Hub : Genes

COBLL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0500	0.0220	0.0040	0.009	0.013	0.017	0.019	0.026	2.4e-02	0.0098	0.0035	0.002	0.00033
2	GTEx	Nerve Tibial	0.1593	0.0601	0.0019	0.010	NA	0.006	NA	0.016	6.3e-02	NA	0.1100	NA	0.02600
3	GTEx	Thyroid	0.0660	0.0290	0.0083	0.051	NA	0.018	NA	0.048	8.8e-05	NA	0.0150	NA	0.00015
4	YFS	Blood	0.0156	0.0076	0.0170	0.011	0.002	0.002	0.004	0.004	1.3e-04	0.0490	0.0720	0.017	0.01100

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.7	1.5	0.3	1.1	0.2	1.2
Bipolar Disorder or Schizophrenia	0.2	0.4	0.7	0.1	0.9	-0.5	0.8
Depressed Affect (Nagel 2018)	0.4	0.9	2.1	0.3	-1.1	0.1	1.4
Depression (Nagel 2018)	1.2	1.7	5.6	-0.0	-1.0	-0.5	2.4
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.4	1.0	1.2	0.7	0.8
Neuroticism (Nagel 2018)	0.3	0.7	2.0	0.9	-0.5	0.3	1.4
Schizophrenia (2018)	0.1	0.2	0.7	-0.1	0.1	-0.8	0.1
Schizophrenia vs Biploar Disorder	1.5	2.0	3.3	-1.8	-0.6	-1.3	-1.6
Worry (Nagel 2018)	0.2	0.5	0.8	0.5	0.9	-0.9	0.2
Alzheimer’s Disease (in mother)	0.3	0.4	0.9	0.3	0.2	0.7	-0.9
Alzheimer’s Disease (in father)	0.8	0.9	2.1	-1.0	1.4	-0.0	0.7
Alzheimer’s Disease (including proxy)	0.4	0.6	1.9	-0.3	1.4	-0.0	0.5
Crohns Disease (2017)	0.8	1.8	3.3	1.1	-0.6	1.8	1.5
Irritable Bowel Disease (IBD)	1.2	3.0	6.2	1.4	-0.8	2.5	1.8
Ulcerative Colitis (UC)	0.4	0.8	2.0	0.7	-0.3	1.4	0.9
Major Depression (MDD)	0.7	0.8	1.5	1.2	-1.2	-0.7	-0.1
Reaction Time	0.2	0.5	0.8	-0.6	0.5	-0.9	0.7
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.3	1.8	0.9	1.1	0.3
Breast Cancer	0.6	1.6	3.5	0.1	-1.9	1.4	-0.8
Ovarian Cancer	3.4	4.5	9.2	1.6	-1.4	3.0	-2.1
Prostate Cancer	0.2	0.3	0.8	0.3	-0.7	0.1	0.9
Age at First Birth	1.1	1.6	3.6	0.3	-1.9	1.6	0.3
Bipolar Disorder (2011)	1.4	1.3	2.1	1.1	1.4	0.4	1.4
Body Mass Index (BMI) (2010)	2.3	3.2	7.6	1.9	-1.1	2.8	-0.7
Coronary Artery Disease (CAD)	1.4	1.7	3.0	-1.4	0.8	-1.7	-1.0
Crohns Disease (2012)	1.7	2.7	5.1	1.8	-1.0	2.2	1.3
Mean Putamen Volume	0.8	0.9	2.1	1.1	-0.6	1.5	0.1
Fasting Glucose	0.9	1.0	3.0	-0.2	0.9	1.7	0.6
HbA1C	0.7	0.8	2.1	-0.9	1.5	-0.6	-0.3
HDL Cholesterol	1.5	2.5	7.6	1.2	-0.8	2.8	-0.7
LDL Cholesterol	1.4	2.2	6.4	-1.4	-0.3	-2.5	-0.3
Lupus	1.0	1.5	3.3	1.4	0.0	1.8	0.6
Neuroticism (2016)	0.7	1.0	1.7	-0.1	-0.9	1.3	1.2
Primary Biliary Cirrhosis	1.4	2.0	7.3	-0.6	0.6	0.0	2.7
Rheumatoid Arthritis	0.4	0.6	1.8	-1.3	-0.0	-0.0	0.8
Schizophrenia (2014)	0.3	0.7	1.8	-0.7	1.3	-0.3	0.6
Triglycerides	2.1	3.5	8.4	-1.3	1.1	-2.9	1.6
Type 2 Diabetes (T2D) (2012)	1.4	1.6	3.3	-1.8	-0.9	-1.5	0.2
Ulcerative Colitis	0.7	1.1	2.1	0.8	0.0	1.4	1.3
Blood Eosinophil Count	0.4	3.2	5.9	-2.0	1.5	-2.4	0.7
