Best TWAS P=2.92e-08 · Best GWAS P=1.86e-08 conditioned to 0.0553
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | DYNC1I2 | 0.12 | 0.14 | lasso | 3 | 0.14 | 1.4e-10 | -5.3 | 5.3 | 1.3e-07 | -0.81 | 0.04 | 0.96 | FALSE |
| 2 | GTEx | Muscle Skeletal | DYNC1I2 | 0.11 | 0.12 | lasso | 2 | 0.12 | 6.5e-12 | -5.4 | 5.5 | 4.7e-08 | -0.84 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | DYNC1I2 | 0.11 | 0.16 | lasso | 1 | 0.15 | 8.9e-13 | -5.3 | 5.3 | 1.5e-07 | -0.80 | 0.04 | 0.96 | FALSE |
| 4 | GTEx | Testis | DYNC1I2 | 0.13 | 0.02 | lasso | 4 | 0.01 | 1.1e-01 | -5.4 | 5.2 | 1.5e-07 | -0.81 | 0.04 | 0.79 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | AC068039.4 | 0.43 | 0.64 | enet | 35 | 0.65 | 1.6e-110 | -5.3 | -5.5 | 2.9e-08 | 0.81 | 0.03 | 0.96 | TRUE |
| 6 | YFS | Blood | SLC25A12 | 0.09 | 0.15 | lasso | 7 | 0.15 | 1.3e-45 | -5.3 | -5.2 | 1.5e-07 | 0.82 | 0.03 | 0.97 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MAP1D | 0.03 | 0.03 | lasso | 2 | 0.02 | 1.5e-03 | -5.3 | 5.2 | 2.3e-07 | -0.68 | 0.00 | 0.97 | FALSE |