TWAS hub - GRB14

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0410	0.0180	0.0048	0.002	0.016	0.002	0.016	0.008	1.9e-01	0.0038	0.1600	0.0045	0.03100
2	GTEx	Artery Tibial	0.1150	0.0488	0.0097	0.004	NA	0.000	NA	0.002	1.5e-01	NA	0.3400	NA	0.19000
3	GTEx	Esophagus Muscularis	0.1370	0.0530	0.0022	0.089	NA	0.028	NA	0.060	4.5e-06	NA	0.0077	NA	0.00016
4	METSIM	Adipose	0.0350	0.0160	0.0060	-0.002	0.008	-0.001	0.008	-0.001	8.6e-01	0.0170	0.6100	0.0160	0.59000
5	ROSMAP	Brain Pre-frontal Cortex	0.0725	0.0277	0.0010	-0.001	0.011	0.002	0.012	0.000	3.9e-01	0.0110	0.1500	0.0096	0.34000
6	TCGA	Colon Adenocarcinoma	0.0880	0.0420	0.0018	0.015	0.034	0.018	NA	0.021	4.5e-02	0.0046	0.0320	NA	0.02100

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Waist Hip Ratio (WHR)	12.2	54.9	123.2	0.4	4.1	11.1	8.9	4.2	9.6
Trunk fat percentage	8.1	32.5	94.7	0.2	-3.1	-9.7	-5.8	-1.3	-7.4
Body fat percentage	7.0	27.7	82.8	0.5	-3.0	-9.1	-5.3	-1.4	-6.7
Hip circumference	6.8	29.3	65.4	0.6	-3.4	-7.6	-5.6	-3.0	-8.1
Arm fat percentage (left)	6.5	26.1	78.0	0.8	-2.3	-8.8	-5.4	-0.3	-6.5
Arm fat percentage (right)	6.3	24.9	71.2	1.1	-2.5	-8.4	-5.5	-0.6	-6.3
HDL Cholesterol	6.0	10.0	38.1	0.2	-1.4	-6.2	-3.1	0.4	-3.2
Triglycerides	6.0	9.8	29.7	-0.9	1.6	5.5	3.9	-0.4	3.1
Type 2 Diabetes (T2D) (2018)	6.0	11.2	26.8	-1.3	0.6	5.2	4.4	0.0	4.3
Glaucoma (self-reported)	5.7	6.7	13.7	-3.7	-2.5	-2.6	-3.2	-0.5	-1.7
Trunk fat mass	5.6	23.9	64.0	-0.0	-2.9	-8.0	-4.9	-1.8	-6.6
Whole body fat mass	4.8	19.8	51.6	0.1	-2.9	-7.2	-4.3	-1.9	-6.1
Impedance of arm (right)	4.6	21.3	47.5	-1.3	-2.8	-6.9	-6.6	-1.1	-5.0
Impedance of arm (left)	4.6	21.4	51.3	-1.5	-2.8	-7.2	-6.5	-0.6	-4.9
Diabetes diagnosed by doctor	4.4	7.3	15.5	-0.9	1.3	3.7	3.9	1.1	3.3
Medication: Gliclazide	4.3	4.8	14.2	0.3	0.4	2.9	3.8	0.2	2.4
Eye problems/disorders: Glaucoma	4.2	4.9	8.8	-3.0	-1.8	-2.8	-2.6	-0.7	-1.6
Arm fat mass (right)	4.1	16.8	42.6	0.6	-2.4	-6.5	-4.2	-1.2	-5.7
Leg fat percentage (right)	3.9	14.1	47.7	1.3	-1.9	-6.9	-2.8	-1.2	-4.7
Arm fat mass (left)	3.8	15.4	42.2	0.5	-2.1	-6.5	-3.9	-1.0	-5.5
Medication: Metformin	3.7	5.2	10.9	-0.3	1.3	3.3	3.0	1.1	2.9
Illnesses of father: High blood pressure	3.7	4.6	14.8	-3.9	-1.6	-1.3	-2.5	-0.8	-1.3
Leg fat percentage (left)	3.5	12.8	41.0	1.2	-1.8	-6.4	-2.8	-1.3	-4.6
Medication: Simvastatin	3.4	5.0	9.0	1.4	2.3	3.0	2.0	2.4	1.9
Leg fat mass (right)	3.4	13.1	37.7	0.7	-2.2	-6.1	-2.8	-1.6	-5.0
Leg fat mass (left)	3.2	12.5	34.2	0.7	-2.1	-5.8	-2.8	-1.7	-5.0
Birth weight of first child	3.0	5.5	11.8	2.3	1.9	3.4	2.9	0.1	1.9
Average weekly spirits intake	2.9	3.6	5.7	2.1	1.3	-0.8	2.2	2.4	1.9
Diabetes (mother)	2.9	3.8	10.9	-0.3	0.8	2.2	2.5	-0.2	3.3
Average weekly champagne plus white wine intake	2.8	3.9	6.9	-1.7	-2.5	-1.6	-1.8	-1.3	-2.6
Intelligence (Savage-Jansen 2018)	2.7	8.2	16.8	-3.9	-2.3	-1.0	-4.1	-2.2	-2.5
Serious illness, injury or assault of a close relative in last 2 years	2.7	3.1	5.9	-2.3	-2.4	-1.3	-1.1	-2.1	-0.4
Diabetes (self-reported)	2.6	4.0	8.2	-1.0	1.0	2.8	2.9	0.4	2.5
Hair/balding pattern: Pattern 3	2.6	3.9	9.2	1.6	3.0	1.6	0.5	2.7	1.2
