Hub : Genes

GRB14

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0410 0.0180 0.0048 0.002 0.016 0.002 0.016 0.008 1.9e-01 0.0038 0.1600 0.0045 0.03100
2 GTEx Artery Tibial 0.1150 0.0488 0.0097 0.004 NA 0.000 NA 0.002 1.5e-01 NA 0.3400 NA 0.19000
3 GTEx Esophagus Muscularis 0.1370 0.0530 0.0022 0.089 NA 0.028 NA 0.060 4.5e-06 NA 0.0077 NA 0.00016
4 METSIM Adipose 0.0350 0.0160 0.0060 -0.002 0.008 -0.001 0.008 -0.001 8.6e-01 0.0170 0.6100 0.0160 0.59000
5 ROSMAP Brain Pre-frontal Cortex 0.0725 0.0277 0.0010 -0.001 0.011 0.002 0.012 0.000 3.9e-01 0.0110 0.1500 0.0096 0.34000
6 TCGA Colon Adenocarcinoma 0.0880 0.0420 0.0018 0.015 0.034 0.018 NA 0.021 4.5e-02 0.0046 0.0320 NA 0.02100

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.5 0.8 2.2 0.6 -0.2 -1.4 0.2 -0.6 -1.5
Bipolar Disorder or Schizophrenia 0.4 1.1 2.6 0.6 1.1 -1.3 0.5 0.4 -1.6
Depressed Affect (Nagel 2018) 2.1 4.3 12.2 3.5 1.6 0.8 1.0 0.5 3.0
Depression (Nagel 2018) 2.4 3.6 8.9 2.7 1.5 0.2 0.5 1.7 3.0
Intelligence (Savage-Jansen 2018) 2.7 8.2 16.8 -3.9 -2.3 -1.0 -4.1 -2.2 -2.5
Neuroticism (Nagel 2018) 0.6 1.3 4.7 1.6 0.6 0.1 0.2 0.3 2.2
Schizophrenia (2018) 0.4 0.9 2.7 0.3 1.6 -0.6 0.5 1.0 -0.9
Schizophrenia vs Biploar Disorder 0.7 0.9 4.2 -0.6 -0.5 2.0 0.2 -0.6 0.3
Worry (Nagel 2018) 0.2 0.5 1.4 -0.1 0.1 -0.8 0.0 1.2 0.9
Alzheimer’s Disease (in mother) 0.6 0.7 2.3 1.5 0.5 -0.3 0.6 0.6 0.8
Alzheimer’s Disease (in father) 0.1 0.1 0.2 -0.5 -0.1 -0.2 0.2 -0.4 -0.3
Alzheimer’s Disease (including proxy) 0.3 0.4 1.8 0.3 -0.1 -0.3 0.7 0.0 1.4
Crohns Disease (2017) 0.2 0.4 1.5 0.0 0.8 -0.4 -0.0 0.2 -1.2
Irritable Bowel Disease (IBD) 0.4 1.0 3.5 0.2 1.9 0.6 1.5 -0.2 -0.2
Ulcerative Colitis (UC) 0.7 1.4 3.6 0.2 1.9 0.7 1.9 -0.7 0.4
Major Depression (MDD) 1.8 2.2 7.3 2.3 0.4 -0.4 -0.1 2.7 0.5
Reaction Time 0.4 0.8 2.2 0.7 -1.3 0.3 -1.5 -0.1 0.1
Verbal and Numeric Reasoning (VNR) 2.2 5.3 11.6 -3.4 -1.1 -1.1 -3.1 -0.7 -2.7
Breast Cancer 0.9 2.3 4.7 -0.6 -1.7 1.0 -0.2 -2.2 -2.1
Ovarian Cancer 1.8 2.4 9.6 -0.9 -0.6 -0.7 -1.7 0.2 -3.1
Prostate Cancer 0.6 0.9 3.9 -0.4 0.5 2.0 0.8 0.2 0.4
Age at First Birth 0.2 0.3 0.9 -0.7 -0.9 -0.2 -0.1 0.1 -0.6
Bipolar Disorder (2011) 0.8 0.7 1.7 -1.1 -0.7 -1.3 -0.7 -0.6 -0.3
Body Mass Index (BMI) (2010) 2.2 3.1 6.9 2.3 1.0 -2.1 -0.5 0.4 -2.6
Coronary Artery Disease (CAD) 1.2 1.5 3.0 0.3 1.7 1.0 1.6 1.2 1.0
Crohns Disease (2012) 0.9 1.5 3.8 1.4 1.9 -0.4 -0.1 1.5 -0.8
Mean Putamen Volume 0.5 0.6 1.6 0.9 -0.4 0.3 0.8 1.3 -0.4
Fasting Glucose 0.9 1.1 4.2 -0.7 2.1 0.6 0.9 -0.8 0.4
HbA1C 2.2 2.4 5.6 -1.1 1.4 2.4 0.7 0.9 2.1
HDL Cholesterol 6.0 10.0 38.1 0.2 -1.4 -6.2 -3.1 0.4 -3.2
LDL Cholesterol 1.8 2.9 7.1 -2.1 0.1 1.9 2.7 0.3 1.6
Lupus 0.4 0.5 1.4 0.8 -0.1 -0.4 -1.0 0.2 -1.2
Neuroticism (2016) 0.8 1.2 4.7 2.2 0.6 -0.2 0.1 0.5 1.3
Primary Biliary Cirrhosis 1.3 1.9 3.1 1.3 1.8 1.7 1.5 -0.8 0.8
Rheumatoid Arthritis 0.7 1.0 3.5 0.9 0.4 -0.7 -1.9 0.8 -0.7
Schizophrenia (2014) 0.3 0.7 2.8 0.9 1.7 -0.5 -0.5 0.2 -0.5
Triglycerides 6.0 9.8 29.7 -0.9 1.6 5.5 3.9 -0.4 3.1
