Hub : Genes

MUC1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Mucosa 0.171 0.0530 5.7e-07 0.200 NA 0.170 NA 0.178 1.9e-13 NA 1.7e-11 NA 5.6e-12
2 GTEx Testis 0.205 0.0680 1.5e-04 0.016 NA 0.061 NA 0.065 6.3e-02 NA 1.1e-03 NA 7.5e-04
3 GTEx Thyroid 0.113 0.0400 6.0e-05 0.016 NA 0.092 NA 0.063 2.1e-02 NA 1.5e-07 NA 1.3e-05
4 TCGA Bladder Urothelial Carcinoma 0.082 0.0430 2.8e-03 -0.001 0.008 0.000 NA 0.002 3.8e-01 0.0590 3.1e-01 NA 2.2e-01
5 TCGA Head and Neck Squamous Cell Carcinoma 0.036 0.0228 3.7e-03 0.009 0.020 0.022 NA 0.013 2.8e-02 0.0024 1.3e-03 NA 1.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 3.9 6.2 9.3 2.9 2.3 -3.1 -0.8 2.6
Bipolar Disorder or Schizophrenia 3.5 8.6 12.5 3.1 3.5 -3.3 -1.0 3.0
Depressed Affect (Nagel 2018) 3.2 6.7 10.4 3.0 1.9 -3.2 2.2 2.3
Depression (Nagel 2018) 1.6 2.3 4.7 2.2 1.6 -0.9 -0.6 1.8
Intelligence (Savage-Jansen 2018) 0.4 1.4 4.3 -0.9 -2.1 0.1 -0.4 -1.3
Neuroticism (Nagel 2018) 1.3 3.0 8.4 1.9 0.0 -2.9 0.3 1.8
Schizophrenia (2018) 1.7 3.6 8.0 1.6 2.8 -2.0 -0.6 1.8
Schizophrenia vs Biploar Disorder 1.4 1.8 3.7 -1.8 -1.9 -0.2 0.4 -1.5
Worry (Nagel 2018) 1.1 2.4 7.9 -0.1 -2.8 -0.5 -1.7 0.9
Alzheimer’s Disease (in mother) 1.1 1.3 3.7 1.3 1.2 -0.0 -0.0 1.9
Alzheimer’s Disease (in father) 1.6 1.8 3.1 -1.7 -1.3 1.1 0.1 -1.8
Alzheimer’s Disease (including proxy) 0.3 0.4 0.9 -0.0 -0.1 1.0 -0.5 0.8
Crohns Disease (2017) 5.3 11.6 21.0 4.6 3.0 -3.5 0.9 3.9
Irritable Bowel Disease (IBD) 7.5 17.9 33.9 5.8 3.8 -3.8 1.1 5.0
Ulcerative Colitis (UC) 5.3 9.9 19.0 4.4 3.1 -2.3 0.6 3.9
Major Depression (MDD) 0.7 0.8 2.4 0.0 -0.6 -0.7 1.6 -0.9
Reaction Time 0.2 0.4 0.8 0.2 0.6 -0.3 0.9 -0.8
Verbal and Numeric Reasoning (VNR) 0.3 0.7 2.2 -0.5 -1.5 -0.1 -0.8 -0.8
Breast Cancer 9.1 21.8 37.9 -6.2 -4.7 3.8 -1.8 -5.6
Ovarian Cancer 0.8 1.0 1.5 -0.6 -1.1 -0.8 1.2 -1.2
Prostate Cancer 1.8 2.5 5.5 1.7 1.3 -2.3 1.1 1.2
Age at First Birth 0.9 1.3 3.2 -1.1 -1.0 1.8 -0.8 -0.7
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.4 2.0 4.5 -1.9 -1.3 2.1 0.0 0.0
Coronary Artery Disease (CAD) 0.2 0.3 1.1 -0.3 -1.0 -0.4 0.0 0.0
Crohns Disease (2012) 4.9 7.9 13.8 3.4 2.0 -3.7 -0.6 3.2
Mean Putamen Volume 1.2 1.4 3.2 0.4 1.8 -0.5 1.8 -0.3
Fasting Glucose 1.1 1.3 3.0 1.2 1.0 -0.4 -0.8 1.7
HbA1C 1.7 1.9 8.2 0.9 -0.5 -2.9 -0.1 0.2
HDL Cholesterol 0.2 0.3 1.2 -0.5 -1.1 -0.1 0.0 0.0
LDL Cholesterol 1.5 2.3 9.4 1.5 0.0 -3.1 0.0 0.0
Lupus 0.7 1.0 1.3 -0.9 -1.0 1.1 -0.9 -1.1
Neuroticism (2016) 0.8 1.2 2.3 1.0 -1.0 0.2 -1.2 1.5
Primary Biliary Cirrhosis 0.5 0.8 2.8 -0.3 -0.5 -0.7 -1.7 0.4
Rheumatoid Arthritis 0.4 0.5 1.3 1.1 0.7 -0.1 0.4 0.8
Schizophrenia (2014) 1.8 4.0 5.3 1.8 2.3 -2.1 -1.6 2.0
Triglycerides 0.6 0.9 2.3 1.5 1.5 -0.5 0.0 0.0
Type 2 Diabetes (T2D) (2012) 0.5 0.6 2.4 0.8 1.5 -0.2 0.0 0.0
Ulcerative Colitis 2.8 4.0 8.0 2.8 1.1 -1.8 -0.8 2.6
