TWAS hub - COL14A1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.065	0.023	7.8e-05	0.023	0.034	0.037	0.035	0.033	0.00072	5.2e-05	2.1e-05	4e-05	5.9e-05
2	GTEx	Thyroid	0.096	0.038	5.2e-03	0.018	NA	0.015	NA	0.013	0.01500	NA	2.3e-02	NA	3.0e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Height	5.4	103.8	156.2	7.2	-12.5
Arm fat-free mass (left)	5.4	27.5	33.6	5.8	-4.6
Arm predicted mass (left)	5.1	25.8	33.9	5.8	-4.2
Arm fat-free mass (right)	5.0	25.5	32.3	5.7	-4.3
Medication: Aspirin	5.0	6.6	8.6	2.1	-2.9
Medication: Aspirin	4.9	6.4	7.5	2.3	-2.7
Arm predicted mass (right)	4.6	23.4	28.7	5.4	-4.2
Hearing difficulty/problems: Yes	4.2	6.4	12.5	0.5	3.5
Leg fat-free mass (right)	4.2	22.3	23.8	4.9	-4.6
Whole body water mass	4.2	24.0	26.2	5.1	-4.7
Leg predicted mass (right)	4.2	22.2	23.5	4.8	-4.6
Trunk predicted mass	4.1	23.6	27.6	5.3	-4.4
Whole body fat-free mass	4.1	23.5	26.1	5.1	-4.6
Trunk fat-free mass	4.0	23.0	26.9	5.2	-4.4
Basal metabolic rate	4.0	22.2	24.4	4.9	-4.5
Father’s age at death	3.9	5.2	9.8	-3.1	0.8
Loud music exposure frequency	3.9	4.2	8.1	0.6	2.8
Commuting to job workplace: Car/motor vehicle	3.9	4.4	4.7	2.0	-2.2
Deep venous thrombosis (DVT) (self-reported)	3.9	5.0	5.1	2.2	-2.2
Prospective memory result	3.8	4.6	5.3	2.0	-2.3
Standing height	3.6	35.3	52.1	4.3	-7.2
Blood clot in the leg (DVT)	3.6	4.6	5.3	2.3	-2.0
Diabetes (mother)	3.5	4.4	5.3	1.9	-2.3
Comparative height size at age 10	3.4	18.9	28.6	3.0	-5.3
Breast cancer (self-reported)	3.3	4.0	4.1	2.0	-2.0
Number of operations (self-reported)	3.3	4.9	8.2	-1.3	2.9
Leg fat-free mass (left)	3.2	16.8	17.7	4.0	-4.2
Leg predicted mass (left)	3.2	17.1	17.8	4.0	-4.2
Ever had stillbirth, spontaneous miscarriage or termination	3.2	3.4	4.1	-2.0	1.7
Waist Hip Ratio (WHR)	3.1	13.8	24.4	-4.9	1.8
Alcohol usually taken with meals	3.1	5.0	6.8	-2.6	1.8
Wheeze or whistling in the chest in last year	3.1	5.5	7.1	-2.7	2.0
Handedness (chirality/laterality): Left-handed	3.1	3.7	5.2	-2.3	-1.5
Had major operations	3.0	3.5	5.9	-1.1	2.4
Pack years of smoking	3.0	4.3	8.4	-2.9	-0.5
Ever used hormone-replacement therapy (HRT)	2.9	3.7	7.2	-2.7	-0.5
Hearing difficulty/problems with background noise	2.9	4.7	8.5	-0.9	2.9
Forced vital capacity (FVC)	2.9	11.2	16.4	2.5	-4.0
Weight	2.9	14.4	15.3	3.7	-3.9
Medication: Blood pressure	2.9	5.6	7.2	2.7	-2.0
Basal cell carcinoma (self-reported)	2.7	3.2	3.8	-1.6	1.9
Asthma	2.6	5.1	6.8	-2.6	1.8
Pain type(s) experienced in last month: Hip pain	2.6	3.3	5.2	-2.3	1.2
Medication: Ibuprofen (e.g. Nurofen)	2.5	3.2	5.9	2.4	-0.7
Heart disease (mother)	2.5	3.0	4.9	-2.2	-1.1
Impedance of arm (right)	2.4	11.3	22.6	-4.7	0.4
Forced vital capacity (FVC), Best measure	2.4	8.9	13.3	2.1	-3.6
Respiratory disease	2.3	5.2	7.0	-2.6	1.8
Birth weight of first child	2.3	4.2	8.4	0.1	-2.9
Mean Putamen Volume	2.2	2.5	4.2	0.9	-2.0
Pack years adult smoking proportion	2.2	3.3	6.6	-2.6	-0.3
Had other major operations	2.2	2.6	3.7	-1.9	1.2