Blood Platelet Count	0.0	0.3	1.1	0.3	0.4	-0.3	-1.0
Blood Red Count	0.9	8.3	20.8	-2.8	2.1	-4.6	0.7
Blood White Count	0.2	1.2	1.8	-1.3	0.3	-1.3	-1.1
Heel T-Score	0.0	0.1	0.2	-0.2	-0.2	-0.4	-0.5
BMI	2.0	11.8	24.2	3.7	-2.8	4.9	1.2
Height	0.1	2.4	6.7	0.4	1.7	0.1	2.6
Waist Hip Ratio (WHR)	14.9	66.9	174.2	-9.4	1.8	-13.2	-1.6
Systolic Blood Pressure	1.2	5.9	11.4	-2.4	2.6	-3.4	-0.1
Smoking Status	0.2	0.4	0.5	-0.7	-0.7	-0.4	0.6
Allergy or Eczema	0.3	0.8	1.5	-1.2	-1.0	-0.6	-0.5
Cardiovascular Disease	1.8	5.9	15.3	-2.4	1.5	-3.9	-0.8
Hypothyroidism (self reported)	0.6	1.5	3.7	-1.1	-0.5	0.8	-1.9
Respiratory disease	0.6	1.4	2.7	1.0	0.2	1.3	1.6
Type 2 Diabetes (T2D) (2018)	5.7	10.7	24.8	-4.1	-0.2	-5.0	-0.9
Lung FEV1/FVC ratio	0.9	4.3	13.5	0.0	3.7	-1.6	1.1
Lung FVC	0.1	0.8	1.8	-0.5	-0.4	-0.9	-1.4
Neuroticism	0.3	0.7	2.4	0.4	-0.3	-0.2	1.6
Chronotype (morning person)	0.6	1.5	3.2	1.4	-0.4	1.8	0.8
Hair Pigment	0.2	4.9	9.3	-3.0	-1.6	-1.0	-2.6
Tanning	0.1	1.3	3.3	1.1	0.8	1.8	-0.3
Hand grip strength (left)	0.7	1.8	4.8	-0.2	2.2	-0.6	1.4
Number of treatments/medications taken	0.8	1.5	4.2	-2.1	-0.2	-1.2	-0.5
Average weekly spirits intake	1.7	2.1	4.1	-1.5	0.0	-1.4	-2.0
Sensitivity / hurt feelings	0.2	0.4	0.6	-0.7	-0.7	0.4	0.5
Frequency of depressed mood in last 2 weeks	1.5	2.1	5.5	0.2	-1.5	0.5	2.4
Hearing difficulty/problems: Yes	0.8	1.2	3.1	-1.1	0.2	-1.8	0.6
Relative age of first facial hair	1.0	2.0	6.0	2.4	0.7	1.2	0.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.7	-0.8	-0.6	0.0	0.3
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.5	-1.2	0.1	0.8	-0.1
Ever had hysterectomy (womb removed)	2.7	3.0	6.5	-1.8	0.7	-2.6	-1.3
Systolic blood pressure, automated reading	0.5	1.3	2.7	-1.5	0.7	-1.6	-0.2
Eye problems/disorders: Diabetes related eye disease	4.0	4.3	8.4	-2.3	1.3	-2.9	-1.5
Angina	0.5	0.7	1.7	-0.8	-0.1	-1.3	0.7
Medication for hormone replacement therapy	0.3	0.3	0.7	-0.0	-0.2	0.6	0.8
Vitamin and mineral supplements	0.7	0.9	2.5	1.6	-0.1	1.1	0.1
Supplements: Zinc	1.2	1.3	2.8	-1.0	-0.3	-1.7	-1.2
Medication: Co-codamol	0.3	0.3	0.6	0.8	-0.7	0.2	0.4
Medication: Metformin	4.7	6.6	12.7	-3.4	0.1	-3.6	-1.5
Diabetes (father)	2.8	3.5	6.7	-2.6	1.2	-2.4	-0.1
Diabetes (mother)	4.1	5.2	14.2	-2.1	0.6	-3.8	1.4
Severe depression (siblings)	1.3	1.5	2.0	1.4	1.4	1.4	0.2
Pack years adult smoking proportion	1.7	2.6	9.7	0.1	0.9	-3.1	0.2
Impedance of leg (right)	0.8	4.0	11.2	2.0	3.3	0.9	0.2
Leg fat-free mass (left)	0.9	4.7	7.7	1.2	-2.3	2.8	2.1
Trunk fat percentage	5.3	21.3	51.4	5.7	-1.1	7.2	0.3
Hand grip strength (right)	0.3	0.8	2.4	0.1	1.6	-0.7	0.5