Blood Eosinophil Count 0.5 3.5 7.6 2.4 1.6 -1.3 0.3 2.8
Blood Platelet Count 2.9 33.7 42.8 6.5 6.5 -5.8 4.5 5.5
Blood Red Count 7.8 75.7 163.8 10.1 8.3 -6.3 1.9 12.8
Blood White Count 0.3 2.5 6.1 1.0 2.3 -0.3 2.5 0.5
Heel T-Score 3.1 24.7 41.3 -6.4 -2.9 5.4 -3.0 -5.9
BMI 2.7 15.4 52.4 -3.2 -0.7 7.2 -0.1 -3.7
Height 1.4 27.4 49.4 -6.3 -7.0 2.1 -4.3 -5.0
Waist Hip Ratio (WHR) 3.9 17.5 25.6 4.4 5.0 -3.5 2.1 5.1
Systolic Blood Pressure 0.2 0.8 2.0 0.0 1.4 1.4 -0.2 0.0
Smoking Status 2.1 5.1 11.0 2.6 3.3 -1.1 1.4 2.1
Allergy or Eczema 4.7 12.4 19.4 3.6 4.3 -4.4 1.3 3.1
Cardiovascular Disease 1.1 3.8 7.5 2.3 2.7 0.6 -0.2 2.4
Hypothyroidism (self reported) 1.5 3.5 8.4 -1.3 -0.5 2.9 -2.6 -0.5
Respiratory disease 1.4 3.1 9.4 1.5 1.4 -3.1 0.3 1.2
Type 2 Diabetes (T2D) (2018) 2.3 4.3 9.1 2.2 1.6 -1.8 3.0 1.2
Lung FEV1/FVC ratio 1.2 6.3 10.5 3.2 1.9 0.7 2.6 3.2
Lung FVC 5.4 27.5 53.6 -7.3 -5.2 1.7 -0.5 -7.3
Neuroticism 2.2 5.3 9.7 2.7 0.3 -3.1 0.4 3.0
Chronotype (morning person) 0.4 1.0 1.8 1.2 1.0 -0.1 0.9 1.4
Hair Pigment 0.5 13.1 39.8 3.8 2.0 -6.3 1.6 2.1
Tanning 0.8 10.1 20.9 2.2 4.4 -4.6 0.4 2.3
Hand grip strength (left) 0.8 2.2 4.3 -2.1 -0.7 -1.7 -0.0 -1.9
Number of treatments/medications taken 1.1 1.9 6.5 1.2 2.5 -1.0 -0.5 0.7
Average weekly spirits intake 1.0 1.2 2.0 -1.4 1.0 1.3 -0.6 -0.9
Sensitivity / hurt feelings 0.9 1.5 3.3 1.4 0.4 -1.5 -0.2 1.8
Frequency of depressed mood in last 2 weeks 2.3 3.2 6.8 2.6 1.7 -0.9 -0.0 2.3
Hearing difficulty/problems: Yes 1.4 2.1 4.3 1.5 0.8 -1.5 -1.1 2.1
Relative age of first facial hair 0.3 0.7 2.1 -1.0 0.2 0.1 0.5 -1.5
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 2.9 1.7 1.6 -0.6 -0.1 1.7
Ever used hormone-replacement therapy (HRT) 2.1 2.6 9.2 -0.8 -0.2 1.8 -3.0 -0.2
Ever had hysterectomy (womb removed) 1.4 1.6 3.8 -0.6 -0.4 1.9 -2.0 0.1
Systolic blood pressure, automated reading 2.0 5.7 9.7 -3.1 -0.7 2.7 -1.6 -2.9
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.7 -0.4 -0.3 0.8 -0.4 -0.7
Angina 0.3 0.4 1.6 0.2 1.3 0.1 0.5 0.2
Medication for hormone replacement therapy 2.2 2.5 7.8 -0.8 0.2 2.8 -1.8 -0.7
Vitamin and mineral supplements 0.3 0.4 0.6 0.8 0.6 0.7 0.4 0.8
Supplements: Zinc 0.5 0.5 1.9 -0.0 -0.6 -1.4 -0.5 0.4
Medication: Co-codamol 0.2 0.3 1.1 -0.3 -0.4 -0.1 0.1 -1.0
Medication: Metformin 2.8 4.0 8.3 2.9 1.3 -1.6 0.9 2.5
Diabetes (father) 0.3 0.4 0.9 -0.5 -1.0 -0.3 -0.6 -0.5
Diabetes (mother) 0.2 0.2 0.4 0.4 0.6 -0.4 0.5 -0.2
Severe depression (siblings) 3.2 3.6 5.7 2.4 1.8 -1.9 0.8 2.1
Pack years adult smoking proportion 1.2 1.8 4.7 -0.2 -0.5 2.2 -2.0 0.2
Impedance of leg (right) 9.0 43.8 60.4 7.8 5.8 -7.7 4.2 7.0
Leg fat-free mass (left) 6.8 35.9 47.1 -6.9 -6.1 6.8 -3.1 -6.2
Trunk fat percentage 1.2 4.7 22.6 -0.1 0.7 4.8 -0.3 -0.5
Hand grip strength (right) 1.2 3.3 8.0 -2.8 -1.0 -0.6 0.1 -2.7
