1.6	-2.5	-1.7	-1.9	-1.9	-1.9	-0.8	1.0
Vascular/heart problems diagnosed by doctor	1.3	3.5	8.7	1.2	1.5	2.3	1.6	1.3	2.7	2.4	1.4	1.9	2.9	0.7	0.6
Body Mass Index (BMI) (2010)	1.2	1.6	4.5	-1.9	-2.0	-0.6	-1.2	0.2	-0.7	-1.9	0.1	0.2	-2.1	-1.1	-0.9
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	3.2	-0.6	0.2	-0.9	-0.2	-1.8	-1.6	-0.7	-1.2	-1.5	-0.3	1.3	1.5
Medication: Atenolol	1.2	1.5	5.3	-0.7	-0.2	-0.3	-0.8	2.3	-0.2	1.8	0.6	0.7	1.0	1.9	-1.7
Length of working week for main job	1.2	1.3	4.4	-2.1	-0.2	0.5	1.3	-1.9	-1.7	0.6	-0.6	-1.4	0.0	0.0	0.8
Birth weight of first child	1.2	2.3	5.8	-1.9	-2.4	-0.5	-1.1	-0.9	-1.4	-1.9	-1.9	-1.8	-0.7	1.2	-1.0
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	5.7	0.2	0.8	1.0	1.5	1.0	1.9	2.3	1.2	1.2	2.4	1.2	0.2
Long-standing illness, disability or infirmity	1.2	1.8	5.5	-2.2	-0.2	-2.3	-0.5	-2.1	-1.4	-0.7	0.7	-0.4	-0.9	0.5	1.5
Ever had bowel cancer screening	1.2	1.4	8.1	-0.8	-1.2	-1.4	-0.3	0.2	0.5	-0.6	1.3	0.9	-0.0	1.0	-2.9
Diabetes diagnosed by doctor	1.2	1.9	6.4	-1.0	-1.0	-2.5	-1.8	-1.2	-1.5	-1.7	-0.0	-0.6	-1.9	0.8	-0.2
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.8	-0.6	-1.9	0.2	-1.6	0.9	0.2	-0.8	0.9	1.3	-1.5	-1.3	-1.6
Average weekly beer plus cider intake	1.2	1.8	4.5	-1.4	0.2	-0.2	1.2	-2.0	-1.5	-1.2	-1.3	-1.8	-0.9	-0.7	2.1
Alcohol drinker status: Previous	1.2	1.4	4.2	-0.8	0.7	-0.1	1.2	-1.1	-1.1	-0.7	-0.1	-0.5	-1.5	-2.0	1.9
Bipolar Disorder (2011)	1.1	1.0	4.8	1.7	-0.2	-0.9	0.2	1.5	0.8	-0.8	0.2	0.2	0.3	0.6	-2.2
Neuroticism (2016)	1.1	1.6	6.6	-1.7	-0.3	0.4	0.5	-0.3	1.5	0.2	2.6	2.4	-0.5	-1.0	-0.4
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.4	-1.8	-1.5	-0.1	-0.8	-1.6	-1.8	-1.7	-0.4	-0.8	-1.4	-0.5	0.4
Trunk fat mass	1.1	4.5	12.5	-2.3	-2.3	-3.2	-2.9	1.8	-1.1	-0.5	0.1	0.6	-2.6	-0.6	-3.5
Qualifications: None of the above	1.1	2.4	5.7	-0.7	-1.0	-0.3	-0.4	-1.5	-2.0	-2.2	-1.7	-2.0	-2.4	-1.6	-0.0
Medication: Cholesterol lowering	1.1	1.8	5.2	0.7	-0.6	-0.5	-1.3	-0.7	-1.7	-2.3	-1.6	-1.4	-1.9	-1.1	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.8	1.2	1.3	1.2	-0.9	0.2	1.1	1.5	0.8	1.3	1.0	-0.7	1.7
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	9.4	-0.0	0.1	-0.0	0.8	-3.1	-0.8	-1.2	-1.7	-1.8	-0.4	0.2	1.6
Breast Cancer	1.0	2.3	7.7	-0.5	2.5	0.2	1.2	0.5	1.6	2.8	1.0	1.6	2.3	0.3	0.9
Other serious medical condition/disability diagnosed by doctor	1.0	1.2	2.2	-0.8	-0.4	-0.3	-1.4	-1.5	-1.4	-0.7	-1.1	-1.5	-1.4	-0.8	1.3