Type 2 Diabetes (T2D) (2012) 2.1 2.4 4.9 0.7 -0.0 1.9 1.8 1.6 2.2
Ulcerative Colitis 1.4 2.0 8.5 -0.1 2.9 0.6 1.8 -0.2 0.1
Blood Eosinophil Count 0.3 2.2 5.7 -0.6 0.5 2.4 1.6 -1.1 1.8
Blood Platelet Count 0.1 1.6 3.6 -1.6 -1.9 -1.4 -0.3 0.0 -1.3
Blood Red Count 1.7 16.2 43.6 -0.6 2.3 5.2 3.9 2.4 6.6
Blood White Count 0.3 2.3 4.8 0.5 1.2 1.9 1.5 1.2 2.2
Heel T-Score 0.2 1.7 4.2 2.0 1.3 -0.3 1.9 -0.7 -0.1
BMI 2.0 11.8 28.8 0.1 -1.5 -4.8 -3.4 -2.2 -5.4
Height 0.4 8.2 16.6 -2.9 -4.1 0.8 -2.7 -3.9 -1.1
Waist Hip Ratio (WHR) 12.2 54.9 123.2 0.4 4.1 11.1 8.9 4.2 9.6
Systolic Blood Pressure 1.8 9.1 28.6 -2.7 1.6 5.3 0.2 3.8 1.5
Smoking Status 0.4 1.0 4.4 0.8 -0.7 0.5 0.6 -2.1 -0.3
Allergy or Eczema 0.8 2.0 6.5 0.0 1.8 -0.9 0.8 2.5 -1.0
Cardiovascular Disease 0.9 3.1 7.4 -1.6 1.4 2.7 -0.1 2.1 1.5
Hypothyroidism (self reported) 0.3 0.6 2.1 1.4 1.1 0.2 -0.1 0.6 -0.4
Respiratory disease 0.2 0.4 0.7 0.5 -0.8 -0.3 -0.8 0.8 -0.3
Type 2 Diabetes (T2D) (2018) 6.0 11.2 26.8 -1.3 0.6 5.2 4.4 0.0 4.3
Lung FEV1/FVC ratio 0.5 2.6 9.9 -3.1 1.1 0.2 -0.6 -2.0 -0.1
Lung FVC 0.7 3.6 8.9 1.6 1.9 0.4 1.6 3.0 1.8
Neuroticism 0.3 0.8 3.0 1.7 0.8 -0.1 -0.2 -0.5 1.0
Chronotype (morning person) 0.1 0.2 0.9 -0.1 -0.4 -0.0 -0.4 -1.0 -0.0
Hair Pigment 0.0 1.2 5.6 0.1 0.5 0.6 2.4 0.9 0.0
Tanning 0.2 1.9 8.8 0.7 3.0 1.1 0.7 0.0 -0.6
Hand grip strength (left) 1.1 2.9 5.6 -2.4 0.2 2.3 1.8 -1.2 1.4
Number of treatments/medications taken 1.0 1.8 4.8 0.3 1.8 0.3 -0.1 2.2 1.7
Average weekly spirits intake 2.9 3.6 5.7 2.1 1.3 -0.8 2.2 2.4 1.9
Sensitivity / hurt feelings 0.2 0.3 1.0 0.1 1.0 0.3 0.1 -0.7 -0.2
Frequency of depressed mood in last 2 weeks 2.0 2.8 11.4 1.7 0.5 0.8 0.5 1.2 3.4
Hearing difficulty/problems: Yes 0.3 0.4 1.2 0.7 -0.8 0.3 -0.1 0.3 1.1
Relative age of first facial hair 0.3 0.7 1.9 -0.3 0.3 -0.4 0.6 -1.3 1.4
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 3.2 -1.0 1.8 1.1 1.1 -0.9 -0.6
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.1 1.0 -0.6 0.8 0.5 -0.5 0.5
Ever had hysterectomy (womb removed) 1.3 1.4 5.0 -0.2 -1.0 1.2 0.7 -0.8 2.2
Systolic blood pressure, automated reading 1.2 3.5 11.7 0.0 1.5 2.1 0.3 3.4 1.6
Eye problems/disorders: Diabetes related eye disease 2.0 2.2 5.1 -0.8 0.3 0.4 2.0 1.8 2.3
Angina 0.6 0.8 1.7 -0.6 0.8 1.3 1.1 0.9 0.5
Medication for hormone replacement therapy 0.6 0.6 2.4 -0.1 -0.1 0.7 -0.6 -1.5 -0.6
Vitamin and mineral supplements 0.4 0.6 1.6 0.4 1.1 0.0 0.6 1.3 -0.2
Supplements: Zinc 1.2 1.3 3.2 -1.6 -1.8 -0.8 -0.2 -0.7 -0.9
Medication: Co-codamol 0.2 0.2 0.6 -0.6 0.2 -0.3 0.5 0.8 -0.2
Medication: Metformin 3.7 5.2 10.9 -0.3 1.3 3.3 3.0 1.1 2.9
Diabetes (father) 1.3 1.6 4.6 -2.2 0.2 1.9 0.4 -0.3 1.0
Diabetes (mother) 2.9 3.8 10.9 -0.3 0.8 2.2 2.5 -0.2 3.3
Severe depression (siblings) 1.2 1.4 5.4 -0.7 0.6 -2.3 -0.4 0.3 -1.3
Pack years adult smoking proportion 0.7 1.1 3.4 -0.3 0.7 0.6 0.8 1.2 1.8
Impedance of leg (right) 0.2 0.8 1.9 -1.0 -0.8 -1.0 -0.3 -1.4 0.3
Leg fat-free mass (left) 1.0 5.2 14.7 -0.1 -1.8 -2.2 -2.3 -1.8 -3.8
