Hub : Genes

GRB14

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0410	0.0180	0.0048	0.002	0.016	0.002	0.016	0.008	1.9e-01	0.0038	0.1600	0.0045	0.03100
2	GTEx	Artery Tibial	0.1150	0.0488	0.0097	0.004	NA	0.000	NA	0.002	1.5e-01	NA	0.3400	NA	0.19000
3	GTEx	Esophagus Muscularis	0.1370	0.0530	0.0022	0.089	NA	0.028	NA	0.060	4.5e-06	NA	0.0077	NA	0.00016
4	METSIM	Adipose	0.0350	0.0160	0.0060	-0.002	0.008	-0.001	0.008	-0.001	8.6e-01	0.0170	0.6100	0.0160	0.59000
5	ROSMAP	Brain Pre-frontal Cortex	0.0725	0.0277	0.0010	-0.001	0.011	0.002	0.012	0.000	3.9e-01	0.0110	0.1500	0.0096	0.34000
6	TCGA	Colon Adenocarcinoma	0.0880	0.0420	0.0018	0.015	0.034	0.018	NA	0.021	4.5e-02	0.0046	0.0320	NA	0.02100

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.5	0.8	2.2	0.6	-0.2	-1.4	0.2	-0.6	-1.5
Bipolar Disorder or Schizophrenia	0.4	1.1	2.6	0.6	1.1	-1.3	0.5	0.4	-1.6
Depressed Affect (Nagel 2018)	2.1	4.3	12.2	3.5	1.6	0.8	1.0	0.5	3.0
Depression (Nagel 2018)	2.4	3.6	8.9	2.7	1.5	0.2	0.5	1.7	3.0
Intelligence (Savage-Jansen 2018)	2.7	8.2	16.8	-3.9	-2.3	-1.0	-4.1	-2.2	-2.5
Neuroticism (Nagel 2018)	0.6	1.3	4.7	1.6	0.6	0.1	0.2	0.3	2.2
Schizophrenia (2018)	0.4	0.9	2.7	0.3	1.6	-0.6	0.5	1.0	-0.9
Schizophrenia vs Biploar Disorder	0.7	0.9	4.2	-0.6	-0.5	2.0	0.2	-0.6	0.3
Worry (Nagel 2018)	0.2	0.5	1.4	-0.1	0.1	-0.8	0.0	1.2	0.9
Alzheimer’s Disease (in mother)	0.6	0.7	2.3	1.5	0.5	-0.3	0.6	0.6	0.8
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.5	-0.1	-0.2	0.2	-0.4	-0.3
Alzheimer’s Disease (including proxy)	0.3	0.4	1.8	0.3	-0.1	-0.3	0.7	0.0	1.4
Crohns Disease (2017)	0.2	0.4	1.5	0.0	0.8	-0.4	-0.0	0.2	-1.2
Irritable Bowel Disease (IBD)	0.4	1.0	3.5	0.2	1.9	0.6	1.5	-0.2	-0.2
Ulcerative Colitis (UC)	0.7	1.4	3.6	0.2	1.9	0.7	1.9	-0.7	0.4
Major Depression (MDD)	1.8	2.2	7.3	2.3	0.4	-0.4	-0.1	2.7	0.5
Reaction Time	0.4	0.8	2.2	0.7	-1.3	0.3	-1.5	-0.1	0.1
Verbal and Numeric Reasoning (VNR)	2.2	5.3	11.6	-3.4	-1.1	-1.1	-3.1	-0.7	-2.7
Breast Cancer	0.9	2.3	4.7	-0.6	-1.7	1.0	-0.2	-2.2	-2.1
Ovarian Cancer	1.8	2.4	9.6	-0.9	-0.6	-0.7	-1.7	0.2	-3.1
Prostate Cancer	0.6	0.9	3.9	-0.4	0.5	2.0	0.8	0.2	0.4
Age at First Birth	0.2	0.3	0.9	-0.7	-0.9	-0.2	-0.1	0.1	-0.6
Bipolar Disorder (2011)	0.8	0.7	1.7	-1.1	-0.7	-1.3	-0.7	-0.6	-0.3
Body Mass Index (BMI) (2010)	2.2	3.1	6.9	2.3	1.0	-2.1	-0.5	0.4	-2.6
Coronary Artery Disease (CAD)	1.2	1.5	3.0	0.3	1.7	1.0	1.6	1.2	1.0
Crohns Disease (2012)	0.9	1.5	3.8	1.4	1.9	-0.4	-0.1	1.5	-0.8
Mean Putamen Volume	0.5	0.6	1.6	0.9	-0.4	0.3	0.8	1.3	-0.4
Fasting Glucose	0.9	1.1	4.2	-0.7	2.1	0.6	0.9	-0.8	0.4
HbA1C	2.2	2.4	5.6	-1.1	1.4	2.4	0.7	0.9	2.1
HDL Cholesterol	6.0	10.0	38.1	0.2	-1.4	-6.2	-3.1	0.4	-3.2
LDL Cholesterol	1.8	2.9	7.1	-2.1	0.1	1.9	2.7	0.3	1.6
Lupus	0.4	0.5	1.4	0.8	-0.1	-0.4	-1.0	0.2	-1.2
Neuroticism (2016)	0.8	1.2	4.7	2.2	0.6	-0.2	0.1	0.5	1.3
Primary Biliary Cirrhosis	1.3	1.9	3.1	1.3	1.8	1.7	1.5	-0.8	0.8
Rheumatoid Arthritis	0.7	1.0	3.5	0.9	0.4	-0.7	-1.9	0.8	-0.7
Schizophrenia (2014)	0.3	0.7	2.8	0.9	1.7	-0.5	-0.5	0.2	-0.5
Triglycerides	6.0	9.8	29.7	-0.9	1.6	5.5	3.9	-0.4	3.1