Townsend deprivation index at recruitment 0.3 0.4 1.0 0.5 0.2 -0.2 1.0 0.6
Current tobacco smoking 0.4 0.7 2.7 0.1 1.6 0.8 0.4 -0.3
Average weekly fortified wine intake 1.0 1.2 2.2 -1.5 -0.9 0.3 -1.1 -1.4
Maternal smoking around birth 0.2 0.3 0.9 -0.1 0.5 0.9 0.1 -0.6
Fed-up feelings 2.2 4.0 6.4 2.3 1.2 -2.5 2.2 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 2.3 3.1 6.7 2.6 1.8 -0.4 -0.2 2.3
Relative age voice broke 0.3 0.5 0.7 -0.3 -0.7 -0.8 -0.8 -0.7
Taking other prescription medications 0.3 0.5 1.1 0.5 0.9 -0.4 -1.0 0.4
Age when periods started (menarche) 0.6 1.4 4.7 0.8 1.1 -0.4 2.2 -0.4
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 1.8 -0.8 -0.1 1.3 -1.4 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 3.9 8.7 17.1 -4.1 -1.9 2.9 -1.8 -3.4
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.7 -0.8 -0.6 -0.1 0.5 -0.3
Qualifications: CSEs or equivalent 0.2 0.3 1.1 0.1 -1.1 0.3 0.4 0.1
Serious illness, injury or assault to yourself 2.5 3.1 5.9 1.9 0.5 -1.8 -1.5 2.4
High blood pressure 0.2 0.5 1.4 0.7 1.2 0.5 -0.3 0.6
Hayfever, allergic rhinitis or eczema 5.2 11.4 15.8 3.7 3.7 -4.0 1.4 3.4
Multivitamins +/- minerals 0.3 0.3 0.8 -0.7 -0.5 0.1 -0.9 -0.5
Stomach or abdominal pain in last month 0.2 0.3 0.7 0.5 0.8 -0.2 -0.1 0.7
Supplements: Glucosamine 1.0 1.3 5.7 -0.8 -0.3 0.2 -2.4 0.2
Diverticular disease/diverticulitis (self-reported) 1.3 1.5 4.0 -1.1 -0.9 1.0 0.7 -2.0
Medication: Atenolol 1.1 1.4 2.5 -1.3 -0.5 1.6 -0.8 -1.4
Medication: Levothyroxine sodium 1.1 1.9 5.0 0.0 0.0 1.9 -2.2 0.7
Sitting height 0.2 1.6 5.0 -1.0 -2.2 0.7 0.5 -1.0
Chronic bronchitis/emphysema (father) 1.1 1.3 3.4 -1.3 -0.7 0.3 -0.7 -1.9
High blood pressure (mother) 4.7 6.7 11.4 -3.3 -2.9 1.4 -1.1 -3.4
Body mass index (BMI) 3.3 14.0 33.8 -3.7 -1.9 5.8 -2.1 -3.8
Impedance of leg (left) 10.2 49.4 70.4 8.4 6.6 -7.5 4.3 7.6
Leg predicted mass (left) 6.7 35.7 47.1 -6.9 -6.2 6.8 -3.1 -6.2
Trunk fat mass 1.8 7.6 29.2 -1.8 -0.8 5.4 -1.0 -2.0
Waist circumference 0.7 2.6 8.9 -1.0 -0.5 3.0 -1.6 -0.6
Number of incorrect matches in round 0.2 0.3 0.7 -0.5 0.2 0.8 -0.8 0.2
Past tobacco smoking 5.8 10.6 17.5 -3.4 -2.7 4.2 -3.3 -2.5
Alcohol usually taken with meals 1.1 1.7 3.6 1.1 -0.5 -1.8 -0.7 1.9
Nervous feelings 3.1 5.9 16.2 -2.5 -4.0 1.1 -1.0 -2.2
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.8 1.1 -0.2 -1.3 -0.4 0.9
Hearing difficulty/problems with background noise 2.9 4.7 9.4 2.7 1.7 -2.0 0.0 3.1
Hair/balding pattern: Pattern 2 0.5 0.7 1.2 0.9 1.1 -1.0 0.3 0.6
Had menopause 1.0 1.2 3.3 -1.1 -0.7 1.0 -0.0 -1.8
Had other major operations 1.3 1.6 4.3 -1.1 -0.5 2.1 -0.4 -1.5
Forced vital capacity (FVC) 4.0 15.3 29.4 -5.4 -4.5 0.8 -1.0 -5.1
Heel bone mineral density (BMD) T-score, automated (right) 2.9 6.7 12.1 -3.5 -1.6 2.8 -1.3 -3.0
