Hub : Genes

UBXN7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.2040	0.0680	0.00018	-0.001	NA	0.019	NA	0.008	0.3500	NA	0.03500	NA	0.12000
2	GTEx	Breast Mammary Tissue (Male)	0.2230	0.1005	0.01700	-0.011	NA	0.002	NA	0.013	0.6800	NA	0.29000	NA	0.16000
3	GTEx	Breast Mammary Tissue (Female)	0.1090	0.0824	0.11000	0.027	NA	-0.003	NA	0.051	0.0540	NA	0.42000	NA	0.01300
4	GTEx	Cells EBV-transformed lymphocytes	0.2080	0.0910	0.00450	0.120	NA	0.108	NA	0.118	0.0001	NA	0.00022	NA	0.00011
5	GTEx	Esophagus Mucosa	0.1670	0.0640	0.00690	0.023	NA	0.000	NA	0.012	0.0110	NA	0.29000	NA	0.05100
6	TCGA	Brain Lower Grade Glioma	0.0242	0.0146	0.00320	0.014	0.017	0.009	NA	0.009	0.0097	0.0042	0.02800	NA	0.03200

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.1	0.1	0.3	0.0	-0.3	0.6	-0.4	0.2	-0.2
Bipolar Disorder or Schizophrenia	0.7	1.7	5.2	0.9	0.1	2.3	-1.1	1.4	0.8
Depressed Affect (Nagel 2018)	2.2	4.5	8.8	-2.4	-0.9	-2.3	1.7	-2.0	-3.0
Depression (Nagel 2018)	3.2	4.7	8.0	-2.4	-1.1	-1.6	1.9	-2.7	-2.8
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.7	0.1	0.9	-1.3	-0.6	0.6	0.6
Neuroticism (Nagel 2018)	0.3	0.7	1.5	-0.6	0.2	-1.1	0.5	-0.9	-1.2
Schizophrenia (2018)	1.1	2.3	6.3	1.2	0.4	2.5	-1.2	1.6	1.2
Schizophrenia vs Biploar Disorder	0.4	0.5	2.2	0.1	0.3	1.5	-0.5	0.2	0.6
Worry (Nagel 2018)	0.7	1.4	3.2	1.8	1.7	0.4	-0.9	0.1	1.2
Alzheimer’s Disease (in mother)	1.3	1.5	2.5	0.9	0.6	0.9	-1.4	1.6	1.6
Alzheimer’s Disease (in father)	0.6	0.6	1.6	-0.3	1.3	-0.8	-0.7	0.8	0.3
Alzheimer’s Disease (including proxy)	1.4	2.0	3.7	1.1	1.5	0.6	-1.5	1.9	1.5
Crohns Disease (2017)	1.5	3.4	4.9	2.2	1.1	1.9	-1.9	1.7	1.9
Irritable Bowel Disease (IBD)	2.7	6.3	8.5	2.5	2.4	2.3	-2.9	2.5	2.4
Ulcerative Colitis (UC)	3.3	6.2	9.7	2.2	2.4	1.9	-3.1	2.8	2.5
Major Depression (MDD)	0.6	0.7	2.0	-0.7	-1.4	-0.3	-0.1	-1.3	-0.3
Reaction Time	0.5	1.0	2.8	1.1	1.7	1.2	-0.6	0.1	0.3
Verbal and Numeric Reasoning (VNR)	0.9	2.1	6.6	1.0	2.6	-1.2	-0.6	1.4	1.0
Breast Cancer	1.1	2.7	7.3	0.6	0.2	2.1	-1.5	2.7	1.2
Ovarian Cancer	0.8	1.0	2.8	-1.0	-1.7	-0.6	0.5	0.9	-1.0
Prostate Cancer	0.6	0.8	2.0	1.4	0.9	0.4	0.4	0.7	1.1
Age at First Birth	0.5	0.7	2.3	0.5	1.1	0.7	1.5	0.1	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.6	-0.1	-0.8	-0.1	-0.6	0.1	0.6
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	2.6	4.2	7.5	2.7	1.3	2.0	-2.0	0.9	2.7
Mean Putamen Volume	1.8	2.0	3.9	2.0	1.5	1.3	-0.7	1.3	1.4
Fasting Glucose	1.4	1.7	3.7	0.2	-0.2	1.6	-1.9	0.4	1.9
HbA1C	0.8	0.9	1.8	-1.3	0.1	-1.1	1.3	-0.2	-0.6
HDL Cholesterol	0.2	0.3	1.0	0.7	-0.3	1.0	-0.2	-0.1	0.6
LDL Cholesterol	0.6	1.0	2.3	0.3	-1.3	-0.0	-1.0	1.0	1.5
Lupus	1.1	1.6	4.1	-0.3	-1.1	-1.1	2.0	-1.4	-0.9
Neuroticism (2016)	0.1	0.2	0.9	0.0	0.1	0.3	0.1	-0.9	0.0
Primary Biliary Cirrhosis	0.4	0.6	1.8	0.8	0.3	0.6	-1.3	0.5	0.8
Rheumatoid Arthritis	1.9	2.7	6.2	-2.3	-0.3	-1.9	0.8	-0.3	-2.5
Schizophrenia (2014)	2.3	5.0	10.2	2.5	1.3	3.2	-1.6	1.8	2.4
Triglycerides	2.1	3.5	8.8	-2.0	-3.0	-1.6	1.4	-1.1	-1.5
Type 2 Diabetes (T2D) (2012)	0.8	0.9	3.4	-0.6	-0.2	-0.6	1.8	-0.7	-0.9