Trunk fat percentage 8.1 32.5 94.7 0.2 -3.1 -9.7 -5.8 -1.3 -7.4
Hand grip strength (right) 0.5 1.3 4.4 -2.1 -0.1 1.3 1.1 -0.4 0.3
Townsend deprivation index at recruitment 0.8 1.1 5.2 2.3 0.5 1.0 0.6 -0.0 -0.0
Current tobacco smoking 0.6 0.9 2.4 0.2 -0.8 1.6 0.2 -1.4 0.8
Average weekly fortified wine intake 1.4 1.7 4.2 1.5 2.0 -0.6 1.4 0.9 -0.2
Maternal smoking around birth 1.4 2.0 5.4 -0.3 -2.3 1.3 -1.1 -2.0 0.1
Fed-up feelings 2.3 4.1 10.2 3.2 1.2 1.4 1.8 0.9 2.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 3.0 1.3 1.3 -0.1 0.8 1.3 1.7
Relative age voice broke 0.2 0.3 0.6 0.6 0.7 0.0 0.5 -0.1 0.8
Taking other prescription medications 0.5 0.8 2.5 0.7 1.2 -0.2 -0.3 1.6 -0.3
Age when periods started (menarche) 0.4 0.9 3.2 1.8 -0.5 -1.0 -0.5 -0.0 0.9
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 7.6 -0.3 -0.5 0.7 -0.0 0.5 2.8
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 4.5 2.1 -0.9 -1.1 0.4 0.1 -0.4
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 2.6 -1.3 -0.4 -0.0 0.5 -0.7 -1.6
Qualifications: CSEs or equivalent 0.9 1.2 2.2 1.5 0.9 0.6 1.1 1.3 0.9
Serious illness, injury or assault to yourself 0.6 0.7 2.7 -1.0 0.4 -0.2 0.5 -1.6 0.4
High blood pressure 0.6 1.7 5.8 -1.0 1.4 1.1 -0.1 2.4 0.6
Hayfever, allergic rhinitis or eczema 0.4 0.8 1.8 -0.6 1.3 -0.5 -0.0 1.4 -1.0
Multivitamins +/- minerals 1.0 1.3 2.9 -1.0 -1.6 -0.5 0.0 -1.1 1.7
Stomach or abdominal pain in last month 0.7 0.9 3.5 1.9 -0.2 -0.6 -0.6 1.0 -0.5
Supplements: Glucosamine 0.8 1.0 4.5 2.1 -0.3 -1.0 0.6 0.1 -0.2
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 4.1 -2.0 -1.3 -0.7 -0.5 -0.4 0.1
Medication: Atenolol 2.3 2.8 5.2 1.1 1.0 0.9 2.2 2.0 2.3
Medication: Levothyroxine sodium 0.2 0.4 1.1 1.1 0.1 0.6 -0.5 0.5 0.5
Sitting height 1.2 8.7 21.6 -2.5 -3.9 0.0 -1.5 -4.7 -2.6
Chronic bronchitis/emphysema (father) 0.8 1.0 2.2 1.1 0.4 -0.5 -0.8 1.5 1.1
High blood pressure (mother) 0.3 0.4 0.7 -0.8 0.8 -0.1 -0.7 0.8 -0.1
Body mass index (BMI) 1.8 7.6 22.4 1.2 -0.9 -4.7 -2.3 -0.2 -4.0
Impedance of leg (left) 0.2 0.9 2.8 -1.3 -0.7 -0.1 -0.2 -1.7 0.6
Leg predicted mass (left) 1.0 5.2 14.6 -0.0 -1.8 -2.2 -2.3 -1.7 -3.8
Trunk fat mass 5.6 23.9 64.0 -0.0 -2.9 -8.0 -4.9 -1.8 -6.6
Waist circumference 0.2 0.7 2.1 1.3 0.0 -0.7 0.3 -0.1 -1.4
Number of incorrect matches in round 1.0 1.6 2.7 1.6 0.3 1.4 -0.7 1.5 1.5
Past tobacco smoking 0.4 0.8 2.3 -1.5 -0.1 -0.1 0.2 0.6 1.3
Alcohol usually taken with meals 2.2 3.6 8.3 -1.8 -0.5 -1.1 -2.0 -2.9 -2.1
Nervous feelings 0.6 1.0 3.0 -0.8 0.0 -1.7 0.0 1.6 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 3.4 0.8 0.5 -1.4 -0.6 1.0 1.9
Hearing difficulty/problems with background noise 0.4 0.6 0.9 -0.6 -0.9 0.9 -0.8 0.8 0.3
Hair/balding pattern: Pattern 2 1.0 1.3 3.9 -0.0 -0.7 -0.4 0.0 -2.0 -1.7
Had menopause 1.6 2.0 4.9 -0.8 -0.4 -2.2 -0.8 -1.1 -2.1
Had other major operations 0.9 1.1 2.8 -1.1 -1.7 -0.5 -0.4 -1.0 -1.2
Forced vital capacity (FVC) 0.1 0.5 1.5 -0.2 -1.0 1.2 -0.3 -0.6 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 3.2 1.4 -0.6 -1.8 0.4 0.5 -0.6