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 0.9 -0.6 -1.0 -0.8 0.8 -0.8
Qualifications: None of the above 0.2 0.3 0.8 -0.7 -0.1 0.9 -0.1 -0.6
Financial difficulties in last 2 years 0.7 1.0 2.9 -0.2 0.5 1.7 0.6 -1.1
Mouth/teeth dental problems 8.6 13.2 18.2 -4.3 -3.6 3.9 -2.6 -3.6
Heart attack 0.2 0.2 0.7 -0.3 0.1 0.6 0.4 -0.8
Allergy 5.0 11.4 16.8 -4.1 -3.2 4.0 -1.4 -3.4
Pain all over the body in last month 0.2 0.2 0.8 0.1 0.3 0.9 0.3 -0.0
Diabetes (self-reported) 4.2 6.4 11.6 3.4 2.5 -1.8 1.7 2.8
Hayfever/allergic rhinitis (self-reported) 3.3 4.4 7.1 2.7 1.8 -2.2 0.4 2.6
Medication: Ramipril 1.5 1.9 3.8 1.7 1.2 -1.2 0.2 1.9
Medication: Simvastatin 0.0 0.1 0.2 -0.1 0.4 0.1 0.2 -0.2
Fluid intelligence score 0.2 0.4 0.9 -0.0 -1.0 -0.2 -1.0 0.0
Illnesses of siblings 1.0 1.4 3.2 1.3 -0.9 -1.1 0.2 1.8
Neuroticism score 1.6 3.2 6.0 2.2 -0.6 -2.4 0.6 2.2
Weight 4.1 20.1 33.8 -4.9 -3.7 5.8 -2.9 -4.5
Impedance of arm (right) 3.1 14.2 29.8 5.5 3.1 -0.9 1.5 5.3
Arm fat percentage (right) 1.9 7.6 31.5 -1.5 -0.5 5.6 -1.0 -1.7
Trunk fat-free mass 5.3 30.6 50.0 -7.1 -6.5 3.5 -3.0 -6.2
Hip circumference 2.8 12.1 22.6 -3.2 -3.2 4.8 -2.9 -3.0
Time employed in main current job 0.8 0.9 1.4 -1.1 -1.2 0.4 -1.0 -0.9
Alcohol intake versus 10 years previously 0.4 0.6 2.0 -0.5 -1.4 0.6 -0.4 -0.2
Father’s age at death 0.8 1.1 3.3 0.5 -0.9 -1.8 1.1 0.3
Worrier / anxious feelings 0.4 0.8 2.6 0.1 -1.6 -1.1 -0.1 0.3
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.2 1.1 0.3 -0.0 0.1 1.0
Falls in the last year 0.2 0.3 1.2 0.1 0.3 -1.1 -0.6 0.0
Hair/balding pattern: Pattern 3 1.6 2.3 4.5 2.1 1.2 -1.1 -0.0 2.1
Number of live births 0.8 1.2 4.3 0.8 0.7 -2.1 0.2 0.7
Forced expiratory volume in 1-second (FEV1) 3.1 10.3 19.1 -4.4 -3.9 1.2 -0.5 -3.9
Pulse rate 0.2 0.4 0.7 0.2 0.7 0.5 -0.6 0.8
Happiness 2.7 3.3 5.7 2.1 0.3 -2.4 1.9 1.6
Noisy workplace 0.2 0.3 0.5 0.5 0.7 0.1 0.7 0.2
Qualifications: A levels/AS levels or equivalent 1.1 2.4 7.8 1.0 -1.1 -2.8 -0.4 1.4
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.3 0.7 0.6 -0.9 -0.2 1.2
Mouth/teeth dental problems: Dentures 11.2 18.8 28.3 5.3 4.3 -4.0 3.4 4.4
Asthma 2.0 4.0 7.4 2.2 1.9 -2.7 -0.5 2.0
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 5.3 -0.4 0.3 2.3 -1.4 0.0
Medication: Cholesterol lowering 2.1 3.2 4.9 2.0 2.2 -1.9 1.5 1.3
Depression (self-reported) 0.6 0.7 1.8 1.0 0.6 -1.4 -0.1 0.7
Medication: Lansoprazole 0.5 0.5 1.1 0.6 1.1 -0.7 0.1 0.8
Prospective memory result 0.5 0.6 1.3 -1.0 -0.5 0.7 -1.1 -0.2
Lung cancer (father) 1.7 2.0 3.3 1.8 1.8 -0.6 0.6 1.6
Illnesses of mother 3.8 4.7 9.1 2.4 3.0 -0.0 -0.2 3.0
Forced expiratory volume in 1-second (FEV1), Best measure 3.1 10.0 17.6 -4.0 -4.2 1.5 0.5 -3.8
Pulse wave Arterial Stiffness index 2.3 2.7 5.2 2.3 1.6 -0.2 1.4 1.9
Impedance of arm (left) 3.1 14.2 30.4 5.4 3.2 -0.6 1.0 5.5