Hearing aid user	2.6	2.9	6.2	2.5	2.4	0.8	1.4	1.5	0.7
Depression (Nagel 2018)	2.4	3.6	8.9	2.7	1.5	0.2	0.5	1.7	3.0
Age started oral contraceptive pill	2.4	3.0	5.9	-2.3	-2.0	0.7	-0.8	-2.4	-1.2
Fed-up feelings	2.3	4.1	10.2	3.2	1.2	1.4	1.8	0.9	2.6
Medication: Atenolol	2.3	2.8	5.2	1.1	1.0	0.9	2.2	2.0	2.3
Mood swings	2.3	4.1	7.9	2.8	2.0	1.4	1.5	1.1	2.7
Verbal and Numeric Reasoning (VNR)	2.2	5.3	11.6	-3.4	-1.1	-1.1	-3.1	-0.7	-2.7
Body Mass Index (BMI) (2010)	2.2	3.1	6.9	2.3	1.0	-2.1	-0.5	0.4	-2.6
HbA1C	2.2	2.4	5.6	-1.1	1.4	2.4	0.7	0.9	2.1
Alcohol usually taken with meals	2.2	3.6	8.3	-1.8	-0.5	-1.1	-2.0	-2.9	-2.1
Weight	2.2	11.1	26.9	-0.1	-2.3	-4.4	-3.2	-2.2	-5.2
Depressed Affect (Nagel 2018)	2.1	4.3	12.2	3.5	1.6	0.8	1.0	0.5	3.0
Type 2 Diabetes (T2D) (2012)	2.1	2.4	4.9	0.7	-0.0	1.9	1.8	1.6	2.2
BMI	2.0	11.8	28.8	0.1	-1.5	-4.8	-3.4	-2.2	-5.4
Frequency of depressed mood in last 2 weeks	2.0	2.8	11.4	1.7	0.5	0.8	0.5	1.2	3.4
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	5.1	-0.8	0.3	0.4	2.0	1.8	2.3
Headache pain in last month	2.0	3.5	4.9	1.5	1.6	1.6	2.2	2.1	2.1
Emphysema/chronic bronchitis	2.0	2.3	7.2	0.2	-2.7	-0.8	-1.0	-2.1	-0.6
Medication: Aspirin	2.0	2.6	5.6	1.4	1.4	1.7	2.4	1.3	1.3
Fractured/broken bones in last 5 years	2.0	2.6	4.5	0.5	1.7	-2.1	-0.9	1.6	-2.1
Medication: Aspirin	1.9	2.5	5.6	1.0	1.4	1.7	2.4	1.1	1.5
Major Depression (MDD)	1.8	2.2	7.3	2.3	0.4	-0.4	-0.1	2.7	0.5
Ovarian Cancer	1.8	2.4	9.6	-0.9	-0.6	-0.7	-1.7	0.2	-3.1
LDL Cholesterol	1.8	2.9	7.1	-2.1	0.1	1.9	2.7	0.3	1.6
Systolic Blood Pressure	1.8	9.1	28.6	-2.7	1.6	5.3	0.2	3.8	1.5
Body mass index (BMI)	1.8	7.6	22.4	1.2	-0.9	-4.7	-2.3	-0.2	-4.0
Qualifications: None of the above	1.8	3.9	6.2	2.5	2.0	1.6	2.0	2.1	1.5
Alcohol intake versus 10 years previously	1.8	2.7	6.3	1.4	0.3	1.8	2.1	-0.4	2.5
Supplements: Vitamin C	1.8	2.1	6.0	2.0	0.8	-0.4	-0.7	1.2	-2.4
Financial situation satisfaction	1.8	2.3	4.4	1.8	0.2	0.3	2.0	1.4	2.1
Ever had prostate specific antigen (PSA) test	1.8	2.1	5.9	1.1	0.4	-2.4	-0.7	2.2	-0.1
Impedance of whole body	1.8	9.2	23.5	-1.4	-1.9	-4.8	-4.2	-0.9	-2.8
Blood Red Count	1.7	16.2	43.6	-0.6	2.3	5.2	3.9	2.4	6.6
Fluid intelligence score	1.7	3.5	7.2	-2.7	-1.5	-0.6	-1.9	-1.6	-2.3
Chronic bronchitis/emphysema (mother)	1.7	2.0	7.4	0.2	-1.4	-1.4	-2.7	-0.4	-0.6
Illnesses of siblings: Diabetes	1.7	2.1	4.3	-2.1	0.2	1.6	1.4	-0.3	1.9
Had menopause	1.6	2.0	4.9	-0.8	-0.4	-2.2	-0.8	-1.1	-2.1
Number of live births	1.6	2.2	4.4	-2.0	-0.5	-0.9	-2.1	-0.6	-1.8
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	6.7	-1.3	-0.8	-1.1	-1.5	-1.6	-2.6
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	4.1	0.3	-0.8	-1.3	-2.0	-1.8	-1.6
Neck or shoulder pain in last month	1.6	2.3	5.6	1.0	0.1	2.3	1.3	-0.2	2.4
Ever depressed for a whole week	1.6	2.0	4.5	1.6	0.5	-1.4	1.2	2.1	1.1
Medication: Blood pressure	1.5	2.7	9.3	0.3	2.5	-0.2	0.6	3.1	-0.2
Average weekly red wine intake	1.5	2.2	6.3	-0.7	-0.7	-1.1	-2.5	-1.3	-1.8
Qualifications: nursing, teaching	1.5	2.3	5.6	-1.3	-1.8	0.3	-1.4	-2.4	-1.1