Asthma (self-reported)	2.2	4.4	6.4	-2.5	1.6
Pulse rate	2.1	3.6	4.1	-1.8	2.0
Impedance of arm (left)	2.0	9.2	18.4	-4.3	0.2
Blood Platelet Count	1.9	21.5	29.2	-3.7	5.4
Diabetes (father)	1.9	2.4	3.4	1.2	-1.9
Emphysema/chronic bronchitis	1.9	2.1	2.8	-1.7	-1.2
Medication for pain relief, constipation, heartburn	1.9	3.3	3.8	-1.9	1.7
Vitamin and mineral supplements	1.8	2.4	4.6	2.1	-0.5
Impedance of leg (right)	1.8	8.5	14.8	-3.9	1.5
Number of live births	1.8	2.6	4.0	2.0	1.1
Gout (self-reported)	1.8	2.5	2.7	1.7	-1.5
Medication: Seretide 50 evohaler	1.8	2.0	4.0	0.4	2.0
Tinnitus: Yes, now most or all of the time	1.8	2.1	3.2	1.8	1.0
Major Depression (MDD)	1.7	2.1	2.3	-1.4	1.5
Ulcerative Colitis	1.7	2.4	2.6	1.5	1.6
Serious illness, injury or assault to yourself	1.7	2.1	2.5	1.6	-1.3
Sitting height	1.7	11.9	14.0	3.1	-3.7
Hip circumference	1.7	7.5	8.5	2.9	-2.5
Noisy workplace	1.7	2.1	3.0	1.1	1.7
Medication: Ibuprofen	1.7	2.0	3.7	1.9	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	4.8	1.5	-2.2
Eye problems/disorders: Cataract	1.7	2.0	3.9	2.0	-0.3
Guilty feelings	1.7	2.6	3.9	-1.1	2.0
Myopia	1.7	2.4	2.6	1.6	-1.5
Trunk fat mass	1.6	6.7	10.1	1.8	-3.2
Time employed in main current job	1.6	1.8	2.3	1.2	-1.5
Osteoarthritis (self-reported)	1.6	2.1	3.7	0.7	-1.9
Average weekly beer plus cider intake	1.6	2.3	4.6	2.1	-0.3
Depression (Nagel 2018)	1.5	2.2	3.4	-1.8	1.0
Lung FEV1/FVC ratio	1.5	7.4	7.9	-2.8	2.6
Sensitivity / hurt feelings	1.5	2.5	4.0	1.0	-2.0
Systolic blood pressure, automated reading	1.5	4.4	4.8	2.2	-2.0
Depression (self-reported)	1.5	1.8	2.3	1.5	-1.2
Breastfed as a baby	1.5	1.8	2.9	1.7	-0.9
Chronic bronchitis/emphysema (mother)	1.5	1.7	2.4	-1.6	-1.0
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	3.4	-0.6	1.8
Medication for cholesterol	1.5	2.2	2.4	-1.4	1.5
Diastolic blood pressure, automated reading	1.5	4.5	7.6	1.2	-2.8
Vascular/heart problems diagnosed by doctor	1.5	4.2	5.7	-2.4	1.6
Supplements: Calcium	1.5	1.6	2.2	-1.0	1.5
Ulcerative Colitis (UC)	1.4	2.7	3.5	1.4	1.9
Bipolar Disorder (2011)	1.4	1.4	1.5	1.2	1.1
Blood White Count	1.4	10.3	12.9	-2.8	3.6
Severe depression (siblings)	1.4	1.5	2.4	0.8	-1.6
Multivitamins +/- minerals	1.4	1.7	2.8	-1.7	0.8
High blood pressure (mother)	1.4	1.9	3.8	2.0	-0.2
Heart attack	1.4	1.8	3.2	1.8	-0.7
Illnesses of mother	1.4	1.8	2.7	-0.9	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	3.5	1.9	-0.4
Diabetes diagnosed by doctor	1.4	2.2	2.4	1.6	-1.4
Age started oral contraceptive pill	1.4	1.8	2.6	1.0	-1.6
Coronary Artery Disease (CAD)	1.3	1.6	2.9	-0.4	1.7
Peak expiratory flow (PEF)	1.3	3.1	5.0	-1.1	2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	2.9	1.7	-0.5
Suffer from ‘nerves’	1.3	2.0	3.9	2.0	0.4
Family relationship satisfaction	1.3	1.7	2.6	-1.6	0.8
Primary Biliary Cirrhosis	1.2	1.7	2.7	0.9	1.6
Qualifications: CSEs or equivalent	1.2	1.6	2.0	-1.1	1.4
High blood pressure	1.2	3.2	5.0	2.2	-1.2