Townsend deprivation index at recruitment	1.1	1.5	3.0	-0.4	-1.5	-0.8	-1.7
Current tobacco smoking	0.4	0.6	1.6	-0.8	-0.0	-1.3	-0.5
Average weekly fortified wine intake	0.5	0.5	1.2	-0.0	-1.1	0.4	-0.9
Maternal smoking around birth	0.4	0.5	1.3	0.8	-0.3	1.1	0.2
Fed-up feelings	0.5	1.0	2.9	-0.6	-1.7	-0.7	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.9	0.2	-1.1	0.0	1.4
Relative age voice broke	1.0	1.6	5.1	2.3	0.0	0.9	-0.7
Taking other prescription medications	0.6	1.0	3.1	-1.8	-0.5	-0.4	-0.5
Age when periods started (menarche)	0.2	0.6	1.1	-0.4	-1.0	0.9	0.6
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	5.1	-1.3	1.3	-2.3	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.5	0.3	-1.2	-0.3	0.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.5	1.2	0.0	0.8	-0.4
Qualifications: CSEs or equivalent	0.2	0.3	0.4	0.5	-0.5	0.5	-0.7
Serious illness, injury or assault to yourself	0.5	0.6	1.5	0.6	-0.6	0.2	1.2
High blood pressure	0.7	1.9	4.2	-1.2	0.1	-2.0	-1.3
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.8	-0.9	-0.4	-0.8	-0.4
Multivitamins +/- minerals	1.1	1.4	2.8	-1.3	1.0	-1.7	-0.1
Stomach or abdominal pain in last month	1.0	1.3	1.5	1.2	-1.1	1.2	-1.0
Supplements: Glucosamine	1.4	1.8	4.3	-1.4	-2.1	-0.6	-0.7
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.1	0.5	1.1	-1.0	0.3
Medication: Atenolol	1.4	1.7	3.5	-1.8	-0.2	-1.9	-0.3
Medication: Levothyroxine sodium	0.8	1.4	3.1	-1.5	-0.2	-0.3	-1.8
Sitting height	0.8	5.5	10.4	2.5	0.8	2.2	3.2
Chronic bronchitis/emphysema (father)	0.5	0.6	1.2	1.0	0.4	0.2	1.1
High blood pressure (mother)	0.6	0.9	1.2	-1.1	-0.8	-1.1	-0.8
Body mass index (BMI)	1.8	7.6	15.0	2.5	-3.1	3.9	0.2
Impedance of leg (left)	1.1	5.6	14.5	2.6	3.8	1.0	0.3
Leg predicted mass (left)	0.9	4.7	7.8	1.2	-2.3	2.8	2.1
Trunk fat mass	3.6	15.5	37.8	4.6	-1.5	6.2	0.9
Waist circumference	0.3	1.2	4.5	-0.2	-2.1	0.5	0.2
Number of incorrect matches in round	0.6	1.0	2.6	-0.7	0.9	-1.6	0.4
Past tobacco smoking	0.2	0.4	0.7	0.9	0.8	0.2	0.0
Alcohol usually taken with meals	1.2	1.9	4.0	1.4	-0.0	2.0	1.4
Nervous feelings	0.8	1.4	2.9	1.4	1.7	0.4	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.3	0.3	0.3	-0.4	1.8
Hearing difficulty/problems with background noise	0.9	1.5	4.4	-1.1	-0.2	-2.1	-0.4
Hair/balding pattern: Pattern 2	1.9	2.4	5.2	1.1	-1.4	2.3	1.0
Had menopause	0.4	0.5	1.6	0.4	-0.6	1.3	0.4
Had other major operations	0.3	0.4	1.3	-0.1	-0.2	0.6	1.1
Forced vital capacity (FVC)	0.2	0.7	1.5	0.2	0.0	1.2	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.8	0.2	-0.9	-0.1	0.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.5	0.4	0.8	-0.3	1.6