Average weekly beer plus cider intake	1.5	2.1	5.4	1.5	1.5	0.7	1.3	2.3	0.9
Heart attack/myocardial infarction (self-reported)	1.5	1.9	4.2	1.2	1.8	-0.2	1.4	2.1	0.8
Ulcerative Colitis	1.4	2.0	8.5	-0.1	2.9	0.6	1.8	-0.2	0.1
Average weekly fortified wine intake	1.4	1.7	4.2	1.5	2.0	-0.6	1.4	0.9	-0.2
Maternal smoking around birth	1.4	2.0	5.4	-0.3	-2.3	1.3	-1.1	-2.0	0.1
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	5.4	1.1	0.4	0.6	1.5	0.8	2.3
Heart attack	1.4	1.8	3.7	1.2	1.8	-0.1	1.4	1.9	0.9
Father’s age at death	1.4	1.9	5.0	-1.1	0.3	-2.1	-0.9	-0.5	-2.2
Medication: Lansoprazole	1.4	1.6	7.8	-0.0	0.2	-1.2	-0.1	2.8	0.0
Worry too long after embarrassment	1.4	2.3	7.6	-0.8	-0.4	-2.1	-2.7	-1.0	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.6	5.7	-0.4	0.4	1.6	1.0	-0.4	2.4
Mother’s age at death	1.4	1.8	4.6	-2.1	0.2	-1.2	-0.8	-1.3	-1.5
Cholesterol lowering medication	1.4	2.0	7.8	-1.0	0.1	2.8	-0.1	0.1	1.8
Supplements: Calcium	1.4	1.5	4.4	-0.1	-0.8	-1.8	-2.1	-0.7	-0.5
Primary Biliary Cirrhosis	1.3	1.9	3.1	1.3	1.8	1.7	1.5	-0.8	0.8
Ever had hysterectomy (womb removed)	1.3	1.4	5.0	-0.2	-1.0	1.2	0.7	-0.8	2.2
Diabetes (father)	1.3	1.6	4.6	-2.2	0.2	1.9	0.4	-0.3	1.0
Medication: Cholesterol lowering	1.3	2.1	5.0	0.3	1.7	1.1	1.0	2.2	1.4
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	4.7	0.4	-2.2	-1.1	-1.0	-2.2	-0.9
Medication for cholesterol	1.3	2.0	5.1	1.7	0.3	-2.3	0.7	1.0	-1.6
Illnesses of father: None of the above (group 1)	1.3	1.6	5.0	2.0	-0.6	0.0	2.2	-0.4	0.5
Medication: Blood pressure	1.3	2.4	7.4	-0.2	0.1	2.7	0.1	1.1	2.4
Pain experienced in last month	1.3	2.1	4.4	-1.9	-1.2	0.4	-1.4	-2.1	-1.2
Coronary Artery Disease (CAD)	1.2	1.5	3.0	0.3	1.7	1.0	1.6	1.2	1.0
Systolic blood pressure, automated reading	1.2	3.5	11.7	0.0	1.5	2.1	0.3	3.4	1.6
Supplements: Zinc	1.2	1.3	3.2	-1.6	-1.8	-0.8	-0.2	-0.7	-0.9
Severe depression (siblings)	1.2	1.4	5.4	-0.7	0.6	-2.3	-0.4	0.3	-1.3
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	7.6	-0.3	-0.5	0.7	-0.0	0.5	2.8
Sitting height	1.2	8.7	21.6	-2.5	-3.9	0.0	-1.5	-4.7	-2.6
Medication: Ramipril	1.2	1.5	5.1	0.6	0.8	0.8	0.2	1.5	2.3
Mouth/teeth dental problems: Dentures	1.2	2.0	3.1	1.6	1.0	1.8	1.6	-0.6	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	4.9	0.7	-0.8	-1.6	-1.4	2.2	0.9
Pulse wave reflection index	1.2	1.5	6.2	1.3	1.0	-0.1	-0.2	2.5	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	4.2	-2.1	-1.0	-0.7	-1.2	0.7	-1.0
Alcohol intake frequency.	1.2	2.8	5.3	-0.3	1.2	1.6	2.3	1.6	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	4.1	0.2	-0.5	-0.4	-0.9	2.0	1.8
Eye problems/disorders: Cataract	1.2	1.3	3.2	-1.8	0.3	0.1	-1.2	-0.3	-1.7
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.8	-0.5	-1.9	-0.4	-1.6	0.0	1.2
Hand grip strength (left)	1.1	2.9	5.6	-2.4	0.2	2.3	1.8	-1.2	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	3.0	1.3	1.3	-0.1	0.8	1.3	1.7
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.6	1.6	0.5	-1.2	-1.0	0.9	-1.3
Gout (self-reported)	1.1	1.5	6.6	-0.7	0.0	2.6	0.7	-0.4	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.3	-0.4	-1.8	-1.7	-1.1	0.3	-0.3