Type 2 Diabetes (T2D) (2012)	2.1	2.4	4.9	0.7	-0.0	1.9	1.8	1.6	2.2
Ulcerative Colitis	1.4	2.0	8.5	-0.1	2.9	0.6	1.8	-0.2	0.1
Blood Eosinophil Count	0.3	2.2	5.7	-0.6	0.5	2.4	1.6	-1.1	1.8
Blood Platelet Count	0.1	1.6	3.6	-1.6	-1.9	-1.4	-0.3	0.0	-1.3
Blood Red Count	1.7	16.2	43.6	-0.6	2.3	5.2	3.9	2.4	6.6
Blood White Count	0.3	2.3	4.8	0.5	1.2	1.9	1.5	1.2	2.2
Heel T-Score	0.2	1.7	4.2	2.0	1.3	-0.3	1.9	-0.7	-0.1
BMI	2.0	11.8	28.8	0.1	-1.5	-4.8	-3.4	-2.2	-5.4
Height	0.4	8.2	16.6	-2.9	-4.1	0.8	-2.7	-3.9	-1.1
Waist Hip Ratio (WHR)	12.2	54.9	123.2	0.4	4.1	11.1	8.9	4.2	9.6
Systolic Blood Pressure	1.8	9.1	28.6	-2.7	1.6	5.3	0.2	3.8	1.5
Smoking Status	0.4	1.0	4.4	0.8	-0.7	0.5	0.6	-2.1	-0.3
Allergy or Eczema	0.8	2.0	6.5	0.0	1.8	-0.9	0.8	2.5	-1.0
Cardiovascular Disease	0.9	3.1	7.4	-1.6	1.4	2.7	-0.1	2.1	1.5
Hypothyroidism (self reported)	0.3	0.6	2.1	1.4	1.1	0.2	-0.1	0.6	-0.4
Respiratory disease	0.2	0.4	0.7	0.5	-0.8	-0.3	-0.8	0.8	-0.3
Type 2 Diabetes (T2D) (2018)	6.0	11.2	26.8	-1.3	0.6	5.2	4.4	0.0	4.3
Lung FEV1/FVC ratio	0.5	2.6	9.9	-3.1	1.1	0.2	-0.6	-2.0	-0.1
Lung FVC	0.7	3.6	8.9	1.6	1.9	0.4	1.6	3.0	1.8
Neuroticism	0.3	0.8	3.0	1.7	0.8	-0.1	-0.2	-0.5	1.0
Chronotype (morning person)	0.1	0.2	0.9	-0.1	-0.4	-0.0	-0.4	-1.0	-0.0
Hair Pigment	0.0	1.2	5.6	0.1	0.5	0.6	2.4	0.9	0.0
Tanning	0.2	1.9	8.8	0.7	3.0	1.1	0.7	0.0	-0.6
Hand grip strength (left)	1.1	2.9	5.6	-2.4	0.2	2.3	1.8	-1.2	1.4
Number of treatments/medications taken	1.0	1.8	4.8	0.3	1.8	0.3	-0.1	2.2	1.7
Average weekly spirits intake	2.9	3.6	5.7	2.1	1.3	-0.8	2.2	2.4	1.9
Sensitivity / hurt feelings	0.2	0.3	1.0	0.1	1.0	0.3	0.1	-0.7	-0.2
Frequency of depressed mood in last 2 weeks	2.0	2.8	11.4	1.7	0.5	0.8	0.5	1.2	3.4
Hearing difficulty/problems: Yes	0.3	0.4	1.2	0.7	-0.8	0.3	-0.1	0.3	1.1
Relative age of first facial hair	0.3	0.7	1.9	-0.3	0.3	-0.4	0.6	-1.3	1.4
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.2	-1.0	1.8	1.1	1.1	-0.9	-0.6
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.1	1.0	-0.6	0.8	0.5	-0.5	0.5
Ever had hysterectomy (womb removed)	1.3	1.4	5.0	-0.2	-1.0	1.2	0.7	-0.8	2.2
Systolic blood pressure, automated reading	1.2	3.5	11.7	0.0	1.5	2.1	0.3	3.4	1.6
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	5.1	-0.8	0.3	0.4	2.0	1.8	2.3
Angina	0.6	0.8	1.7	-0.6	0.8	1.3	1.1	0.9	0.5
Medication for hormone replacement therapy	0.6	0.6	2.4	-0.1	-0.1	0.7	-0.6	-1.5	-0.6
Vitamin and mineral supplements	0.4	0.6	1.6	0.4	1.1	0.0	0.6	1.3	-0.2
Supplements: Zinc	1.2	1.3	3.2	-1.6	-1.8	-0.8	-0.2	-0.7	-0.9
Medication: Co-codamol	0.2	0.2	0.6	-0.6	0.2	-0.3	0.5	0.8	-0.2
Medication: Metformin	3.7	5.2	10.9	-0.3	1.3	3.3	3.0	1.1	2.9
Diabetes (father)	1.3	1.6	4.6	-2.2	0.2	1.9	0.4	-0.3	1.0
Diabetes (mother)	2.9	3.8	10.9	-0.3	0.8	2.2	2.5	-0.2	3.3
Severe depression (siblings)	1.2	1.4	5.4	-0.7	0.6	-2.3	-0.4	0.3	-1.3
Pack years adult smoking proportion	0.7	1.1	3.4	-0.3	0.7	0.6	0.8	1.2	1.8
Impedance of leg (right)	0.2	0.8	1.9	-1.0	-0.8	-1.0	-0.3	-1.4	0.3
Leg fat-free mass (left)	1.0	5.2	14.7	-0.1	-1.8	-2.2	-2.3	-1.8	-3.8