Ever unenthusiastic/disinterested for a whole week 1.4 1.7 5.4 1.1 0.4 0.6 1.5 0.8 2.3
Qualifications: None of the above 1.8 3.9 6.2 2.5 2.0 1.6 2.0 2.1 1.5
Financial difficulties in last 2 years 0.4 0.6 1.6 1.3 -0.1 0.3 0.2 -0.8 -1.0
Mouth/teeth dental problems 0.4 0.7 1.8 -1.3 0.1 0.7 0.3 1.3 0.1
Heart attack 1.4 1.8 3.7 1.2 1.8 -0.1 1.4 1.9 0.9
Allergy 0.3 0.8 2.1 -0.3 -1.4 0.6 -0.0 -1.4 0.4
Pain all over the body in last month 0.8 0.8 2.0 -1.4 0.1 -1.1 -1.1 0.3 -0.6
Diabetes (self-reported) 2.6 4.0 8.2 -1.0 1.0 2.8 2.9 0.4 2.5
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 2.6 0.2 1.4 -1.6 -0.5 0.8 -0.8
Medication: Ramipril 1.2 1.5 5.1 0.6 0.8 0.8 0.2 1.5 2.3
Medication: Simvastatin 3.4 5.0 9.0 1.4 2.3 3.0 2.0 2.4 1.9
Fluid intelligence score 1.7 3.5 7.2 -2.7 -1.5 -0.6 -1.9 -1.6 -2.3
Illnesses of siblings 0.5 0.7 1.4 0.9 -0.1 0.2 1.2 -1.1 -0.9
Neuroticism score 0.7 1.4 4.9 2.2 1.2 -0.2 0.1 0.6 1.2
Weight 2.2 11.1 26.9 -0.1 -2.3 -4.4 -3.2 -2.2 -5.2
Impedance of arm (right) 4.6 21.3 47.5 -1.3 -2.8 -6.9 -6.6 -1.1 -5.0
Arm fat percentage (right) 6.3 24.9 71.2 1.1 -2.5 -8.4 -5.5 -0.6 -6.3
Trunk fat-free mass 0.5 2.6 9.5 -0.7 -0.5 3.1 1.0 -2.1 -0.3
Hip circumference 6.8 29.3 65.4 0.6 -3.4 -7.6 -5.6 -3.0 -8.1
Time employed in main current job 0.3 0.4 1.3 1.1 -0.6 -0.5 0.1 0.6 -0.1
Alcohol intake versus 10 years previously 1.8 2.7 6.3 1.4 0.3 1.8 2.1 -0.4 2.5
Father’s age at death 1.4 1.9 5.0 -1.1 0.3 -2.1 -0.9 -0.5 -2.2
Worrier / anxious feelings 0.7 1.4 2.7 1.3 -0.2 -1.1 -1.6 -0.4 -1.5
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.2 5.5 -1.0 0.2 0.6 0.2 -0.8 2.3
Falls in the last year 0.4 0.5 2.2 0.3 1.5 0.2 0.7 -0.3 0.2
Hair/balding pattern: Pattern 3 2.6 3.9 9.2 1.6 3.0 1.6 0.5 2.7 1.2
Number of live births 1.6 2.2 4.4 -2.0 -0.5 -0.9 -2.1 -0.6 -1.8
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 1.9 -1.2 -0.5 1.4 -0.3 -1.0 -0.0
Pulse rate 1.0 1.7 3.7 0.3 -0.2 1.9 1.8 -0.7 1.7
Happiness 0.6 0.7 1.3 1.2 -0.4 -0.8 -0.8 1.0 0.7
Noisy workplace 0.5 0.6 1.2 1.1 -0.1 -1.0 0.6 0.9 0.3
Qualifications: A levels/AS levels or equivalent 0.7 1.5 3.6 -1.5 -0.5 -0.7 -1.1 -1.1 -1.9
Serious illness, injury or assault of a close relative in last 2 years 2.7 3.1 5.9 -2.3 -2.4 -1.3 -1.1 -2.1 -0.4
Mouth/teeth dental problems: Dentures 1.2 2.0 3.1 1.6 1.0 1.8 1.6 -0.6 1.6
Asthma 0.1 0.2 0.6 -0.5 0.8 -0.6 -0.2 0.2 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 0.9 -0.7 0.5 0.6 0.9 0.4 0.9
Medication: Cholesterol lowering 1.3 2.1 5.0 0.3 1.7 1.1 1.0 2.2 1.4
Depression (self-reported) 0.9 1.0 2.5 0.1 0.1 -1.1 -1.5 1.6 0.5
Medication: Lansoprazole 1.4 1.6 7.8 -0.0 0.2 -1.2 -0.1 2.8 0.0
Prospective memory result 1.0 1.2 2.9 0.5 1.1 1.7 1.6 0.1 0.7
Lung cancer (father) 0.5 0.6 1.4 -0.2 -1.2 0.8 -0.6 -0.3 1.1
Illnesses of mother 0.2 0.2 0.5 0.5 -0.7 0.3 0.6 0.0 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.0 -0.9 0.1 1.0 -0.2 -0.8 -0.0
Pulse wave Arterial Stiffness index 0.2 0.3 1.4 -0.0 -0.2 0.0 0.1 1.2 0.5