Arm fat mass (right) 3.1 12.9 36.5 -3.2 -1.9 6.0 -2.0 -3.2
Trunk predicted mass 5.2 29.9 48.9 -7.0 -6.5 3.4 -3.0 -6.2
Standing height 0.8 8.2 20.2 -3.4 -4.5 1.0 -1.7 -2.3
Length of working week for main job 1.7 1.8 4.7 -1.1 -0.9 0.3 2.2 -1.6
Exposure to tobacco smoke at home 0.1 0.1 0.3 0.5 0.5 0.3 0.3 -0.2
Breastfed as a baby 1.6 2.0 7.1 1.1 2.7 -0.2 -0.9 1.0
Tense / ‘highly strung’ 2.0 3.3 7.3 2.2 -0.3 -2.0 -0.7 2.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 1.0 3.8 -0.2 -0.9 0.6 -1.9 -0.1
Hair/balding pattern: Pattern 4 2.9 6.9 12.0 -3.3 -3.5 1.5 -0.5 -3.1
Birth weight of first child 0.6 1.1 2.0 -0.1 0.6 1.4 1.4 -1.1
Peak expiratory flow (PEF) 0.7 1.7 4.1 -1.3 -1.1 2.0 -1.0 -0.6
Pulse wave reflection index 2.6 3.3 4.8 2.2 1.3 -2.0 1.8 1.7
Ever highly irritable/argumentative for 2 days 0.2 0.3 1.2 0.1 1.1 -0.3 -0.1 0.1
Loud music exposure frequency 1.4 1.5 3.4 -1.8 -1.1 0.8 0.0 -1.5
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.2 0.4 -0.1 -0.4 -0.3 0.4
Mouth/teeth dental problems: Bleeding gums 2.0 2.6 5.7 1.8 0.9 -1.5 2.4 1.1
Blood clot in the leg (DVT) 1.4 1.8 3.6 1.7 0.5 -1.9 1.3 0.7
Medication: Paracetamol 0.0 0.1 0.2 0.1 0.5 -0.0 0.3 -0.2
Headache pain in last month 0.5 0.9 2.1 1.2 0.8 0.4 -0.6 1.5
Medication for cholesterol, blood pressure or diabetes 3.3 5.5 9.2 -3.0 -2.7 2.1 -1.1 -2.3
Glaucoma (self-reported) 0.4 0.5 1.9 0.0 -0.3 -1.4 0.1 0.6
Gout (self-reported) 11.0 15.1 22.9 -4.8 -3.4 4.0 -1.4 -4.8
Hypothyroidism/myxoedema (self-reported) 2.1 4.1 8.1 -1.7 -1.0 2.8 -2.9 -0.7
Medication: Amlodipine 0.2 0.3 0.6 0.8 0.1 -0.2 0.8 0.5
Medication: Ventolin 100micrograms inhaler 0.8 1.1 2.3 1.5 0.4 -1.4 0.7 0.7
Birth weight 0.6 1.3 2.7 -1.3 -0.8 0.9 0.9 -1.6
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.1 -0.1 -0.8 -1.1 -0.4 -0.7
High blood pressure (siblings) 1.4 2.0 5.7 -1.8 0.2 1.0 -0.3 -2.4
Forced vital capacity (FVC), Best measure 3.6 13.3 23.5 -4.8 -4.6 1.1 -0.0 -4.6
Body fat percentage 1.0 3.9 18.5 -0.1 0.9 4.3 -0.2 -0.6
Leg fat percentage (right) 0.4 1.6 5.8 -0.1 1.3 2.4 -0.4 -0.3
Arm fat-free mass (right) 4.0 20.6 33.6 -5.8 -5.0 3.3 -1.9 -5.5
Exposure to tobacco smoke outside home 0.6 0.8 1.5 1.1 1.1 0.1 -0.3 1.2
Comparative body size at age 10 1.0 2.7 6.8 -1.7 -1.1 2.6 0.1 -1.6
Number of full brothers 0.3 0.4 1.1 0.0 1.1 -0.2 0.9 -0.2
Worry too long after embarrassment 2.5 4.2 10.5 2.3 -1.1 -3.2 -0.4 1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 3.0 0.8 -0.1 -1.7 0.4 0.1
Wheeze or whistling in the chest in last year 1.7 3.1 7.3 2.0 1.3 -2.7 0.4 1.4
Number of children fathered 0.8 1.0 2.8 -1.7 0.1 0.7 -0.6 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 3.0 -0.3 -0.7 0.1 -1.7 0.4
Age at first live birth 0.4 0.7 1.7 -0.4 -1.0 -1.3 0.6 -0.1
Pulse wave peak to peak time 2.7 3.1 6.0 -2.4 -1.9 0.3 -1.4 -2.0
