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chr17:1,151,592-2,923,933

Best TWAS P=5.63e-13 · Best GWAS P=2.54e-20 conditioned to 6.3e-11

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
19	GTEx	Liver	SRR	0.31	0.00	lasso	7	0.00	3.0e-01	-6.6	7.2	5.6e-13	-0.40	0.06	0.14	TRUE
50	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SGSM2	0.13	0.01	blup	81	0.01	1.1e-01	4.4	-6.2	6.9e-10	0.08	0.02	0.40	TRUE
26	GTEx	Skin Sun Exposed Lower leg	RTN4RL1	0.19	0.11	lasso	6	0.11	2.0e-09	-4.2	5.1	2.6e-07	-0.28	1.00	0.00	TRUE
1	GTEx	Adipose Subcutaneous	SRR	0.16	0.16	lasso	9	0.18	1.9e-14	-5.6	6.4	1.8e-10	-0.07	1.00	0.00	FALSE
16	GTEx	Esophagus Mucosa	SRR	0.23	0.24	lasso	5	0.24	2.0e-16	-5.6	5.8	6.0e-09	-0.06	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SRR	0.30	0.40	lasso	7	0.39	8.5e-47	-5.6	5.8	6.5e-09	-0.07	0.00	1.00	FALSE
9	GTEx	Brain Cerebellum	SRR	0.26	0.20	lasso	3	0.21	8.7e-07	-5.1	5.8	7.6e-09	-0.03	0.39	0.04	FALSE
5	GTEx	Artery Coronary	SRR	0.44	0.28	lasso	8	0.26	2.5e-09	-5.6	5.7	8.9e-09	-0.06	0.99	0.00	FALSE
11	GTEx	Breast Mammary Tissue	SRR	0.20	0.21	lasso	3	0.20	8.2e-11	-5.6	5.7	1.1e-08	-0.07	1.00	0.00	FALSE
12	GTEx	Breast Mammary Tissue (Female)	SRR	0.24	0.25	lasso	3	0.21	6.3e-07	-5.6	5.7	1.1e-08	-0.07	0.78	0.02	FALSE
3	GTEx	Adrenal Gland	SRR	0.38	0.37	lasso	6	0.38	8.1e-15	-5.1	5.7	1.2e-08	-0.06	1.00	0.00	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	SRR	0.29	0.26	lasso	2	0.27	1.9e-30	-5.6	5.7	1.2e-08	-0.07	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SRR	0.27	0.19	enet	5	0.21	8.9e-09	-5.6	5.7	1.2e-08	-0.07	0.00	1.00	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	SRR	0.16	0.16	lasso	5	0.16	2.3e-32	-5.6	5.7	1.3e-08	-0.07	0.00	1.00	FALSE
44	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SRR	0.16	0.20	lasso	3	0.20	2.8e-13	-5.6	5.7	1.3e-08	-0.07	0.01	0.99	FALSE
37	The Cancer Genome Atlas	Esophageal Carcinoma	SRR	0.32	0.13	lasso	2	0.16	9.2e-06	-5.7	5.6	1.7e-08	-0.07	0.00	0.99	FALSE
27	GTEx	Spleen	SRR	0.21	0.10	lasso	4	0.04	3.1e-02	-5.1	5.6	1.8e-08	-0.04	0.14	0.06	FALSE
29	GTEx	Testis	SRR	0.13	0.12	lasso	2	0.09	6.6e-05	-5.7	5.6	2.0e-08	-0.07	0.57	0.02	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	SRR	0.39	0.34	lasso	5	0.35	3.1e-12	-5.1	5.6	2.2e-08	-0.04	1.00	0.00	FALSE
49	The Cancer Genome Atlas	Skin Cutaneous Melanoma	SRR	0.16	0.03	blup	61	0.02	8.7e-02	-5.7	5.6	2.8e-08	-0.07	0.01	0.71	FALSE
18	GTEx	Heart Atrial Appendage	SRR	0.35	0.30	lasso	7	0.29	1.4e-13	-5.6	5.5	2.9e-08	-0.05	1.00	0.00	FALSE
22	GTEx	Nerve Tibial	SRR	0.15	0.13	lasso	3	0.13	2.9e-09	-5.6	5.5	3.1e-08	-0.06	1.00	0.00	FALSE
28	GTEx	Stomach	SRR	0.27	0.30	lasso	7	0.28	7.1e-14	-5.6	5.5	3.2e-08	-0.07	1.00	0.00	FALSE
6	GTEx	Artery Tibial	SRR	0.22	0.23	lasso	4	0.24	3.9e-19	-5.6	5.5	3.3e-08	-0.06	1.00	0.00	FALSE
7	GTEx	Brain Caudate basal ganglia	SRR	0.26	0.03	lasso	3	0.02	8.6e-02	-4.4	5.5	3.7e-08	-0.03	0.13	0.06	FALSE
