Hub : Genes

SGSM2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1310 0.0410 1.6e-03 0.077 0.011 0.040 0.058 0.067 1.2e-09 1.3e-02 1.1e-05 1.2e-07 1.3e-08
2 GTEx Artery Aorta 0.1390 0.0520 3.3e-03 -0.004 NA 0.001 NA -0.004 6.8e-01 NA 2.9e-01 NA 6.4e-01
3 GTEx Artery Tibial 0.1219 0.0475 4.8e-04 0.017 NA 0.046 NA 0.037 1.5e-02 NA 1.6e-04 NA 6.5e-04
4 GTEx Esophagus Mucosa 0.2770 0.0610 3.1e-11 0.317 NA 0.315 NA 0.320 1.1e-21 NA 1.5e-21 NA 6.8e-22
5 GTEx Nerve Tibial 0.2418 0.0734 2.2e-03 0.085 NA 0.030 NA 0.079 1.2e-06 NA 3.2e-03 NA 3.3e-06
6 GTEx Skin Not Sun Exposed Suprapubic 0.3730 0.0760 2.9e-07 0.353 NA 0.407 NA 0.398 3.4e-20 NA 6.6e-24 NA 3.0e-23
7 GTEx Skin Sun Exposed Lower leg 0.4990 0.0630 5.6e-17 0.469 NA 0.508 NA 0.505 3.5e-43 NA 3.3e-48 NA 7.7e-48
8 YFS Blood 0.0535 0.0144 1.4e-07 0.026 0.022 0.033 0.030 0.033 3.7e-09 7.6e-08 5.6e-11 3.6e-10 3.9e-11
9 TCGA Testicular Germ Cell Tumors 0.1260 0.0590 8.8e-03 0.008 0.013 -0.008 NA 0.008 1.6e-01 1.1e-01 8.4e-01 NA 1.6e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.5 0.8 2.9 -1.7 1.3 -0.1 0.6 -1.0 0.3 0.4 0.2 1.0
Bipolar Disorder or Schizophrenia 1.7 4.1 12.3 -1.7 0.6 -1.6 2.5 -1.6 2.0 2.3 -1.0 3.5
Depressed Affect (Nagel 2018) 0.5 1.1 4.1 -0.5 -1.3 -0.5 -0.2 -0.3 -1.1 -1.2 1.0 -2.0
Depression (Nagel 2018) 0.8 1.3 5.9 -0.2 -0.6 -0.3 -0.8 0.1 -0.9 -1.3 1.4 -2.4
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.7 0.2 0.6 0.9 0.3 0.4 1.1 0.9 1.2 1.3
Neuroticism (Nagel 2018) 1.0 2.3 8.6 -0.8 -2.6 -0.6 0.4 -0.5 -1.3 -1.1 0.9 -2.9
Schizophrenia (2018) 2.5 5.3 13.8 -0.8 -0.2 -2.5 2.7 -1.2 2.4 2.6 -2.4 3.7
Schizophrenia vs Biploar Disorder 1.1 1.4 3.2 0.6 -1.8 -1.7 1.2 -0.2 0.3 0.4 -1.8 1.1
Worry (Nagel 2018) 1.2 2.5 8.3 -0.6 -2.4 0.5 -0.3 0.1 -2.1 -1.6 1.0 -2.9
Alzheimer’s Disease (in mother) 0.3 0.3 1.7 0.0 1.3 0.3 0.2 0.3 0.7 0.3 0.3 -0.4
Alzheimer’s Disease (in father) 0.6 0.7 4.8 0.3 2.2 0.5 -0.1 -0.0 -0.2 0.3 -0.3 -0.8
Alzheimer’s Disease (including proxy) 0.5 0.7 5.1 0.3 2.3 0.7 -0.4 0.3 -0.2 -0.2 -0.2 -0.5
Crohns Disease (2017) 0.8 1.7 5.4 0.2 0.5 -0.5 1.8 0.3 2.3 1.9 1.0 1.3
Irritable Bowel Disease (IBD) 1.7 4.1 11.7 -1.6 0.9 0.1 2.4 -1.1 3.4 3.0 1.7 1.7
Ulcerative Colitis (UC) 1.8 3.3 8.2 -1.8 1.2 0.7 1.8 -1.2 2.9 2.6 1.6 1.5
Major Depression (MDD) 0.2 0.2 0.7 0.0 0.1 0.5 -0.4 0.9 0.0 -0.2 0.2 0.7
Reaction Time 0.4 0.8 1.7 -0.9 1.3 0.7 -1.3 -0.8 -0.9 -1.1 0.6 0.1
Verbal and Numeric Reasoning (VNR) 0.2 0.4 2.3 -0.6 0.5 0.7 -0.1 0.1 -0.3 -0.2 1.5 -0.6
Breast Cancer 0.9 2.1 9.9 1.3 -3.1 -0.5 0.2 1.0 -0.1 -0.1 -0.2 2.4
Ovarian Cancer 0.6 0.8 3.0 -1.7 -0.8 0.1 -0.7 -1.6 -0.3 -0.6 0.4 0.6
Prostate Cancer 0.2 0.2 0.6 0.4 0.8 0.3 -0.6 0.4 -0.7 -0.2 -0.7 -0.2
Age at First Birth 0.5 0.8 2.8 1.3 0.4 0.8 -0.1 1.7 -0.1 0.1 0.2 1.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.5 2.1 7.8 -1.5 -0.7 1.1 -1.3 -1.0 -0.9 -1.3 1.4 -2.8
Coronary Artery Disease (CAD) 2.3 2.7 10.0 -0.5 0.3 2.6 -1.0 -0.5 -0.8 -0.8 2.1 -3.2
Crohns Disease (2012) 0.7 1.1 3.5 0.4 -0.7 0.0 1.7 0.2 1.7 1.9 0.1 0.7
Mean Putamen Volume 0.7 0.7 2.4 -1.4 0.8 -0.6 0.7 -1.6 0.6 0.6 0.5 -0.1
Fasting Glucose 0.2 0.3 1.0 -0.3 -0.4 -1.0 0.1 -0.4 -0.5 -0.4 -0.1 0.7
HbA1C 0.3 0.3 1.9 0.7 1.4 0.1 -0.0 0.3 0.5 0.1 -0.2 0.3
HDL Cholesterol 1.7 2.9 5.2 0.6 -2.0 -2.3 2.3 0.4 1.8 1.8 -1.7 1.5
LDL Cholesterol 2.4 3.8 11.4 -0.9 -1.9 -3.1 1.9 -1.3 1.3 1.3 -3.4 0.4
Lupus 0.2 0.4 1.1 -0.4 -1.0 -1.0 0.0 -0.5 0.5 -0.1 -0.2 0.7
Neuroticism (2016) 1.6 2.3 8.4 -1.1 -2.9 -2.0 1.4 -0.8 0.5 0.3 -1.3 -1.7
Primary Biliary Cirrhosis 0.6 0.9 2.1 -1.4 -0.9 0.7 0.6 -0.6 0.7 0.5 1.4 1.0
Rheumatoid Arthritis 0.7 1.0 4.4 -0.5 -1.5 0.3 -0.3 -0.6 -0.5 -0.5 0.9 -2.1