Health satisfaction 0.4 0.5 1.3 -0.8 -1.1 -0.1 0.3 -0.7
Shortness of breath walking on level ground 0.1 0.1 0.5 -0.3 -0.1 -0.1 -0.7 0.2
Qualifications: College or University degree 0.4 1.2 2.7 0.6 -0.9 -1.6 -0.6 1.4
Eye problems/disorders: None of the above 3.2 3.7 5.5 -1.9 -2.3 2.2 -1.2 -1.8
Mouth/teeth dental problems: Loose teeth 1.0 1.1 2.6 1.0 1.6 -1.0 0.1 1.0
Emphysema/chronic bronchitis 2.9 3.3 7.8 2.2 0.4 -2.8 1.1 1.5
Medication for pain relief, constipation, heartburn 0.9 1.5 4.2 -1.3 -2.0 -0.4 0.2 -1.1
Neck or shoulder pain in last month 0.2 0.3 0.8 -0.4 -0.6 0.2 -0.2 -0.9
Medication: Blood pressure 3.0 5.2 9.3 3.1 2.5 -1.4 0.4 2.9
Angina (self-reported) 0.2 0.3 1.1 0.1 1.0 -0.1 0.5 0.1
Migraine (self-reported) 0.6 0.8 1.4 0.9 -0.5 -0.1 -1.2 1.2
Medication: Ibuprofen 1.3 1.5 2.6 0.3 1.4 1.4 -1.6 0.9
Medication: Allopurinol 12.7 16.9 28.3 -5.3 -3.4 4.0 -0.7 -5.3
Medication: Omeprazole 3.1 3.7 7.7 2.2 2.8 -0.8 1.2 2.0
Medication: Seretide 50 evohaler 0.7 0.9 2.9 0.1 -0.3 -1.7 1.0 -0.6
Mean time to correctly identify matches 0.5 0.9 2.2 0.4 1.0 -0.8 1.5 -0.8
Heart disease (mother) 1.0 1.2 3.2 -1.2 -0.8 0.3 0.9 -1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 4.9 5.9 11.4 3.4 2.3 -1.8 1.0 2.9
Whole body fat mass 2.0 8.3 28.1 -2.3 -1.0 5.3 -1.2 -2.4
Leg fat mass (right) 1.4 5.4 17.5 -1.9 -0.7 4.2 -0.7 -2.2
Arm predicted mass (right) 4.2 21.7 36.1 -6.0 -5.1 3.4 -2.3 -5.4
Pulse rate, automated reading 0.1 0.2 1.1 0.0 1.1 0.1 0.3 0.0
Alcohol intake frequency. 0.5 1.2 2.5 -0.7 -1.6 1.3 -0.1 -1.1
Comparative height size at age 10 0.9 4.9 8.5 -2.4 -2.9 1.7 -2.6 -0.8
Number of full sisters 0.7 0.8 1.9 -1.0 -0.1 1.1 -0.1 -1.4
Suffer from ‘nerves’ 0.5 0.8 1.6 0.7 -1.3 -0.1 -0.9 1.1
Overall health rating 0.3 0.6 1.3 0.5 -0.3 1.1 1.1 -0.2
Chest pain or discomfort 1.6 2.3 5.0 1.8 2.2 -1.3 0.6 1.0
Had major operations 1.3 1.5 2.3 1.2 1.4 -1.5 0.1 1.3
Age at last live birth 0.5 0.8 3.1 -0.1 -0.3 -1.8 0.7 -0.3
Family relationship satisfaction 3.2 3.9 7.1 2.0 1.9 -2.7 1.1 1.9
Leg pain on walking 0.8 1.0 2.9 -1.3 0.0 0.8 0.1 -1.7
Qualifications: NVQ or HND or HNC or equivalent 1.4 1.7 2.9 1.5 1.7 1.4 0.6 0.9
Commuting to job workplace: Car/motor vehicle 1.7 2.0 5.4 1.3 2.3 -0.5 0.9 1.3
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 2.4 -0.2 -0.0 -0.2 1.5 -0.6
Medication: Aspirin 2.2 2.9 6.2 2.1 2.5 -1.0 0.8 1.6
Supplements: Vitamin C 0.6 0.7 2.1 0.7 0.6 -1.4 0.3 0.6
Knee pain experienced in last month 2.6 4.0 7.5 -2.2 -1.1 2.0 -2.7 -1.7
Hypertension (Self-reported) 0.3 0.9 2.6 1.1 1.6 0.2 0.2 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.9 2.2 5.6 1.2 2.4 -0.1 -0.3 1.9
Illnesses of father: Heart disease 4.7 6.6 11.9 -2.6 -1.8 3.4 -2.0 -2.7
Illnesses of siblings: Diabetes 0.7 0.8 3.8 -0.1 0.2 -0.5 -1.9 0.4
Smoking status: Previous 6.4 9.6 18.1 3.1 2.0 -4.3 3.4 2.0