Qualifications: None of the above	1.2	2.7	4.2	-1.4	-2.0	-0.6	-2.1
Financial difficulties in last 2 years	1.1	1.4	4.8	-0.0	-2.2	1.0	-0.1
Mouth/teeth dental problems	1.3	2.0	7.2	-0.2	0.9	-0.4	-2.7
Heart attack	0.8	1.0	2.6	-1.0	0.2	-1.6	-0.6
Allergy	0.1	0.3	0.8	-0.6	-0.2	-0.2	-0.9
Pain all over the body in last month	0.3	0.4	1.3	0.4	1.1	0.1	0.2
Diabetes (self-reported)	3.7	5.7	12.2	-3.0	-0.1	-3.5	-1.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.7	-0.9	0.3	0.0	-0.3
Medication: Ramipril	1.1	1.4	3.4	-1.3	0.1	-1.9	-0.6
Medication: Simvastatin	1.8	2.7	6.1	-2.0	-0.3	-2.5	-0.8
Fluid intelligence score	0.7	1.5	4.4	2.1	0.3	1.0	0.7
Illnesses of siblings	0.5	0.7	1.5	-0.6	-1.2	0.5	-0.9
Neuroticism score	0.1	0.3	0.7	-0.0	-0.8	0.2	0.5
Weight	2.0	9.6	20.7	3.2	-2.1	4.5	1.8
Impedance of arm (right)	2.3	10.5	17.5	4.1	2.7	4.2	-0.8
Arm fat percentage (right)	4.1	16.0	39.6	4.3	-2.4	6.3	-0.3
Trunk fat-free mass	0.6	3.2	8.2	-1.1	-1.8	-0.3	2.9
Hip circumference	6.2	26.6	68.6	5.4	-2.8	8.3	1.0
Time employed in main current job	1.0	1.1	3.2	-0.5	-1.8	0.8	-0.6
Alcohol intake versus 10 years previously	0.6	0.8	1.9	-1.4	-1.2	0.3	0.2
Father’s age at death	0.4	0.6	1.5	0.2	-0.7	1.2	0.4
Worrier / anxious feelings	0.4	0.8	2.4	1.0	-0.2	1.5	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.9	0.0	0.1	-0.7	1.7
Falls in the last year	0.7	1.0	1.7	1.3	0.1	1.2	0.9
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.1	-0.1	-0.4	-0.3
Number of live births	0.9	1.2	2.9	0.7	1.0	0.7	-1.7
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.3	0.7	1.2	1.1	1.5
Pulse rate	0.2	0.3	0.6	-0.8	-0.0	-0.5	0.7
Happiness	0.5	0.6	2.0	0.0	-0.1	-0.5	1.4
Noisy workplace	1.2	1.5	2.3	1.1	-1.3	1.5	-0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.6	0.6	-0.6	0.8	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.3	-0.2	0.8	0.0	-1.1
Mouth/teeth dental problems: Dentures	1.2	2.0	4.4	-1.0	-1.6	-0.2	2.1
Asthma	0.9	1.8	5.1	0.5	1.3	-0.4	2.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.3	-0.4	-1.1	0.6	-0.6
Medication: Cholesterol lowering	0.5	0.7	2.4	-0.6	0.5	-1.5	0.1
Depression (self-reported)	0.9	1.1	2.1	0.2	1.1	-1.5	0.9
Medication: Lansoprazole	0.2	0.2	0.8	-0.1	-0.9	-0.2	-0.4
Prospective memory result	1.6	2.0	3.4	-1.1	0.9	-1.6	-1.8
Lung cancer (father)	0.2	0.2	0.6	-0.4	-0.2	-0.8	0.3
Illnesses of mother	0.3	0.4	1.0	0.7	-0.2	1.0	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	4.2	0.7	2.1	0.6	1.7
Pulse wave Arterial Stiffness index	0.8	0.9	3.3	-0.1	0.3	-0.4	-1.8
Impedance of arm (left)	2.4	11.0	17.6	4.2	3.1	3.9	-1.0
Arm fat mass (right)	2.9	12.0	28.0	3.5	-2.6	5.3	0.7