Medication for hormone replacement therapy	1.0	1.1	3.3	1.0	0.7	1.5	1.8	-1.1	-0.2	-0.3	0.1	-0.7	1.4	1.6	0.5
High blood pressure	1.0	2.8	9.4	-0.7	-1.0	-1.9	-1.4	-1.1	-2.6	-2.2	-1.0	-1.5	-3.1	-1.0	-0.6
High blood pressure (mother)	1.0	1.5	4.2	1.2	-1.2	-0.9	-1.5	0.3	-0.5	-1.5	-1.7	-0.8	-0.1	1.1	-2.0
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.1	-1.3	-0.6	-1.8	-1.1	-1.5	-1.1	-1.4	0.7	-0.2	-1.3	0.0	0.7
Diabetes (self-reported)	1.0	1.5	6.8	-0.8	-0.5	-2.6	-1.1	-1.3	-1.6	-1.3	-0.2	-0.8	-1.6	0.8	0.3
Medication: Lansoprazole	1.0	1.2	5.5	-2.3	-1.1	-1.6	-0.8	-0.6	-1.2	-0.8	0.4	-0.1	-1.3	-0.1	0.1
Illnesses of mother	1.0	1.2	3.8	0.6	1.8	1.7	0.8	0.7	0.3	2.0	0.5	0.4	1.2	0.5	1.0
Ever highly irritable/argumentative for 2 days	1.0	1.2	4.0	-1.8	-0.8	0.5	-0.5	-0.3	1.0	0.2	2.0	1.8	-0.4	-0.1	-1.3
Gout (self-reported)	1.0	1.4	5.2	-2.1	-0.7	-0.9	-1.4	-2.3	-1.1	-0.9	-0.2	-0.5	-0.3	1.0	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	5.6	-0.4	0.5	0.1	-0.7	0.6	0.9	1.1	0.3	0.3	2.1	2.4	0.0
Average weekly champagne plus white wine intake	1.0	1.4	4.8	1.1	-1.4	-0.3	-1.8	1.0	0.8	-0.2	0.1	0.4	1.5	2.2	-1.4
Illnesses of father: High blood pressure	1.0	1.3	5.4	2.3	-0.5	-0.1	-0.8	2.3	0.9	-0.1	-0.7	0.1	0.3	0.2	-1.6
Leg fat percentage (left)	1.0	3.8	10.4	-3.0	-2.1	-2.3	-1.7	0.2	-2.1	-1.6	-0.9	-0.6	-3.2	-1.3	-1.7
Depression (Nagel 2018)	0.9	1.3	6.1	-2.5	-0.7	0.6	-0.5	-1.3	-0.8	-0.8	0.5	0.2	-1.6	-1.5	0.7
Reaction Time	0.9	1.7	4.3	0.5	1.5	-1.0	2.1	0.2	0.2	0.4	-1.3	-1.4	2.0	2.0	-0.0
Prostate Cancer	0.9	1.3	3.1	-1.8	-0.3	-1.5	-1.7	-0.0	0.7	1.6	1.4	1.3	0.2	-0.5	-0.4
Blood Eosinophil Count	0.9	6.6	18.5	0.5	0.2	-0.2	0.1	4.3	3.2	3.6	1.8	2.7	3.2	3.1	-2.7
Pack years adult smoking proportion	0.9	1.4	3.1	-1.6	-1.8	-1.3	-0.6	-0.6	-1.6	-1.5	-0.4	-0.4	-1.7	-0.5	-0.7
Stomach or abdominal pain in last month	0.9	1.1	2.7	0.5	-0.3	-0.8	0.2	-1.5	-1.0	-1.3	-0.5	-0.9	-1.6	-1.6	0.9
Medication: Levothyroxine sodium	0.9	1.6	4.1	-1.0	-1.1	-0.2	-0.6	-1.3	-1.9	-1.5	-1.4	-2.0	-1.2	0.2	-0.9
Pain all over the body in last month	0.9	0.9	3.2	-1.5	0.1	-1.3	-1.8	-0.7	-0.7	-0.2	-1.0	-0.5	-0.3	1.2	0.6
Pulse rate	0.9	1.6	7.0	2.7	-0.1	-0.2	-0.1	1.8	1.4	-0.0	1.1	1.0	-0.6	-1.6	-1.2
Leg fat percentage (right)	0.9	3.3	8.9	-2.6	-2.0	-1.9	-1.8	0.6	-1.5	-1.5	-0.6	-0.2	-3.0	-1.6	-2.2
Mouth/teeth dental problems: Loose teeth	0.9	1.1	4.0	-0.8	-1.6	-0.4	-0.4	-0.8	-0.9	-2.0	-0.3	-0.4	-1.8	-0.8	0.0