Nervous feelings	1.2	2.2	4.2	2.1	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.7	4.9	1.6	-2.2
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	1.5	1.1	-1.2
Shortness of breath walking on level ground	1.2	1.4	2.1	0.9	-1.4
Whole body fat mass	1.2	4.9	6.6	1.8	-2.6
Overall health rating	1.2	2.7	4.1	2.0	-1.1
Supplements: Vitamin C	1.2	1.4	1.8	1.0	-1.4
Hypertension (Self-reported)	1.2	3.3	4.8	2.2	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.5	2.5	-1.6	-0.6
Heart attack/myocardial infarction (self-reported)	1.2	1.5	2.7	1.6	-0.6
Impedance of whole body	1.2	6.1	12.1	-3.5	0.4
Lung FVC	1.1	5.8	10.2	1.1	-3.2
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	2.7	-0.5	1.6
Financial difficulties in last 2 years	1.1	1.5	2.6	1.6	-0.7
Leg pain on walking	1.1	1.4	2.6	1.6	0.5
Number of self-reported non-cancer illnesses	1.1	1.9	1.9	1.4	-1.4
Leg fat mass (left)	1.1	4.2	4.8	2.2	-1.9
Medication: Co-codamol	1.0	1.2	2.4	-0.0	-1.5
Current tobacco smoking	1.0	1.6	2.0	-1.4	-1.1
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	2.0	-0.0	1.4
Hair/balding pattern: Pattern 2	1.0	1.3	1.7	-1.3	0.9
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	3.9	1.8	-2.0
Back pain experienced in last month	1.0	1.5	3.0	-1.7	-0.0
Worry (Nagel 2018)	0.9	1.9	3.6	1.9	-0.4
Alzheimer’s Disease (in mother)	0.9	1.1	2.2	1.5	0.2
Medication: Atenolol	0.9	1.2	2.0	0.6	-1.4
Number of incorrect matches in round	0.9	1.4	2.7	-1.6	-0.5
Illnesses of siblings	0.9	1.2	2.0	-0.7	1.4
Medication: Cholesterol lowering	0.9	1.4	1.7	1.3	-1.0
Arm fat mass (right)	0.9	3.7	4.1	1.8	-2.0
Number of children fathered	0.9	1.0	1.4	1.2	-0.8
Mean time to correctly identify matches	0.9	1.8	2.7	-0.9	-1.6
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	2.4	-1.6	0.8
Mineral and other dietary supplements	0.9	1.2	1.5	1.2	-0.9
Smoking status: Current	0.9	1.5	1.8	-1.4	-1.1
Hearing aid user	0.9	1.0	1.6	-1.3	0.7
Medication: Bendroflumethiazide	0.9	1.4	2.3	1.5	-0.7
Fasting Glucose	0.8	1.0	2.0	0.1	-1.4
Ever highly irritable/argumentative for 2 days	0.8	0.9	1.8	1.4	-0.0
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.1	-1.0	1.0
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.8	-0.0	1.3
Reaction Time	0.7	1.3	1.4	-1.1	-1.2
Breast Cancer	0.7	1.8	2.8	-1.7	-0.9
HDL Cholesterol	0.7	1.1	2.0	-1.4	-0.4
Triglycerides	0.7	1.2	1.8	1.4	0.7
Heel T-Score	0.7	5.5	5.8	-2.4	2.3
Trunk fat percentage	0.7	2.9	5.4	0.5	-2.3
Hand grip strength (right)	0.7	1.9	3.5	1.9	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.4	-1.2	0.7
Taking other prescription medications	0.7	1.1	2.2	-0.1	-1.5
Medication: Ramipril	0.7	0.8	1.2	1.1	-0.7
Medication: Allopurinol	0.7	1.0	1.8	0.3	-1.4
Pulse rate, automated reading	0.7	2.1	4.0	-0.6	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.5	-1.2	0.3
Arm fat mass (left)	0.7	3.0	3.2	1.7	-1.8
Mother’s age at death	0.7	0.9	1.4	-1.2	0.6
Pain experienced in last month	0.7	1.2	1.3	1.1	1.1
Ovarian Cancer	0.6	0.7	0.8	-0.8	0.9