Mouth/teeth dental problems: Loose teeth	1.1	1.3	4.7	-2.2	0.5	-1.1	-0.5	-1.1	0.5
Medication: Omeprazole	1.1	1.3	4.2	0.9	0.5	-0.3	0.1	1.6	2.1
Chest pain or discomfort	1.1	1.6	6.6	0.9	0.5	1.3	0.4	0.2	2.6
Ever had bowel cancer screening	1.1	1.2	2.7	-1.2	1.6	-1.4	0.3	-0.7	-0.8
Alcohol drinker status: Never	1.1	1.3	4.5	2.1	-0.1	-0.0	0.8	1.0	1.3
Ever smoked	1.1	1.9	7.0	0.7	-0.5	0.6	-0.6	-1.7	-2.6
Number of treatments/medications taken	1.0	1.8	4.8	0.3	1.8	0.3	-0.1	2.2	1.7
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.2	-1.0	1.8	1.1	1.1	-0.9	-0.6
Leg fat-free mass (left)	1.0	5.2	14.7	-0.1	-1.8	-2.2	-2.3	-1.8	-3.8
Multivitamins +/- minerals	1.0	1.3	2.9	-1.0	-1.6	-0.5	0.0	-1.1	1.7
Leg predicted mass (left)	1.0	5.2	14.6	-0.0	-1.8	-2.2	-2.3	-1.7	-3.8
Number of incorrect matches in round	1.0	1.6	2.7	1.6	0.3	1.4	-0.7	1.5	1.5
Hair/balding pattern: Pattern 2	1.0	1.3	3.9	-0.0	-0.7	-0.4	0.0	-2.0	-1.7
Pulse rate	1.0	1.7	3.7	0.3	-0.2	1.9	1.8	-0.7	1.7
Prospective memory result	1.0	1.2	2.9	0.5	1.1	1.7	1.6	0.1	0.7
Length of working week for main job	1.0	1.2	3.5	-1.5	-1.9	0.3	-0.4	-0.9	0.3
Loud music exposure frequency	1.0	1.1	2.0	-0.7	-1.4	0.1	-0.8	-1.1	-1.4
Medication: Amlodipine	1.0	1.4	6.3	0.6	0.7	-0.2	-0.4	2.5	1.1
Shortness of breath walking on level ground	1.0	1.2	2.6	1.6	0.1	0.7	1.4	-0.7	1.3
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.1	-0.7	-0.5	-1.5	-2.0	0.3	-1.6
Number of operations (self-reported)	1.0	1.5	3.6	-1.6	0.6	1.9	0.6	-0.8	-1.0
Myopia	1.0	1.4	3.2	1.0	1.1	-0.3	0.3	-1.6	-1.8
Heart disease (siblings)	1.0	1.2	2.2	1.4	0.5	0.8	-1.5	0.3	1.4
Breast Cancer	0.9	2.3	4.7	-0.6	-1.7	1.0	-0.2	-2.2	-2.1
Crohns Disease (2012)	0.9	1.5	3.8	1.4	1.9	-0.4	-0.1	1.5	-0.8
Fasting Glucose	0.9	1.1	4.2	-0.7	2.1	0.6	0.9	-0.8	0.4
Cardiovascular Disease	0.9	3.1	7.4	-1.6	1.4	2.7	-0.1	2.1	1.5
Qualifications: CSEs or equivalent	0.9	1.2	2.2	1.5	0.9	0.6	1.1	1.3	0.9
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	4.1	-2.0	-1.3	-0.7	-0.5	-0.4	0.1
Had other major operations	0.9	1.1	2.8	-1.1	-1.7	-0.5	-0.4	-1.0	-1.2
Depression (self-reported)	0.9	1.0	2.5	0.1	0.1	-1.1	-1.5	1.6	0.5
Standing height	0.9	8.5	20.3	-3.0	-2.9	0.7	-2.1	-4.5	-2.9
Breastfed as a baby	0.9	1.1	1.9	1.4	1.2	0.7	0.5	-1.1	-1.0
Comparative body size at age 10	0.9	2.4	5.6	0.6	1.4	-1.5	-0.0	2.4	-2.1
Medication: Allopurinol	0.9	1.1	4.5	0.3	-1.0	2.1	-0.5	-0.6	0.8
Friendships satisfaction	0.9	1.1	3.2	-0.3	-1.8	-1.0	-1.5	-0.2	-0.3
Osteoarthritis (self-reported)	0.9	1.2	1.7	1.1	0.9	1.1	1.0	1.3	1.1
Ever taken oral contraceptive pill	0.9	1.1	2.7	-1.6	0.8	0.5	0.9	-0.2	1.4
Medication: Lisinopril	0.9	1.2	4.3	-1.1	1.2	2.1	0.3	0.2	0.4
Irritability	0.9	1.5	3.2	1.6	-1.0	1.5	-0.4	-1.8	-0.5
Diastolic blood pressure, automated reading	0.9	2.6	10.4	1.8	1.5	-0.5	0.1	3.2	0.1
Bipolar Disorder (2011)	0.8	0.7	1.7	-1.1	-0.7	-1.3	-0.7	-0.6	-0.3
Neuroticism (2016)	0.8	1.2	4.7	2.2	0.6	-0.2	0.1	0.5	1.3
Allergy or Eczema	0.8	2.0	6.5	0.0	1.8	-0.9	0.8	2.5	-1.0
