Best TWAS P=2.47e-11 · Best GWAS P=1e-14 conditioned to 0.0322
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | HIST2H2AA3 | 0.22 | 0.02 | enet | 20 | 0.12 | 1.8e-09 | 7.7 | 5.6 | 2.1e-08 | 0.73 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Artery Tibial | RP11-196G18.22 | 0.25 | 0.05 | lasso | 5 | 0.07 | 1.8e-06 | 4.2 | 6.3 | 2.5e-10 | 0.81 | 0.00 | 1.00 | TRUE |
| 3 | GTEx | Artery Tibial | RP11-196G18.24 | 0.31 | 0.08 | enet | 26 | 0.10 | 6.1e-08 | 7.7 | 5.4 | 7.7e-08 | 0.77 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | ECM1 | 0.27 | 0.09 | lasso | 6 | 0.04 | 3.2e-02 | 4.3 | 5.2 | 2.4e-07 | 0.12 | 0.02 | 0.92 | FALSE |
| 5 | GTEx | Brain Cerebellum | ECM1 | 0.34 | 0.21 | lasso | 6 | 0.19 | 3.2e-06 | 5.0 | 5.6 | 2.2e-08 | 0.14 | 0.01 | 0.98 | TRUE |
| 6 | GTEx | Breast Mammary Tissue (Male) | RP11-54A4.2 | 0.07 | 0.01 | enet | 2 | 0.03 | 7.4e-02 | 5.2 | 5.2 | 1.9e-07 | 0.07 | 0.02 | 0.29 | FALSE |
| 7 | GTEx | Thyroid | ANP32E | 0.08 | 0.00 | enet | 15 | 0.01 | 8.6e-02 | -3.1 | 6.7 | 2.5e-11 | 0.41 | 0.03 | 0.23 | TRUE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BNIPL | 0.03 | 0.02 | blup | 35 | 0.02 | 6.4e-03 | 3.8 | 5.3 | 1.4e-07 | 0.13 | 0.00 | 0.22 | FALSE |