Impedance of arm (left) 4.6 21.4 51.3 -1.5 -2.8 -7.2 -6.5 -0.6 -4.9
Arm fat mass (right) 4.1 16.8 42.6 0.6 -2.4 -6.5 -4.2 -1.2 -5.7
Trunk predicted mass 0.5 2.7 9.7 -0.6 -0.5 3.1 1.0 -2.2 -0.2
Standing height 0.9 8.5 20.3 -3.0 -2.9 0.7 -2.1 -4.5 -2.9
Length of working week for main job 1.0 1.2 3.5 -1.5 -1.9 0.3 -0.4 -0.9 0.3
Exposure to tobacco smoke at home 0.5 0.5 1.6 0.3 0.9 -0.5 -0.6 -0.3 -1.2
Breastfed as a baby 0.9 1.1 1.9 1.4 1.2 0.7 0.5 -1.1 -1.0
Tense / ‘highly strung’ 0.3 0.5 1.7 -0.4 0.7 -0.4 0.7 1.3 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.9 4.9 0.7 -0.8 -1.6 -1.4 2.2 0.9
Hair/balding pattern: Pattern 4 0.5 1.2 4.4 -0.9 -0.4 -0.9 2.1 0.2 1.1
Birth weight of first child 3.0 5.5 11.8 2.3 1.9 3.4 2.9 0.1 1.9
Peak expiratory flow (PEF) 0.4 0.9 3.0 -1.7 0.5 1.5 -0.1 -0.6 -0.0
Pulse wave reflection index 1.2 1.5 6.2 1.3 1.0 -0.1 -0.2 2.5 0.4
Ever highly irritable/argumentative for 2 days 1.1 1.3 2.6 1.6 0.5 -1.2 -1.0 0.9 -1.3
Loud music exposure frequency 1.0 1.1 2.0 -0.7 -1.4 0.1 -0.8 -1.1 -1.4
Qualifications: O levels/GCSEs or equivalent 1.6 2.5 6.7 -1.3 -0.8 -1.1 -1.5 -1.6 -2.6
Mouth/teeth dental problems: Bleeding gums 1.6 2.0 4.1 0.3 -0.8 -1.3 -2.0 -1.8 -1.6
Blood clot in the leg (DVT) 0.8 1.0 3.2 -1.0 0.7 -0.3 0.6 -0.9 -1.8
Medication: Paracetamol 0.3 0.4 1.2 0.2 -0.3 0.4 -0.4 1.1 0.9
Headache pain in last month 2.0 3.5 4.9 1.5 1.6 1.6 2.2 2.1 2.1
Medication for cholesterol, blood pressure or diabetes 1.3 2.1 4.7 0.4 -2.2 -1.1 -1.0 -2.2 -0.9
Glaucoma (self-reported) 5.7 6.7 13.7 -3.7 -2.5 -2.6 -3.2 -0.5 -1.7
Gout (self-reported) 1.1 1.5 6.6 -0.7 0.0 2.6 0.7 -0.4 1.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.4 1.2 -0.0 0.8 -0.4 0.1 0.4
Medication: Amlodipine 1.0 1.4 6.3 0.6 0.7 -0.2 -0.4 2.5 1.1
Medication: Ventolin 100micrograms inhaler 0.6 0.7 2.4 -1.5 -0.6 -0.4 -0.0 -1.1 0.6
Birth weight 0.6 1.4 4.2 1.4 1.0 -0.8 -0.2 0.4 -2.0
Chronic bronchitis/emphysema (mother) 1.7 2.0 7.4 0.2 -1.4 -1.4 -2.7 -0.4 -0.6
High blood pressure (siblings) 0.7 1.0 3.1 -1.8 -0.5 -0.0 -1.1 1.1 0.3
Forced vital capacity (FVC), Best measure 0.1 0.3 0.7 -0.4 -0.3 0.8 -0.6 -0.7 -0.2
Body fat percentage 7.0 27.7 82.8 0.5 -3.0 -9.1 -5.3 -1.4 -6.7
Leg fat percentage (right) 3.9 14.1 47.7 1.3 -1.9 -6.9 -2.8 -1.2 -4.7
Arm fat-free mass (right) 0.4 2.1 5.0 -0.7 -0.7 2.2 1.2 -2.1 -0.6
Exposure to tobacco smoke outside home 0.1 0.1 0.3 -0.2 0.2 -0.1 -0.0 -0.2 -0.5
Comparative body size at age 10 0.9 2.4 5.6 0.6 1.4 -1.5 -0.0 2.4 -2.1
Number of full brothers 0.7 0.9 2.4 -0.7 0.3 -1.3 1.0 1.5 -0.1
Worry too long after embarrassment 1.4 2.3 7.6 -0.8 -0.4 -2.1 -2.7 -1.0 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 3.1 0.4 -0.3 -1.8 -0.5 1.1 -0.5
Wheeze or whistling in the chest in last year 0.2 0.4 2.3 0.3 -0.2 0.0 -0.1 -1.5 0.0
Number of children fathered 0.4 0.5 1.1 1.0 -0.7 0.0 0.2 -0.6 0.9
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 3.3 -0.4 -1.8 -1.7 -1.1 0.3 -0.3
Age at first live birth 0.2 0.4 0.7 0.3 0.8 -0.8 -0.4 -0.3 -0.6
Pulse wave peak to peak time 0.3 0.4 1.8 0.0 0.2 0.0 -0.0 -1.3 -0.8