Townsend deprivation index at recruitment	0.8	1.1	5.2	2.3	0.5	1.0	0.6	-0.0	-0.0
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.6	-1.3	-0.4	-0.0	0.5	-0.7	-1.6
Supplements: Glucosamine	0.8	1.0	4.5	2.1	-0.3	-1.0	0.6	0.1	-0.2
Chronic bronchitis/emphysema (father)	0.8	1.0	2.2	1.1	0.4	-0.5	-0.8	1.5	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.4	0.8	0.5	-1.4	-0.6	1.0	1.9
Pain all over the body in last month	0.8	0.8	2.0	-1.4	0.1	-1.1	-1.1	0.3	-0.6
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.6	0.2	1.4	-1.6	-0.5	0.8	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	5.5	-1.0	0.2	0.6	0.2	-0.8	2.3
Blood clot in the leg (DVT)	0.8	1.0	3.2	-1.0	0.7	-0.3	0.6	-0.9	-1.8
Health satisfaction	0.8	1.1	2.2	1.5	0.9	-0.4	0.1	1.4	1.1
Eye problems/disorders: None of the above	0.8	0.9	2.8	1.7	-0.4	0.2	0.7	-0.5	1.3
Illnesses of father: Heart disease	0.8	1.1	4.5	-0.1	0.7	0.2	-2.1	0.8	1.0
Loneliness, isolation	0.8	1.2	2.6	1.5	0.2	0.3	1.2	0.7	1.6
Back pain experienced in last month	0.8	1.1	2.2	0.6	1.5	0.3	1.5	-0.2	1.3
Number of self-reported non-cancer illnesses	0.8	1.3	4.8	0.7	1.6	0.1	-0.3	2.2	0.4
Miserableness	0.8	1.4	3.8	1.6	0.8	0.4	-1.1	0.1	1.9
Vascular/heart problems diagnosed by doctor	0.8	2.1	7.8	1.0	-1.6	-0.9	0.1	-2.8	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	2.3	0.7	-0.3	-0.3	-0.7	1.5	1.5
Schizophrenia vs Biploar Disorder	0.7	0.9	4.2	-0.6	-0.5	2.0	0.2	-0.6	0.3
Ulcerative Colitis (UC)	0.7	1.4	3.6	0.2	1.9	0.7	1.9	-0.7	0.4
Rheumatoid Arthritis	0.7	1.0	3.5	0.9	0.4	-0.7	-1.9	0.8	-0.7
Lung FVC	0.7	3.6	8.9	1.6	1.9	0.4	1.6	3.0	1.8
Pack years adult smoking proportion	0.7	1.1	3.4	-0.3	0.7	0.6	0.8	1.2	1.8
Stomach or abdominal pain in last month	0.7	0.9	3.5	1.9	-0.2	-0.6	-0.6	1.0	-0.5
Neuroticism score	0.7	1.4	4.9	2.2	1.2	-0.2	0.1	0.6	1.2
Worrier / anxious feelings	0.7	1.4	2.7	1.3	-0.2	-1.1	-1.6	-0.4	-1.5
Qualifications: A levels/AS levels or equivalent	0.7	1.5	3.6	-1.5	-0.5	-0.7	-1.1	-1.1	-1.9
High blood pressure (siblings)	0.7	1.0	3.1	-1.8	-0.5	-0.0	-1.1	1.1	0.3
Number of full brothers	0.7	0.9	2.4	-0.7	0.3	-1.3	1.0	1.5	-0.1
Medication: Ibuprofen	0.7	0.8	2.8	-1.7	0.3	0.9	1.0	-0.2	0.4
Suffer from ‘nerves’	0.7	1.1	3.6	0.3	0.4	-0.5	0.5	1.4	1.9
Hypertension (Self-reported)	0.7	1.8	6.4	-0.6	1.3	1.2	0.2	2.5	1.0
Leg fat-free mass (right)	0.7	3.9	12.0	-0.3	-1.6	-1.3	-2.0	-1.8	-3.5
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.5	-0.9	-1.2	-0.6	-0.2	-0.7	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.8	-0.7	-0.7	-0.9	-0.9	-1.4	-0.7
Mineral and other dietary supplements	0.7	1.0	1.7	-1.1	0.7	0.2	1.1	1.1	1.3
Leg predicted mass (right)	0.7	3.8	11.6	-0.4	-1.6	-1.2	-1.9	-1.8	-3.4
Wears glasses or contact lenses	0.7	0.8	2.2	-1.0	-0.1	-0.8	-0.1	-1.0	-1.5
Supplements: Fish oil (including cod liver oil)	0.7	1.0	1.9	0.6	1.0	0.7	-0.8	-1.2	-1.4
Risk taking	0.7	1.0	5.2	-2.3	-0.0	-0.1	-0.5	-0.4	-0.7
Commuting to job workplace: Cycle	0.7	0.9	1.8	-1.3	-0.6	-0.6	-1.0	1.3	0.5
Neuroticism (Nagel 2018)	0.6	1.3	4.7	1.6	0.6	0.1	0.2	0.3	2.2
Alzheimer’s Disease (in mother)	0.6	0.7	2.3	1.5	0.5	-0.3	0.6	0.6	0.8