Schizophrenia (2014) 2.6 5.7 15.1 -0.7 -0.8 -2.7 2.9 -1.0 2.2 2.4 -2.7 3.9
Triglycerides 0.1 0.2 0.8 0.2 -0.2 -0.1 0.5 0.3 0.2 0.4 -0.9 -0.3
Type 2 Diabetes (T2D) (2012) 1.1 1.2 4.3 0.7 1.3 1.8 -0.9 0.7 -0.4 -0.4 2.1 0.2
Ulcerative Colitis 3.1 4.5 9.8 -2.5 0.4 1.1 2.3 -1.8 3.1 3.1 1.5 1.6
Blood Eosinophil Count 0.6 5.0 15.8 1.5 2.6 4.0 -1.9 1.3 -0.9 -1.0 3.5 0.3
Blood Platelet Count 3.3 38.1 84.8 0.8 -1.4 -8.0 9.2 -1.3 4.9 6.4 -8.3 7.4
Blood Red Count 0.3 3.1 10.3 0.3 -0.7 2.4 -3.2 0.3 -2.0 -2.3 0.4 -1.3
Blood White Count 2.1 15.5 34.8 -0.9 0.5 -4.1 5.2 -2.2 4.5 4.8 -3.3 5.9
Heel T-Score 3.8 30.1 84.1 -0.0 -0.1 5.8 -7.2 1.4 -4.4 -5.3 7.2 -9.2
BMI 1.6 9.2 50.7 -0.5 0.5 0.8 -3.1 -0.7 -2.8 -3.6 0.7 -7.1
Height 0.2 3.1 7.6 1.0 -2.5 1.9 -0.6 1.7 0.6 -0.1 2.8 2.4
Waist Hip Ratio (WHR) 1.6 7.4 15.4 0.5 0.5 3.0 -3.9 0.9 -3.1 -3.8 2.3 -3.4
Systolic Blood Pressure 1.8 8.9 16.6 4.1 -3.9 0.4 -1.2 3.2 -3.1 -2.7 -2.2 -3.8
Smoking Status 2.2 5.3 13.1 0.8 1.6 -2.1 2.0 0.4 3.6 3.0 -1.3 3.4
Allergy or Eczema 3.4 8.9 34.7 -1.9 1.6 -0.9 3.0 -1.7 3.7 3.5 0.3 5.9
Cardiovascular Disease 0.5 1.8 9.4 1.4 -1.3 0.3 -0.3 1.4 -0.8 -0.8 0.1 -3.1
Hypothyroidism (self reported) 0.3 0.6 1.8 -1.3 0.1 -1.3 0.1 -1.0 0.6 0.3 -0.4 -0.5
Respiratory disease 0.6 1.4 3.8 0.6 0.5 1.3 -1.9 0.5 -1.0 -1.3 0.8 -1.7
Type 2 Diabetes (T2D) (2018) 0.2 0.5 3.1 0.1 1.8 0.4 -0.1 0.0 0.8 0.3 0.3 -0.3
Lung FEV1/FVC ratio 2.3 11.5 25.2 -1.4 0.4 -3.7 4.5 -2.2 3.8 4.0 -2.7 5.0
Lung FVC 0.8 4.0 11.0 1.8 -0.6 0.9 -2.2 1.1 -2.8 -2.6 0.2 -3.3
Neuroticism 1.3 3.0 9.9 -2.0 -3.1 -1.8 0.9 -1.8 -0.3 -0.3 -0.3 -2.4
Chronotype (morning person) 0.2 0.5 1.5 1.2 -1.1 -0.6 0.1 0.9 0.4 0.4 -0.5 -0.2
Hair Pigment 0.1 2.3 6.0 0.5 1.8 2.4 -2.1 0.1 -1.0 -1.1 1.6 -1.3
Tanning 0.1 1.3 3.3 1.6 -1.1 0.4 -0.6 1.7 -1.8 -0.9 0.2 -0.5
Hand grip strength (left) 1.4 3.8 6.6 2.6 0.2 2.5 -1.7 2.4 -1.6 -1.5 2.3 -1.5
Number of treatments/medications taken 0.3 0.6 2.7 0.6 -0.3 -0.3 -0.2 0.7 -0.4 -0.7 -0.9 -1.6
Average weekly spirits intake 0.7 0.9 2.4 1.2 1.6 0.5 -0.0 1.5 0.6 0.2 0.8 -0.6
Sensitivity / hurt feelings 0.9 1.5 4.2 -1.0 -2.0 -2.1 1.2 -1.4 0.6 0.3 -0.6 -0.5
Frequency of depressed mood in last 2 weeks 0.8 1.1 3.3 0.4 0.2 -0.3 -0.8 0.9 -1.2 -1.5 1.3 -1.8
Hearing difficulty/problems: Yes 0.9 1.3 3.9 0.6 -2.0 -1.0 1.9 0.7 1.3 0.9 0.3 -0.2
Relative age of first facial hair 1.9 4.0 7.7 -0.2 -2.5 -2.4 1.8 -1.3 1.9 1.8 -2.8 2.1
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.7 0.3 0.5 -0.3 0.1 0.1 0.1 0.2 -0.8 -0.2
Ever used hormone-replacement therapy (HRT) 2.3 2.9 8.2 1.1 -2.9 -1.6 1.5 0.1 1.9 1.8 -2.4 0.0
Ever had hysterectomy (womb removed) 0.7 0.8 5.7 -0.7 -2.4 -0.1 0.4 -0.6 0.2 0.1 -0.3 -0.6
Systolic blood pressure, automated reading 2.5 7.3 25.4 2.7 -3.3 0.7 -1.5 2.0 -2.8 -2.5 -1.2 -5.0
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 3.2 0.8 1.8 0.2 -0.1 0.4 0.6 0.2 0.6 0.5
Angina 1.7 2.2 3.6 1.5 -0.6 1.5 -1.7 1.5 -1.9 -1.8 0.0 -1.5
Medication for hormone replacement therapy 2.3 2.6 6.6 2.5 -2.6 -1.2 -0.3 1.6 -1.0 -1.0 -2.0 -0.7
Vitamin and mineral supplements 1.1 1.5 8.5 -0.9 -1.2 -0.0 -0.6 -1.2 -0.3 -0.6 0.5 -2.9
Supplements: Zinc 0.6 0.7 4.8 -0.5 -0.1 0.3 0.2 -0.2 0.3 0.5 0.8 2.2
Medication: Co-codamol 2.8 3.3 8.1 -0.4 1.7 -2.8 2.0 -0.8 2.4 1.9 -1.8 1.1
Medication: Metformin 1.1 1.6 8.4 1.5 2.9 -0.3 0.3 1.3 0.6 0.4 -0.7 0.8
Diabetes (father) 1.9 2.3 5.3 -0.7 -1.2 -1.5 1.4 -1.1 1.4 1.5 -2.3 1.9
Diabetes (mother) 0.2 0.3 1.0 -0.9 0.3 0.0 -0.3 -1.0 -0.6 -0.3 -0.2 -0.5
Severe depression (siblings) 1.7 1.9 6.4 -2.5 -0.4 -1.2 0.5 -2.5 0.6 0.3 -1.4 0.7
Pack years adult smoking proportion 2.0 3.1 9.6 0.4 -1.6 -3.1 1.8 -0.2 0.9 1.4 -3.0 0.3