Mean time to correctly identify matches	0.9	1.7	5.2	0.5	1.6	-1.3	2.2	0.7	1.0	1.0	-0.1	-0.3	2.3	2.0	-0.3
Alcohol intake frequency.	0.9	2.0	9.2	-0.1	0.6	0.2	1.1	-0.6	-1.5	-0.9	-0.3	-0.9	-3.0	-2.8	1.1
Age at last live birth	0.9	1.3	3.3	1.1	1.4	-0.9	0.7	1.0	1.5	0.9	1.4	0.8	1.8	1.1	-0.1
Commuting to job workplace: Walk	0.9	0.9	4.6	-1.1	0.8	0.6	2.1	-0.2	0.7	0.4	0.8	0.2	1.1	0.7	1.2
Diastolic blood pressure, automated reading	0.9	2.9	10.5	0.6	3.2	1.2	2.2	-1.6	0.3	0.5	-0.6	-0.5	-0.5	-2.3	2.9
Pack years of smoking	0.9	1.3	3.4	-1.6	-1.8	-1.1	-0.4	-0.5	-1.5	-1.5	-0.3	-0.2	-1.6	-0.3	-0.7
HbA1C	0.8	0.9	3.2	-0.8	-0.4	-0.1	1.0	-1.8	-1.0	-1.1	-0.7	-1.1	-0.5	0.4	1.1
Triglycerides	0.8	1.2	4.7	-1.0	-1.1	-1.0	-0.9	1.2	0.2	-0.2	1.0	0.8	-1.4	-1.1	-2.2
Smoking Status	0.8	1.9	5.2	-1.0	-2.3	-0.8	-2.0	-0.0	-1.1	-1.3	-1.5	-1.1	-1.7	-0.3	-1.6
Taking other prescription medications	0.8	1.2	4.7	-0.3	0.8	0.1	0.1	1.4	1.2	1.1	2.2	1.6	0.9	0.4	-0.6
Father’s age at death	0.8	1.1	2.9	0.3	-0.3	-0.3	-0.6	1.7	1.3	0.8	1.5	1.5	0.4	0.2	-1.6
Breastfed as a baby	0.8	1.0	4.6	0.8	-0.3	1.4	-2.2	0.9	0.3	0.6	0.5	0.8	-0.4	-0.0	-1.5
Emphysema/chronic bronchitis	0.8	0.9	4.5	-2.1	-0.9	-1.1	0.0	-0.1	-0.5	-0.6	1.2	0.6	-1.4	-0.5	-0.5
Medication: Allopurinol	0.8	1.0	3.6	-1.9	0.2	-0.8	-1.5	-1.9	-1.0	-0.5	-0.0	-0.2	-0.4	0.1	0.7
Medication for cholesterol	0.8	1.2	2.6	0.4	1.4	0.3	1.0	1.4	1.4	1.6	0.8	1.3	1.4	0.0	0.6
Number of self-reported non-cancer illnesses	0.8	1.3	4.4	-0.0	-1.2	-1.3	-0.7	1.6	0.6	0.5	1.8	1.0	0.1	0.5	-2.1
Medication: Blood pressure	0.8	1.5	2.6	-1.1	-1.5	-1.5	-1.6	-0.6	-1.5	-0.8	-0.7	-0.8	-1.3	1.0	-1.4
Medication: Lisinopril	0.8	1.0	2.5	-1.5	-0.5	-1.2	-0.8	-1.1	-1.6	-0.7	-0.4	-0.4	-1.5	-0.6	0.4
Hypothyroidism (self reported)	0.7	1.7	4.8	-2.2	-0.5	-0.7	-0.8	-0.5	-2.1	-1.0	-1.1	-1.5	-2.0	-1.0	-0.1
Townsend deprivation index at recruitment	0.7	0.9	3.1	0.5	0.6	-1.1	-0.7	-0.5	-1.0	-0.7	-1.6	-1.8	-0.7	-0.9	0.5
Qualifications: CSEs or equivalent	0.7	1.0	2.3	-1.3	-0.4	-0.6	0.6	-1.4	-0.9	-1.0	-1.3	-1.5	-0.6	0.3	0.8
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	5.6	-0.1	-0.2	-2.4	-1.2	0.7	0.2	0.0	0.5	0.4	-0.8	-0.3	-1.0
Past tobacco smoking	0.7	1.3	3.8	0.8	1.3	1.7	1.9	-0.1	0.1	0.6	1.1	0.3	0.4	-0.6	2.0
Forced vital capacity (FVC)	0.7	2.6	15.4	-0.5	1.9	0.3	-0.5	0.5	1.3	3.9	1.4	1.0	2.3	0.3	1.0