Forced expiratory volume in 1-second (FEV1), predicted 2.4 5.0 12.3 -2.6 -3.5 0.6 -0.3 -2.4
Whole body fat-free mass 5.8 33.1 50.8 -7.1 -6.5 4.8 -3.0 -6.4
Leg fat-free mass (right) 6.8 36.4 47.9 -6.9 -6.1 6.9 -3.4 -6.2
Arm fat percentage (left) 2.1 8.3 34.9 -1.4 -0.5 5.9 -1.5 -1.5
Average weekly red wine intake 1.3 1.9 3.4 1.5 1.8 -0.9 -0.2 1.8
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.1 -0.9 -0.6 0.1 -1.1 -0.6
Mood swings 2.2 4.1 7.2 2.7 1.2 -2.2 1.9 1.9
Loneliness, isolation 2.0 2.8 4.8 2.2 0.6 -2.2 1.0 1.8
Long-standing illness, disability or infirmity 0.8 1.3 2.0 1.3 1.1 -1.4 0.2 1.1
Ever had bowel cancer screening 0.4 0.5 0.8 -0.9 -0.9 -0.2 0.2 -0.9
Diabetes diagnosed by doctor 2.8 4.6 8.0 2.8 1.6 -2.4 1.3 2.3
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 2.4 1.3 1.5 -1.3 1.3 0.8
Friendships satisfaction 0.4 0.4 1.1 0.7 0.6 -1.0 -0.2 0.6
Qualifications: nursing, teaching 0.7 1.1 2.0 0.2 -1.1 -1.2 -1.4 0.9
Commuting to job workplace: Walk 1.0 1.0 2.8 -0.7 -1.0 1.7 -0.4 -0.8
Eye problems/disorders: Cataract 0.8 0.9 2.2 0.8 1.5 -1.1 0.2 0.8
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.1 -0.8 -0.6 0.4 -1.0 -0.6
Medication for cholesterol 0.8 1.2 2.6 0.2 -1.6 -1.1 1.4 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 3.6 0.1 -0.5 1.9 -0.3 -0.1
Back pain experienced in last month 1.8 2.6 4.1 -1.9 -1.2 2.0 -1.3 -1.3
Mineral and other dietary supplements 0.9 1.2 4.3 0.6 0.3 1.1 2.1 -0.2
Breast cancer (self-reported) 0.2 0.2 0.6 -0.2 0.8 -0.1 -0.7 -0.1
Asthma (self-reported) 2.0 4.0 8.0 2.2 1.9 -2.8 -0.4 1.9
Osteoporosis (self-reported) 0.6 0.8 1.3 0.9 -0.9 -0.9 0.5 1.1
Osteoarthritis (self-reported) 0.5 0.6 1.7 -1.3 0.5 0.4 -0.2 -1.0
Medication: Aspirin 2.5 3.3 5.9 2.3 2.4 -1.2 0.2 1.9
Medication: Gliclazide 4.6 5.2 10.8 2.8 0.7 -3.3 1.7 2.0
Illnesses of father: None of the above (group 1) 2.0 2.5 4.8 1.7 0.8 -2.0 0.6 2.2
Smoking status: Current 0.6 1.0 3.6 0.3 1.9 1.0 0.5 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.4 5.1 13.0 -3.6 -2.0 0.8 0.0 -2.8
Whole body water mass 5.8 33.1 50.8 -7.1 -6.4 4.9 -3.0 -6.4
Leg predicted mass (right) 6.7 36.0 47.6 -6.9 -6.0 6.9 -3.3 -6.1
Arm fat mass (left) 3.4 13.8 37.3 -3.4 -2.3 6.1 -2.1 -3.2
Number of self-reported non-cancer illnesses 2.8 4.8 12.2 2.3 3.5 -1.6 0.5 2.0
Average weekly champagne plus white wine intake 0.3 0.4 1.1 -0.5 -0.4 0.9 -1.1 -0.2
Miserableness 4.3 7.5 11.2 3.3 1.9 -3.3 1.5 3.1
Guilty feelings 0.4 0.6 1.7 0.3 0.1 -1.3 -0.9 0.7
Wears glasses or contact lenses 1.5 1.7 2.9 1.4 1.5 -1.0 0.5 1.7
Ever taken oral contraceptive pill 5.5 6.2 11.4 3.2 2.8 -1.1 0.1 3.4
Hearing aid user 1.2 1.4 3.7 -1.9 -0.2 -0.3 0.2 -1.8
Mother’s age at death 0.6 0.7 1.8 -0.0 -0.4 -1.3 -1.1 0.7
Financial situation satisfaction 1.0 1.2 2.2 1.5 1.1 -0.7 0.7 1.2
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.3 0.1 -0.4 0.6 -0.1 0.3