Impedance of leg (right) 5.5 26.5 54.3 1.8 -4.9 -5.4 6.6 0.9 5.0 5.7 -5.0 7.4
Leg fat-free mass (left) 1.8 9.6 23.3 -0.0 2.0 3.0 -4.1 0.6 -3.0 -3.8 3.1 -4.8
Trunk fat percentage 1.4 5.6 19.5 0.6 -2.9 -2.6 -0.5 -0.3 -1.3 -1.8 -3.1 -4.4
Hand grip strength (right) 0.5 1.3 1.9 1.3 -1.4 1.1 -1.2 0.8 -1.3 -1.3 0.8 -0.9
Townsend deprivation index at recruitment 2.7 3.8 10.0 -0.1 0.7 -1.5 2.6 -0.1 3.2 3.1 -1.0 2.0
Current tobacco smoking 3.8 6.2 11.2 0.5 0.7 -3.1 3.0 -0.0 3.3 3.2 -2.1 3.3
Average weekly fortified wine intake 2.5 2.9 10.9 -1.3 3.3 -0.1 1.2 -1.3 2.2 2.0 0.5 1.1
Maternal smoking around birth 1.5 2.2 6.7 0.2 1.4 -2.6 0.6 -0.4 1.5 1.3 -2.2 1.5
Fed-up feelings 0.1 0.3 1.3 -0.5 0.4 -0.5 0.4 -0.0 0.1 -0.1 1.1 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 3.6 0.1 -0.1 -0.6 0.2 0.2 0.3 -0.0 0.4 -1.9
Relative age voice broke 1.2 1.8 5.0 -0.3 -0.7 -1.8 1.0 0.0 1.4 1.3 -1.6 2.2
Taking other prescription medications 0.4 0.7 3.5 0.1 -0.5 -0.8 0.3 0.1 0.2 -0.2 -1.3 -1.9
Age when periods started (menarche) 1.7 4.2 13.7 -0.6 0.1 -1.9 2.2 -1.1 1.9 2.1 -2.4 3.7
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 1.0 0.4 -1.0 0.4 -0.5 0.8 -0.1 -0.4 0.7 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.7 3.9 15.6 -0.5 -0.3 1.9 -2.1 -0.2 -1.2 -1.4 2.9 -3.9
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.6 0.7 0.9 0.1 -0.4 0.1 0.5 0.2 0.2 1.3
Qualifications: CSEs or equivalent 1.9 2.5 4.8 0.7 0.1 -2.0 2.1 0.4 1.9 1.9 -2.2 1.1
Serious illness, injury or assault to yourself 0.4 0.5 2.0 0.1 -0.8 -0.3 0.1 0.6 0.4 0.1 -1.1 -1.4
High blood pressure 1.7 4.9 25.8 0.4 -0.6 0.9 -1.7 0.9 -2.5 -2.4 0.8 -5.1
Hayfever, allergic rhinitis or eczema 2.7 5.9 24.4 -1.3 1.8 0.5 2.1 -0.8 2.9 2.7 1.7 4.9
Multivitamins +/- minerals 0.8 1.0 2.9 0.9 1.6 0.9 -0.5 1.2 -0.3 -0.1 0.6 1.7
Stomach or abdominal pain in last month 0.6 0.7 2.3 -1.5 0.2 0.8 -0.2 -1.2 0.1 -0.1 1.4 -0.2
Supplements: Glucosamine 3.8 4.9 9.5 0.7 1.6 2.4 -3.1 1.3 -2.7 -2.8 2.4 -1.8
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 2.5 0.8 -0.6 -0.6 1.6 0.3 1.1 1.5 -0.6 -0.7
Medication: Atenolol 1.3 1.6 5.5 -0.7 -0.7 0.3 -1.4 -0.5 -1.4 -1.7 0.9 -2.3
Medication: Levothyroxine sodium 0.4 0.6 1.4 -0.3 0.1 -0.2 0.9 0.3 1.2 1.2 0.8 -1.1
Sitting height 0.2 1.5 3.8 1.6 -0.8 0.5 -0.5 2.0 -1.7 -1.5 0.2 -0.9
Chronic bronchitis/emphysema (father) 0.3 0.4 0.8 0.1 0.9 -0.9 0.6 0.1 0.5 0.5 -0.6 -0.6
High blood pressure (mother) 0.7 1.0 3.8 2.0 0.8 -0.5 -0.4 1.6 -0.2 -0.3 -1.0 -0.2
Body mass index (BMI) 1.4 5.9 35.5 0.2 -0.4 -0.1 -2.4 -0.1 -2.0 -2.8 -0.3 -6.0
Impedance of leg (left) 6.1 29.8 57.0 1.4 -5.0 -6.0 7.0 0.4 5.3 6.1 -5.6 7.5
Leg predicted mass (left) 1.8 9.6 23.7 -0.1 1.9 3.0 -4.1 0.6 -3.0 -3.8 3.1 -4.9
Trunk fat mass 1.1 4.6 21.5 0.6 -2.0 -1.5 -1.4 0.1 -1.6 -2.4 -1.7 -4.6
Waist circumference 1.4 5.0 25.3 0.0 -0.3 0.4 -2.5 0.1 -2.0 -3.0 0.4 -5.0
Number of incorrect matches in round 1.0 1.7 3.4 1.2 0.3 -0.7 1.8 0.9 1.5 1.7 -0.8 1.7
Past tobacco smoking 1.1 2.0 6.9 -1.2 -1.4 -0.0 -0.4 -1.2 -1.9 -1.3 -0.7 -2.6
Alcohol usually taken with meals 3.3 5.4 15.4 -0.4 3.9 3.7 -2.1 0.9 -0.8 -0.9 3.4 0.9
Nervous feelings 1.0 1.9 8.5 0.6 -2.5 0.1 0.8 1.0 -0.7 -0.4 0.4 -2.9
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 6.6 -1.3 -0.8 -0.9 0.8 -0.9 0.0 -0.2 0.6 -2.6
Hearing difficulty/problems with background noise 2.3 3.6 9.7 -1.8 -1.4 -1.8 3.0 -0.8 3.1 2.2 0.2 0.8
Hair/balding pattern: Pattern 2 2.2 2.8 6.2 -0.9 -1.6 -1.6 2.5 -1.0 1.6 1.8 -1.0 2.4
Had menopause 0.7 0.9 1.8 -0.0 -0.7 -1.1 1.3 -0.0 1.4 1.2 -1.1 -0.2
Had other major operations 0.5 0.6 1.8 0.3 0.8 -1.2 0.4 0.2 1.3 0.9 -0.7 0.3