Health satisfaction 0.8 1.1 2.2 1.5 0.9 -0.4 0.1 1.4 1.1
Shortness of breath walking on level ground 1.0 1.2 2.6 1.6 0.1 0.7 1.4 -0.7 1.3
Qualifications: College or University degree 0.6 2.0 4.8 -1.5 -0.3 -1.0 -0.9 -1.6 -2.2
Eye problems/disorders: None of the above 0.8 0.9 2.8 1.7 -0.4 0.2 0.7 -0.5 1.3
Mouth/teeth dental problems: Loose teeth 1.1 1.3 4.7 -2.2 0.5 -1.1 -0.5 -1.1 0.5
Emphysema/chronic bronchitis 2.0 2.3 7.2 0.2 -2.7 -0.8 -1.0 -2.1 -0.6
Medication for pain relief, constipation, heartburn 0.6 1.0 3.1 -0.4 -0.6 -0.5 -0.2 -1.4 -1.8
Neck or shoulder pain in last month 1.6 2.3 5.6 1.0 0.1 2.3 1.3 -0.2 2.4
Medication: Blood pressure 1.5 2.7 9.3 0.3 2.5 -0.2 0.6 3.1 -0.2
Angina (self-reported) 0.5 0.7 1.1 -0.6 0.6 1.0 1.0 0.8 0.8
Migraine (self-reported) 0.6 0.7 2.1 -0.5 -0.1 1.5 1.3 0.4 0.3
Medication: Ibuprofen 0.7 0.8 2.8 -1.7 0.3 0.9 1.0 -0.2 0.4
Medication: Allopurinol 0.9 1.1 4.5 0.3 -1.0 2.1 -0.5 -0.6 0.8
Medication: Omeprazole 1.1 1.3 4.2 0.9 0.5 -0.3 0.1 1.6 2.1
Medication: Seretide 50 evohaler 0.2 0.3 0.9 -0.1 -0.6 -0.5 -0.9 0.4 -0.1
Mean time to correctly identify matches 0.3 0.5 1.7 0.3 -1.3 -0.0 -1.1 -0.4 0.1
Heart disease (mother) 0.6 0.8 2.4 0.6 -0.2 0.5 -1.6 0.9 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 4.2 -2.1 -1.0 -0.7 -1.2 0.7 -1.0
Whole body fat mass 4.8 19.8 51.6 0.1 -2.9 -7.2 -4.3 -1.9 -6.1
Leg fat mass (right) 3.4 13.1 37.7 0.7 -2.2 -6.1 -2.8 -1.6 -5.0
Arm predicted mass (right) 0.4 2.0 4.7 -0.8 -1.0 1.9 1.0 -2.2 -0.9
Pulse rate, automated reading 0.5 1.7 3.1 0.2 0.9 1.7 1.8 1.1 1.5
Alcohol intake frequency. 1.2 2.8 5.3 -0.3 1.2 1.6 2.3 1.6 2.2
Comparative height size at age 10 0.5 2.8 5.6 -2.4 -1.7 -0.1 -1.6 -1.1 -2.0
Number of full sisters 0.4 0.5 1.5 -0.4 0.4 1.2 0.9 0.1 0.7
Suffer from ‘nerves’ 0.7 1.1 3.6 0.3 0.4 -0.5 0.5 1.4 1.9
Overall health rating 0.5 1.1 2.3 0.9 1.5 -1.0 0.9 1.2 0.6
Chest pain or discomfort 1.1 1.6 6.6 0.9 0.5 1.3 0.4 0.2 2.6
Had major operations 0.4 0.4 0.9 -1.0 0.8 -0.7 0.3 -0.1 -0.8
Age at last live birth 0.5 0.7 2.5 0.7 1.6 -0.1 -0.5 0.4 -1.0
Family relationship satisfaction 0.4 0.5 2.9 -0.0 -1.7 -0.2 -0.3 -0.1 -0.2
Leg pain on walking 0.4 0.5 1.2 1.1 -0.4 -0.7 0.8 -0.5 0.1
Qualifications: NVQ or HND or HNC or equivalent 1.4 1.6 5.7 -0.4 0.4 1.6 1.0 -0.4 2.4
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.6 0.7 -0.7 0.6 -0.5 -0.2 0.1
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.7 -0.0 0.9 0.0 0.2 0.1 0.6
Medication: Aspirin 2.0 2.6 5.6 1.4 1.4 1.7 2.4 1.3 1.3
Supplements: Vitamin C 1.8 2.1 6.0 2.0 0.8 -0.4 -0.7 1.2 -2.4
Knee pain experienced in last month 0.6 1.0 2.4 1.3 -0.6 -1.5 -0.2 0.4 -1.0
Hypertension (Self-reported) 0.7 1.8 6.4 -0.6 1.3 1.2 0.2 2.5 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 4.1 0.2 -0.5 -0.4 -0.9 2.0 1.8
Illnesses of father: Heart disease 0.8 1.1 4.5 -0.1 0.7 0.2 -2.1 0.8 1.0
Illnesses of siblings: Diabetes 1.7 2.1 4.3 -2.1 0.2 1.6 1.4 -0.3 1.9