Prostate Cancer	0.6	0.9	3.9	-0.4	0.5	2.0	0.8	0.2	0.4
Angina	0.6	0.8	1.7	-0.6	0.8	1.3	1.1	0.9	0.5
Medication for hormone replacement therapy	0.6	0.6	2.4	-0.1	-0.1	0.7	-0.6	-1.5	-0.6
Current tobacco smoking	0.6	0.9	2.4	0.2	-0.8	1.6	0.2	-1.4	0.8
Serious illness, injury or assault to yourself	0.6	0.7	2.7	-1.0	0.4	-0.2	0.5	-1.6	0.4
High blood pressure	0.6	1.7	5.8	-1.0	1.4	1.1	-0.1	2.4	0.6
Nervous feelings	0.6	1.0	3.0	-0.8	0.0	-1.7	0.0	1.6	-0.1
Happiness	0.6	0.7	1.3	1.2	-0.4	-0.8	-0.8	1.0	0.7
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.4	-1.5	-0.6	-0.4	-0.0	-1.1	0.6
Birth weight	0.6	1.4	4.2	1.4	1.0	-0.8	-0.2	0.4	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	3.1	0.4	-0.3	-1.8	-0.5	1.1	-0.5
Qualifications: College or University degree	0.6	2.0	4.8	-1.5	-0.3	-1.0	-0.9	-1.6	-2.2
Medication for pain relief, constipation, heartburn	0.6	1.0	3.1	-0.4	-0.6	-0.5	-0.2	-1.4	-1.8
Migraine (self-reported)	0.6	0.7	2.1	-0.5	-0.1	1.5	1.3	0.4	0.3
Heart disease (mother)	0.6	0.8	2.4	0.6	-0.2	0.5	-1.6	0.9	0.9
Knee pain experienced in last month	0.6	1.0	2.4	1.3	-0.6	-1.5	-0.2	0.4	-1.0
Long-standing illness, disability or infirmity	0.6	1.0	3.2	0.0	1.8	0.1	0.5	1.4	0.7
Breast cancer (self-reported)	0.6	0.8	2.6	0.5	-1.2	-0.2	-0.1	-1.6	-0.4
High cholesterol (Self-reported)	0.6	1.1	3.4	-1.2	0.5	1.8	0.1	0.2	1.3
Medication: Bendroflumethiazide	0.6	0.9	2.7	-0.8	-0.7	-0.9	0.0	1.6	0.7
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.4	-0.6	0.4	-0.2	0.9	-0.8	-1.6
Alcohol drinker status: Previous	0.6	0.7	1.3	-0.8	-1.0	0.7	1.1	-0.3	-0.8
Pack years of smoking	0.6	0.9	2.5	-0.1	0.8	0.7	0.8	1.0	1.6
Bipolar Disorder (2018)	0.5	0.8	2.2	0.6	-0.2	-1.4	0.2	-0.6	-1.5
Mean Putamen Volume	0.5	0.6	1.6	0.9	-0.4	0.3	0.8	1.3	-0.4
Lung FEV1/FVC ratio	0.5	2.6	9.9	-3.1	1.1	0.2	-0.6	-2.0	-0.1
Hand grip strength (right)	0.5	1.3	4.4	-2.1	-0.1	1.3	1.1	-0.4	0.3
Taking other prescription medications	0.5	0.8	2.5	0.7	1.2	-0.2	-0.3	1.6	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	4.5	2.1	-0.9	-1.1	0.4	0.1	-0.4
Illnesses of siblings	0.5	0.7	1.4	0.9	-0.1	0.2	1.2	-1.1	-0.9
Trunk fat-free mass	0.5	2.6	9.5	-0.7	-0.5	3.1	1.0	-2.1	-0.3
Noisy workplace	0.5	0.6	1.2	1.1	-0.1	-1.0	0.6	0.9	0.3
Lung cancer (father)	0.5	0.6	1.4	-0.2	-1.2	0.8	-0.6	-0.3	1.1
Trunk predicted mass	0.5	2.7	9.7	-0.6	-0.5	3.1	1.0	-2.2	-0.2
Exposure to tobacco smoke at home	0.5	0.5	1.6	0.3	0.9	-0.5	-0.6	-0.3	-1.2
Hair/balding pattern: Pattern 4	0.5	1.2	4.4	-0.9	-0.4	-0.9	2.1	0.2	1.1
Angina (self-reported)	0.5	0.7	1.1	-0.6	0.6	1.0	1.0	0.8	0.8
Pulse rate, automated reading	0.5	1.7	3.1	0.2	0.9	1.7	1.8	1.1	1.5
Comparative height size at age 10	0.5	2.8	5.6	-2.4	-1.7	-0.1	-1.6	-1.1	-2.0
Overall health rating	0.5	1.1	2.3	0.9	1.5	-1.0	0.9	1.2	0.6
Age at last live birth	0.5	0.7	2.5	0.7	1.6	-0.1	-0.5	0.4	-1.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.8	0.9	0.4	-1.3	-0.9	-0.1	-0.3
Osteoporosis (self-reported)	0.5	0.6	2.8	-0.1	0.0	-0.8	-0.6	-0.2	-1.7
Smoking status: Current	0.5	0.7	1.6	0.4	-0.9	1.3	-0.0	-1.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	4.7	0.5	0.0	0.9	0.5	-0.8	2.2