Trunk predicted mass	0.5	3.1	7.8	-1.0	-1.9	-0.2	2.8
Standing height	0.5	5.3	12.6	1.7	1.8	1.6	3.5
Length of working week for main job	1.1	1.2	3.3	-0.4	-0.6	-0.9	-1.8
Exposure to tobacco smoke at home	0.3	0.3	0.5	0.7	0.6	0.6	-0.1
Breastfed as a baby	1.4	1.8	3.5	0.0	-0.8	1.7	1.9
Tense / ‘highly strung’	0.4	0.6	1.5	1.2	-0.0	-0.0	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.2	0.6	0.3	-0.3	1.1
Hair/balding pattern: Pattern 4	1.2	2.9	6.1	-2.5	1.0	-2.1	-0.2
Birth weight of first child	1.3	2.4	4.2	-1.0	-1.7	1.1	2.1
Peak expiratory flow (PEF)	0.6	1.4	4.5	0.2	2.1	0.3	0.9
Pulse wave reflection index	1.2	1.4	4.4	-0.6	0.1	-1.0	-2.1
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	0.5	-1.0	0.5	-0.2
Loud music exposure frequency	1.9	2.1	3.8	1.0	-1.3	1.9	1.3
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.2	1.0	-0.5	0.6	1.5
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.8	1.0	-0.3	1.3	0.2
Blood clot in the leg (DVT)	3.7	4.7	10.0	2.7	-0.3	3.2	1.2
Medication: Paracetamol	1.4	2.3	4.6	-2.2	-1.6	-0.4	-1.4
Headache pain in last month	0.6	1.0	3.6	-0.6	-1.9	-0.3	-0.0
Medication for cholesterol, blood pressure or diabetes	1.6	2.7	7.1	1.6	-0.9	2.7	0.4
Glaucoma (self-reported)	1.3	1.6	4.9	1.0	2.2	-0.4	0.2
Gout (self-reported)	0.7	0.9	1.3	-1.2	-1.1	-0.7	-0.6
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.8	-1.3	-0.7	0.2	-1.4
Medication: Amlodipine	1.0	1.3	3.4	0.3	1.8	-1.4	0.2
Medication: Ventolin 100micrograms inhaler	1.2	1.5	2.7	1.6	0.8	0.6	1.6
Birth weight	1.1	2.3	3.3	1.7	-1.6	1.8	0.7
Chronic bronchitis/emphysema (mother)	2.0	2.3	4.5	2.1	0.5	2.0	0.7
High blood pressure (siblings)	0.3	0.4	0.7	0.4	0.9	-0.9	0.0
Forced vital capacity (FVC), Best measure	0.3	1.0	1.6	0.7	1.1	0.9	1.3
Body fat percentage	5.0	19.6	47.5	5.3	-1.6	6.9	0.2
Leg fat percentage (right)	3.0	10.9	26.9	3.5	-2.1	5.2	-0.1
Arm fat-free mass (right)	0.4	2.1	6.1	-0.3	-1.5	0.2	2.5
Exposure to tobacco smoke outside home	0.4	0.5	1.3	1.1	0.3	-0.2	-0.8
Comparative body size at age 10	0.7	1.8	3.0	-0.6	-1.7	-1.3	-1.5
Number of full brothers	0.6	0.7	1.6	1.1	0.4	-1.3	-0.1
Worry too long after embarrassment	1.3	2.1	3.0	1.2	1.1	1.7	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	0.6	-0.2	0.1	-0.6
Wheeze or whistling in the chest in last year	0.7	1.3	3.1	0.8	-1.2	0.4	1.8
Number of children fathered	0.2	0.2	0.8	0.2	-0.9	-0.0	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.7	-0.1	-0.5	-0.4	-0.8
Age at first live birth	0.8	1.5	3.4	0.6	-0.3	1.5	1.8
Pulse wave peak to peak time	1.0	1.2	4.5	0.1	-0.4	0.4	2.1
Health satisfaction	0.2	0.2	0.5	0.7	-0.2	0.6	0.2
Shortness of breath walking on level ground	2.2	2.6	5.3	1.4	-1.3	2.3	1.1