Trunk fat percentage	8.1	32.5	94.7	0.2	-3.1	-9.7	-5.8	-1.3	-7.4
Hand grip strength (right)	0.5	1.3	4.4	-2.1	-0.1	1.3	1.1	-0.4	0.3
Townsend deprivation index at recruitment	0.8	1.1	5.2	2.3	0.5	1.0	0.6	-0.0	-0.0
Current tobacco smoking	0.6	0.9	2.4	0.2	-0.8	1.6	0.2	-1.4	0.8
Average weekly fortified wine intake	1.4	1.7	4.2	1.5	2.0	-0.6	1.4	0.9	-0.2
Maternal smoking around birth	1.4	2.0	5.4	-0.3	-2.3	1.3	-1.1	-2.0	0.1
Fed-up feelings	2.3	4.1	10.2	3.2	1.2	1.4	1.8	0.9	2.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	3.0	1.3	1.3	-0.1	0.8	1.3	1.7
Relative age voice broke	0.2	0.3	0.6	0.6	0.7	0.0	0.5	-0.1	0.8
Taking other prescription medications	0.5	0.8	2.5	0.7	1.2	-0.2	-0.3	1.6	-0.3
Age when periods started (menarche)	0.4	0.9	3.2	1.8	-0.5	-1.0	-0.5	-0.0	0.9
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	7.6	-0.3	-0.5	0.7	-0.0	0.5	2.8
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	4.5	2.1	-0.9	-1.1	0.4	0.1	-0.4
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.6	-1.3	-0.4	-0.0	0.5	-0.7	-1.6
Qualifications: CSEs or equivalent	0.9	1.2	2.2	1.5	0.9	0.6	1.1	1.3	0.9
Serious illness, injury or assault to yourself	0.6	0.7	2.7	-1.0	0.4	-0.2	0.5	-1.6	0.4
High blood pressure	0.6	1.7	5.8	-1.0	1.4	1.1	-0.1	2.4	0.6
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.8	-0.6	1.3	-0.5	-0.0	1.4	-1.0
Multivitamins +/- minerals	1.0	1.3	2.9	-1.0	-1.6	-0.5	0.0	-1.1	1.7
Stomach or abdominal pain in last month	0.7	0.9	3.5	1.9	-0.2	-0.6	-0.6	1.0	-0.5
Supplements: Glucosamine	0.8	1.0	4.5	2.1	-0.3	-1.0	0.6	0.1	-0.2
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	4.1	-2.0	-1.3	-0.7	-0.5	-0.4	0.1
Medication: Atenolol	2.3	2.8	5.2	1.1	1.0	0.9	2.2	2.0	2.3
Medication: Levothyroxine sodium	0.2	0.4	1.1	1.1	0.1	0.6	-0.5	0.5	0.5
Sitting height	1.2	8.7	21.6	-2.5	-3.9	0.0	-1.5	-4.7	-2.6
Chronic bronchitis/emphysema (father)	0.8	1.0	2.2	1.1	0.4	-0.5	-0.8	1.5	1.1
High blood pressure (mother)	0.3	0.4	0.7	-0.8	0.8	-0.1	-0.7	0.8	-0.1
Body mass index (BMI)	1.8	7.6	22.4	1.2	-0.9	-4.7	-2.3	-0.2	-4.0
Impedance of leg (left)	0.2	0.9	2.8	-1.3	-0.7	-0.1	-0.2	-1.7	0.6
Leg predicted mass (left)	1.0	5.2	14.6	-0.0	-1.8	-2.2	-2.3	-1.7	-3.8
Trunk fat mass	5.6	23.9	64.0	-0.0	-2.9	-8.0	-4.9	-1.8	-6.6
Waist circumference	0.2	0.7	2.1	1.3	0.0	-0.7	0.3	-0.1	-1.4
Number of incorrect matches in round	1.0	1.6	2.7	1.6	0.3	1.4	-0.7	1.5	1.5
Past tobacco smoking	0.4	0.8	2.3	-1.5	-0.1	-0.1	0.2	0.6	1.3
Alcohol usually taken with meals	2.2	3.6	8.3	-1.8	-0.5	-1.1	-2.0	-2.9	-2.1
Nervous feelings	0.6	1.0	3.0	-0.8	0.0	-1.7	0.0	1.6	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.4	0.8	0.5	-1.4	-0.6	1.0	1.9
Hearing difficulty/problems with background noise	0.4	0.6	0.9	-0.6	-0.9	0.9	-0.8	0.8	0.3
Hair/balding pattern: Pattern 2	1.0	1.3	3.9	-0.0	-0.7	-0.4	0.0	-2.0	-1.7
Had menopause	1.6	2.0	4.9	-0.8	-0.4	-2.2	-0.8	-1.1	-2.1
Had other major operations	0.9	1.1	2.8	-1.1	-1.7	-0.5	-0.4	-1.0	-1.2
Forced vital capacity (FVC)	0.1	0.5	1.5	-0.2	-1.0	1.2	-0.3	-0.6	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	3.2	1.4	-0.6	-1.8	0.4	0.5	-0.6