HbA1C	0.6	0.7	1.0	1.0	-0.5
Neuroticism (2016)	0.6	0.9	1.3	1.1	0.7
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	0.8	0.7	-0.9
Maternal smoking around birth	0.6	0.9	1.8	-0.2	1.3
Supplements: Glucosamine	0.6	0.8	1.0	-1.0	-0.8
Impedance of leg (left)	0.6	2.9	5.4	-2.3	0.7
Diabetes (self-reported)	0.6	0.9	1.1	0.8	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.9	1.4	-0.3
Medication: Paracetamol	0.6	1.0	1.9	1.4	0.0
Leg fat mass (right)	0.6	2.5	2.5	1.6	-1.6
Ever had bowel cancer screening	0.6	0.7	0.8	-0.8	0.9
Qualifications: nursing, teaching	0.6	0.9	1.2	-1.1	0.8
Wears glasses or contact lenses	0.6	0.7	1.0	-0.7	-1.0
Ever taken oral contraceptive pill	0.6	0.6	0.9	0.9	-0.6
Commuting to job workplace: Public transport	0.6	0.7	1.5	-1.2	0.1
Alcohol drinker status: Previous	0.6	0.7	1.0	1.0	0.6
LDL Cholesterol	0.5	0.7	1.5	1.2	0.1
Blood Red Count	0.5	5.1	6.2	-2.0	2.5
Systolic Blood Pressure	0.5	2.6	4.8	2.2	-0.6
Townsend deprivation index at recruitment	0.5	0.8	1.1	-0.6	1.1
Relative age voice broke	0.5	0.8	1.3	1.2	-0.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.2	-0.0	-1.1
Chronic bronchitis/emphysema (father)	0.5	0.6	1.0	-1.0	0.4
Body mass index (BMI)	0.5	2.2	3.8	2.0	-0.8
Medication: Simvastatin	0.5	0.8	0.9	1.0	-0.8
Fluid intelligence score	0.5	1.0	1.7	-1.3	0.5
Alcohol intake versus 10 years previously	0.5	0.8	1.6	-0.1	1.3
Medication: Lansoprazole	0.5	0.6	0.8	-0.7	0.9
Exposure to tobacco smoke at home	0.5	0.6	0.9	0.9	-0.5
Tense / ‘highly strung’	0.5	0.9	1.2	1.1	0.7
Headache pain in last month	0.5	0.9	1.0	0.9	1.0
Worry too long after embarrassment	0.5	0.8	1.2	-0.7	1.1
Health satisfaction	0.5	0.6	0.7	0.7	-0.8
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.9	-1.0	-0.6
Alcohol intake frequency.	0.5	1.1	2.2	0.1	1.5
Smoking status: Previous	0.5	0.7	1.2	1.1	-0.5
Schizophrenia vs Biploar Disorder	0.4	0.5	0.8	0.4	0.9
Crohns Disease (2017)	0.4	0.8	1.1	-0.8	-1.0
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.6	-0.5	1.3
Hypothyroidism (self reported)	0.4	1.0	1.3	1.1	-0.9
Chronotype (morning person)	0.4	0.9	1.8	-0.0	1.3
Relative age of first facial hair	0.4	0.8	1.5	-1.2	0.1
Ever had hysterectomy (womb removed)	0.4	0.4	0.5	-0.7	0.6
Fed-up feelings	0.4	0.7	1.2	1.1	-0.3
Stomach or abdominal pain in last month	0.4	0.5	1.0	-1.0	0.2
Had menopause	0.4	0.5	0.6	-0.7	-0.8
Pulse wave reflection index	0.4	0.5	1.1	0.0	-1.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	0.7	0.7	-0.8
Eye problems/disorders: None of the above	0.4	0.5	1.0	-1.0	-0.1
Number of full sisters	0.4	0.5	0.6	0.8	0.6
Friendships satisfaction	0.4	0.5	0.9	0.1	-1.0
Commuting to job workplace: Walk	0.4	0.4	0.7	-0.8	0.4
Osteoporosis (self-reported)	0.4	0.5	0.5	0.7	-0.7
Miserableness	0.4	0.7	1.2	1.1	-0.5
Risk taking	0.4	0.6	1.1	0.3	-1.0
Ever depressed for a whole week	0.4	0.5	1.0	-0.3	1.0
Commuting to job workplace: Cycle	0.4	0.5	0.8	0.5	0.9
Alzheimer’s Disease (in father)	0.3	0.3	0.3	-0.6	0.5