Medication: Simvastatin	0.7	1.0	3.4	0.7	-0.8	-1.0	-1.9	-0.1	-1.0	-1.2	0.0	0.0	-1.4	-0.7	-1.0
Standing height	0.7	7.4	41.1	-0.4	3.5	-0.3	0.2	1.5	2.6	6.4	3.3	2.5	3.0	0.2	0.7
Peak expiratory flow (PEF)	0.7	1.5	4.6	-0.4	-0.4	0.3	-1.2	1.6	1.0	1.2	2.1	2.0	-0.7	-1.3	-0.9
Number of full brothers	0.7	0.8	6.0	2.4	-0.4	1.3	0.3	-0.2	0.1	-0.9	-0.5	-0.4	-0.0	-0.1	-0.8
Eye problems/disorders: None of the above	0.7	0.9	2.2	1.0	0.2	0.0	0.1	0.9	1.0	1.0	0.2	0.7	1.5	1.4	-1.4
Smoking status: Previous	0.7	1.1	2.5	-0.2	-1.2	-1.4	-1.6	-0.4	-0.4	-1.2	-1.5	-0.6	-0.4	0.5	-1.6
Mood swings	0.7	1.2	5.6	-2.4	-1.4	-0.8	0.1	0.1	-0.4	-1.2	1.2	0.9	-1.3	-0.9	-0.1
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.4	-0.2	0.3	0.2	1.6	0.1	1.5	1.2	1.1	0.8	1.2	0.2	0.8
Medication: Atorvastatin	0.7	0.9	2.4	-0.0	-0.7	-0.1	-1.2	-0.6	-0.8	-1.4	-0.9	-0.9	-1.5	-1.1	0.4
Ever smoked	0.7	1.2	4.9	-0.5	-0.8	-1.6	-1.7	0.6	0.6	-0.2	-0.4	0.4	0.5	1.5	-2.2
Fractured/broken bones in last 5 years	0.7	0.9	3.4	-0.0	-0.9	0.9	-1.5	1.3	0.3	0.4	-0.6	0.3	0.7	0.7	-1.8
HDL Cholesterol	0.6	0.9	2.1	0.4	1.4	1.0	1.4	-1.1	0.8	0.4	0.6	0.2	1.1	0.7	1.3
Height	0.6	11.6	66.3	-0.2	5.2	0.1	0.4	1.1	2.5	8.1	3.1	2.3	4.3	0.8	1.7
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.3	-0.2	-1.1	0.2	-0.6	-0.6	-1.1	-1.5	-1.0	-0.8	-1.2	-0.2	-0.4
Multivitamins +/- minerals	0.6	0.8	2.1	-0.1	-0.6	1.2	-1.1	0.8	1.5	0.0	1.0	1.3	-0.1	-0.4	-0.8
Hair/balding pattern: Pattern 2	0.6	0.8	2.9	0.1	-0.4	1.0	0.5	1.7	1.1	0.6	1.1	1.0	0.5	-0.9	0.0
Worrier / anxious feelings	0.6	1.1	3.1	0.5	0.3	-0.9	-0.0	1.1	1.6	0.9	1.8	1.4	1.1	0.9	-0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	3.2	-0.8	-0.7	-0.2	-0.3	-0.7	-1.6	-1.4	-1.6	-1.8	-1.4	-0.4	-0.5
Comparative height size at age 10	0.6	3.1	17.1	-4.1	0.3	-0.7	-1.9	-2.5	-1.1	2.0	0.7	0.3	-1.4	-0.7	0.8
Suffer from ‘nerves’	0.6	0.9	3.6	0.9	-1.1	-0.1	-0.6	0.3	-0.1	-1.6	1.0	-0.1	-0.1	1.1	-1.9
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.4	-0.8	0.3	0.9	-0.2	-1.5	-0.6	0.1	-1.2	-0.7	-0.8	-1.1	0.9
Illnesses of siblings: Diabetes	0.6	0.8	1.6	-0.5	-0.9	-0.7	-1.3	0.1	-1.0	-1.2	-0.5	-0.7	-0.6	1.2	-1.2
Eye problems/disorders: Cataract	0.6	0.7	2.9	-1.0	-1.7	-0.6	-0.8	-0.2	-0.9	-0.4	-0.5	-0.9	-0.8	-0.7	-0.4
Wears glasses or contact lenses	0.6	0.7	2.8	0.4	0.6	0.7	-0.6	0.4	0.5	0.2	1.7	1.5	-0.6	-0.8	0.4
Hearing aid user	0.6	0.6	3.0	-1.7	-1.2	-0.3	-1.2	-0.8	-0.6	-0.1	0.3	0.4	-0.4	0.1	0.2