Ulcerative Colitis	1.5	2.2	4.4	1.4	2.1	0.9	-1.5	1.1	1.5
Blood Eosinophil Count	0.3	2.4	5.2	-0.2	-1.5	-0.1	2.0	-1.7	-2.3
Blood Platelet Count	0.9	10.6	35.5	6.0	4.4	2.2	0.1	-1.1	1.7
Blood Red Count	1.8	17.2	45.4	-3.7	-6.7	2.0	-2.4	5.6	1.7
Blood White Count	0.3	2.1	8.5	2.9	-0.0	1.6	1.1	-0.6	-0.3
Heel T-Score	0.1	0.9	3.1	1.0	1.8	-0.0	0.1	1.1	0.2
BMI	5.7	33.3	51.7	-7.2	-4.7	-5.7	6.0	-3.1	-6.9
Height	0.3	6.6	13.2	-3.3	-1.6	-3.2	1.2	-0.9	-3.6
Waist Hip Ratio (WHR)	0.1	0.4	1.5	-0.0	-0.4	0.9	0.2	-1.2	-0.1
Systolic Blood Pressure	5.1	25.3	39.9	4.9	0.9	5.4	-5.4	5.4	6.3
Smoking Status	3.6	8.5	14.7	-3.5	-2.4	-2.7	1.6	-3.8	-2.9
Allergy or Eczema	1.7	4.5	6.7	2.5	2.1	1.8	-0.8	2.6	2.4
Cardiovascular Disease	0.4	1.3	2.3	0.8	-0.5	1.4	-1.5	0.6	1.5
Hypothyroidism (self reported)	0.5	1.2	2.6	0.4	1.0	-1.1	1.1	-1.6	-0.8
Respiratory disease	1.0	2.3	6.2	2.5	2.1	1.1	-0.5	1.4	0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	-0.8	0.4	0.5	-0.2	-0.1	-0.4
Lung FEV1/FVC ratio	1.8	9.1	12.8	-3.3	-2.8	-3.2	3.4	-1.2	-3.6
Lung FVC	2.9	14.8	33.3	4.4	1.3	3.5	-3.4	3.2	5.8
Neuroticism	1.3	3.2	6.3	-1.1	-0.1	-1.9	1.7	-2.5	-2.2
Chronotype (morning person)	2.4	5.6	9.1	2.1	0.1	3.0	-2.4	2.4	3.0
Hair Pigment	0.0	1.1	2.6	0.3	-1.3	1.6	-0.8	0.7	1.0
Tanning	0.0	0.5	1.4	-0.4	-0.2	-1.2	0.9	-0.3	-0.6
Hand grip strength (left)	0.5	1.2	5.7	-1.0	-2.4	-0.4	-0.3	0.1	0.4
Number of treatments/medications taken	0.3	0.5	1.8	-0.5	-0.6	-0.3	0.5	-0.7	-1.3
Average weekly spirits intake	4.1	5.1	9.5	-3.1	-1.9	-2.5	1.7	-1.1	-2.7
Sensitivity / hurt feelings	0.5	0.8	2.5	-0.8	-1.6	-1.1	-0.2	0.8	-0.4
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.3	-0.6	-0.6	-0.1	1.2	-1.5	-1.5
Hearing difficulty/problems: Yes	0.2	0.3	0.9	0.2	1.0	-0.4	0.3	-0.4	-0.4
Relative age of first facial hair	0.2	0.5	2.2	-0.7	-0.2	0.2	-0.2	1.5	-0.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.2	-0.6	1.0	-0.9	-0.5	0.7	-1.1
Ever used hormone-replacement therapy (HRT)	2.8	3.5	7.0	-2.3	-0.9	-1.9	1.2	-1.7	-2.6
Ever had hysterectomy (womb removed)	0.8	1.0	2.0	-1.2	-0.9	-0.4	1.1	-0.4	-1.4
Systolic blood pressure, automated reading	0.7	2.0	3.2	0.5	-1.1	1.4	-1.7	1.8	1.5
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	4.9	-2.2	-1.5	-0.8	0.5	0.1	-1.6
Angina	1.0	1.3	2.7	-1.3	-0.9	-1.1	1.2	0.4	-1.6
Medication for hormone replacement therapy	1.1	1.2	3.6	-0.1	-1.0	0.5	-1.9	0.9	1.2
Vitamin and mineral supplements	0.4	0.6	2.0	-0.9	-1.4	-0.2	0.7	0.3	-0.3
Supplements: Zinc	1.5	1.6	3.0	1.6	0.2	1.1	-1.6	0.7	1.7
Medication: Co-codamol	0.3	0.4	1.1	-1.1	0.4	-0.0	0.2	-0.0	-1.0
Medication: Metformin	0.4	0.5	1.5	-1.2	-0.5	0.6	-0.4	0.6	-0.8
Diabetes (father)	1.1	1.4	3.2	1.4	1.8	-0.1	-1.1	1.4	0.5
Diabetes (mother)	0.2	0.2	1.1	0.4	0.1	1.0	-0.1	0.2	0.3
Severe depression (siblings)	0.3	0.4	1.3	0.1	0.4	0.6	-0.3	-1.2	0.5
Pack years adult smoking proportion	3.6	5.5	11.4	-2.5	-0.6	-2.7	2.3	-1.6	-3.4
Impedance of leg (right)	2.1	10.2	17.1	4.1	4.1	2.7	-3.2	1.8	2.6
Leg fat-free mass (left)	3.8	19.9	30.3	-5.5	-5.2	-4.0	3.7	-2.7	-5.0
Trunk fat percentage	3.2	12.9	26.7	-4.3	-3.2	-3.0	3.2	-1.6	-5.2