Commuting to job workplace: Public transport 5.7 6.8 13.5 -3.2 -3.7 0.1 -0.2 -3.3
Eye problems/disorders: Glaucoma 0.3 0.3 0.9 0.2 0.3 -0.8 0.0 0.9
Medication: Blood pressure 0.6 1.2 2.9 -0.9 0.4 1.7 -1.2 -0.8
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.8 -0.1 -0.5 0.4 -0.9 -0.1
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.1 -0.7 -0.3 -1.1 -1.0 -0.3
High cholesterol (Self-reported) 1.7 3.0 5.5 1.8 2.1 -2.4 0.7 1.2
Medication: Bendroflumethiazide 0.5 0.8 3.1 0.7 1.8 -0.1 -0.2 0.5
Medication: Paracetamol 0.2 0.3 0.5 0.7 0.6 -0.7 0.0 0.4
Medication: Lisinopril 0.9 1.1 2.5 0.8 1.0 0.2 -1.6 1.2
Medication: Atorvastatin 6.2 7.6 12.2 3.4 2.4 -3.5 0.4 2.9
Illnesses of father: High blood pressure 0.2 0.2 0.9 0.4 0.9 0.2 0.1 0.3
Alcohol drinker status: Never 1.3 1.5 6.5 -0.8 0.1 0.6 -2.5 0.1
Ever smoked 2.6 4.6 8.8 2.0 1.9 -3.0 2.2 1.5
Basal metabolic rate 5.6 31.2 45.2 -6.7 -6.0 5.4 -3.2 -6.0
Leg fat percentage (left) 0.5 2.0 7.0 0.1 1.6 2.7 -0.4 -0.2
Arm fat-free mass (left) 4.8 24.4 39.9 -6.3 -5.5 3.5 -2.3 -5.8
Number of operations (self-reported) 0.3 0.4 1.2 0.8 1.1 0.4 -0.0 -0.0
Average weekly beer plus cider intake 0.4 0.6 2.3 0.4 -0.3 -0.2 -1.5 0.8
Irritability 1.8 3.1 10.1 1.4 0.3 -3.2 0.8 1.6
Risk taking 5.8 8.5 18.4 3.2 3.3 -1.9 -0.1 4.3
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.5 -1.2 -0.0 -0.7 0.2 -0.7
Fractured/broken bones in last 5 years 0.2 0.2 0.6 0.8 0.1 -0.7 0.0 0.3
Age started oral contraceptive pill 0.3 0.3 0.9 0.3 0.4 0.5 -1.0 0.5
Diastolic blood pressure, automated reading 1.5 4.7 8.4 -2.7 -1.2 2.9 -1.6 -2.0
Ever depressed for a whole week 0.4 0.4 1.8 0.0 0.3 -1.4 0.3 -0.5
Unable to work because of sickness or disability 0.1 0.1 0.3 -0.2 -0.5 -0.2 -0.1 -0.5
Commuting to job workplace: Cycle 0.9 1.1 1.6 1.0 -0.5 -1.2 -1.3 1.2
Myopia 1.2 1.8 3.4 1.9 1.3 -0.9 -0.4 1.6
Vascular/heart problems diagnosed by doctor 0.3 0.8 2.4 -0.8 -1.5 -0.6 -0.1 -0.7
Cholesterol lowering medication 0.8 1.2 2.0 0.9 1.4 -1.2 -0.6 1.1
Medication: Omeprazole (e.g. Zanprol) 2.3 2.8 5.9 1.7 2.4 -0.1 1.5 1.7
Pain experienced in last month 3.1 5.2 8.4 2.3 1.8 -2.5 2.9 1.7
Supplements: Calcium 1.0 1.2 1.9 1.1 0.7 -1.1 1.4 0.9
Basal cell carcinoma (self-reported) 0.4 0.4 1.2 -0.4 -0.5 0.4 1.1 -0.6
Heart attack/myocardial infarction (self-reported) 0.3 0.3 0.9 -0.5 0.2 0.7 0.1 -1.0
Deep venous thrombosis (DVT) (self-reported) 1.3 1.7 3.0 1.7 0.8 -1.7 1.0 0.8
Heart disease (siblings) 0.7 0.9 1.9 -0.9 0.0 1.4 0.8 -1.0
Alcohol drinker status: Previous 0.2 0.3 0.4 0.6 0.4 -0.7 -0.3 0.6
Pack years of smoking 0.9 1.3 3.7 0.2 -0.3 1.9 -1.6 0.3
Impedance of whole body 6.1 31.0 53.0 7.3 5.1 -4.3 2.8 7.0
Leg fat mass (left) 1.6 6.2 20.7 -2.0 -0.6 4.5 -0.8 -2.2
Arm predicted mass (left) 4.8 24.3 39.9 -6.3 -5.6 3.4 -2.1 -5.8