Qualifications: College or University degree	0.3	1.0	2.4	1.6	0.3	0.5	1.2
Eye problems/disorders: None of the above	1.1	1.3	2.8	-1.3	0.8	-1.7	0.2
Mouth/teeth dental problems: Loose teeth	2.4	2.8	8.8	1.1	1.2	-0.1	3.0
Emphysema/chronic bronchitis	2.2	2.5	5.8	2.4	1.4	1.3	0.9
Medication for pain relief, constipation, heartburn	0.3	0.5	0.9	1.0	0.6	-0.6	0.5
Neck or shoulder pain in last month	0.5	0.7	1.6	0.1	-1.1	0.0	1.2
Medication: Blood pressure	1.3	2.2	3.9	-1.5	1.1	-2.0	-1.3
Angina (self-reported)	0.5	0.7	1.7	-0.6	0.1	-1.3	0.8
Migraine (self-reported)	0.0	0.1	0.1	0.1	-0.1	0.3	-0.3
Medication: Ibuprofen	0.3	0.3	1.0	0.3	-0.3	1.0	-0.2
Medication: Allopurinol	0.6	0.8	1.0	-0.4	-1.0	-0.9	-1.0
Medication: Omeprazole	0.4	0.5	1.3	-0.6	-0.1	-1.2	0.4
Medication: Seretide 50 evohaler	1.0	1.2	2.6	1.6	0.4	0.9	1.1
Mean time to correctly identify matches	0.2	0.4	0.7	-0.7	0.2	-0.8	0.7
Heart disease (mother)	0.7	0.9	1.8	-0.2	1.4	-1.1	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.1	-0.2	0.3	-1.5	0.1
Whole body fat mass	3.2	13.5	31.4	4.3	-1.8	5.6	0.9
Leg fat mass (right)	2.8	11.0	25.6	3.5	-2.4	5.1	0.7
Arm predicted mass (right)	0.5	2.6	7.1	-0.2	-1.7	0.5	2.7
Pulse rate, automated reading	1.0	3.2	6.5	-2.5	-0.8	-2.4	-0.1
Alcohol intake frequency.	0.2	0.4	0.9	-0.2	-0.6	-1.0	0.5
Comparative height size at age 10	0.7	3.7	8.2	1.7	1.7	1.0	2.9
Number of full sisters	0.1	0.2	0.4	-0.7	-0.1	-0.2	0.4
Suffer from ‘nerves’	0.4	0.7	1.1	-1.0	-0.4	-1.1	-0.7
Overall health rating	0.3	0.6	1.2	-0.5	0.6	-0.6	1.1
Chest pain or discomfort	2.2	3.1	5.8	2.4	0.1	1.9	1.8
Had major operations	0.4	0.5	1.7	1.3	-0.3	-0.2	0.4
Age at last live birth	0.3	0.4	0.9	0.6	-0.3	0.7	0.9
Family relationship satisfaction	0.4	0.5	0.9	0.8	-0.7	0.2	0.9
Leg pain on walking	4.4	5.5	8.5	1.8	-2.1	2.9	2.3
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	4.4	0.7	0.6	0.2	2.1
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.6	-0.8	-0.7	0.2	0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.4	0.1	0.4	-0.2	1.2
Medication: Aspirin	0.5	0.7	1.5	-0.7	-1.2	0.2	-0.9
Supplements: Vitamin C	1.7	2.0	5.1	-0.8	-2.3	0.5	-1.4
Knee pain experienced in last month	0.7	1.1	2.4	-1.2	-1.6	-0.6	0.2
Hypertension (Self-reported)	0.9	2.6	4.5	-1.6	-0.4	-2.1	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.8	-0.2	1.3	-1.0	0.4
Illnesses of father: Heart disease	1.2	1.7	4.2	0.7	2.0	-0.7	1.2
Illnesses of siblings: Diabetes	3.2	3.9	8.2	-2.2	1.5	-2.9	0.8
Smoking status: Previous	0.1	0.1	0.3	-0.5	0.2	0.2	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.5	-0.2	-0.2	0.3	1.9