Forced vital capacity (FVC) 1.2 4.7 8.1 1.7 0.2 2.7 -2.7 1.9 -2.4 -2.3 2.8 -1.7
Heel bone mineral density (BMD) T-score, automated (right) 1.6 3.6 13.1 0.9 -0.7 1.8 -2.0 1.3 -1.4 -1.5 2.2 -3.6
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 2.1 -1.4 -0.1 -0.8 0.7 -1.1 0.8 0.7 -0.7 -0.2
Qualifications: None of the above 1.0 2.1 4.5 1.5 -2.1 -1.9 1.0 0.5 -0.1 0.2 -2.1 -1.8
Financial difficulties in last 2 years 2.4 3.2 7.3 0.2 -1.0 -2.3 2.7 -0.3 2.6 2.3 -1.5 0.4
Mouth/teeth dental problems 0.3 0.4 1.5 -0.1 -1.2 -0.9 -0.2 0.0 -1.0 -0.7 -0.0 -0.3
Heart attack 0.4 0.5 2.7 -0.4 0.3 0.8 -0.9 0.1 -0.3 -0.4 0.2 -1.6
Allergy 1.6 3.7 10.6 1.2 -2.0 -0.8 -1.2 0.8 -2.5 -2.0 -1.9 -3.3
Pain all over the body in last month 0.7 0.7 1.9 -0.7 0.4 -0.7 -0.2 -1.2 -0.5 -0.4 -1.4 -1.3
Diabetes (self-reported) 0.7 1.1 4.8 0.6 2.2 0.6 -0.9 0.8 -0.5 -1.0 -0.1 -1.2
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 5.2 0.4 -0.3 -0.1 0.6 0.4 1.6 1.3 0.2 2.3
Medication: Ramipril 0.3 0.4 1.2 0.1 1.1 1.0 -0.8 -0.3 -0.2 -0.4 0.1 -0.9
Medication: Simvastatin 1.2 1.7 4.0 1.0 -1.9 -1.4 1.1 0.4 1.1 0.9 -2.0 -1.1
Fluid intelligence score 0.2 0.4 0.9 -0.4 -0.6 -0.1 -0.7 0.1 -0.8 -0.9 0.9 -0.6
Illnesses of siblings 1.6 2.3 6.7 -0.6 -1.5 -1.4 1.8 -0.7 1.4 1.6 -1.2 2.6
Neuroticism score 0.7 1.5 5.2 -0.8 -1.7 -1.5 1.2 -0.8 0.0 0.2 0.5 -2.3
Weight 1.0 4.8 22.8 0.3 -0.3 0.5 -2.6 0.5 -2.0 -3.0 0.5 -4.8
Impedance of arm (right) 0.3 1.4 4.9 0.5 -1.6 -1.4 1.0 0.1 -0.7 -0.0 -2.2 1.4
Arm fat percentage (right) 2.0 7.9 38.0 0.7 -1.4 -0.6 -2.7 0.1 -2.9 -3.6 -1.3 -6.2
Trunk fat-free mass 1.0 5.8 15.9 -0.3 2.0 3.0 -3.1 0.8 -1.4 -2.3 4.0 -2.3
Hip circumference 0.4 1.9 10.9 -0.1 -0.7 -0.7 -0.9 0.2 -1.0 -1.7 -0.4 -3.3
Time employed in main current job 1.1 1.2 3.2 1.6 0.0 1.5 -0.9 1.8 -0.5 -0.6 1.2 -0.3
Alcohol intake versus 10 years previously 1.0 1.5 4.7 0.6 1.2 1.0 -2.2 0.3 -1.5 -1.5 -0.5 -0.8
Father’s age at death 1.5 2.0 6.3 -0.9 1.3 -1.0 1.5 -0.4 1.9 1.5 -0.5 2.5
Worrier / anxious feelings 0.7 1.3 7.8 -0.9 -1.0 0.3 0.7 0.0 -0.1 -0.2 2.8 -1.2
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.6 8.3 -2.0 -1.3 -2.9 1.6 -2.1 0.7 0.2 -0.6 -1.4
Falls in the last year 0.3 0.4 1.0 -0.8 -0.9 -0.4 0.2 -0.5 -0.5 -0.3 0.0 -1.0
Hair/balding pattern: Pattern 3 0.4 0.6 1.5 -1.0 -0.2 0.3 -0.5 -0.9 -0.3 -0.4 1.2 -1.2
Number of live births 0.5 0.7 2.2 0.9 1.5 0.5 -0.1 1.2 0.9 0.4 0.4 0.7
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 3.6 1.2 0.4 1.3 -1.7 1.1 -1.8 -1.6 1.9 -0.4
Pulse rate 0.6 1.0 3.7 -0.2 -0.5 0.2 1.6 -0.5 1.3 1.9 0.3 0.1
Happiness 2.4 2.9 4.9 -1.4 -1.6 -2.2 2.2 -1.5 1.6 1.6 -0.9 1.9
Noisy workplace 0.9 1.1 4.8 0.2 -2.2 -1.0 0.7 -0.2 0.5 0.4 -1.6 -0.9
Qualifications: A levels/AS levels or equivalent 1.1 2.4 10.1 -1.1 0.8 -0.2 1.4 -0.7 1.7 1.8 0.9 3.2
Serious illness, injury or assault of a close relative in last 2 years 2.2 2.5 6.8 1.5 2.6 0.3 0.6 1.5 2.0 1.4 0.6 2.2
Mouth/teeth dental problems: Dentures 0.3 0.6 3.1 0.5 -0.8 0.0 0.2 -0.3 0.3 0.4 -1.8 -0.8
Asthma 0.5 0.9 2.7 0.2 1.1 1.6 -1.6 0.2 -0.3 -0.7 0.8 -0.8
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.3 2.8 -0.3 0.8 -0.8 1.6 -0.5 1.4 1.7 -1.1 1.5
Medication: Cholesterol lowering 1.0 1.5 7.6 1.3 -2.8 -0.8 -0.0 0.9 -0.0 -0.4 -1.3 -0.9
Depression (self-reported) 0.4 0.4 0.9 0.3 0.4 -0.5 0.9 0.4 1.0 0.9 0.8 -0.1
Medication: Lansoprazole 1.1 1.2 4.4 -1.5 0.9 0.7 -0.4 -0.8 -0.0 -0.4 2.1 -1.4
Prospective memory result 0.2 0.2 0.7 -0.3 -0.3 0.2 -0.3 -0.3 -0.8 -0.4 -0.6 -0.7
Lung cancer (father) 0.1 0.1 0.3 -0.5 0.0 -0.1 -0.6 -0.5 -0.3 -0.2 0.5 -0.2
Illnesses of mother 0.8 0.9 2.0 -1.4 0.0 0.1 1.2 -1.3 1.0 1.2 0.2 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.2 4.7 0.3 -0.0 1.9 -1.9 0.5 -2.0 -1.8 2.2 -0.5