Commuting to job workplace: Public transport	0.5	0.6	1.9	-1.4	-0.1	-0.3	-0.9	-0.7	-0.7
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.2	-0.5	-1.1	0.5	0.2	-1.5	0.4
Basal metabolic rate	0.5	2.6	7.1	-0.4	-1.5	-0.2	-1.0	-2.3	-2.7
Bipolar Disorder or Schizophrenia	0.4	1.1	2.6	0.6	1.1	-1.3	0.5	0.4	-1.6
Schizophrenia (2018)	0.4	0.9	2.7	0.3	1.6	-0.6	0.5	1.0	-0.9
Irritable Bowel Disease (IBD)	0.4	1.0	3.5	0.2	1.9	0.6	1.5	-0.2	-0.2
Reaction Time	0.4	0.8	2.2	0.7	-1.3	0.3	-1.5	-0.1	0.1
Lupus	0.4	0.5	1.4	0.8	-0.1	-0.4	-1.0	0.2	-1.2
Height	0.4	8.2	16.6	-2.9	-4.1	0.8	-2.7	-3.9	-1.1
Smoking Status	0.4	1.0	4.4	0.8	-0.7	0.5	0.6	-2.1	-0.3
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.1	1.0	-0.6	0.8	0.5	-0.5	0.5
Vitamin and mineral supplements	0.4	0.6	1.6	0.4	1.1	0.0	0.6	1.3	-0.2
Age when periods started (menarche)	0.4	0.9	3.2	1.8	-0.5	-1.0	-0.5	-0.0	0.9
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.8	-0.6	1.3	-0.5	-0.0	1.4	-1.0
Past tobacco smoking	0.4	0.8	2.3	-1.5	-0.1	-0.1	0.2	0.6	1.3
Hearing difficulty/problems with background noise	0.4	0.6	0.9	-0.6	-0.9	0.9	-0.8	0.8	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	3.2	1.4	-0.6	-1.8	0.4	0.5	-0.6
Financial difficulties in last 2 years	0.4	0.6	1.6	1.3	-0.1	0.3	0.2	-0.8	-1.0
Mouth/teeth dental problems	0.4	0.7	1.8	-1.3	0.1	0.7	0.3	1.3	0.1
Falls in the last year	0.4	0.5	2.2	0.3	1.5	0.2	0.7	-0.3	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.9	-0.7	0.5	0.6	0.9	0.4	0.9
Peak expiratory flow (PEF)	0.4	0.9	3.0	-1.7	0.5	1.5	-0.1	-0.6	-0.0
Arm fat-free mass (right)	0.4	2.1	5.0	-0.7	-0.7	2.2	1.2	-2.1	-0.6
Number of children fathered	0.4	0.5	1.1	1.0	-0.7	0.0	0.2	-0.6	0.9
Arm predicted mass (right)	0.4	2.0	4.7	-0.8	-1.0	1.9	1.0	-2.2	-0.9
Number of full sisters	0.4	0.5	1.5	-0.4	0.4	1.2	0.9	0.1	0.7
Had major operations	0.4	0.4	0.9	-1.0	0.8	-0.7	0.3	-0.1	-0.8
Family relationship satisfaction	0.4	0.5	2.9	-0.0	-1.7	-0.2	-0.3	-0.1	-0.2
Leg pain on walking	0.4	0.5	1.2	1.1	-0.4	-0.7	0.8	-0.5	0.1
Smoking status: Previous	0.4	0.6	1.4	1.2	0.4	-0.9	-0.6	-0.1	-1.0
Medication: Paracetamol	0.4	0.6	0.9	-0.5	-0.9	0.7	0.4	0.9	0.9
Medication: Atorvastatin	0.4	0.6	1.3	-0.9	0.1	1.1	-0.4	0.0	1.1
Arm fat-free mass (left)	0.4	2.2	6.0	-0.6	-0.9	1.8	0.8	-2.4	-1.4
Basal cell carcinoma (self-reported)	0.4	0.5	1.8	1.4	-0.4	0.8	0.1	0.5	-0.1
Arm predicted mass (left)	0.4	1.8	5.3	-0.4	-0.9	1.6	0.7	-2.3	-1.2
Alzheimer’s Disease (including proxy)	0.3	0.4	1.8	0.3	-0.1	-0.3	0.7	0.0	1.4
Schizophrenia (2014)	0.3	0.7	2.8	0.9	1.7	-0.5	-0.5	0.2	-0.5
Blood Eosinophil Count	0.3	2.2	5.7	-0.6	0.5	2.4	1.6	-1.1	1.8
Blood White Count	0.3	2.3	4.8	0.5	1.2	1.9	1.5	1.2	2.2
Hypothyroidism (self reported)	0.3	0.6	2.1	1.4	1.1	0.2	-0.1	0.6	-0.4
Neuroticism	0.3	0.8	3.0	1.7	0.8	-0.1	-0.2	-0.5	1.0
Hearing difficulty/problems: Yes	0.3	0.4	1.2	0.7	-0.8	0.3	-0.1	0.3	1.1
Relative age of first facial hair	0.3	0.7	1.9	-0.3	0.3	-0.4	0.6	-1.3	1.4
High blood pressure (mother)	0.3	0.4	0.7	-0.8	0.8	-0.1	-0.7	0.8	-0.1