Hand grip strength (right)	0.3	0.9	3.5	-0.8	-1.9	-0.7	-0.4	0.5	0.4
Townsend deprivation index at recruitment	0.3	0.5	1.0	0.5	1.0	0.8	-0.7	-0.1	0.7
Current tobacco smoking	0.5	0.8	1.6	-0.9	-0.9	-1.0	0.4	-1.3	-0.4
Average weekly fortified wine intake	0.8	1.0	2.6	-0.8	-1.6	-0.8	0.7	-1.0	-0.6
Maternal smoking around birth	0.6	0.8	3.2	-0.8	0.7	-0.3	0.5	-0.2	-1.8
Fed-up feelings	1.3	2.4	4.8	-2.0	-1.1	-1.4	1.4	-0.1	-2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	4.2	-0.5	-0.2	0.0	1.2	-2.0	-1.0
Relative age voice broke	0.3	0.4	1.4	0.4	0.6	0.6	-0.2	1.2	0.0
Taking other prescription medications	1.3	2.0	5.5	-1.0	0.2	-0.6	1.7	-1.5	-2.4
Age when periods started (menarche)	0.1	0.3	0.6	0.2	0.8	-0.4	-0.6	-0.6	-0.1
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	5.8	-2.4	-2.2	-0.3	-0.3	0.3	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	2.9	-1.1	-0.9	-0.9	0.9	-0.2	-1.7
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.9	0.9	0.9	0.7	-0.4	0.9	0.4
Qualifications: CSEs or equivalent	0.2	0.2	1.1	-0.5	0.2	0.0	-0.2	-1.0	-0.2
Serious illness, injury or assault to yourself	0.5	0.6	1.0	0.8	0.6	0.9	-0.7	1.0	0.3
High blood pressure	0.4	1.2	3.2	0.6	-0.3	1.8	-0.9	1.0	1.2
Hayfever, allergic rhinitis or eczema	1.2	2.5	4.2	2.0	1.9	0.9	-0.2	2.1	1.5
Multivitamins +/- minerals	0.5	0.6	1.6	1.1	1.3	0.4	-0.7	-0.0	0.4
Stomach or abdominal pain in last month	0.1	0.1	0.3	-0.3	0.6	0.3	-0.2	-0.1	-0.3
Supplements: Glucosamine	0.7	1.0	1.8	-0.3	0.1	-1.2	1.3	-1.0	-1.3
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	3.5	1.4	0.7	1.5	-0.9	1.7	1.9
Medication: Atenolol	0.3	0.3	0.9	-0.3	-0.1	0.8	0.4	1.0	0.1
Medication: Levothyroxine sodium	0.1	0.1	0.5	0.4	0.7	-0.0	0.2	-0.3	-0.2
Sitting height	0.1	0.6	1.4	-0.3	-1.2	0.1	-0.9	1.0	0.1
Chronic bronchitis/emphysema (father)	0.3	0.3	0.9	0.2	0.5	0.1	0.9	-0.0	-0.8
High blood pressure (mother)	0.9	1.2	5.5	-0.2	-2.4	0.6	-0.5	0.9	0.5
Body mass index (BMI)	5.0	21.3	32.8	-5.7	-5.0	-3.8	4.3	-2.5	-5.6
Impedance of leg (left)	2.0	9.9	16.7	3.8	4.1	2.4	-3.2	2.1	2.8
Leg predicted mass (left)	3.8	20.1	30.1	-5.5	-5.2	-4.0	3.7	-2.8	-5.0
Trunk fat mass	4.3	18.5	34.6	-5.3	-4.1	-3.7	3.7	-2.0	-5.9
Waist circumference	4.5	16.5	26.2	-5.1	-4.2	-3.4	3.7	-2.1	-5.1
Number of incorrect matches in round	2.0	3.3	8.6	1.8	0.1	2.9	-1.2	1.8	1.8
Past tobacco smoking	4.7	8.5	16.3	4.0	2.4	2.6	-1.7	2.9	3.3
Alcohol usually taken with meals	0.5	0.8	2.0	-0.2	-0.4	-1.4	1.1	-0.9	-0.8
Nervous feelings	1.4	2.7	6.2	2.1	1.0	1.1	-1.6	0.9	2.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.9	0.5	0.7	0.5	1.0	-0.4	-0.6
Hearing difficulty/problems with background noise	0.1	0.1	0.2	0.2	0.5	-0.1	-0.1	-0.4	0.5
Hair/balding pattern: Pattern 2	0.2	0.2	1.2	0.2	-0.2	-0.1	0.0	1.1	0.0
Had menopause	0.5	0.7	1.4	-1.0	-0.5	-0.2	1.2	-0.7	-0.9
Had other major operations	0.3	0.4	0.8	-0.7	0.8	-0.9	0.1	-0.2	-0.6
Forced vital capacity (FVC)	1.0	3.8	9.6	1.8	-1.2	1.1	-1.9	1.8	3.1
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.1	7.2	-2.1	-1.6	-1.5	1.5	-0.2	-2.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.6	0.5	0.2	0.6	-0.8	0.0	0.2