Whole body fat-free mass	0.6	3.2	7.5	-0.0	-2.1	1.0	2.7
Leg fat-free mass (right)	0.7	3.8	5.4	1.1	-2.0	2.3	2.1
Arm fat percentage (left)	3.8	15.0	36.6	4.2	-2.3	6.0	-0.5
Average weekly red wine intake	0.1	0.2	0.6	0.0	0.2	0.8	0.2
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.1	-1.0	-1.0	-0.4	-0.9
Mood swings	0.6	1.1	1.4	-1.1	-1.0	-0.7	1.2
Loneliness, isolation	0.9	1.2	3.9	-0.0	-2.0	-0.9	0.4
Long-standing illness, disability or infirmity	0.2	0.3	1.2	-1.1	-0.2	-0.0	0.3
Ever had bowel cancer screening	0.3	0.4	0.5	0.6	0.7	0.6	0.6
Diabetes diagnosed by doctor	5.4	8.9	19.7	-3.6	-0.4	-4.4	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.7	0.6	-0.8	0.1	-0.7
Friendships satisfaction	0.1	0.1	0.2	0.4	-0.2	-0.4	0.5
Qualifications: nursing, teaching	0.9	1.4	3.3	0.6	1.8	0.4	1.3
Commuting to job workplace: Walk	0.1	0.1	0.2	0.0	-0.0	-0.3	-0.4
Eye problems/disorders: Cataract	0.4	0.5	1.0	0.9	-0.4	1.0	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.4	0.5	0.5	0.6	0.6
Medication for cholesterol	1.3	1.9	3.9	1.2	-1.3	2.0	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	0.8	-0.7	0.7	0.8	-0.9
Back pain experienced in last month	0.1	0.1	0.2	-0.2	-0.4	-0.3	0.4
Mineral and other dietary supplements	0.1	0.2	0.5	0.3	0.7	0.2	0.2
Breast cancer (self-reported)	0.8	0.9	3.3	0.4	-0.4	0.4	1.8
Asthma (self-reported)	1.1	2.1	5.8	0.6	1.5	-0.4	2.4
Osteoporosis (self-reported)	0.3	0.3	0.7	-0.9	-0.4	0.2	-0.6
Osteoarthritis (self-reported)	0.7	0.9	2.6	-1.6	-0.2	-0.9	0.1
Medication: Aspirin	0.3	0.4	0.7	-0.7	-0.9	0.1	-0.6
Medication: Gliclazide	0.8	0.9	2.4	-1.5	-0.8	-0.5	0.5
Illnesses of father: None of the above (group 1)	2.5	3.1	8.1	-1.6	-2.9	0.6	-1.2
Smoking status: Current	0.2	0.3	0.6	-0.7	-0.3	-0.7	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.8	0.6	0.5	0.7	0.9
Whole body water mass	0.5	3.1	7.4	-0.0	-2.0	1.0	2.7
Leg predicted mass (right)	0.7	3.6	5.0	1.1	-2.0	2.2	2.1
Arm fat mass (left)	2.6	10.7	24.5	3.5	-2.4	5.0	0.7
Number of self-reported non-cancer illnesses	1.1	1.9	5.0	-2.2	0.3	-1.5	-0.5
Average weekly champagne plus white wine intake	0.4	0.6	0.9	0.9	-0.4	0.6	0.9
Miserableness	0.7	1.2	3.2	0.8	0.9	0.1	1.8
Guilty feelings	0.7	1.0	1.9	1.4	-0.6	0.8	1.1
Wears glasses or contact lenses	3.0	3.5	8.5	2.9	0.6	1.7	1.5
Ever taken oral contraceptive pill	0.7	0.7	1.3	-0.0	1.2	-1.0	0.8
Hearing aid user	0.5	0.5	1.1	-0.6	-1.1	-0.1	-0.9
Mother’s age at death	0.5	0.6	2.3	0.3	1.5	0.4	-0.1
Financial situation satisfaction	3.0	3.7	6.5	-2.5	-1.4	-2.5	-0.7
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.0	1.0	0.8	-0.1	0.3
Commuting to job workplace: Public transport	1.0	1.2	3.1	-0.2	1.7	-0.7	1.1
