Best TWAS P=6.39e-13 · Best GWAS P=3.79e-14 conditioned to 1.05e-237
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | COL14A1 | 0.07 | 0.02 | enet | 21 | 0.04 | 2.1e-05 | -2.0 | 5.7 | 1.4e-08 | -0.01 | 0.01 | 0.99 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | NOV | 0.06 | 0.02 | enet | 8 | 0.05 | 1.5e-06 | -4.1 | -5.3 | 1.1e-07 | 0.71 | 0.10 | 0.90 | TRUE |
| 3 | GTEx | Artery Aorta | NOV | 0.12 | 0.05 | enet | 18 | 0.04 | 3.7e-03 | -5.0 | -6.3 | 2.6e-10 | 0.79 | 0.04 | 0.83 | TRUE |
| 4 | GTEx | Colon Sigmoid | NOV | 0.15 | 0.16 | lasso | 4 | 0.15 | 6.6e-06 | -7.3 | -7.2 | 6.4e-13 | 0.91 | 0.03 | 0.96 | TRUE |
| 5 | GTEx | Lung | NOV | 0.06 | 0.02 | enet | 23 | 0.03 | 2.5e-03 | -3.0 | -5.4 | 6.3e-08 | 0.66 | 0.19 | 0.47 | FALSE |
| 6 | GTEx | Nerve Tibial | TAF2 | 0.14 | 0.04 | enet | 10 | 0.07 | 1.5e-05 | 4.1 | -5.3 | 9.2e-08 | 0.19 | 0.90 | 0.04 | TRUE |
| 7 | GTEx | Skin Sun Exposed Lower leg | NOV | 0.11 | 0.03 | lasso | 7 | 0.04 | 1.4e-04 | -6.9 | -6.2 | 5.0e-10 | 0.95 | 0.01 | 0.99 | TRUE |
| 8 | NTR | Blood | NOV | 0.02 | 0.01 | bslmm | 481 | 0.01 | 1.7e-04 | -7.3 | -5.9 | 3.7e-09 | 0.78 | 0.02 | 0.98 | TRUE |
| 9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | NOV | 0.03 | 0.00 | blup | 42 | 0.01 | 5.3e-02 | -6.9 | -7.2 | 7.5e-13 | 0.97 | 0.02 | 0.78 | FALSE |
| 10 | The Cancer Genome Atlas | Colon Adenocarcinoma | NOV | 0.31 | 0.10 | blup | 42 | 0.10 | 1.2e-06 | -7.6 | -6.1 | 9.0e-10 | 0.83 | 0.01 | 0.99 | FALSE |
| 11 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NOV | 0.11 | 0.02 | enet | 15 | 0.05 | 2.9e-03 | -7.6 | -7.1 | 9.6e-13 | 0.84 | 0.01 | 0.64 | TRUE |
| 12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NOV | 0.04 | 0.05 | blup | 42 | 0.05 | 8.7e-06 | -7.3 | -6.2 | 7.4e-10 | 0.82 | 0.03 | 0.96 | TRUE |