Qualifications: None of the above	1.2	2.6	5.5	-2.0	-1.0	0.2	1.6	-1.5	-2.3
Financial difficulties in last 2 years	0.2	0.3	1.6	-0.1	-0.3	1.3	0.0	-0.0	-0.0
Mouth/teeth dental problems	1.1	1.8	7.2	-1.3	-2.7	-0.6	0.3	0.9	-0.5
Heart attack	0.8	1.0	3.4	0.1	0.7	0.8	-0.9	1.8	0.9
Allergy	1.4	3.3	9.0	-2.5	-3.0	-1.0	-0.0	-1.8	-0.7
Pain all over the body in last month	0.3	0.3	0.7	-0.8	0.6	-0.6	-0.4	-0.2	-0.5
Diabetes (self-reported)	0.4	0.6	2.7	-1.6	-0.5	-0.2	-0.1	0.4	-0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.2	0.5	0.4	1.1	-0.4	0.7	0.6
Medication: Ramipril	1.0	1.3	3.8	-1.0	-0.3	-0.5	2.0	0.7	-1.4
Medication: Simvastatin	0.3	0.4	1.5	-0.7	-1.2	0.5	-0.1	-0.3	-0.4
Fluid intelligence score	0.4	0.9	2.2	-0.6	1.5	-1.5	0.2	0.7	-0.4
Illnesses of siblings	0.5	0.8	2.1	0.6	0.5	0.1	-1.3	1.5	0.2
Neuroticism score	0.3	0.6	1.1	-0.5	-0.4	-0.9	0.7	-0.8	-1.0
Weight	4.8	23.8	36.8	-6.1	-5.1	-4.5	4.2	-2.4	-6.0
Impedance of arm (right)	2.6	12.1	20.6	4.5	4.3	3.3	-3.0	1.6	3.4
Arm fat percentage (right)	3.1	12.0	20.1	-4.2	-3.5	-2.8	3.3	-2.0	-4.5
Trunk fat-free mass	2.6	14.9	21.9	-4.7	-4.5	-4.0	3.0	-2.4	-4.0
Hip circumference	3.9	16.8	28.2	-5.1	-3.8	-3.9	3.3	-2.3	-5.3
Time employed in main current job	0.4	0.4	1.2	-0.3	1.1	-0.8	-0.8	0.3	0.1
Alcohol intake versus 10 years previously	0.8	1.2	4.8	-1.1	-2.2	0.3	0.3	-0.3	-0.9
Father’s age at death	0.2	0.2	0.9	0.6	0.1	1.0	0.1	-0.1	0.3
Worrier / anxious feelings	0.1	0.2	0.4	0.3	0.7	-0.6	0.2	0.1	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	1.0	-0.2	-0.1	-0.1	0.3	-0.4	-1.0
Falls in the last year	1.3	1.8	3.6	-1.1	0.5	-0.9	1.8	-1.3	-1.9
Hair/balding pattern: Pattern 3	0.3	0.5	2.2	0.0	-0.7	-0.2	0.2	-1.5	-0.0
Number of live births	0.5	0.7	2.3	-1.5	-1.1	0.4	-0.4	-0.4	-0.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	3.9	1.0	-1.8	0.6	-1.0	1.2	2.0
Pulse rate	1.5	2.5	3.9	2.0	1.2	1.9	-1.4	1.1	1.7
Happiness	2.1	2.5	5.4	1.7	2.3	1.5	-1.1	1.5	1.0
Noisy workplace	0.4	0.5	1.1	-0.3	-1.1	0.3	0.8	0.3	-1.0
Qualifications: A levels/AS levels or equivalent	3.9	8.6	14.4	3.3	2.9	2.1	-2.5	2.6	3.8
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.0	0.3	0.8	-0.3	0.8	-1.4	-0.7
Mouth/teeth dental problems: Dentures	0.2	0.4	1.4	-0.1	1.2	0.1	0.6	-0.3	-0.6
Asthma	2.7	5.3	10.0	3.2	2.8	2.3	-1.4	2.2	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.4	-0.5	-0.7	-1.2	1.2	-0.1	-1.1
Medication: Cholesterol lowering	0.3	0.4	0.8	-0.8	0.3	0.1	0.7	-0.9	-0.6
Depression (self-reported)	0.0	0.0	0.1	0.3	0.4	0.0	-0.2	0.0	0.1
Medication: Lansoprazole	0.5	0.5	0.9	-0.3	-0.3	-0.9	0.9	0.6	-1.0
Prospective memory result	0.6	0.7	1.9	-1.4	-0.9	0.1	-1.0	0.7	-0.3
Lung cancer (father)	1.4	1.6	3.2	-1.1	-0.5	-0.5	1.7	-1.8	-1.4
Illnesses of mother	0.5	0.6	2.5	0.7	1.6	-0.5	-0.2	-0.5	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	4.8	0.6	-2.2	0.3	-0.3	0.8	1.4
Pulse wave Arterial Stiffness index	0.4	0.4	2.4	0.5	1.5	-0.0	0.3	-0.1	-0.1
Impedance of arm (left)	2.5	11.4	20.7	4.5	4.5	3.0	-2.6	1.7	3.0