Smoking status: Previous 0.4 0.6 1.4 1.2 0.4 -0.9 -0.6 -0.1 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 2.1 -0.9 0.1 0.5 -0.1 -1.5 -0.5
Whole body fat-free mass 0.3 1.7 4.9 -0.5 -1.1 1.2 -0.1 -2.2 -1.6
Leg fat-free mass (right) 0.7 3.9 12.0 -0.3 -1.6 -1.3 -2.0 -1.8 -3.5
Arm fat percentage (left) 6.5 26.1 78.0 0.8 -2.3 -8.8 -5.4 -0.3 -6.5
Average weekly red wine intake 1.5 2.2 6.3 -0.7 -0.7 -1.1 -2.5 -1.3 -1.8
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.8 0.9 0.4 -1.3 -0.9 -0.1 -0.3
Mood swings 2.3 4.1 7.9 2.8 2.0 1.4 1.5 1.1 2.7
Loneliness, isolation 0.8 1.2 2.6 1.5 0.2 0.3 1.2 0.7 1.6
Long-standing illness, disability or infirmity 0.6 1.0 3.2 0.0 1.8 0.1 0.5 1.4 0.7
Ever had bowel cancer screening 1.1 1.2 2.7 -1.2 1.6 -1.4 0.3 -0.7 -0.8
Diabetes diagnosed by doctor 4.4 7.3 15.5 -0.9 1.3 3.7 3.9 1.1 3.3
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.5 -0.9 -1.2 -0.6 -0.2 -0.7 -1.2
Friendships satisfaction 0.9 1.1 3.2 -0.3 -1.8 -1.0 -1.5 -0.2 -0.3
Qualifications: nursing, teaching 1.5 2.3 5.6 -1.3 -1.8 0.3 -1.4 -2.4 -1.1
Commuting to job workplace: Walk 0.2 0.2 0.5 -0.6 0.4 -0.2 -0.1 0.7 -0.0
Eye problems/disorders: Cataract 1.2 1.3 3.2 -1.8 0.3 0.1 -1.2 -0.3 -1.7
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 4.1 -0.7 -0.5 -1.5 -2.0 0.3 -1.6
Medication for cholesterol 1.3 2.0 5.1 1.7 0.3 -2.3 0.7 1.0 -1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 1.8 -0.7 -0.7 -0.9 -0.9 -1.4 -0.7
Back pain experienced in last month 0.8 1.1 2.2 0.6 1.5 0.3 1.5 -0.2 1.3
Mineral and other dietary supplements 0.7 1.0 1.7 -1.1 0.7 0.2 1.1 1.1 1.3
Breast cancer (self-reported) 0.6 0.8 2.6 0.5 -1.2 -0.2 -0.1 -1.6 -0.4
Asthma (self-reported) 0.1 0.2 0.5 -0.4 0.7 -0.6 -0.3 0.3 0.2
Osteoporosis (self-reported) 0.5 0.6 2.8 -0.1 0.0 -0.8 -0.6 -0.2 -1.7
Osteoarthritis (self-reported) 0.9 1.2 1.7 1.1 0.9 1.1 1.0 1.3 1.1
Medication: Aspirin 1.9 2.5 5.6 1.0 1.4 1.7 2.4 1.1 1.5
Medication: Gliclazide 4.3 4.8 14.2 0.3 0.4 2.9 3.8 0.2 2.4
Illnesses of father: None of the above (group 1) 1.3 1.6 5.0 2.0 -0.6 0.0 2.2 -0.4 0.5
Smoking status: Current 0.5 0.7 1.6 0.4 -0.9 1.3 -0.0 -1.2 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 4.7 0.5 0.0 0.9 0.5 -0.8 2.2
Whole body water mass 0.3 1.8 5.0 -0.6 -1.1 1.3 -0.1 -2.2 -1.6
Leg predicted mass (right) 0.7 3.8 11.6 -0.4 -1.6 -1.2 -1.9 -1.8 -3.4
Arm fat mass (left) 3.8 15.4 42.2 0.5 -2.1 -6.5 -3.9 -1.0 -5.5
Number of self-reported non-cancer illnesses 0.8 1.3 4.8 0.7 1.6 0.1 -0.3 2.2 0.4
Average weekly champagne plus white wine intake 2.8 3.9 6.9 -1.7 -2.5 -1.6 -1.8 -1.3 -2.6
Miserableness 0.8 1.4 3.8 1.6 0.8 0.4 -1.1 0.1 1.9
Guilty feelings 0.3 0.4 1.2 1.1 0.6 -0.3 0.3 0.4 0.8
Wears glasses or contact lenses 0.7 0.8 2.2 -1.0 -0.1 -0.8 -0.1 -1.0 -1.5
Ever taken oral contraceptive pill 0.9 1.1 2.7 -1.6 0.8 0.5 0.9 -0.2 1.4
Hearing aid user 2.6 2.9 6.2 2.5 2.4 0.8 1.4 1.5 0.7
Mother’s age at death 1.4 1.8 4.6 -2.1 0.2 -1.2 -0.8 -1.3 -1.5
Financial situation satisfaction 1.8 2.3 4.4 1.8 0.2 0.3 2.0 1.4 2.1
Tinnitus: Yes, now most or all of the time 1.2 1.4 3.8 -0.5 -1.9 -0.4 -1.6 0.0 1.2
