Best TWAS P=8.24e-10 · Best GWAS P=4.92e-09 conditioned to 0.00552
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Thyroid | THBS3 | 0.12 | 0.09 | enet | 8 | 0.09 | 3.6e-07 | 4.4 | -6.1 | 8.2e-10 | 0.59 | 0.19 | 0.80 | TRUE |
| 2 | GTEx | Thyroid | MUC1 | 0.11 | 0.02 | enet | 15 | 0.09 | 1.5e-07 | 4.0 | 5.6 | 1.9e-08 | -0.26 | 0.33 | 0.65 | FALSE |
| 3 | YFS | Blood | THBS3 | 0.29 | 0.22 | enet | 38 | 0.31 | 6.4e-105 | 4.3 | -5.4 | 6.1e-08 | 0.39 | 0.71 | 0.27 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | THBS3 | 0.04 | 0.01 | blup | 25 | 0.03 | 3.1e-04 | -5.0 | -5.9 | 4.5e-09 | 0.64 | 0.04 | 0.59 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GBAP1 | 0.04 | 0.04 | blup | 26 | 0.04 | 2.5e-05 | -4.8 | 5.4 | 7.3e-08 | -0.45 | 0.19 | 0.66 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | GBAP1 | 0.04 | 0.02 | blup | 27 | 0.03 | 4.7e-04 | 4.3 | 5.3 | 1.5e-07 | -0.55 | 0.02 | 0.65 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GBA | 0.05 | 0.01 | lasso | 2 | 0.01 | 2.3e-02 | -5.8 | 6.0 | 2.6e-09 | -0.93 | 0.00 | 0.87 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GBAP1 | 0.06 | 0.06 | lasso | 9 | 0.06 | 3.5e-07 | -4.8 | 5.7 | 1.2e-08 | -0.55 | 0.22 | 0.76 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | THBS3 | 0.14 | 0.03 | enet | 16 | 0.08 | 3.8e-08 | 4.0 | -5.2 | 2.3e-07 | 0.69 | 0.00 | 0.99 | FALSE |