Arm fat mass (right)	4.6	18.7	29.6	-5.3	-4.5	-3.6	3.9	-2.5	-5.4
Trunk predicted mass	2.6	15.1	22.1	-4.7	-4.6	-4.1	3.0	-2.4	-4.0
Standing height	0.2	2.0	4.3	-1.6	-1.0	-2.1	0.3	-0.3	-1.9
Length of working week for main job	0.3	0.3	1.1	0.6	1.0	-0.1	-0.6	0.3	-0.1
Exposure to tobacco smoke at home	0.2	0.2	0.6	-0.3	-0.8	0.8	0.1	0.2	-0.3
Breastfed as a baby	0.8	1.0	2.6	-0.5	0.4	-1.6	-0.0	-1.6	-0.7
Tense / ‘highly strung’	2.3	3.9	6.9	2.6	1.8	2.1	-1.8	0.6	2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.0	0.8	1.0	0.7	1.4	-1.3	-0.3
Hair/balding pattern: Pattern 4	0.1	0.2	0.8	0.6	0.9	-0.4	-0.2	0.1	-0.1
Birth weight of first child	1.3	2.3	5.2	-1.5	0.2	-2.3	0.6	-1.2	-2.2
Peak expiratory flow (PEF)	0.5	1.1	4.0	-0.9	-2.0	-0.4	0.9	0.5	-0.8
Pulse wave reflection index	0.9	1.1	2.4	-0.3	0.9	-0.9	1.3	-1.5	-0.9
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.8	-1.3	-1.0	-0.3	0.1	0.1	-1.7
Loud music exposure frequency	0.9	1.0	2.5	1.3	-0.2	1.6	-0.8	0.2	1.1
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	5.6	2.1	2.4	-0.2	-1.1	0.6	1.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.4	0.6	1.2	0.3	-0.1	-1.1	0.2
Blood clot in the leg (DVT)	1.4	1.8	4.6	-1.2	1.1	-0.9	1.3	-1.1	-2.1
Medication: Paracetamol	0.5	0.9	3.0	-0.4	-1.7	1.1	0.2	-0.4	-0.8
Headache pain in last month	0.7	1.1	3.1	-0.6	-0.3	-0.6	1.3	-1.1	-1.8
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.3	0.2	-0.5	-0.5	-0.3	0.4	0.1
Glaucoma (self-reported)	1.0	1.1	2.7	-1.6	-1.6	-0.9	0.2	0.2	-0.9
Gout (self-reported)	0.3	0.4	1.6	-0.7	0.1	0.2	-0.0	0.1	-1.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.9	1.0	0.3	0.0	-0.5	-0.7	0.5
Medication: Amlodipine	1.1	1.6	2.9	0.9	1.0	1.5	-0.8	1.7	1.4
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.4	0.1	-0.3	-0.6	-0.6	0.3	-0.5
Birth weight	0.1	0.2	0.3	-0.5	0.3	0.5	-0.5	0.4	0.1
Chronic bronchitis/emphysema (mother)	1.0	1.1	3.9	-0.5	-0.4	-0.6	0.8	-2.0	-1.2
High blood pressure (siblings)	0.5	0.7	1.3	1.2	0.4	1.0	0.7	-0.6	0.9
Forced vital capacity (FVC), Best measure	0.8	3.1	7.1	1.5	-1.5	1.1	-1.6	1.8	2.7
Body fat percentage	3.1	12.4	25.5	-4.4	-3.1	-2.9	3.1	-1.5	-5.1
Leg fat percentage (right)	2.8	10.1	22.5	-3.8	-2.9	-2.2	2.8	-1.5	-4.7
Arm fat-free mass (right)	4.1	21.1	32.7	-5.7	-5.0	-4.7	3.7	-2.6	-5.1
Exposure to tobacco smoke outside home	1.3	1.7	3.5	-1.3	-0.2	-1.1	1.5	-1.9	-1.1
Comparative body size at age 10	1.4	3.7	7.8	-2.8	-2.5	-1.2	1.0	-1.1	-2.2
Number of full brothers	0.1	0.2	0.7	-0.0	0.3	-0.2	0.3	0.5	-0.8
Worry too long after embarrassment	0.1	0.2	0.6	0.5	0.8	0.1	0.6	-0.3	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	5.7	1.9	2.4	0.9	-0.3	-0.1	1.7
Wheeze or whistling in the chest in last year	0.8	1.5	5.0	-1.0	0.3	-0.5	1.5	-0.6	-2.2
Number of children fathered	1.3	1.5	3.7	-1.0	-0.6	-1.3	1.0	-1.9	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.7	0.5	-0.8	0.7	0.3	-0.7	0.8
Age at first live birth	0.5	0.9	2.3	1.1	1.5	-0.1	0.8	-1.0	0.7
Pulse wave peak to peak time	0.4	0.4	2.4	-0.4	-1.5	0.1	-0.3	0.2	0.0
Health satisfaction	0.1	0.1	0.4	0.5	0.1	0.6	0.3	-0.1	-0.2