Allergy	0.3	0.8	2.1	-0.3	-1.4	0.6	-0.0	-1.4	0.4
Time employed in main current job	0.3	0.4	1.3	1.1	-0.6	-0.5	0.1	0.6	-0.1
Tense / ‘highly strung’	0.3	0.5	1.7	-0.4	0.7	-0.4	0.7	1.3	0.4
Medication: Paracetamol	0.3	0.4	1.2	0.2	-0.3	0.4	-0.4	1.1	0.9
Pulse wave peak to peak time	0.3	0.4	1.8	0.0	0.2	0.0	-0.0	-1.3	-0.8
Mean time to correctly identify matches	0.3	0.5	1.7	0.3	-1.3	-0.0	-1.1	-0.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.1	-0.9	0.1	0.5	-0.1	-1.5	-0.5
Whole body fat-free mass	0.3	1.7	4.9	-0.5	-1.1	1.2	-0.1	-2.2	-1.6
Whole body water mass	0.3	1.8	5.0	-0.6	-1.1	1.3	-0.1	-2.2	-1.6
Guilty feelings	0.3	0.4	1.2	1.1	0.6	-0.3	0.3	0.4	0.8
Unable to work because of sickness or disability	0.3	0.4	1.5	-0.3	0.1	0.3	0.2	1.2	0.9
Worry (Nagel 2018)	0.2	0.5	1.4	-0.1	0.1	-0.8	0.0	1.2	0.9
Crohns Disease (2017)	0.2	0.4	1.5	0.0	0.8	-0.4	-0.0	0.2	-1.2
Age at First Birth	0.2	0.3	0.9	-0.7	-0.9	-0.2	-0.1	0.1	-0.6
Heel T-Score	0.2	1.7	4.2	2.0	1.3	-0.3	1.9	-0.7	-0.1
Respiratory disease	0.2	0.4	0.7	0.5	-0.8	-0.3	-0.8	0.8	-0.3
Tanning	0.2	1.9	8.8	0.7	3.0	1.1	0.7	0.0	-0.6
Sensitivity / hurt feelings	0.2	0.3	1.0	0.1	1.0	0.3	0.1	-0.7	-0.2
Medication: Co-codamol	0.2	0.2	0.6	-0.6	0.2	-0.3	0.5	0.8	-0.2
Impedance of leg (right)	0.2	0.8	1.9	-1.0	-0.8	-1.0	-0.3	-1.4	0.3
Relative age voice broke	0.2	0.3	0.6	0.6	0.7	0.0	0.5	-0.1	0.8
Medication: Levothyroxine sodium	0.2	0.4	1.1	1.1	0.1	0.6	-0.5	0.5	0.5
Impedance of leg (left)	0.2	0.9	2.8	-1.3	-0.7	-0.1	-0.2	-1.7	0.6
Waist circumference	0.2	0.7	2.1	1.3	0.0	-0.7	0.3	-0.1	-1.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.9	-1.2	-0.5	1.4	-0.3	-1.0	-0.0
Illnesses of mother	0.2	0.2	0.5	0.5	-0.7	0.3	0.6	0.0	-0.1
Pulse wave Arterial Stiffness index	0.2	0.3	1.4	-0.0	-0.2	0.0	0.1	1.2	0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.4	1.2	-0.0	0.8	-0.4	0.1	0.4
Wheeze or whistling in the chest in last year	0.2	0.4	2.3	0.3	-0.2	0.0	-0.1	-1.5	0.0
Age at first live birth	0.2	0.4	0.7	0.3	0.8	-0.8	-0.4	-0.3	-0.6
Medication: Seretide 50 evohaler	0.2	0.3	0.9	-0.1	-0.6	-0.5	-0.9	0.4	-0.1
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.6	0.7	-0.7	0.6	-0.5	-0.2	0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.7	-0.0	0.9	0.0	0.2	0.1	0.6
Commuting to job workplace: Walk	0.2	0.2	0.5	-0.6	0.4	-0.2	-0.1	0.7	-0.0
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.5	-0.1	-0.2	0.2	-0.4	-0.3
Blood Platelet Count	0.1	1.6	3.6	-1.6	-1.9	-1.4	-0.3	0.0	-1.3
Chronotype (morning person)	0.1	0.2	0.9	-0.1	-0.4	-0.0	-0.4	-1.0	-0.0
Forced vital capacity (FVC)	0.1	0.5	1.5	-0.2	-1.0	1.2	-0.3	-0.6	-0.1
Asthma	0.1	0.2	0.6	-0.5	0.8	-0.6	-0.2	0.2	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.0	-0.9	0.1	1.0	-0.2	-0.8	-0.0
Forced vital capacity (FVC), Best measure	0.1	0.3	0.7	-0.4	-0.3	0.8	-0.6	-0.7	-0.2
Exposure to tobacco smoke outside home	0.1	0.1	0.3	-0.2	0.2	-0.1	-0.0	-0.2	-0.5
Asthma (self-reported)	0.1	0.2	0.5	-0.4	0.7	-0.6	-0.3	0.3	0.2
Hair Pigment	0.0	1.2	5.6	0.1	0.5	0.6	2.4	0.9	0.0

Hub : Genes

GRB14

Models

Trait associations