Pulse wave Arterial Stiffness index 0.5 0.5 1.8 0.3 -1.3 -0.4 1.1 0.2 0.9 0.8 -0.3 0.6
Impedance of arm (left) 0.6 2.7 6.5 0.3 -2.0 -2.2 1.9 -0.3 0.3 0.9 -2.5 2.1
Arm fat mass (right) 1.6 6.8 33.2 0.5 -0.8 -0.1 -2.9 0.2 -2.6 -3.4 -0.5 -5.8
Trunk predicted mass 1.0 5.8 15.5 -0.2 1.9 3.1 -3.1 0.9 -1.4 -2.3 3.9 -2.4
Standing height 0.1 1.1 3.3 0.2 -0.1 1.1 -0.8 1.1 -0.4 -0.8 1.8 1.6
Length of working week for main job 1.8 2.0 6.8 0.2 -2.2 1.1 -1.1 -0.3 -1.6 -1.2 -0.2 -2.6
Exposure to tobacco smoke at home 1.7 1.9 4.6 0.5 -1.9 -1.4 1.3 -0.2 1.2 1.2 -2.2 -1.6
Breastfed as a baby 3.6 4.5 8.3 2.7 1.6 2.7 -2.3 2.9 -2.1 -1.7 1.5 -0.4
Tense / ‘highly strung’ 0.7 1.2 2.4 -1.0 -1.5 -0.3 0.2 -0.5 -1.2 -1.1 1.4 -1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.9 0.2 -0.3 0.2 0.7 0.7 1.4 1.0 0.6 0.6
Hair/balding pattern: Pattern 4 1.7 4.1 12.5 2.5 -0.8 -0.3 -0.6 2.2 -2.6 -2.1 -1.1 -3.5
Birth weight of first child 0.7 1.3 3.3 0.8 -0.7 -0.9 1.8 0.7 1.2 1.1 -1.5 1.2
Peak expiratory flow (PEF) 0.3 0.8 1.3 1.0 -0.4 0.2 -1.1 1.1 -1.0 -1.1 0.9 -0.4
Pulse wave reflection index 1.4 1.8 3.8 -0.4 -1.0 -1.2 1.9 -0.5 1.4 1.6 -1.5 1.5
Ever highly irritable/argumentative for 2 days 1.0 1.3 3.8 -0.6 0.3 -1.9 1.5 0.0 1.3 1.1 -0.7 1.1
Loud music exposure frequency 1.1 1.3 2.6 -0.9 -1.2 -1.6 1.5 -0.7 1.4 1.2 -0.1 -0.3
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 3.9 -0.9 0.7 -0.4 0.8 -0.7 1.3 1.2 0.9 2.0
Mouth/teeth dental problems: Bleeding gums 1.2 1.5 5.3 -1.1 1.5 1.7 -0.9 -0.6 -0.5 -0.8 2.3 -0.4
Blood clot in the leg (DVT) 0.9 1.1 2.9 -0.9 1.7 1.5 -0.3 -1.0 0.7 0.5 1.5 0.4
Medication: Paracetamol 1.5 2.5 7.1 0.9 0.2 -0.7 1.8 0.8 2.2 2.2 -0.1 2.7
Headache pain in last month 1.5 2.5 4.0 1.6 1.4 0.2 1.8 1.8 1.4 1.9 1.6 2.0
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 5.9 -0.5 2.2 0.9 0.1 -0.7 0.3 0.5 1.0 2.4
Glaucoma (self-reported) 2.4 2.8 6.3 -0.3 -1.4 -1.9 2.1 -0.8 1.9 1.8 -1.4 2.5
Gout (self-reported) 1.6 2.2 4.6 1.1 0.9 0.7 -1.8 1.0 -2.1 -2.1 0.0 -2.1
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 1.4 -1.0 -0.4 -0.7 0.9 -0.6 1.2 1.0 0.1 -0.8
Medication: Amlodipine 0.8 1.2 4.3 0.2 0.0 0.2 -1.2 0.5 -1.5 -1.6 -0.1 -2.1
Medication: Ventolin 100micrograms inhaler 0.9 1.1 2.1 -0.6 0.1 1.4 -1.4 -0.3 -1.4 -1.5 0.5 -1.1
Birth weight 1.6 3.5 15.8 1.3 -1.7 0.3 -1.2 0.9 -2.3 -1.9 -0.4 -4.0
Chronic bronchitis/emphysema (mother) 1.0 1.1 2.5 -0.0 -1.1 -1.6 1.1 -0.3 1.5 1.0 -1.3 0.5
High blood pressure (siblings) 1.9 2.8 13.6 0.9 0.5 0.7 -1.7 0.7 -1.5 -1.7 1.1 -3.7
Forced vital capacity (FVC), Best measure 1.2 4.3 8.4 0.6 -0.7 2.9 -2.7 1.1 -2.6 -2.4 2.6 -1.4
Body fat percentage 1.3 5.3 17.9 1.0 -3.0 -2.6 -0.2 0.0 -0.9 -1.4 -3.1 -4.2
Leg fat percentage (right) 1.4 5.0 11.5 1.6 -3.4 -3.4 1.2 0.7 0.7 0.2 -3.4 -2.3
Arm fat-free mass (right) 0.4 2.1 5.9 -0.7 1.2 1.4 -1.8 0.0 -0.4 -1.2 2.4 -2.2
Exposure to tobacco smoke outside home 2.0 2.6 7.3 0.3 -0.2 -2.6 2.1 -0.3 1.1 1.1 -2.7 -1.6
Comparative body size at age 10 6.3 17.3 53.1 -0.1 0.1 2.9 -5.0 0.9 -5.5 -5.7 2.2 -7.3
Number of full brothers 2.6 3.2 5.6 2.4 0.9 -2.0 1.9 1.7 1.8 1.9 -1.8 1.6
Worry too long after embarrassment 2.8 4.7 8.7 -2.3 -2.8 -3.0 2.2 -2.6 0.7 0.6 -0.6 -2.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 4.8 -0.0 -2.2 -0.2 -0.7 -0.1 -1.0 -1.0 -0.6 -0.5
Wheeze or whistling in the chest in last year 0.5 0.9 3.3 -0.2 1.5 1.8 -0.3 0.5 0.5 0.3 1.4 -0.1
Number of children fathered 0.8 0.9 2.6 0.6 0.5 0.9 -1.6 0.5 -1.2 -1.4 0.4 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.8 0.3 0.2 0.4 0.6 0.9 -0.2 0.4 0.7 0.2