Shortness of breath walking on level ground	1.1	1.4	4.4	-2.1	-1.4	-0.8	0.1	0.1	-1.1
Qualifications: College or University degree	3.1	9.8	20.5	4.5	2.3	2.6	-2.8	1.2	4.0
Eye problems/disorders: None of the above	2.4	2.8	5.1	2.3	1.7	1.8	-1.3	0.7	1.8
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.4	-0.1	0.4	-0.7	-0.3	0.4	-0.4
Emphysema/chronic bronchitis	0.8	0.9	1.8	-1.1	0.1	-1.0	0.5	-1.3	-1.0
Medication for pain relief, constipation, heartburn	0.7	1.1	4.4	1.2	0.7	-0.1	-0.6	0.3	2.1
Neck or shoulder pain in last month	4.7	6.6	9.0	-2.4	-1.3	-2.6	2.7	-2.9	-3.0
Medication: Blood pressure	0.2	0.3	1.1	-0.1	0.1	1.1	-0.3	0.8	0.4
Angina (self-reported)	1.2	1.5	3.1	-1.4	-1.0	-1.0	1.4	0.3	-1.8
Migraine (self-reported)	0.1	0.1	0.3	-0.5	0.2	0.5	-0.2	-0.5	-0.0
Medication: Ibuprofen	0.8	0.9	2.0	-0.5	-1.4	-1.1	1.0	0.6	-0.8
Medication: Allopurinol	0.3	0.3	0.9	-0.4	-0.3	-0.4	0.9	-0.1	-0.9
Medication: Omeprazole	2.9	3.5	7.2	-0.6	0.0	-0.9	2.6	-2.7	-2.4
Medication: Seretide 50 evohaler	0.1	0.1	0.3	0.1	-0.4	0.2	0.4	-0.5	-0.4
Mean time to correctly identify matches	0.4	0.7	2.5	0.3	1.6	0.5	0.6	-0.8	-0.8
Heart disease (mother)	2.5	3.1	7.0	-2.5	-1.0	-1.4	1.3	-0.6	-2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.8	0.3	-0.2	1.1	-0.7	1.3	0.2
Whole body fat mass	4.5	18.6	33.1	-5.4	-4.2	-3.7	3.8	-2.1	-5.8
Leg fat mass (right)	4.7	18.3	32.1	-5.2	-4.4	-3.3	3.8	-2.4	-5.7
Arm predicted mass (right)	3.8	19.3	31.2	-5.6	-4.9	-4.3	3.4	-2.4	-5.1
Pulse rate, automated reading	0.3	1.0	2.1	0.4	0.0	1.2	-1.4	1.4	0.8
Alcohol intake frequency.	1.9	4.5	10.8	-3.0	-3.3	-0.8	0.9	-0.9	-2.3
Comparative height size at age 10	0.4	2.3	4.1	-1.3	-1.3	-1.7	1.8	-0.5	-2.0
Number of full sisters	0.3	0.3	0.6	0.6	0.8	0.7	0.3	-0.7	0.3
Suffer from ‘nerves’	0.1	0.2	0.6	0.3	-0.1	0.5	0.3	-0.8	0.1
Overall health rating	0.6	1.4	5.0	-0.7	0.1	0.1	1.3	-1.0	-2.2
Chest pain or discomfort	1.1	1.6	5.2	0.7	2.3	-0.4	-0.7	1.8	0.2
Had major operations	0.3	0.3	0.7	-0.8	-0.0	-0.8	0.6	0.1	-0.4
Age at last live birth	0.3	0.4	1.6	0.4	0.4	-0.0	0.5	-1.3	0.5
Family relationship satisfaction	0.8	0.9	2.0	1.0	0.3	1.4	-1.2	-0.1	1.1
Leg pain on walking	3.3	4.1	6.7	-2.2	-1.8	-1.4	1.9	-2.1	-2.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	2.0	-0.7	-1.4	0.3	-0.0	0.0	0.0
Commuting to job workplace: Car/motor vehicle	1.8	2.1	4.0	-1.3	-0.7	-1.8	1.4	-2.0	-1.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	3.1	0.5	0.1	-0.2	-0.9	0.2	1.8
Medication: Aspirin	0.5	0.7	1.6	0.2	0.5	0.9	-1.3	1.1	0.2
Supplements: Vitamin C	0.1	0.1	0.5	0.4	-0.7	0.1	-0.3	-0.1	0.3
Knee pain experienced in last month	2.6	4.0	10.3	-1.4	-2.3	-1.1	1.7	-3.2	-1.6
Hypertension (Self-reported)	0.4	1.2	3.2	0.7	-0.1	1.8	-0.8	1.2	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.0	-0.1	-0.3	-0.3	0.6	-0.8	-1.0
Illnesses of father: Heart disease	0.5	0.6	2.2	-0.8	-0.1	-0.5	-1.5	0.8	-0.2
Illnesses of siblings: Diabetes	1.7	2.1	4.3	-2.0	-0.5	-1.2	1.2	-1.1	-2.1
Smoking status: Previous	4.3	6.4	11.7	-3.4	-2.1	-1.9	1.8	-2.4	-3.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.9	0.1	-0.3	0.7	-0.4	1.7	0.6
