Best TWAS P=7.38e-10 · Best GWAS P=3.97e-08 conditioned to 0.164
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | ZNF232 | 0.13 | 0.06 | enet | 41 | 0.10 | 2.0e-08 | -1.9 | -5.3 | 1.4e-07 | -0.46 | 0.91 | 0.02 | FALSE |
2 | GTEx | Brain Putamen basal ganglia | AC012146.7 | 0.30 | 0.03 | enet | 23 | 0.03 | 7.6e-02 | 4.2 | -6.2 | 7.4e-10 | -0.74 | 0.08 | 0.20 | TRUE |
3 | GTEx | Colon Sigmoid | GP1BA | 0.25 | 0.17 | lasso | 4 | 0.12 | 3.6e-05 | 5.1 | 5.2 | 2.6e-07 | 0.82 | 0.02 | 0.89 | FALSE |
4 | GTEx | Esophagus Gastroesophageal Junction | GP1BA | 0.35 | 0.16 | lasso | 11 | 0.18 | 5.9e-07 | 4.6 | 5.7 | 1.1e-08 | 0.77 | 0.05 | 0.91 | FALSE |
5 | GTEx | Skin Sun Exposed Lower leg | AC012146.7 | 0.21 | 0.07 | enet | 17 | 0.18 | 1.3e-14 | 2.6 | -5.5 | 3.6e-08 | -0.60 | 0.90 | 0.04 | FALSE |
6 | GTEx | Whole Blood | RP5-1050D4.2 | 0.05 | 0.02 | enet | 11 | 0.04 | 3.1e-04 | 4.6 | 5.1 | 3.1e-07 | 0.68 | 0.10 | 0.85 | FALSE |
7 | NTR | Blood | MINK1 | 0.11 | 0.15 | lasso | 3 | 0.15 | 2.1e-46 | 5.5 | 5.4 | 8.5e-08 | 0.98 | 0.00 | 1.00 | FALSE |
8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C17orf107 | 0.03 | 0.01 | enet | 8 | 0.03 | 5.1e-04 | 3.2 | 5.4 | 6.1e-08 | 0.70 | 0.01 | 0.73 | FALSE |
9 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | PFN1 | 0.16 | 0.00 | blup | 47 | 0.03 | 2.7e-02 | 4.5 | -5.2 | 2.2e-07 | -0.78 | 0.00 | 0.54 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GP1BA | 0.02 | 0.02 | blup | 49 | 0.02 | 9.3e-03 | 4.2 | 5.5 | 4.2e-08 | 0.86 | 0.01 | 0.74 | FALSE |
11 | The Cancer Genome Atlas | Soft Tissue Sarcoma | INCA1 | 0.06 | 0.00 | enet | 11 | 0.00 | 1.7e-01 | 4.6 | 5.2 | 2.1e-07 | 0.72 | 0.00 | 0.42 | FALSE |
12 | The Cancer Genome Atlas | Stomach Adenocarcinoma | C17orf107 | 0.05 | 0.01 | blup | 40 | 0.03 | 2.0e-03 | 5.5 | 5.4 | 6.2e-08 | 0.75 | 0.01 | 0.95 | FALSE |