TWAS
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Models
Genes
Traits
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Traits
:
Arm fat percentage (right)
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chr2:164,657,815-166,396,485
Best TWAS P=3.06e-17 · Best GWAS P=1.16e-19 conditioned to 0.0244
164.6M
164.8M
165M
165.2M
165.4M
165.6M
165.8M
166M
166.2M
166.4M
0
5
10
15
20
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Esophagus Muscularis
GRB14
0.14
0.09
lasso
7
0.06
0.00016
8.2
-8.4
3.1e-17
-0.47
0.26
0.47
TRUE
2
GTEx
Thyroid
COBLL1
0.07
0.05
lasso
3
0.05
0.00015
-6.0
6.3
3.2e-10
0.57
0.57
0.25
TRUE
4
The Cancer Genome Atlas
Colon Adenocarcinoma
GRB14
0.09
0.01
blup
82
0.03
0.00464
7.5
-6.3
2.3e-10
-0.55
0.02
0.64
FALSE
3
METSIM
Adipose
GRB14
0.04
0.00
bslmm
376
0.01
0.01630
-3.4
-5.5
4.5e-08
-0.26
0.12
0.14
FALSE