Whole body fat-free mass	3.2	18.1	28.3	-5.3	-5.0	-4.2	3.3	-2.5	-4.5
Leg fat-free mass (right)	3.6	19.1	29.3	-5.4	-5.1	-4.0	3.7	-2.7	-4.7
Arm fat percentage (left)	3.1	12.2	21.6	-4.1	-3.4	-2.7	3.5	-1.9	-4.7
Average weekly red wine intake	0.4	0.6	2.1	1.4	0.4	-0.2	-0.4	-0.5	0.9
Handedness (chirality/laterality): Left-handed	2.6	3.1	7.1	2.7	1.6	1.0	-1.8	1.1	1.9
Mood swings	2.7	4.9	7.5	-2.2	-1.5	-1.9	1.9	-2.7	-2.7
Loneliness, isolation	0.5	0.8	2.4	1.3	1.6	0.1	-0.1	-0.1	0.6
Long-standing illness, disability or infirmity	1.6	2.4	5.7	-0.2	2.0	-1.5	1.0	-1.1	-2.4
Ever had bowel cancer screening	0.3	0.4	1.4	0.4	1.2	0.5	-0.1	0.7	0.2
Diabetes diagnosed by doctor	0.4	0.7	2.5	-1.6	-0.2	-0.1	0.2	-0.1	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.2	3.7	1.1	-0.0	1.9	-1.0	-0.7	1.0
Friendships satisfaction	2.9	3.6	6.5	2.5	1.1	2.0	-1.6	1.6	2.2
Qualifications: nursing, teaching	1.6	2.5	7.6	2.3	2.8	0.5	-0.4	0.3	1.2
Commuting to job workplace: Walk	1.6	1.7	3.4	1.3	1.2	0.9	-1.8	0.6	1.7
Eye problems/disorders: Cataract	1.9	2.2	4.1	-2.0	-0.7	-1.9	1.4	-0.4	-1.8
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	5.5	2.3	1.7	1.4	-0.7	0.2	1.3
Medication for cholesterol	0.4	0.7	1.3	-0.5	0.1	-0.1	1.1	-1.0	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.5	-1.2	-1.1	0.3	-0.2	0.3	-0.9
Back pain experienced in last month	0.3	0.4	1.7	-0.4	-1.3	0.2	-0.2	0.2	-0.4
Mineral and other dietary supplements	0.7	0.9	3.6	-1.3	-1.9	-0.3	0.2	0.3	-0.2
Breast cancer (self-reported)	1.0	1.2	3.2	-1.8	-0.3	-1.0	0.5	-0.8	-1.5
Asthma (self-reported)	2.2	4.3	7.7	2.8	2.6	2.1	-1.1	2.2	0.9
Osteoporosis (self-reported)	1.5	1.9	4.3	-1.9	-1.1	-2.1	1.0	0.2	-1.2
Osteoarthritis (self-reported)	0.7	0.9	3.1	-0.6	0.7	-0.4	1.8	-0.2	-1.0
Medication: Aspirin	0.4	0.5	0.8	0.4	0.6	0.8	-0.9	0.9	0.3
Medication: Gliclazide	0.3	0.3	0.6	-0.2	0.7	-0.1	-0.7	0.8	0.3
Illnesses of father: None of the above (group 1)	1.1	1.3	2.6	-0.8	-1.0	-0.4	1.6	-1.6	-0.9
Smoking status: Current	0.4	0.6	1.6	-0.6	-0.7	-1.0	0.1	-1.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.5	0.6	-1.9	-0.0	1.0	-0.3	0.8
Whole body water mass	3.1	17.5	26.8	-5.2	-5.0	-4.1	3.3	-2.4	-4.4
Leg predicted mass (right)	3.6	19.4	29.5	-5.4	-5.1	-4.1	3.7	-2.8	-4.7
Arm fat mass (left)	4.6	18.8	29.9	-5.2	-4.5	-3.8	4.0	-2.4	-5.5
Number of self-reported non-cancer illnesses	0.5	0.8	1.6	0.6	1.2	1.1	-0.6	1.3	-0.1
Average weekly champagne plus white wine intake	1.4	1.9	3.2	1.0	0.3	1.5	-1.3	1.8	1.7
Miserableness	3.2	5.6	10.1	-2.4	-1.7	-2.2	2.5	-1.9	-3.2
Guilty feelings	0.2	0.3	0.6	0.7	0.5	0.4	0.6	-0.7	-0.5
Wears glasses or contact lenses	1.5	1.7	2.9	-1.4	-0.3	-1.7	1.4	-0.8	-1.7
Ever taken oral contraceptive pill	1.5	1.7	5.7	0.3	0.7	1.4	-2.4	1.0	0.9
Hearing aid user	0.8	0.9	1.8	-1.3	0.1	-1.3	0.6	0.6	-1.1
Mother’s age at death	0.7	0.9	3.7	0.0	1.0	-0.5	1.9	-0.5	-0.5
Financial situation satisfaction	1.7	2.1	4.1	1.9	0.5	2.0	-1.3	0.7	1.6
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.1	-1.1	0.1	-0.8	0.6	0.2	-1.0