Medication: Paracetamol	0.6	0.9	3.5	1.9	-0.2	-0.1	-0.7	1.4	0.9	-0.9	0.3	0.9	0.2	0.6	-1.5
Number of operations (self-reported)	0.6	0.8	3.6	-0.5	-0.8	-1.4	0.3	0.0	0.6	0.4	1.9	1.6	-0.1	-0.3	-0.4
Ever depressed for a whole week	0.6	0.8	2.2	-0.5	-1.1	-1.2	-0.6	0.2	0.4	-0.1	1.3	1.0	0.4	0.9	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.2	-0.6	0.3	-1.5	-0.8	-0.4	-1.4	-0.4	-0.5	-1.1	-1.0	-0.1	-0.9
Worry (Nagel 2018)	0.5	1.0	3.1	-1.1	-1.1	-0.8	-0.1	-0.1	0.6	-0.4	1.8	1.1	0.2	1.3	-1.4
Systolic Blood Pressure	0.5	2.6	8.2	2.1	2.9	-0.3	2.2	1.0	2.0	1.5	1.4	1.4	0.9	-0.9	1.2
Neuroticism	0.5	1.2	3.9	-0.0	-1.0	0.4	-0.4	1.0	1.4	-0.4	2.0	1.9	0.0	0.3	-1.4
Sensitivity / hurt feelings	0.5	0.9	2.9	0.4	-1.1	0.1	-1.7	1.6	0.8	-0.0	-0.2	0.3	0.6	0.8	-1.3
Relative age voice broke	0.5	0.7	2.4	0.1	0.2	0.1	0.8	0.3	0.7	0.7	1.6	1.2	1.4	0.9	0.6
Chronic bronchitis/emphysema (father)	0.5	0.6	2.9	0.0	0.0	-1.7	0.4	-0.2	-1.0	-1.0	-0.5	-0.7	-1.0	-0.6	0.2
Nervous feelings	0.5	1.0	3.9	-0.3	-2.0	-1.4	-0.4	0.0	0.8	-0.8	0.8	0.4	0.5	1.6	-0.9
Had menopause	0.5	0.7	2.9	-0.6	-1.1	-0.3	-1.4	0.3	-0.1	0.1	0.7	0.7	-0.3	0.7	-1.7
Mouth/teeth dental problems	0.5	0.7	5.4	0.2	0.7	2.3	0.2	-0.7	-0.3	0.3	-0.2	0.1	0.4	-0.1	1.3
Neuroticism score	0.5	1.0	3.6	-0.1	-1.1	0.0	-0.1	0.7	1.4	-0.4	1.9	1.6	0.3	0.6	-1.2
Alcohol intake versus 10 years previously	0.5	0.8	2.6	1.6	1.0	1.1	-1.1	0.0	-0.6	0.1	-0.4	-0.2	-0.9	-1.5	0.6
Hair/balding pattern: Pattern 3	0.5	0.8	1.7	-1.0	-1.3	-0.5	-0.5	-1.2	-1.0	-0.9	-0.7	-0.9	-1.2	-0.6	0.3
Number of live births	0.5	0.8	3.5	0.5	0.2	0.5	0.3	0.6	0.8	0.7	0.3	0.2	1.9	1.7	-0.4
Exposure to tobacco smoke at home	0.5	0.6	2.2	-0.8	-0.1	-0.6	-1.5	-0.9	-1.2	-0.0	-0.3	-0.3	-1.1	-0.4	0.1
Tense / ‘highly strung’	0.5	0.8	3.3	-0.7	-0.9	1.0	0.1	0.3	0.8	0.2	1.8	1.4	-0.1	-0.1	-0.6
Hair/balding pattern: Pattern 4	0.5	1.3	2.8	1.4	1.3	-0.1	0.1	1.5	1.7	0.8	1.1	1.5	0.8	0.4	-1.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.9	-0.8	-0.5	-1.1	-0.6	-0.5	-1.4	-0.6	-1.0	-1.1	-0.5	0.3	0.2
Blood clot in the leg (DVT)	0.5	0.7	3.4	0.1	-0.9	0.5	-0.5	-1.9	-0.6	-1.0	-0.8	-0.7	-0.6	0.4	-0.6
Headache pain in last month	0.5	0.9	1.6	-0.7	-0.7	-0.7	-0.7	-1.1	-1.3	-1.2	-1.3	-1.2	-1.1	-0.5	0.0
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.8	0.2	-0.9	-1.7	-0.1	-0.1	-0.2	-0.9	-0.7	-0.6	-0.5	-0.2	-1.3
High blood pressure (siblings)	0.5	0.8	2.3	1.4	-1.1	0.2	0.6	0.4	-0.1	-1.5	-0.6	-0.5	-1.1	-0.3	-0.8