Eye problems/disorders: Glaucoma	2.0	2.4	4.7	2.2	2.1	0.9	0.0
Medication: Blood pressure	0.8	1.5	4.0	-1.4	-0.0	-2.0	0.4
Pain type(s) experienced in last month: Hip pain	1.0	1.3	3.0	-0.3	-1.3	-0.6	1.7
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.3	0.8	-1.1	0.3	-0.3
High cholesterol (Self-reported)	1.6	2.9	6.9	-1.4	1.4	-2.6	0.8
Medication: Bendroflumethiazide	0.4	0.7	1.4	-0.7	0.7	-1.2	-0.5
Medication: Paracetamol	0.5	0.7	0.8	-0.9	-0.8	0.7	-0.9
Medication: Lisinopril	0.2	0.2	0.6	-0.2	0.6	-0.7	0.1
Medication: Atorvastatin	0.7	0.9	2.5	-0.1	1.6	-0.5	0.9
Illnesses of father: High blood pressure	2.0	2.5	4.7	2.0	2.2	0.2	1.0
Alcohol drinker status: Never	0.4	0.5	0.8	0.9	-0.9	-0.7	-0.1
Ever smoked	0.7	1.3	2.0	-1.2	-1.4	-0.9	-0.9
Basal metabolic rate	0.7	4.0	7.0	0.8	-2.1	2.0	2.6
Leg fat percentage (left)	3.0	11.0	26.3	3.7	-2.0	5.1	-0.1
Arm fat-free mass (left)	0.6	3.1	6.3	0.4	-2.2	1.2	2.5
Number of operations (self-reported)	0.9	1.4	3.1	-1.5	-0.3	-1.8	0.3
Average weekly beer plus cider intake	1.7	2.4	5.3	-1.2	0.5	-1.6	-2.3
Irritability	1.7	2.9	6.4	0.3	-2.5	2.0	0.9
Risk taking	0.5	0.7	1.7	-0.4	0.6	-1.3	-0.8
Ever had prostate specific antigen (PSA) test	0.8	1.0	2.7	-0.5	-0.9	-0.2	-1.7
Fractured/broken bones in last 5 years	0.4	0.5	1.1	0.6	-0.3	1.0	-0.8
Age started oral contraceptive pill	0.2	0.2	0.7	0.0	-0.1	0.8	0.6
Diastolic blood pressure, automated reading	0.1	0.4	1.0	-1.0	-0.5	-0.7	-0.1
Ever depressed for a whole week	0.3	0.3	1.0	-0.1	-0.4	-1.0	-0.5
Unable to work because of sickness or disability	0.2	0.2	0.4	0.6	-0.3	-0.6	-0.2
Commuting to job workplace: Cycle	0.6	0.7	1.4	-1.1	-0.1	-1.2	-0.6
Myopia	2.1	3.0	7.4	2.7	-0.6	1.5	1.4
Vascular/heart problems diagnosed by doctor	0.6	1.6	4.5	1.0	-0.3	2.1	1.0
Cholesterol lowering medication	0.8	1.2	3.0	-0.9	0.8	-1.7	0.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.9	-0.3	0.2	-0.9	0.6
Pain experienced in last month	1.1	1.8	4.5	0.8	2.1	1.0	1.0
Supplements: Calcium	0.2	0.2	0.4	0.0	0.0	0.7	-0.5
Basal cell carcinoma (self-reported)	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.3
Heart attack/myocardial infarction (self-reported)	1.0	1.2	3.2	-1.1	0.2	-1.8	-0.6
Deep venous thrombosis (DVT) (self-reported)	4.6	5.9	13.1	2.9	-0.7	3.6	1.2
Heart disease (siblings)	2.1	2.5	5.7	1.5	-0.1	1.5	2.4
Alcohol drinker status: Previous	1.4	1.5	3.6	1.1	-1.9	1.1	0.3
Pack years of smoking	0.9	1.3	4.2	0.6	0.5	-2.0	0.5
Impedance of whole body	2.0	10.3	17.2	4.2	3.8	3.1	-0.4
Leg fat mass (left)	3.0	11.6	26.1	3.7	-2.4	5.1	0.8
Arm predicted mass (left)	0.5	2.7	5.4	0.3	-2.1	1.0	2.3