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	5.4	1.1	0.4	0.6	1.5	0.8	2.3
Qualifications: None of the above	1.8	3.9	6.2	2.5	2.0	1.6	2.0	2.1	1.5
Financial difficulties in last 2 years	0.4	0.6	1.6	1.3	-0.1	0.3	0.2	-0.8	-1.0
Mouth/teeth dental problems	0.4	0.7	1.8	-1.3	0.1	0.7	0.3	1.3	0.1
Heart attack	1.4	1.8	3.7	1.2	1.8	-0.1	1.4	1.9	0.9
Allergy	0.3	0.8	2.1	-0.3	-1.4	0.6	-0.0	-1.4	0.4
Pain all over the body in last month	0.8	0.8	2.0	-1.4	0.1	-1.1	-1.1	0.3	-0.6
Diabetes (self-reported)	2.6	4.0	8.2	-1.0	1.0	2.8	2.9	0.4	2.5
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.6	0.2	1.4	-1.6	-0.5	0.8	-0.8
Medication: Ramipril	1.2	1.5	5.1	0.6	0.8	0.8	0.2	1.5	2.3
Medication: Simvastatin	3.4	5.0	9.0	1.4	2.3	3.0	2.0	2.4	1.9
Fluid intelligence score	1.7	3.5	7.2	-2.7	-1.5	-0.6	-1.9	-1.6	-2.3
Illnesses of siblings	0.5	0.7	1.4	0.9	-0.1	0.2	1.2	-1.1	-0.9
Neuroticism score	0.7	1.4	4.9	2.2	1.2	-0.2	0.1	0.6	1.2
Weight	2.2	11.1	26.9	-0.1	-2.3	-4.4	-3.2	-2.2	-5.2
Impedance of arm (right)	4.6	21.3	47.5	-1.3	-2.8	-6.9	-6.6	-1.1	-5.0
Arm fat percentage (right)	6.3	24.9	71.2	1.1	-2.5	-8.4	-5.5	-0.6	-6.3
Trunk fat-free mass	0.5	2.6	9.5	-0.7	-0.5	3.1	1.0	-2.1	-0.3
Hip circumference	6.8	29.3	65.4	0.6	-3.4	-7.6	-5.6	-3.0	-8.1
Time employed in main current job	0.3	0.4	1.3	1.1	-0.6	-0.5	0.1	0.6	-0.1
Alcohol intake versus 10 years previously	1.8	2.7	6.3	1.4	0.3	1.8	2.1	-0.4	2.5
Father’s age at death	1.4	1.9	5.0	-1.1	0.3	-2.1	-0.9	-0.5	-2.2
Worrier / anxious feelings	0.7	1.4	2.7	1.3	-0.2	-1.1	-1.6	-0.4	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	5.5	-1.0	0.2	0.6	0.2	-0.8	2.3
Falls in the last year	0.4	0.5	2.2	0.3	1.5	0.2	0.7	-0.3	0.2
Hair/balding pattern: Pattern 3	2.6	3.9	9.2	1.6	3.0	1.6	0.5	2.7	1.2
Number of live births	1.6	2.2	4.4	-2.0	-0.5	-0.9	-2.1	-0.6	-1.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.9	-1.2	-0.5	1.4	-0.3	-1.0	-0.0
Pulse rate	1.0	1.7	3.7	0.3	-0.2	1.9	1.8	-0.7	1.7
Happiness	0.6	0.7	1.3	1.2	-0.4	-0.8	-0.8	1.0	0.7
Noisy workplace	0.5	0.6	1.2	1.1	-0.1	-1.0	0.6	0.9	0.3
Qualifications: A levels/AS levels or equivalent	0.7	1.5	3.6	-1.5	-0.5	-0.7	-1.1	-1.1	-1.9
Serious illness, injury or assault of a close relative in last 2 years	2.7	3.1	5.9	-2.3	-2.4	-1.3	-1.1	-2.1	-0.4
Mouth/teeth dental problems: Dentures	1.2	2.0	3.1	1.6	1.0	1.8	1.6	-0.6	1.6
Asthma	0.1	0.2	0.6	-0.5	0.8	-0.6	-0.2	0.2	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.9	-0.7	0.5	0.6	0.9	0.4	0.9
Medication: Cholesterol lowering	1.3	2.1	5.0	0.3	1.7	1.1	1.0	2.2	1.4
Depression (self-reported)	0.9	1.0	2.5	0.1	0.1	-1.1	-1.5	1.6	0.5
Medication: Lansoprazole	1.4	1.6	7.8	-0.0	0.2	-1.2	-0.1	2.8	0.0
Prospective memory result	1.0	1.2	2.9	0.5	1.1	1.7	1.6	0.1	0.7
Lung cancer (father)	0.5	0.6	1.4	-0.2	-1.2	0.8	-0.6	-0.3	1.1
Illnesses of mother	0.2	0.2	0.5	0.5	-0.7	0.3	0.6	0.0	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.0	-0.9	0.1	1.0	-0.2	-0.8	-0.0
Pulse wave Arterial Stiffness index	0.2	0.3	1.4	-0.0	-0.2	0.0	0.1	1.2	0.5
