Best TWAS P=3.06e-17 · Best GWAS P=1.16e-19 conditioned to 0.0244
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Muscularis | GRB14 | 0.14 | 0.09 | lasso | 7 | 0.06 | 0.00016 | 8.2 | -8.4 | 3.1e-17 | -0.47 | 0.26 | 0.47 | TRUE |
| 2 | GTEx | Thyroid | COBLL1 | 0.07 | 0.05 | lasso | 3 | 0.05 | 0.00015 | -6.0 | 6.3 | 3.2e-10 | 0.57 | 0.57 | 0.25 | TRUE |
| 3 | METSIM | Adipose | GRB14 | 0.04 | 0.00 | bslmm | 376 | 0.01 | 0.01630 | -3.4 | -5.5 | 4.5e-08 | -0.26 | 0.12 | 0.14 | FALSE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | GRB14 | 0.09 | 0.01 | blup | 82 | 0.03 | 0.00464 | 7.5 | -6.3 | 2.3e-10 | -0.55 | 0.02 | 0.64 | FALSE |