Age at first live birth 2.0 3.5 6.9 -1.8 0.5 2.6 -2.4 -1.1 -2.0 -1.9 2.6 0.1
Pulse wave peak to peak time 0.3 0.3 1.2 -0.2 1.1 0.2 -0.9 -0.2 -0.6 -0.6 0.2 -0.2
Health satisfaction 0.8 1.0 4.2 -1.3 -0.3 -0.7 -0.3 -1.3 -0.4 -0.8 0.0 -2.1
Shortness of breath walking on level ground 0.5 0.6 1.6 -0.2 -1.0 -1.1 0.2 -0.4 0.5 0.1 -0.9 -1.2
Qualifications: College or University degree 0.9 2.7 8.2 -1.4 2.9 1.9 -1.2 -0.6 -0.9 -0.8 0.9 2.5
Eye problems/disorders: None of the above 1.4 1.6 3.8 1.3 -0.6 0.8 -1.1 2.0 -1.2 -1.2 0.7 -1.8
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.5 -0.8 -0.7 -0.8 0.1 -0.8 0.3 0.2 -1.2 -1.1
Emphysema/chronic bronchitis 0.7 0.8 2.8 -0.4 -1.1 -1.0 0.2 -0.8 0.1 -0.1 -1.1 -1.7
Medication for pain relief, constipation, heartburn 0.8 1.3 3.2 -1.0 -0.5 -0.3 -1.4 -0.9 -1.5 -1.8 0.1 -1.5
Neck or shoulder pain in last month 1.7 2.4 5.4 2.2 -0.7 0.8 1.4 2.3 2.0 1.8 1.0 0.3
Medication: Blood pressure 1.0 1.7 8.8 -0.8 -1.5 -0.3 -0.6 -0.5 -1.0 -1.1 -0.6 -3.0
Angina (self-reported) 1.5 2.0 3.3 1.5 -0.4 1.4 -1.7 1.5 -1.8 -1.8 0.1 -1.4
Migraine (self-reported) 1.1 1.4 5.7 0.3 -0.1 -0.9 2.4 -0.5 1.5 1.8 -0.2 0.7
Medication: Ibuprofen 1.3 1.5 2.6 -0.8 1.1 -1.0 1.6 -1.0 1.4 1.6 -1.1 1.2
Medication: Allopurinol 0.5 0.7 1.5 0.4 1.0 -0.3 -0.8 0.2 -1.1 -1.2 -0.1 -1.2
Medication: Omeprazole 1.6 1.9 4.1 1.5 0.3 -0.4 1.7 1.6 2.0 1.8 -0.3 1.6
Medication: Seretide 50 evohaler 0.9 1.0 2.8 1.5 -1.3 0.8 0.6 1.7 0.9 0.7 -0.2 0.4
Mean time to correctly identify matches 0.4 0.7 1.8 -0.8 0.7 0.6 -1.3 -0.8 -0.8 -1.2 0.3 -0.4
Heart disease (mother) 1.6 2.0 6.8 2.6 -1.2 -0.3 -0.4 2.6 -0.6 -0.5 -1.0 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 3.5 1.7 -1.6 -0.4 -0.3 1.9 0.2 -0.1 -0.3 -0.8
Whole body fat mass 1.1 4.6 22.1 0.7 -2.1 -1.4 -1.4 0.3 -1.5 -2.3 -1.7 -4.7
Leg fat mass (right) 0.8 3.2 14.1 1.0 -2.1 -1.8 -0.5 0.5 -0.4 -1.3 -1.8 -3.8
Arm predicted mass (right) 0.4 2.1 6.1 -0.3 1.0 1.4 -1.8 0.3 -0.5 -1.3 2.5 -2.2
Pulse rate, automated reading 0.7 2.1 4.4 -0.6 -2.1 -1.3 2.0 -1.2 1.5 1.7 -1.2 -1.0
Alcohol intake frequency. 1.5 3.6 14.1 0.9 -0.8 -3.1 1.8 -0.1 1.3 1.3 -3.8 -0.1
Comparative height size at age 10 0.5 2.8 5.6 0.9 0.7 2.2 -2.2 1.1 -1.4 -1.8 2.4 -1.4
Number of full sisters 2.3 2.8 5.2 0.2 -1.1 -2.3 2.1 -0.1 2.2 2.1 -2.2 0.7
Suffer from ‘nerves’ 1.6 2.5 6.8 1.8 -1.0 0.6 -0.8 2.0 -1.8 -1.6 1.1 -2.6
Overall health rating 1.5 3.1 7.8 -1.5 -2.1 -2.8 1.6 -1.8 0.9 0.3 -1.3 -2.4
Chest pain or discomfort 0.2 0.2 1.6 0.2 0.2 1.3 -0.4 0.1 0.4 0.0 -0.2 -0.4
Had major operations 2.6 3.1 10.7 -0.2 -1.5 1.6 -2.0 -0.1 -1.8 -2.2 0.3 -3.3
Age at last live birth 1.2 1.8 3.3 -1.3 1.8 1.5 -1.4 -0.9 -1.0 -0.8 1.7 1.2
Family relationship satisfaction 3.4 4.1 9.6 -2.6 -2.0 -2.6 1.3 -3.1 0.8 0.8 -2.4 1.3
Leg pain on walking 0.8 1.0 2.4 1.3 0.2 0.1 -1.1 1.2 -1.6 -1.4 -0.5 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.8 2.5 0.6 -1.0 -1.3 0.8 0.3 0.5 0.6 -1.6 -0.3
Commuting to job workplace: Car/motor vehicle 2.4 2.7 6.2 2.2 -1.5 0.7 -1.3 2.5 -1.7 -1.7 -0.5 -1.7
Illness, injury, bereavement, stress in last 2 years 2.5 3.1 7.0 -1.9 -2.6 0.7 -1.4 -1.5 -2.1 -1.7 1.2 -1.9
Medication: Aspirin 2.2 2.9 5.9 0.8 0.8 1.7 -2.2 1.1 -2.4 -2.1 0.4 -2.3
Supplements: Vitamin C 1.1 1.3 6.3 -0.0 1.0 1.5 -0.9 -0.1 -0.7 -0.6 0.8 2.5
Knee pain experienced in last month 1.9 3.0 4.9 1.1 1.9 1.8 -1.7 1.1 -1.4 -1.9 2.0 -2.2
Hypertension (Self-reported) 1.5 4.2 23.5 0.5 -1.1 0.7 -1.3 0.9 -2.2 -2.2 0.7 -4.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.6 1.6 0.4 -0.4 -1.3 1.1 -0.0 1.1 0.8 -0.8 0.1
Illnesses of father: Heart disease 2.0 2.7 5.1 -1.6 0.2 2.3 -2.1 -0.8 -1.2 -1.8 2.0 -1.8
Illnesses of siblings: Diabetes 0.8 1.0 3.5 -1.5 0.6 -0.8 0.8 -1.9 0.5 0.6 -0.9 -0.3