Forced vital capacity (FVC), Best measure	0.5	1.8	10.3	-0.1	2.1	1.0	-0.4	-0.2	0.6	3.2	0.4	0.1	1.5	-0.5	1.7
Number of children fathered	0.5	0.6	2.1	1.2	0.2	0.9	0.5	1.4	0.1	0.3	0.3	0.7	-0.6	-1.0	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.7	1.7	1.0	0.8	0.8	1.3	0.1	1.1	0.5	0.9	0.4	1.0	0.2	0.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	4.0	0.2	-0.2	-1.2	-2.0	0.7	-0.4	-0.4	0.1	0.3	-0.1	1.0	0.2
Qualifications: nursing, teaching	0.5	0.8	2.3	-0.0	0.7	-1.5	0.3	0.7	0.8	1.3	1.2	0.8	0.9	0.6	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.0	-0.2	0.2	0.0	0.1	-1.3	-0.4	-0.5	0.9	0.2	-0.7	-1.4	1.1
Ever taken oral contraceptive pill	0.5	0.5	1.6	0.6	0.5	1.3	0.3	0.4	1.0	1.2	0.3	0.5	0.9	-0.4	0.3
Neuroticism (Nagel 2018)	0.4	0.9	3.4	-1.1	-0.8	-0.6	-0.3	0.1	1.0	-0.5	1.9	1.5	-0.2	0.4	-0.9
Alzheimer’s Disease (in father)	0.4	0.4	1.2	0.5	-0.5	0.3	0.6	-0.9	-0.2	-1.0	-0.9	-1.1	-0.4	-0.2	-0.5
Ovarian Cancer	0.4	0.6	3.0	-1.7	0.4	-0.4	0.9	-0.5	-0.4	0.8	-0.1	-0.4	0.1	0.5	1.2
Age at First Birth	0.4	0.6	2.9	-0.5	0.6	0.2	1.2	-0.3	0.4	0.2	0.3	0.2	-0.2	-1.4	1.7
Coronary Artery Disease (CAD)	0.4	0.5	3.1	0.8	0.2	0.4	-0.2	1.8	0.4	0.1	-0.4	0.4	0.6	0.9	-0.6
Systolic blood pressure, automated reading	0.4	1.2	4.5	0.3	1.5	0.4	0.5	1.0	1.3	1.2	1.0	1.3	-0.4	-2.1	0.6
Medication: Co-codamol	0.4	0.5	1.7	-0.8	-0.5	-0.7	-1.3	-0.2	-0.4	-0.3	0.7	0.3	-0.8	-0.7	-0.9
Average weekly fortified wine intake	0.4	0.5	1.7	0.8	-0.7	-1.0	0.4	0.7	0.5	0.4	1.3	0.7	0.3	-0.1	-0.3
Age when periods started (menarche)	0.4	1.0	3.0	-1.2	0.4	-1.4	1.5	0.3	-0.7	0.0	0.2	-0.7	1.4	1.7	0.3
Sitting height	0.4	3.0	9.6	-0.6	0.4	-1.1	-2.2	1.9	1.6	3.1	2.0	1.9	0.7	0.3	-2.2
Number of incorrect matches in round	0.4	0.6	1.4	-1.2	-0.7	0.2	1.1	0.9	0.0	0.6	1.2	1.0	-0.1	-0.3	-0.5
Noisy workplace	0.4	0.4	1.5	-0.7	0.6	0.6	0.5	-1.2	-0.6	0.0	0.4	-0.3	-0.7	-0.6	1.0
Depression (self-reported)	0.4	0.5	1.6	-0.6	-0.6	-1.2	-0.0	0.7	0.2	-0.8	1.3	0.7	-0.4	0.0	-0.7
Loud music exposure frequency	0.4	0.5	1.3	0.4	0.8	0.1	0.6	0.2	0.6	1.0	1.2	0.9	0.8	0.1	0.6
Medication: Paracetamol	0.4	0.6	2.3	1.5	-0.1	-0.6	-0.1	1.0	0.9	-0.7	0.0	0.6	0.3	0.7	-1.3
Qualifications: College or University degree	0.4	1.1	3.5	1.7	1.1	1.9	-0.9	-0.5	0.4	0.5	-0.1	0.4	1.5	1.2	-0.2
Migraine (self-reported)	0.4	0.5	2.6	-0.5	0.6	-0.6	-0.0	-1.3	0.4	0.4	0.1	0.1	0.6	1.6	0.5