Impedance of arm (left)	4.6	21.4	51.3	-1.5	-2.8	-7.2	-6.5	-0.6	-4.9
Arm fat mass (right)	4.1	16.8	42.6	0.6	-2.4	-6.5	-4.2	-1.2	-5.7
Trunk predicted mass	0.5	2.7	9.7	-0.6	-0.5	3.1	1.0	-2.2	-0.2
Standing height	0.9	8.5	20.3	-3.0	-2.9	0.7	-2.1	-4.5	-2.9
Length of working week for main job	1.0	1.2	3.5	-1.5	-1.9	0.3	-0.4	-0.9	0.3
Exposure to tobacco smoke at home	0.5	0.5	1.6	0.3	0.9	-0.5	-0.6	-0.3	-1.2
Breastfed as a baby	0.9	1.1	1.9	1.4	1.2	0.7	0.5	-1.1	-1.0
Tense / ‘highly strung’	0.3	0.5	1.7	-0.4	0.7	-0.4	0.7	1.3	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	4.9	0.7	-0.8	-1.6	-1.4	2.2	0.9
Hair/balding pattern: Pattern 4	0.5	1.2	4.4	-0.9	-0.4	-0.9	2.1	0.2	1.1
Birth weight of first child	3.0	5.5	11.8	2.3	1.9	3.4	2.9	0.1	1.9
Peak expiratory flow (PEF)	0.4	0.9	3.0	-1.7	0.5	1.5	-0.1	-0.6	-0.0
Pulse wave reflection index	1.2	1.5	6.2	1.3	1.0	-0.1	-0.2	2.5	0.4
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.6	1.6	0.5	-1.2	-1.0	0.9	-1.3
Loud music exposure frequency	1.0	1.1	2.0	-0.7	-1.4	0.1	-0.8	-1.1	-1.4
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	6.7	-1.3	-0.8	-1.1	-1.5	-1.6	-2.6
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	4.1	0.3	-0.8	-1.3	-2.0	-1.8	-1.6
Blood clot in the leg (DVT)	0.8	1.0	3.2	-1.0	0.7	-0.3	0.6	-0.9	-1.8
Medication: Paracetamol	0.3	0.4	1.2	0.2	-0.3	0.4	-0.4	1.1	0.9
Headache pain in last month	2.0	3.5	4.9	1.5	1.6	1.6	2.2	2.1	2.1
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	4.7	0.4	-2.2	-1.1	-1.0	-2.2	-0.9
Glaucoma (self-reported)	5.7	6.7	13.7	-3.7	-2.5	-2.6	-3.2	-0.5	-1.7
Gout (self-reported)	1.1	1.5	6.6	-0.7	0.0	2.6	0.7	-0.4	1.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.4	1.2	-0.0	0.8	-0.4	0.1	0.4
Medication: Amlodipine	1.0	1.4	6.3	0.6	0.7	-0.2	-0.4	2.5	1.1
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.4	-1.5	-0.6	-0.4	-0.0	-1.1	0.6
Birth weight	0.6	1.4	4.2	1.4	1.0	-0.8	-0.2	0.4	-2.0
Chronic bronchitis/emphysema (mother)	1.7	2.0	7.4	0.2	-1.4	-1.4	-2.7	-0.4	-0.6
High blood pressure (siblings)	0.7	1.0	3.1	-1.8	-0.5	-0.0	-1.1	1.1	0.3
Forced vital capacity (FVC), Best measure	0.1	0.3	0.7	-0.4	-0.3	0.8	-0.6	-0.7	-0.2
Body fat percentage	7.0	27.7	82.8	0.5	-3.0	-9.1	-5.3	-1.4	-6.7
Leg fat percentage (right)	3.9	14.1	47.7	1.3	-1.9	-6.9	-2.8	-1.2	-4.7
Arm fat-free mass (right)	0.4	2.1	5.0	-0.7	-0.7	2.2	1.2	-2.1	-0.6
Exposure to tobacco smoke outside home	0.1	0.1	0.3	-0.2	0.2	-0.1	-0.0	-0.2	-0.5
Comparative body size at age 10	0.9	2.4	5.6	0.6	1.4	-1.5	-0.0	2.4	-2.1
Number of full brothers	0.7	0.9	2.4	-0.7	0.3	-1.3	1.0	1.5	-0.1
Worry too long after embarrassment	1.4	2.3	7.6	-0.8	-0.4	-2.1	-2.7	-1.0	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	3.1	0.4	-0.3	-1.8	-0.5	1.1	-0.5
Wheeze or whistling in the chest in last year	0.2	0.4	2.3	0.3	-0.2	0.0	-0.1	-1.5	0.0
Number of children fathered	0.4	0.5	1.1	1.0	-0.7	0.0	0.2	-0.6	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.3	-0.4	-1.8	-1.7	-1.1	0.3	-0.3
Age at first live birth	0.2	0.4	0.7	0.3	0.8	-0.8	-0.4	-0.3	-0.6
Pulse wave peak to peak time	0.3	0.4	1.8	0.0	0.2	0.0	-0.0	-1.3	-0.8