Commuting to job workplace: Public transport 0.5 0.6 1.9 -1.4 -0.1 -0.3 -0.9 -0.7 -0.7
Eye problems/disorders: Glaucoma 4.2 4.9 8.8 -3.0 -1.8 -2.8 -2.6 -0.7 -1.6
Medication: Blood pressure 1.3 2.4 7.4 -0.2 0.1 2.7 0.1 1.1 2.4
Pain type(s) experienced in last month: Hip pain 0.5 0.7 2.2 -0.5 -1.1 0.5 0.2 -1.5 0.4
Supplements: Fish oil (including cod liver oil) 0.7 1.0 1.9 0.6 1.0 0.7 -0.8 -1.2 -1.4
High cholesterol (Self-reported) 0.6 1.1 3.4 -1.2 0.5 1.8 0.1 0.2 1.3
Medication: Bendroflumethiazide 0.6 0.9 2.7 -0.8 -0.7 -0.9 0.0 1.6 0.7
Medication: Paracetamol 0.4 0.6 0.9 -0.5 -0.9 0.7 0.4 0.9 0.9
Medication: Lisinopril 0.9 1.2 4.3 -1.1 1.2 2.1 0.3 0.2 0.4
Medication: Atorvastatin 0.4 0.6 1.3 -0.9 0.1 1.1 -0.4 0.0 1.1
Illnesses of father: High blood pressure 3.7 4.6 14.8 -3.9 -1.6 -1.3 -2.5 -0.8 -1.3
Alcohol drinker status: Never 1.1 1.3 4.5 2.1 -0.1 -0.0 0.8 1.0 1.3
Ever smoked 1.1 1.9 7.0 0.7 -0.5 0.6 -0.6 -1.7 -2.6
Basal metabolic rate 0.5 2.6 7.1 -0.4 -1.5 -0.2 -1.0 -2.3 -2.7
Leg fat percentage (left) 3.5 12.8 41.0 1.2 -1.8 -6.4 -2.8 -1.3 -4.6
Arm fat-free mass (left) 0.4 2.2 6.0 -0.6 -0.9 1.8 0.8 -2.4 -1.4
Number of operations (self-reported) 1.0 1.5 3.6 -1.6 0.6 1.9 0.6 -0.8 -1.0
Average weekly beer plus cider intake 1.5 2.1 5.4 1.5 1.5 0.7 1.3 2.3 0.9
Irritability 0.9 1.5 3.2 1.6 -1.0 1.5 -0.4 -1.8 -0.5
Risk taking 0.7 1.0 5.2 -2.3 -0.0 -0.1 -0.5 -0.4 -0.7
Ever had prostate specific antigen (PSA) test 1.8 2.1 5.9 1.1 0.4 -2.4 -0.7 2.2 -0.1
Fractured/broken bones in last 5 years 2.0 2.6 4.5 0.5 1.7 -2.1 -0.9 1.6 -2.1
Age started oral contraceptive pill 2.4 3.0 5.9 -2.3 -2.0 0.7 -0.8 -2.4 -1.2
Diastolic blood pressure, automated reading 0.9 2.6 10.4 1.8 1.5 -0.5 0.1 3.2 0.1
Ever depressed for a whole week 1.6 2.0 4.5 1.6 0.5 -1.4 1.2 2.1 1.1
Unable to work because of sickness or disability 0.3 0.4 1.5 -0.3 0.1 0.3 0.2 1.2 0.9
Commuting to job workplace: Cycle 0.7 0.9 1.8 -1.3 -0.6 -0.6 -1.0 1.3 0.5
Myopia 1.0 1.4 3.2 1.0 1.1 -0.3 0.3 -1.6 -1.8
Vascular/heart problems diagnosed by doctor 0.8 2.1 7.8 1.0 -1.6 -0.9 0.1 -2.8 -0.4
Cholesterol lowering medication 1.4 2.0 7.8 -1.0 0.1 2.8 -0.1 0.1 1.8
Medication: Omeprazole (e.g. Zanprol) 0.8 0.9 2.3 0.7 -0.3 -0.3 -0.7 1.5 1.5
Pain experienced in last month 1.3 2.1 4.4 -1.9 -1.2 0.4 -1.4 -2.1 -1.2
Supplements: Calcium 1.4 1.5 4.4 -0.1 -0.8 -1.8 -2.1 -0.7 -0.5
Basal cell carcinoma (self-reported) 0.4 0.5 1.8 1.4 -0.4 0.8 0.1 0.5 -0.1
Heart attack/myocardial infarction (self-reported) 1.5 1.9 4.2 1.2 1.8 -0.2 1.4 2.1 0.8
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 2.4 -0.6 0.4 -0.2 0.9 -0.8 -1.6
Heart disease (siblings) 1.0 1.2 2.2 1.4 0.5 0.8 -1.5 0.3 1.4
Alcohol drinker status: Previous 0.6 0.7 1.3 -0.8 -1.0 0.7 1.1 -0.3 -0.8
Pack years of smoking 0.6 0.9 2.5 -0.1 0.8 0.7 0.8 1.0 1.6
Impedance of whole body 1.8 9.2 23.5 -1.4 -1.9 -4.8 -4.2 -0.9 -2.8
Leg fat mass (left) 3.2 12.5 34.2 0.7 -2.1 -5.8 -2.8 -1.7 -5.0
Arm predicted mass (left) 0.4 1.8 5.3 -0.4 -0.9 1.6 0.7 -2.3 -1.2