Pulse rate, automated reading	0.4	1.4	5.1	1.5	0.3	-0.3	-0.0	-0.2	-1.3	-0.9	-1.0	-1.2	-1.9	-2.2	0.7
Illnesses of father: Heart disease	0.4	0.6	2.6	-1.2	0.5	-0.3	0.3	0.3	-0.0	1.1	1.6	0.9	0.4	0.7	-0.0
Loneliness, isolation	0.4	0.6	3.0	-0.2	-1.4	0.3	-0.3	-0.1	-0.3	-1.7	-0.6	-0.6	-0.5	-0.5	-0.6
Illnesses of father: None of the above (group 1)	0.4	0.5	1.5	-0.2	-0.5	0.3	-0.2	-1.0	-0.4	-0.1	-1.2	-0.9	0.5	0.5	1.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.8	0.6	-1.0	0.4	-0.3	-1.3	-0.3	-0.9	-0.7	-0.5	-0.3	0.7	-1.0
Depressed Affect (Nagel 2018)	0.3	0.6	1.6	-0.8	-0.6	0.1	-0.2	0.8	0.5	-0.5	1.3	1.3	-0.8	-1.1	-0.5
LDL Cholesterol	0.3	0.5	2.3	-0.6	-0.7	-0.0	0.7	0.7	0.3	0.2	0.4	0.1	-0.9	-1.5	-0.6
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.4	-0.7	0.9	0.1	0.3	-0.7	-0.0	1.2	0.0	0.4	0.3	0.3	0.5
Tanning	0.3	3.1	11.1	-0.6	0.5	1.2	0.1	-3.3	-1.6	-0.5	-2.3	-2.9	-1.0	-1.1	2.4
Number of treatments/medications taken	0.3	0.5	1.7	-0.8	0.0	-0.3	-0.9	-0.1	-0.5	-0.9	0.5	0.1	-1.3	-0.9	-0.8
Severe depression (siblings)	0.3	0.4	1.0	0.6	0.4	1.0	0.9	-0.3	0.0	0.3	-0.3	-0.6	1.0	0.8	-0.0
Maternal smoking around birth	0.3	0.4	1.2	-0.4	-0.7	0.3	0.3	-0.2	-0.7	-1.0	-0.8	-0.5	-1.1	-0.6	0.2
Fed-up feelings	0.3	0.5	2.8	-0.2	0.4	0.3	0.6	0.5	0.5	-0.4	1.7	1.2	0.4	0.3	0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.9	-0.8	-0.6	0.1	-0.3	-0.2	0.0	-0.4	1.0	0.4	-0.9	-0.3	-0.2
Serious illness, injury or assault to yourself	0.3	0.3	1.2	-0.0	-1.1	1.0	-0.3	0.2	0.1	0.1	0.3	-0.1	-0.3	-0.9	-0.9
Financial difficulties in last 2 years	0.3	0.4	1.8	-0.2	-0.0	0.8	-0.4	-0.3	0.0	0.3	0.4	0.3	-0.9	-1.3	-0.6
Illnesses of siblings	0.3	0.5	1.4	-1.1	0.1	-0.5	-1.2	-0.2	-0.0	1.0	0.0	0.3	0.9	0.9	0.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.2	5.3	-1.0	0.3	-0.6	-1.9	0.5	0.4	2.3	1.0	0.7	1.1	0.7	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.5	-1.1	-0.2	-1.2	0.2	-0.3	-0.1	-0.4	1.2	0.5	-0.2	0.6	0.4
Wheeze or whistling in the chest in last year	0.3	0.5	2.3	0.3	0.2	-0.0	-0.3	0.4	-0.6	-0.6	-0.4	-0.5	-1.5	-1.5	-0.0
Medication: Ibuprofen	0.3	0.4	1.2	0.3	-0.3	0.5	-1.1	-0.2	-0.9	-1.1	-0.1	-0.2	-1.0	0.1	-0.6
Medication: Omeprazole	0.3	0.3	0.9	-0.4	0.8	-0.6	0.3	-0.3	-0.9	-0.0	-0.5	-0.9	-0.2	0.7	-0.4
Chest pain or discomfort	0.3	0.4	2.0	-0.3	0.2	-0.3	0.4	-0.4	-0.0	-0.7	0.7	0.6	-1.4	-0.8	0.6