Smoking status: Previous 0.7 1.0 2.0 1.1 1.4 0.8 -0.9 1.3 0.6 -0.1 0.7 1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 5.1 1.9 -0.9 -0.3 0.7 2.3 0.8 0.9 1.0 1.9
Whole body fat-free mass 1.2 6.9 13.8 -0.2 1.9 3.0 -3.5 0.7 -2.0 -2.8 3.7 -3.4
Leg fat-free mass (right) 1.8 9.4 21.5 -0.5 2.3 3.0 -4.1 0.2 -2.9 -3.7 3.2 -4.6
Arm fat percentage (left) 1.7 6.8 35.2 0.6 -1.5 -0.9 -2.3 -0.2 -2.5 -3.1 -1.4 -5.9
Average weekly red wine intake 1.7 2.5 7.7 0.6 1.4 2.8 -1.6 1.7 -1.1 -1.0 2.4 -0.1
Handedness (chirality/laterality): Left-handed 0.3 0.3 1.1 0.9 -0.4 0.5 -0.2 1.0 -0.1 0.3 -0.2 0.6
Mood swings 0.4 0.7 3.0 -0.2 -1.7 -0.3 0.4 -0.0 -0.5 -0.5 0.7 -1.5
Loneliness, isolation 0.1 0.2 0.5 0.2 -0.3 -0.4 0.7 -0.2 -0.1 0.1 -0.4 -0.7
Long-standing illness, disability or infirmity 0.5 0.8 3.7 -0.8 0.1 -0.5 -0.5 -0.8 -0.7 -0.8 -0.6 -1.9
Ever had bowel cancer screening 2.6 3.1 9.3 -1.1 -1.8 1.0 -2.0 -0.6 -1.8 -2.2 0.4 -3.0
Diabetes diagnosed by doctor 0.3 0.6 4.1 0.3 2.0 0.1 0.1 0.3 0.6 0.2 -0.5 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.3 0.8 -0.1 1.1 -0.3 1.0 0.5 0.5 0.6 -0.1
Friendships satisfaction 0.7 0.8 1.3 -1.0 -0.8 -0.9 1.1 -0.9 0.5 0.5 -1.1 1.1
Qualifications: nursing, teaching 1.7 2.7 5.0 -1.3 1.1 0.2 1.9 -0.6 2.2 2.1 1.8 2.1
Commuting to job workplace: Walk 3.7 4.0 10.1 -1.7 0.2 -2.6 3.2 -1.8 2.1 2.4 -1.2 1.0
Eye problems/disorders: Cataract 0.6 0.7 2.7 -1.1 0.3 -0.7 0.2 -1.6 0.4 0.4 -1.0 -0.1
Mouth/teeth dental problems: Mouth ulcers 1.6 2.6 7.6 0.7 0.5 0.8 2.4 0.7 2.6 2.8 0.4 1.2
Medication for cholesterol 1.0 1.5 5.1 -1.3 0.5 0.7 0.9 -0.8 0.9 1.1 1.6 2.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.9 6.1 1.9 0.1 1.9 -0.7 2.5 -0.1 -0.5 1.8 -0.2
Back pain experienced in last month 1.7 2.5 5.2 2.0 1.2 -0.8 1.2 1.4 2.3 1.9 -0.9 1.9
Mineral and other dietary supplements 0.3 0.4 1.2 -1.0 0.1 0.4 -0.2 -1.1 0.5 0.2 -0.8 0.2
Breast cancer (self-reported) 0.8 1.0 3.4 0.4 0.3 -1.5 -0.5 0.0 -0.6 -0.9 -1.2 -1.8
Asthma (self-reported) 0.4 0.8 2.9 0.4 1.3 1.7 -1.4 0.3 -0.1 -0.4 0.8 -0.4
Osteoporosis (self-reported) 0.3 0.3 2.1 0.3 0.6 0.5 0.0 -0.0 0.0 -0.1 -1.4 0.6
Osteoarthritis (self-reported) 0.4 0.6 2.0 -0.7 1.4 -0.1 -0.8 -0.7 -0.2 -0.5 1.0 0.4
Medication: Aspirin 2.8 3.6 7.5 0.4 0.8 1.9 -2.6 0.6 -2.7 -2.6 0.6 -2.6
Medication: Gliclazide 2.0 2.3 3.9 1.9 2.0 0.6 -1.3 1.4 -1.8 -1.9 0.4 -1.4
Illnesses of father: None of the above (group 1) 0.5 0.6 1.6 0.8 -0.6 -1.3 0.8 0.3 0.4 0.6 -0.9 0.9
Smoking status: Current 4.1 6.5 13.1 0.4 0.6 -2.9 3.0 -0.1 3.6 3.5 -1.6 3.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.4 7.4 -0.9 -1.3 1.3 -2.0 -1.1 -2.6 -2.4 1.2 -2.7
Whole body water mass 1.2 6.7 12.4 -0.2 2.0 2.9 -3.4 0.6 -2.0 -2.8 3.5 -3.4
Leg predicted mass (right) 1.8 9.7 22.1 -0.4 2.4 3.1 -4.1 0.3 -2.9 -3.7 3.3 -4.7
Arm fat mass (left) 1.4 5.6 28.6 0.5 -0.7 -0.3 -2.6 0.1 -2.2 -3.0 -0.7 -5.4
Number of self-reported non-cancer illnesses 0.2 0.3 0.9 -0.1 -0.2 0.2 -0.1 0.3 0.9 0.2 0.7 -1.0
Average weekly champagne plus white wine intake 1.5 2.1 5.6 -0.0 1.7 1.9 -1.7 0.7 -1.2 -1.4 2.4 -0.5
Miserableness 0.3 0.5 1.3 0.4 -0.2 -1.1 1.1 0.5 0.6 0.6 -0.1 -0.6
Guilty feelings 1.5 2.2 6.3 -2.0 -2.1 -0.7 0.6 -2.1 0.2 -0.1 0.2 -2.5
Wears glasses or contact lenses 0.2 0.3 0.8 -0.6 -0.5 -0.3 0.3 -0.8 0.2 -0.3 -0.2 -0.9
Ever taken oral contraceptive pill 0.2 0.3 1.7 -0.1 1.3 0.1 0.0 0.1 0.2 0.2 0.5 0.7
Hearing aid user 0.7 0.8 3.6 0.4 -1.9 0.5 -0.1 0.4 -1.0 -1.0 0.5 -0.7
Mother’s age at death 0.2 0.3 1.1 -0.0 0.4 1.0 -0.1 0.3 0.1 0.1 1.1 0.6
Financial situation satisfaction 1.1 1.4 3.4 -1.5 1.1 -0.9 0.9 -1.9 1.0 1.1 -0.8 1.1
