Best TWAS P=2.08e-11 · Best GWAS P=9.14e-09 conditioned to 0.0449
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | RP1-283E3.4 | 0.65 | 0.14 | lasso | 9 | 0.33 | 5.1e-28 | -3.3 | -5.9 | 4.0e-09 | 0.00 | 0.88 | 0.03 | FALSE |
2 | GTEx | Adipose Visceral Omentum | RP1-283E3.4 | 0.26 | 0.05 | enet | 25 | 0.16 | 1.5e-08 | -3.3 | -5.9 | 4.6e-09 | -0.02 | 0.14 | 0.09 | FALSE |
3 | GTEx | Artery Aorta | RP1-283E3.4 | 0.60 | 0.12 | lasso | 9 | 0.27 | 3.2e-15 | -3.3 | -5.3 | 9.4e-08 | -0.01 | 0.49 | 0.05 | FALSE |
4 | GTEx | Artery Tibial | RP1-283E3.4 | 0.66 | 0.09 | lasso | 6 | 0.38 | 4.9e-31 | -3.3 | -5.5 | 3.0e-08 | 0.01 | 0.88 | 0.03 | FALSE |
5 | GTEx | Artery Tibial | RP11-345P4.10 | 0.61 | 0.10 | lasso | 10 | 0.36 | 3.1e-29 | -3.1 | 5.3 | 1.1e-07 | 0.01 | 0.90 | 0.01 | FALSE |
6 | GTEx | Brain Cerebellar Hemisphere | RP5-890O3.9 | 0.24 | 0.02 | lasso | 9 | 0.02 | 1.3e-01 | -5.1 | 5.6 | 2.1e-08 | -0.01 | 0.02 | 0.54 | TRUE |
7 | GTEx | Cells Transformed fibroblasts | RP1-283E3.4 | 0.59 | 0.13 | lasso | 8 | 0.29 | 3.0e-22 | 3.4 | -6.2 | 7.3e-10 | 0.01 | 0.88 | 0.03 | FALSE |
8 | GTEx | Cells Transformed fibroblasts | RP11-345P4.10 | 0.66 | 0.17 | lasso | 13 | 0.32 | 7.5e-25 | -3.1 | 5.1 | 2.7e-07 | 0.00 | 0.90 | 0.01 | FALSE |
9 | GTEx | Esophagus Mucosa | TMEM52 | 0.17 | 0.18 | lasso | 2 | 0.20 | 2.9e-13 | -5.2 | 5.1 | 3.0e-07 | 0.02 | 0.02 | 0.98 | FALSE |
10 | GTEx | Esophagus Mucosa | RP1-283E3.4 | 0.53 | 0.12 | enet | 20 | 0.22 | 4.1e-15 | -3.3 | -6.5 | 6.9e-11 | 0.02 | 0.88 | 0.03 | FALSE |
11 | GTEx | Esophagus Muscularis | RP1-283E3.4 | 0.46 | 0.14 | enet | 23 | 0.24 | 1.6e-14 | -3.3 | -6.7 | 2.1e-11 | 0.01 | 0.84 | 0.03 | TRUE |
12 | GTEx | Esophagus Muscularis | RP3-395M20.12 | 0.08 | 0.06 | enet | 6 | 0.06 | 2.3e-04 | 4.2 | -5.6 | 2.1e-08 | 0.78 | 0.01 | 0.98 | TRUE |
13 | GTEx | Heart Atrial Appendage | RP11-345P4.10 | 0.36 | 0.11 | enet | 15 | 0.16 | 1.1e-07 | -3.1 | 5.5 | 4.6e-08 | -0.01 | 0.09 | 0.04 | FALSE |
14 | GTEx | Lung | RP1-283E3.4 | 0.58 | 0.07 | lasso | 7 | 0.34 | 8.8e-27 | -3.3 | -5.6 | 2.3e-08 | 0.02 | 0.88 | 0.03 | FALSE |
15 | GTEx | Muscle Skeletal | TMEM52 | 0.11 | 0.08 | lasso | 6 | 0.10 | 7.2e-10 | -5.0 | 5.5 | 4.9e-08 | -0.02 | 0.04 | 0.96 | FALSE |
16 | GTEx | Muscle Skeletal | SLC35E2B | 0.35 | 0.06 | lasso | 4 | 0.19 | 3.2e-18 | -3.1 | 5.7 | 1.4e-08 | 0.01 | 0.88 | 0.01 | FALSE |
17 | GTEx | Muscle Skeletal | RP1-283E3.4 | 0.51 | 0.12 | lasso | 6 | 0.29 | 2.4e-28 | -3.3 | -5.4 | 5.1e-08 | 0.01 | 0.88 | 0.03 | FALSE |
18 | GTEx | Muscle Skeletal | RP11-345P4.10 | 0.54 | 0.06 | lasso | 7 | 0.29 | 4.7e-29 | -3.1 | 5.5 | 3.8e-08 | 0.00 | 0.89 | 0.02 | FALSE |
19 | GTEx | Skin Not Sun Exposed Suprapubic | TMEM52 | 0.19 | 0.18 | lasso | 4 | 0.14 | 2.6e-08 | 4.9 | 5.1 | 2.8e-07 | -0.01 | 0.03 | 0.96 | FALSE |
20 | GTEx | Skin Not Sun Exposed Suprapubic | RP1-283E3.4 | 0.48 | 0.12 | lasso | 5 | 0.31 | 1.1e-17 | -3.3 | -5.9 | 3.0e-09 | 0.01 | 0.40 | 0.14 | FALSE |
21 | GTEx | Skin Sun Exposed Lower leg | TMEM52 | 0.17 | 0.14 | lasso | 7 | 0.15 | 2.0e-12 | 5.1 | 5.3 | 1.1e-07 | -0.01 | 0.02 | 0.98 | FALSE |
22 | GTEx | Thyroid | RP1-283E3.4 | 0.59 | 0.04 | lasso | 10 | 0.22 | 3.8e-17 | -3.3 | -6.2 | 5.3e-10 | 0.00 | 0.65 | 0.04 | FALSE |
23 | ROSMAP | Brain Pre-frontal Cortex | MMP23B | 0.05 | 0.04 | lasso | 2 | 0.03 | 1.9e-04 | -5.2 | -5.2 | 1.9e-07 | 0.02 | 0.02 | 0.98 | FALSE |