Best TWAS P=6.05e-10 · Best GWAS P=3.64e-06 conditioned to 0.0157
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | DCAF4 | 0.23 | 0.07 | enet | 30 | 0.13 | 4.3e-07 | 3.7 | 5.5 | 3.1e-08 | -0.35 | 0.07 | 0.70 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | RP11-109N23.6 | 0.14 | 0.11 | enet | 15 | 0.13 | 2.2e-07 | -4.1 | 5.6 | 2.4e-08 | -0.78 | 0.01 | 0.93 | FALSE |
| 3 | GTEx | Colon Sigmoid | DCAF4 | 0.30 | 0.10 | lasso | 9 | 0.11 | 1.3e-04 | 4.2 | 5.1 | 2.7e-07 | -0.34 | 0.03 | 0.38 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | DCAF4 | 0.18 | 0.01 | enet | 10 | 0.06 | 3.0e-03 | 4.2 | 6.2 | 6.0e-10 | -0.39 | 0.03 | 0.29 | TRUE |
| 5 | GTEx | Esophagus Mucosa | DCAF4 | 0.30 | 0.19 | enet | 35 | 0.23 | 1.3e-15 | 4.2 | 5.5 | 4.5e-08 | -0.48 | 0.04 | 0.86 | FALSE |
| 6 | GTEx | Esophagus Mucosa | ZFYVE1 | 0.10 | 0.00 | lasso | 7 | 0.00 | 2.0e-01 | 4.2 | 5.6 | 2.2e-08 | -0.67 | 0.03 | 0.63 | FALSE |
| 7 | GTEx | Spleen | DCAF4 | 0.47 | 0.12 | enet | 10 | 0.19 | 1.5e-05 | 3.7 | 5.2 | 2.5e-07 | -0.46 | 0.09 | 0.54 | FALSE |