Tinnitus: Yes, now most or all of the time 0.6 0.7 3.2 0.1 -0.1 0.8 0.9 0.8 0.7 0.8 1.8 -0.3
Commuting to job workplace: Public transport 1.5 1.8 6.2 -2.5 1.0 -1.1 0.6 -2.4 0.8 0.7 0.4 1.0
Eye problems/disorders: Glaucoma 1.4 1.6 5.1 0.1 -0.0 -1.0 1.6 -0.2 1.6 1.6 -0.8 2.3
Medication: Blood pressure 0.8 1.6 7.0 -0.9 0.9 0.7 -1.3 -0.8 -0.9 -1.3 0.3 -2.6
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.4 0.0 -1.1 -1.1 0.5 0.0 1.0 0.5 -1.2 0.7
Supplements: Fish oil (including cod liver oil) 0.3 0.3 0.8 0.8 -0.7 -0.6 0.9 0.5 0.2 0.7 0.0 -0.0
High cholesterol (Self-reported) 0.6 1.1 2.3 0.9 -0.9 -1.4 0.9 0.5 1.3 1.0 -1.5 0.7
Medication: Bendroflumethiazide 0.5 0.8 2.2 1.5 0.4 -0.2 -0.6 1.2 -0.7 -0.6 -0.4 -1.5
Medication: Paracetamol 0.6 0.9 2.7 0.4 0.3 -0.6 0.9 0.4 1.5 1.3 0.0 1.6
Medication: Lisinopril 0.3 0.4 0.8 -0.9 -0.6 -0.7 0.6 -0.5 0.5 0.3 0.0 -0.8
Medication: Atorvastatin 0.6 0.7 2.8 0.1 -0.7 -1.6 0.3 -0.3 0.3 -0.2 -1.7 0.5
Illnesses of father: High blood pressure 1.7 2.2 6.9 -1.4 -2.6 0.4 -1.1 -1.3 -1.5 -1.7 0.1 -1.5
Alcohol drinker status: Never 0.9 1.1 3.5 0.7 -0.0 -1.1 -0.5 0.2 -1.5 -0.9 -1.9 -0.9
Ever smoked 1.5 2.6 11.8 0.8 1.7 -0.2 0.6 0.7 2.0 1.6 0.7 3.4
Basal metabolic rate 1.0 5.7 13.2 0.0 1.4 2.3 -3.2 0.7 -2.0 -2.9 2.8 -3.6
Leg fat percentage (left) 1.4 5.2 12.8 1.2 -3.3 -3.6 1.3 0.4 0.8 0.2 -3.6 -2.7
Arm fat-free mass (left) 0.6 3.0 7.2 0.1 1.1 1.8 -2.3 0.8 -1.0 -1.8 2.3 -2.7
Number of operations (self-reported) 0.8 1.2 6.2 0.6 -0.8 0.8 -1.1 0.9 -0.4 -1.0 0.1 -2.5
Average weekly beer plus cider intake 0.7 1.0 3.9 1.0 -0.0 -2.0 0.2 0.2 -0.3 -0.1 -1.9 -0.7
Irritability 0.1 0.2 0.7 0.3 0.0 -0.7 0.6 0.4 0.2 0.6 0.1 0.8
Risk taking 1.7 2.5 8.6 0.8 2.0 -0.3 1.4 0.9 1.6 2.0 -0.2 2.9
Ever had prostate specific antigen (PSA) test 1.4 1.6 4.2 -1.2 -1.0 2.0 -0.9 -0.5 -0.3 -0.8 2.0 -1.5
Fractured/broken bones in last 5 years 0.5 0.6 3.1 -0.9 1.8 0.9 -0.3 -0.4 0.3 0.3 0.3 0.2
Age started oral contraceptive pill 1.2 1.5 5.1 -1.2 -1.4 -2.3 1.0 -1.2 0.3 0.3 -1.5 -0.7
Diastolic blood pressure, automated reading 3.2 9.9 33.2 2.6 -2.3 1.5 -2.8 2.2 -3.8 -3.6 0.4 -5.8
Ever depressed for a whole week 0.8 1.0 3.4 -0.3 0.2 -0.7 1.1 0.1 1.9 1.4 -0.4 1.1
Unable to work because of sickness or disability 0.8 1.0 5.2 0.0 -1.0 -2.3 0.9 0.7 0.9 0.7 -0.7 -0.5
Commuting to job workplace: Cycle 2.0 2.4 8.1 0.3 2.5 2.8 -0.3 0.5 0.7 0.7 1.7 1.6
Myopia 0.5 0.7 2.2 -1.5 -0.2 -1.5 -0.3 -1.1 -0.1 -0.7 -0.3 -0.4
Vascular/heart problems diagnosed by doctor 1.9 5.1 24.4 -0.9 0.2 -1.4 1.9 -1.5 2.5 2.4 -1.0 4.9
Cholesterol lowering medication 0.4 0.7 2.2 1.0 0.5 -1.1 0.3 0.6 0.7 0.5 -1.5 -0.5
Medication: Omeprazole (e.g. Zanprol) 2.6 3.1 8.4 0.8 0.0 -0.9 2.6 1.0 2.9 2.6 -0.3 2.0
Pain experienced in last month 0.9 1.5 3.1 -1.1 -1.8 -0.6 -1.1 -0.8 -1.7 -1.2 -1.4 -0.8
Supplements: Calcium 0.6 0.7 1.5 -0.3 1.1 -0.5 -1.2 -0.4 -0.8 -1.1 0.3 0.7
Basal cell carcinoma (self-reported) 2.0 2.4 6.2 -0.0 0.1 -1.1 1.7 -0.5 2.1 2.4 -0.1 2.5
Heart attack/myocardial infarction (self-reported) 0.4 0.5 3.0 -0.5 0.1 0.6 -0.7 -0.0 -0.3 -0.3 0.0 -1.7
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 3.8 -1.0 2.0 1.4 -0.5 -1.0 0.5 0.3 1.6 0.3
Heart disease (siblings) 0.7 0.8 1.7 -0.8 0.6 1.0 -1.2 -0.8 -0.6 -0.9 0.6 -1.3
Alcohol drinker status: Previous 0.9 1.0 3.4 -0.5 -0.8 -1.4 0.3 -0.9 0.6 0.3 -1.9 -1.1
Pack years of smoking 2.0 2.9 9.1 0.7 -2.1 -2.9 1.6 0.1 0.6 1.1 -3.0 0.1
Impedance of whole body 2.6 13.4 24.4 0.8 -3.8 -4.4 4.6 -0.0 2.7 3.5 -4.6 4.9
Leg fat mass (left) 0.9 3.3 15.5 0.9 -2.2 -1.8 -0.4 0.5 -0.4 -1.2 -1.9 -3.9
Arm predicted mass (left) 0.5 2.5 5.7 -0.0 1.3 1.6 -2.2 0.6 -0.9 -1.7 2.1 -2.4