Health satisfaction	0.8	1.1	2.2	1.5	0.9	-0.4	0.1	1.4	1.1
Shortness of breath walking on level ground	1.0	1.2	2.6	1.6	0.1	0.7	1.4	-0.7	1.3
Qualifications: College or University degree	0.6	2.0	4.8	-1.5	-0.3	-1.0	-0.9	-1.6	-2.2
Eye problems/disorders: None of the above	0.8	0.9	2.8	1.7	-0.4	0.2	0.7	-0.5	1.3
Mouth/teeth dental problems: Loose teeth	1.1	1.3	4.7	-2.2	0.5	-1.1	-0.5	-1.1	0.5
Emphysema/chronic bronchitis	2.0	2.3	7.2	0.2	-2.7	-0.8	-1.0	-2.1	-0.6
Medication for pain relief, constipation, heartburn	0.6	1.0	3.1	-0.4	-0.6	-0.5	-0.2	-1.4	-1.8
Neck or shoulder pain in last month	1.6	2.3	5.6	1.0	0.1	2.3	1.3	-0.2	2.4
Medication: Blood pressure	1.5	2.7	9.3	0.3	2.5	-0.2	0.6	3.1	-0.2
Angina (self-reported)	0.5	0.7	1.1	-0.6	0.6	1.0	1.0	0.8	0.8
Migraine (self-reported)	0.6	0.7	2.1	-0.5	-0.1	1.5	1.3	0.4	0.3
Medication: Ibuprofen	0.7	0.8	2.8	-1.7	0.3	0.9	1.0	-0.2	0.4
Medication: Allopurinol	0.9	1.1	4.5	0.3	-1.0	2.1	-0.5	-0.6	0.8
Medication: Omeprazole	1.1	1.3	4.2	0.9	0.5	-0.3	0.1	1.6	2.1
Medication: Seretide 50 evohaler	0.2	0.3	0.9	-0.1	-0.6	-0.5	-0.9	0.4	-0.1
Mean time to correctly identify matches	0.3	0.5	1.7	0.3	-1.3	-0.0	-1.1	-0.4	0.1
Heart disease (mother)	0.6	0.8	2.4	0.6	-0.2	0.5	-1.6	0.9	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	4.2	-2.1	-1.0	-0.7	-1.2	0.7	-1.0
Whole body fat mass	4.8	19.8	51.6	0.1	-2.9	-7.2	-4.3	-1.9	-6.1
Leg fat mass (right)	3.4	13.1	37.7	0.7	-2.2	-6.1	-2.8	-1.6	-5.0
Arm predicted mass (right)	0.4	2.0	4.7	-0.8	-1.0	1.9	1.0	-2.2	-0.9
Pulse rate, automated reading	0.5	1.7	3.1	0.2	0.9	1.7	1.8	1.1	1.5
Alcohol intake frequency.	1.2	2.8	5.3	-0.3	1.2	1.6	2.3	1.6	2.2
Comparative height size at age 10	0.5	2.8	5.6	-2.4	-1.7	-0.1	-1.6	-1.1	-2.0
Number of full sisters	0.4	0.5	1.5	-0.4	0.4	1.2	0.9	0.1	0.7
Suffer from ‘nerves’	0.7	1.1	3.6	0.3	0.4	-0.5	0.5	1.4	1.9
Overall health rating	0.5	1.1	2.3	0.9	1.5	-1.0	0.9	1.2	0.6
Chest pain or discomfort	1.1	1.6	6.6	0.9	0.5	1.3	0.4	0.2	2.6
Had major operations	0.4	0.4	0.9	-1.0	0.8	-0.7	0.3	-0.1	-0.8
Age at last live birth	0.5	0.7	2.5	0.7	1.6	-0.1	-0.5	0.4	-1.0
Family relationship satisfaction	0.4	0.5	2.9	-0.0	-1.7	-0.2	-0.3	-0.1	-0.2
Leg pain on walking	0.4	0.5	1.2	1.1	-0.4	-0.7	0.8	-0.5	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.6	5.7	-0.4	0.4	1.6	1.0	-0.4	2.4
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.6	0.7	-0.7	0.6	-0.5	-0.2	0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.7	-0.0	0.9	0.0	0.2	0.1	0.6
Medication: Aspirin	2.0	2.6	5.6	1.4	1.4	1.7	2.4	1.3	1.3
Supplements: Vitamin C	1.8	2.1	6.0	2.0	0.8	-0.4	-0.7	1.2	-2.4
Knee pain experienced in last month	0.6	1.0	2.4	1.3	-0.6	-1.5	-0.2	0.4	-1.0
Hypertension (Self-reported)	0.7	1.8	6.4	-0.6	1.3	1.2	0.2	2.5	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	4.1	0.2	-0.5	-0.4	-0.9	2.0	1.8
Illnesses of father: Heart disease	0.8	1.1	4.5	-0.1	0.7	0.2	-2.1	0.8	1.0
Illnesses of siblings: Diabetes	1.7	2.1	4.3	-2.1	0.2	1.6	1.4	-0.3	1.9