23	GTEx	Pancreas	SRR	0.13	0.17	lasso	3	0.15	5.2e-07	-5.6	5.5	3.7e-08	-0.06	0.96	0.00	FALSE
35	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SRR	0.11	0.09	lasso	4	0.10	6.8e-09	-5.1	5.5	3.7e-08	-0.04	0.01	0.99	FALSE
45	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SRR	0.34	0.30	lasso	4	0.30	2.9e-13	-5.1	5.4	5.3e-08	-0.04	0.01	0.99	FALSE
2	GTEx	Adipose Visceral Omentum	SRR	0.29	0.26	lasso	5	0.25	1.8e-13	-5.1	5.4	5.5e-08	-0.05	1.00	0.00	FALSE
15	GTEx	Colon Sigmoid	SRR	0.32	0.35	enet	8	0.32	9.2e-12	-5.1	5.4	5.6e-08	-0.05	1.00	0.00	FALSE
34	YFS	Blood	SRR	0.17	0.22	lasso	7	0.23	2.5e-72	-5.1	5.4	5.8e-08	-0.04	1.00	0.00	FALSE
31	GTEx	Whole Blood	SRR	0.09	0.03	enet	8	0.02	4.5e-03	-5.1	5.4	5.9e-08	-0.04	0.75	0.01	FALSE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	SRR	0.30	0.35	lasso	3	0.36	7.5e-39	-5.1	5.4	6.0e-08	-0.04	0.02	0.98	FALSE
32	METSIM	Adipose	SRR	0.07	0.07	enet	21	0.06	4.4e-09	-5.1	5.4	6.1e-08	-0.01	1.00	0.00	FALSE
48	The Cancer Genome Atlas	Soft Tissue Sarcoma	SRR	0.20	0.18	lasso	2	0.20	8.8e-12	-5.1	5.4	6.5e-08	-0.05	0.01	0.99	FALSE
21	GTEx	Muscle Skeletal	SRR	0.27	0.27	lasso	6	0.27	7.1e-27	-5.1	5.3	9.9e-08	-0.04	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SRR	0.08	0.09	enet	3	0.08	1.7e-04	-5.1	5.3	1.1e-07	-0.04	0.01	0.96	FALSE
43	The Cancer Genome Atlas	Lung Adenocarcinoma	SRR	0.14	0.18	lasso	2	0.18	4.3e-21	-5.1	5.3	1.1e-07	-0.04	0.02	0.98	FALSE
25	GTEx	Skin Sun Exposed Lower leg	SRR	0.13	0.15	lasso	4	0.14	2.0e-11	-5.1	5.3	1.2e-07	-0.04	1.00	0.00	FALSE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SRR	0.10	0.10	lasso	2	0.09	1.0e-10	-5.1	5.3	1.2e-07	-0.04	0.01	0.99	FALSE
14	GTEx	Cells Transformed fibroblasts	SRR	0.36	0.38	lasso	4	0.38	8.2e-30	-5.1	5.3	1.3e-07	-0.03	1.00	0.00	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	SRR	0.25	0.39	lasso	3	0.39	5.6e-53	-5.1	5.3	1.4e-07	-0.03	1.00	0.00	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	SRR	0.56	0.50	lasso	4	0.50	5.2e-55	-5.1	5.3	1.4e-07	-0.03	0.07	0.92	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	SRR	0.18	0.16	enet	18	0.19	7.9e-11	-5.1	5.2	1.5e-07	-0.04	0.98	0.00	FALSE
8	GTEx	Brain Cerebellar Hemisphere	SRR	0.37	0.24	lasso	7	0.22	2.1e-06	-5.1	5.2	1.8e-07	-0.02	0.62	0.02	FALSE
10	GTEx	Brain Frontal Cortex BA9	SRR	0.25	0.24	lasso	3	0.21	3.5e-06	-5.1	5.2	2.1e-07	-0.03	0.27	0.07	FALSE
40	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SRR	0.22	0.23	lasso	2	0.21	2.3e-12	-5.1	5.2	2.5e-07	-0.03	0.02	0.98	FALSE
17	GTEx	Esophagus Muscularis	SRR	0.30	0.39	lasso	3	0.38	3.4e-24	-5.1	5.1	2.6e-07	-0.03	1.00	0.00	FALSE
30	GTEx	Thyroid	SRR	0.26	0.27	lasso	4	0.25	2.0e-19	-5.1	5.1	2.7e-07	-0.03	1.00	0.00	FALSE
4	GTEx	Artery Aorta	SRR	0.33	0.33	lasso	2	0.32	6.1e-18	-5.1	5.1	2.8e-07	-0.03	1.00	0.00	FALSE
20	GTEx	Lung	SRR	0.24	0.28	lasso	2	0.26	3.4e-20	-5.1	5.1	2.9e-07	-0.04	1.00	0.00	FALSE