Commuting to job workplace: Public transport	0.4	0.5	2.0	-0.0	-0.2	-0.5	0.4	-1.4	-0.9
Eye problems/disorders: Glaucoma	2.0	2.4	6.2	-2.5	-2.2	-0.8	-0.0	-0.6	-1.5
Medication: Blood pressure	0.3	0.5	1.3	-0.4	-0.8	-0.7	1.2	-0.1	-0.6
Pain type(s) experienced in last month: Hip pain	1.9	2.4	5.4	-2.1	-2.3	-1.4	-0.6	-0.5	-1.4
Supplements: Fish oil (including cod liver oil)	0.7	1.0	3.1	1.0	1.8	0.8	-0.7	-0.7	0.2
High cholesterol (Self-reported)	0.3	0.6	2.2	0.1	-0.4	1.0	-0.6	-1.5	0.3
Medication: Bendroflumethiazide	0.2	0.2	1.2	0.1	0.5	0.0	1.1	0.1	-0.2
Medication: Paracetamol	0.8	1.3	4.1	0.0	-2.0	1.5	-0.8	0.7	0.4
Medication: Lisinopril	1.6	2.1	4.5	1.8	0.8	2.1	-1.2	0.7	1.5
Medication: Atorvastatin	1.2	1.5	2.3	1.4	1.5	1.5	-0.6	1.0	1.2
Illnesses of father: High blood pressure	5.4	6.7	10.0	2.8	1.5	2.6	-2.5	2.7	3.2
Alcohol drinker status: Never	0.0	0.0	0.1	-0.0	-0.1	-0.4	-0.2	-0.0	0.0
Ever smoked	3.6	6.4	12.1	-3.5	-2.5	-2.3	1.3	-2.6	-2.5
Basal metabolic rate	3.5	19.5	29.6	-5.4	-5.1	-4.3	3.6	-2.6	-4.9
Leg fat percentage (left)	2.9	10.3	21.0	-4.2	-3.0	-2.3	2.8	-1.2	-4.6
Arm fat-free mass (left)	4.0	20.1	31.8	-5.6	-5.0	-4.6	3.6	-2.6	-4.8
Number of operations (self-reported)	0.9	1.3	3.3	-1.8	-0.5	-0.4	0.9	0.1	-1.7
Average weekly beer plus cider intake	0.1	0.1	0.2	0.2	0.1	-0.5	0.5	-0.2	0.1
Irritability	0.1	0.2	0.7	-0.3	0.1	-0.6	-0.2	-0.1	-0.8
Risk taking	0.2	0.3	0.9	0.7	0.1	0.9	-0.2	-0.2	0.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.5	-0.1	-0.2	-0.3	-0.5	-0.1	0.7
Fractured/broken bones in last 5 years	1.5	1.9	4.4	-0.9	0.8	-1.4	1.0	-1.5	-2.1
Age started oral contraceptive pill	1.1	1.4	2.2	-1.5	0.6	-1.3	1.0	-1.0	-1.4
Diastolic blood pressure, automated reading	1.3	3.9	6.9	1.6	-1.3	1.8	-1.9	2.6	2.4
Ever depressed for a whole week	0.9	1.1	2.1	1.4	1.4	0.5	-1.2	0.2	0.9
Unable to work because of sickness or disability	0.6	0.7	1.8	-1.0	-0.2	-0.9	0.1	-0.9	-1.3
Commuting to job workplace: Cycle	6.4	7.7	15.6	4.0	2.9	2.4	-2.4	1.2	3.1
Myopia	0.8	1.1	3.4	-0.1	1.8	-0.9	1.1	-0.5	-1.0
Vascular/heart problems diagnosed by doctor	0.3	0.7	2.0	-0.2	0.5	-1.4	0.5	-0.9	-0.8
Cholesterol lowering medication	0.2	0.3	0.9	0.1	-1.0	0.7	-0.6	0.0	-0.0
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	5.7	-0.0	0.3	-0.5	2.0	-2.4	-1.8
Pain experienced in last month	2.3	3.8	7.5	2.0	1.1	1.8	-1.7	2.0	2.7
Supplements: Calcium	0.2	0.2	0.6	-0.5	0.0	-0.4	-0.1	-0.8	-0.4
Basal cell carcinoma (self-reported)	0.4	0.5	1.3	-1.1	-1.1	-0.1	-0.1	-0.4	-0.4
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.8	0.2	0.7	0.9	-0.9	1.7	1.0
Deep venous thrombosis (DVT) (self-reported)	1.4	1.7	4.7	-1.5	0.8	-1.1	1.0	-0.9	-2.2
Heart disease (siblings)	0.6	0.7	2.1	-1.4	-0.9	-0.2	0.7	-0.9	-0.4
Alcohol drinker status: Previous	0.2	0.2	0.4	0.1	-0.4	0.4	-0.6	0.6	0.3
Pack years of smoking	4.0	5.9	12.6	-2.7	-0.8	-2.6	2.4	-1.5	-3.6
Impedance of whole body	2.4	12.0	21.5	4.3	4.6	2.9	-3.3	1.9	3.1
Leg fat mass (left)	4.9	19.0	31.8	-5.5	-4.5	-3.5	3.8	-2.3	-5.6
Arm predicted mass (left)	4.0	20.1	32.6	-5.7	-4.9	-4.5	3.6	-2.6	-4.9