Smoking status: Previous	0.4	0.6	1.4	1.2	0.4	-0.9	-0.6	-0.1	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.1	-0.9	0.1	0.5	-0.1	-1.5	-0.5
Whole body fat-free mass	0.3	1.7	4.9	-0.5	-1.1	1.2	-0.1	-2.2	-1.6
Leg fat-free mass (right)	0.7	3.9	12.0	-0.3	-1.6	-1.3	-2.0	-1.8	-3.5
Arm fat percentage (left)	6.5	26.1	78.0	0.8	-2.3	-8.8	-5.4	-0.3	-6.5
Average weekly red wine intake	1.5	2.2	6.3	-0.7	-0.7	-1.1	-2.5	-1.3	-1.8
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.8	0.9	0.4	-1.3	-0.9	-0.1	-0.3
Mood swings	2.3	4.1	7.9	2.8	2.0	1.4	1.5	1.1	2.7
Loneliness, isolation	0.8	1.2	2.6	1.5	0.2	0.3	1.2	0.7	1.6
Long-standing illness, disability or infirmity	0.6	1.0	3.2	0.0	1.8	0.1	0.5	1.4	0.7
Ever had bowel cancer screening	1.1	1.2	2.7	-1.2	1.6	-1.4	0.3	-0.7	-0.8
Diabetes diagnosed by doctor	4.4	7.3	15.5	-0.9	1.3	3.7	3.9	1.1	3.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.5	-0.9	-1.2	-0.6	-0.2	-0.7	-1.2
Friendships satisfaction	0.9	1.1	3.2	-0.3	-1.8	-1.0	-1.5	-0.2	-0.3
Qualifications: nursing, teaching	1.5	2.3	5.6	-1.3	-1.8	0.3	-1.4	-2.4	-1.1
Commuting to job workplace: Walk	0.2	0.2	0.5	-0.6	0.4	-0.2	-0.1	0.7	-0.0
Eye problems/disorders: Cataract	1.2	1.3	3.2	-1.8	0.3	0.1	-1.2	-0.3	-1.7
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.1	-0.7	-0.5	-1.5	-2.0	0.3	-1.6
Medication for cholesterol	1.3	2.0	5.1	1.7	0.3	-2.3	0.7	1.0	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.8	-0.7	-0.7	-0.9	-0.9	-1.4	-0.7
Back pain experienced in last month	0.8	1.1	2.2	0.6	1.5	0.3	1.5	-0.2	1.3
Mineral and other dietary supplements	0.7	1.0	1.7	-1.1	0.7	0.2	1.1	1.1	1.3
Breast cancer (self-reported)	0.6	0.8	2.6	0.5	-1.2	-0.2	-0.1	-1.6	-0.4
Asthma (self-reported)	0.1	0.2	0.5	-0.4	0.7	-0.6	-0.3	0.3	0.2
Osteoporosis (self-reported)	0.5	0.6	2.8	-0.1	0.0	-0.8	-0.6	-0.2	-1.7
Osteoarthritis (self-reported)	0.9	1.2	1.7	1.1	0.9	1.1	1.0	1.3	1.1
Medication: Aspirin	1.9	2.5	5.6	1.0	1.4	1.7	2.4	1.1	1.5
Medication: Gliclazide	4.3	4.8	14.2	0.3	0.4	2.9	3.8	0.2	2.4
Illnesses of father: None of the above (group 1)	1.3	1.6	5.0	2.0	-0.6	0.0	2.2	-0.4	0.5
Smoking status: Current	0.5	0.7	1.6	0.4	-0.9	1.3	-0.0	-1.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	4.7	0.5	0.0	0.9	0.5	-0.8	2.2
Whole body water mass	0.3	1.8	5.0	-0.6	-1.1	1.3	-0.1	-2.2	-1.6
Leg predicted mass (right)	0.7	3.8	11.6	-0.4	-1.6	-1.2	-1.9	-1.8	-3.4
Arm fat mass (left)	3.8	15.4	42.2	0.5	-2.1	-6.5	-3.9	-1.0	-5.5
Number of self-reported non-cancer illnesses	0.8	1.3	4.8	0.7	1.6	0.1	-0.3	2.2	0.4
Average weekly champagne plus white wine intake	2.8	3.9	6.9	-1.7	-2.5	-1.6	-1.8	-1.3	-2.6
Miserableness	0.8	1.4	3.8	1.6	0.8	0.4	-1.1	0.1	1.9
Guilty feelings	0.3	0.4	1.2	1.1	0.6	-0.3	0.3	0.4	0.8
Wears glasses or contact lenses	0.7	0.8	2.2	-1.0	-0.1	-0.8	-0.1	-1.0	-1.5
Ever taken oral contraceptive pill	0.9	1.1	2.7	-1.6	0.8	0.5	0.9	-0.2	1.4
Hearing aid user	2.6	2.9	6.2	2.5	2.4	0.8	1.4	1.5	0.7
Mother’s age at death	1.4	1.8	4.6	-2.1	0.2	-1.2	-0.8	-1.3	-1.5
Financial situation satisfaction	1.8	2.3	4.4	1.8	0.2	0.3	2.0	1.4	2.1
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.8	-0.5	-1.9	-0.4	-1.6	0.0	1.2
