Best TWAS P=2.5e-08 · Best GWAS P=9.25e-09 conditioned to 0.044
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | RAC1 | 0.19 | 0.07 | enet | 28 | 0.09 | 6.2e-07 | 4.7 | 5.2 | 2.1e-07 | 0.56 | 0.42 | 0.55 | FALSE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | DAGLB | 0.09 | 0.06 | lasso | 5 | 0.06 | 4.8e-08 | 5.6 | -5.6 | 2.5e-08 | -0.83 | 0.01 | 0.99 | TRUE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RAC1 | 0.03 | 0.02 | enet | 7 | 0.02 | 6.8e-05 | 4.4 | 5.5 | 3.9e-08 | 0.69 | 0.11 | 0.78 | FALSE |
| 4 | The Cancer Genome Atlas | Thyroid Carcinoma | DAGLB | 0.06 | 0.02 | blup | 71 | 0.03 | 7.4e-04 | 4.7 | -5.3 | 8.7e-08 | -0.70 | 0.01 | 0.77 | FALSE |