Best TWAS P=2.47e-10 · Best GWAS P=4.3e-08 conditioned to 0.0265
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | SLC51A | 0.28 | 0.17 | lasso | 9 | 0.21 | 4.3e-16 | 4.9 | -5.2 | 1.5e-07 | -0.86 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | PCYT1A | 0.11 | 0.03 | lasso | 3 | 0.00 | 3.9e-01 | 5.5 | -5.4 | 6.8e-08 | -0.96 | 0.01 | 0.90 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | SLC51A | 0.28 | 0.06 | lasso | 6 | 0.14 | 1.3e-07 | 3.8 | -6.3 | 2.5e-10 | -0.58 | 0.02 | 0.96 | TRUE |
| 4 | GTEx | Breast Mammary Tissue | UBXN7 | 0.20 | 0.00 | enet | 16 | 0.02 | 3.5e-02 | -4.1 | -5.5 | 4.1e-08 | -0.65 | 0.03 | 0.86 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Male) | UBXN7 | 0.22 | -0.01 | lasso | 4 | 0.01 | 1.6e-01 | -5.3 | -5.2 | 1.9e-07 | -0.52 | 0.02 | 0.53 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | SLC51A | 0.30 | 0.22 | lasso | 4 | 0.24 | 5.0e-18 | 3.8 | -5.3 | 1.2e-07 | -0.66 | 0.58 | 0.35 | FALSE |
| 7 | GTEx | Heart Atrial Appendage | SLC51A | 0.27 | 0.11 | lasso | 4 | 0.15 | 2.9e-07 | 3.8 | -5.4 | 5.7e-08 | -0.70 | 0.04 | 0.95 | FALSE |
| 8 | GTEx | Nerve Tibial | SLC51A | 0.26 | 0.12 | lasso | 7 | 0.22 | 1.9e-15 | 3.8 | -5.4 | 7.5e-08 | -0.73 | 0.04 | 0.95 | FALSE |
| 9 | GTEx | Stomach | SLC51A | 0.13 | 0.06 | enet | 12 | 0.03 | 1.9e-02 | 4.8 | -5.6 | 1.7e-08 | -0.86 | 0.01 | 0.96 | FALSE |
| 10 | GTEx | Thyroid | SLC51A | 0.17 | 0.06 | enet | 17 | 0.06 | 1.9e-05 | 4.8 | -5.2 | 2.2e-07 | -0.78 | 0.03 | 0.97 | FALSE |
| 11 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PCYT1A | 0.12 | 0.05 | blup | 68 | 0.06 | 2.0e-04 | 4.9 | -6.3 | 2.5e-10 | -0.75 | 0.01 | 0.90 | FALSE |