Commuting to job workplace: Public transport	0.5	0.6	1.9	-1.4	-0.1	-0.3	-0.9	-0.7	-0.7
Eye problems/disorders: Glaucoma	4.2	4.9	8.8	-3.0	-1.8	-2.8	-2.6	-0.7	-1.6
Medication: Blood pressure	1.3	2.4	7.4	-0.2	0.1	2.7	0.1	1.1	2.4
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.2	-0.5	-1.1	0.5	0.2	-1.5	0.4
Supplements: Fish oil (including cod liver oil)	0.7	1.0	1.9	0.6	1.0	0.7	-0.8	-1.2	-1.4
High cholesterol (Self-reported)	0.6	1.1	3.4	-1.2	0.5	1.8	0.1	0.2	1.3
Medication: Bendroflumethiazide	0.6	0.9	2.7	-0.8	-0.7	-0.9	0.0	1.6	0.7
Medication: Paracetamol	0.4	0.6	0.9	-0.5	-0.9	0.7	0.4	0.9	0.9
Medication: Lisinopril	0.9	1.2	4.3	-1.1	1.2	2.1	0.3	0.2	0.4
Medication: Atorvastatin	0.4	0.6	1.3	-0.9	0.1	1.1	-0.4	0.0	1.1
Illnesses of father: High blood pressure	3.7	4.6	14.8	-3.9	-1.6	-1.3	-2.5	-0.8	-1.3
Alcohol drinker status: Never	1.1	1.3	4.5	2.1	-0.1	-0.0	0.8	1.0	1.3
Ever smoked	1.1	1.9	7.0	0.7	-0.5	0.6	-0.6	-1.7	-2.6
Basal metabolic rate	0.5	2.6	7.1	-0.4	-1.5	-0.2	-1.0	-2.3	-2.7
Leg fat percentage (left)	3.5	12.8	41.0	1.2	-1.8	-6.4	-2.8	-1.3	-4.6
Arm fat-free mass (left)	0.4	2.2	6.0	-0.6	-0.9	1.8	0.8	-2.4	-1.4
Number of operations (self-reported)	1.0	1.5	3.6	-1.6	0.6	1.9	0.6	-0.8	-1.0
Average weekly beer plus cider intake	1.5	2.1	5.4	1.5	1.5	0.7	1.3	2.3	0.9
Irritability	0.9	1.5	3.2	1.6	-1.0	1.5	-0.4	-1.8	-0.5
Risk taking	0.7	1.0	5.2	-2.3	-0.0	-0.1	-0.5	-0.4	-0.7
Ever had prostate specific antigen (PSA) test	1.8	2.1	5.9	1.1	0.4	-2.4	-0.7	2.2	-0.1
Fractured/broken bones in last 5 years	2.0	2.6	4.5	0.5	1.7	-2.1	-0.9	1.6	-2.1
Age started oral contraceptive pill	2.4	3.0	5.9	-2.3	-2.0	0.7	-0.8	-2.4	-1.2
Diastolic blood pressure, automated reading	0.9	2.6	10.4	1.8	1.5	-0.5	0.1	3.2	0.1
Ever depressed for a whole week	1.6	2.0	4.5	1.6	0.5	-1.4	1.2	2.1	1.1
Unable to work because of sickness or disability	0.3	0.4	1.5	-0.3	0.1	0.3	0.2	1.2	0.9
Commuting to job workplace: Cycle	0.7	0.9	1.8	-1.3	-0.6	-0.6	-1.0	1.3	0.5
Myopia	1.0	1.4	3.2	1.0	1.1	-0.3	0.3	-1.6	-1.8
Vascular/heart problems diagnosed by doctor	0.8	2.1	7.8	1.0	-1.6	-0.9	0.1	-2.8	-0.4
Cholesterol lowering medication	1.4	2.0	7.8	-1.0	0.1	2.8	-0.1	0.1	1.8
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	2.3	0.7	-0.3	-0.3	-0.7	1.5	1.5
Pain experienced in last month	1.3	2.1	4.4	-1.9	-1.2	0.4	-1.4	-2.1	-1.2
Supplements: Calcium	1.4	1.5	4.4	-0.1	-0.8	-1.8	-2.1	-0.7	-0.5
Basal cell carcinoma (self-reported)	0.4	0.5	1.8	1.4	-0.4	0.8	0.1	0.5	-0.1
Heart attack/myocardial infarction (self-reported)	1.5	1.9	4.2	1.2	1.8	-0.2	1.4	2.1	0.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.4	-0.6	0.4	-0.2	0.9	-0.8	-1.6
Heart disease (siblings)	1.0	1.2	2.2	1.4	0.5	0.8	-1.5	0.3	1.4
Alcohol drinker status: Previous	0.6	0.7	1.3	-0.8	-1.0	0.7	1.1	-0.3	-0.8
Pack years of smoking	0.6	0.9	2.5	-0.1	0.8	0.7	0.8	1.0	1.6
Impedance of whole body	1.8	9.2	23.5	-1.4	-1.9	-4.8	-4.2	-0.9	-2.8
Leg fat mass (left)	3.2	12.5	34.2	0.7	-2.1	-5.8	-2.8	-1.7	-5.0
Arm predicted mass (left)	0.4	1.8	5.3	-0.4	-0.9	1.6	0.7	-2.3	-1.2