Had major operations	0.3	0.3	0.9	-0.8	-0.9	-0.3	1.0	-0.4	-0.2	-0.5	0.2	0.1	0.2	0.6	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.2	-0.6	0.8	-0.4	1.1	0.0	-0.6	0.8	-0.4	-0.5	0.2	0.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.6	-0.9	-0.3	0.2	-0.5	-0.8	-0.6	0.7	-1.2	-1.3	0.2	-0.1	0.8
Average weekly red wine intake	0.3	0.5	1.4	0.8	-0.9	0.6	-0.8	0.5	0.4	0.1	-1.0	-0.5	0.3	-0.2	-1.2
Smoking status: Current	0.3	0.5	1.2	-0.7	-0.4	0.2	-0.5	-0.7	-1.0	0.1	-0.6	-1.0	-1.1	-0.5	0.2
Guilty feelings	0.3	0.5	1.4	0.9	-0.3	1.2	-0.9	-1.0	0.6	-0.2	0.4	0.2	0.4	1.0	-0.3
Age started oral contraceptive pill	0.3	0.4	1.9	-0.6	-1.4	-0.9	-0.2	-0.2	-0.1	0.1	-0.1	-0.2	0.3	0.9	-0.4
Heart disease (siblings)	0.3	0.4	2.1	-0.0	-0.1	0.1	0.1	-0.4	-0.6	-0.4	-0.7	-1.1	-0.5	-1.4	0.1
Heel T-Score	0.2	1.6	6.2	-1.2	-2.5	0.8	-1.9	0.2	-1.0	-0.9	-0.8	-1.0	-1.6	-0.1	-0.9
Lung FVC	0.2	0.9	7.4	-0.8	-0.6	-0.1	-2.7	-0.5	-0.8	0.9	-0.1	-0.8	0.4	0.2	-0.6
Relative age of first facial hair	0.2	0.5	1.6	-0.6	-1.3	-0.7	-0.9	0.5	-0.0	-0.7	0.9	0.9	0.1	-0.2	-0.2
Current tobacco smoking	0.2	0.4	1.1	-0.6	-0.2	0.5	-0.4	-0.7	-0.9	0.3	-0.5	-0.9	-1.0	-0.8	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.0	0.4	-0.3	1.4	-0.3	0.9	-0.3	0.6	-1.0	-0.6	-0.3	-0.6	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	2.6	0.5	-0.5	0.5	-0.6	1.3	0.4	0.6	-0.4	0.3	-0.6	-1.6	-0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.2	-0.2	-0.5	-1.1	-0.5	-0.5	-0.7	-0.5	-0.0	-0.6	0.2	1.1	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.9	0.4	-0.2	-0.1	-0.7	0.0	-0.3	-0.9	0.0	0.2	-0.7	0.1	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	3.7	-0.6	0.4	-0.5	-1.9	0.3	0.2	1.9	0.4	0.4	0.3	-0.3	-0.1
Worry too long after embarrassment	0.2	0.3	1.4	0.3	-0.4	-0.3	-1.0	-0.5	1.2	-0.0	-0.1	0.1	0.3	0.4	-0.2
Miserableness	0.2	0.4	1.1	0.9	-0.1	0.2	-0.1	1.0	0.5	-0.9	0.1	0.4	-0.5	-0.8	-0.7
Alzheimer’s Disease (in mother)	0.1	0.2	0.6	-0.2	0.4	-0.8	0.0	0.4	-0.7	0.5	-0.2	-0.1	0.1	0.1	0.4
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	0.0	0.4	-0.2	0.1	-0.3	-0.4	0.1	-0.3	-0.3	-0.3	-0.5	0.6
Hair Pigment	0.1	1.8	7.6	0.4	1.8	2.8	0.6	-0.2	0.7	1.7	0.3	0.4	1.4	0.2	2.1
Breast cancer (self-reported)	0.1	0.2	1.2	-0.2	-0.2	-0.4	-1.1	-0.4	0.0	-0.1	0.0	0.1	-0.3	-0.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.8	0.2	-0.5	0.9	0.2	-0.2	0.9	0.2	-0.2	0.0	0.5	-0.3	-0.0
Risk taking	0.1	0.2	0.6	-0.5	0.3	0.4	-0.1	0.1	0.3	0.8	0.3	0.7	-0.2	-0.7	-0.5

Hub : Genes

PLCL1

Models

Trait associations