Alzheimer’s Disease (including proxy)	0.3	0.4	0.6	0.5	0.8
Age at First Birth	0.3	0.5	0.6	0.6	0.7
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.7	0.8	-0.7
Hand grip strength (left)	0.3	0.9	1.6	1.3	0.5
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.6	-0.8	0.6
Past tobacco smoking	0.3	0.5	0.8	-0.9	0.4
Mouth/teeth dental problems	0.3	0.4	0.6	0.4	0.8
Hair/balding pattern: Pattern 3	0.3	0.4	0.8	0.2	-0.9
Hair/balding pattern: Pattern 4	0.3	0.7	1.3	1.1	0.2
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.0	-1.0	0.3
Medication: Amlodipine	0.3	0.4	0.8	-0.3	-0.9
High blood pressure (siblings)	0.3	0.5	0.6	0.6	-0.8
Body fat percentage	0.3	1.1	2.0	0.5	-1.4
Comparative body size at age 10	0.3	0.8	0.9	-0.8	0.9
High cholesterol (Self-reported)	0.3	0.5	0.6	0.6	-0.8
Medication: Atorvastatin	0.3	0.4	0.7	-0.3	0.8
Leg fat percentage (left)	0.3	1.0	1.1	1.1	-0.9
Unable to work because of sickness or disability	0.3	0.4	0.7	-0.3	0.8
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.7	-0.1	0.8
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.0	-1.0	0.4
Prostate Cancer	0.2	0.3	0.5	0.7	0.1
Crohns Disease (2012)	0.2	0.3	0.5	0.2	-0.7
Lupus	0.2	0.3	0.5	-0.7	-0.2
Schizophrenia (2014)	0.2	0.5	0.7	0.8	0.6
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.3	-0.3	-0.6
Allergy or Eczema	0.2	0.7	1.2	-1.1	-0.3
Cardiovascular Disease	0.2	0.6	1.0	1.0	-0.5
Neuroticism	0.2	0.4	0.6	0.8	-0.5
Number of treatments/medications taken	0.2	0.4	0.6	0.5	-0.8
Average weekly spirits intake	0.2	0.3	0.4	0.6	-0.4
Supplements: Zinc	0.2	0.2	0.4	-0.3	0.6
Medication: Metformin	0.2	0.3	0.3	0.5	0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	0.7	-0.1
Waist circumference	0.2	0.6	1.2	0.3	-1.1
Qualifications: None of the above	0.2	0.4	0.8	0.9	0.1
Allergy	0.2	0.4	0.8	0.9	-0.1
Falls in the last year	0.2	0.3	0.4	0.7	0.4
Happiness	0.2	0.2	0.3	-0.6	0.3
Mouth/teeth dental problems: Dentures	0.2	0.3	0.5	-0.7	-0.3
Length of working week for main job	0.2	0.2	0.4	-0.7	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.5	0.7	0.3
Number of full brothers	0.2	0.2	0.3	-0.3	0.6
Qualifications: College or University degree	0.2	0.6	0.9	1.0	0.6
Angina (self-reported)	0.2	0.3	0.3	-0.6	-0.5
Age at last live birth	0.2	0.3	0.5	0.7	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.4	0.5	-0.6
Medication: Paracetamol	0.2	0.3	0.6	0.8	-0.3
Medication: Lisinopril	0.2	0.3	0.5	0.7	0.3
Illnesses of father: High blood pressure	0.2	0.2	0.4	-0.6	-0.0
Bipolar Disorder (2018)	0.1	0.2	0.4	0.1	0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.4	0.7	0.4
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	-0.3	-0.6
Schizophrenia (2018)	0.1	0.3	0.5	0.7	-0.0
Irritable Bowel Disease (IBD)	0.1	0.2	0.3	0.6	0.2
Body Mass Index (BMI) (2010)	0.1	0.2	0.2	0.5	0.3
BMI	0.1	0.3	0.4	0.4	0.6
Angina	0.1	0.1	0.1	-0.3	-0.4
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.1	-0.5
Age when periods started (menarche)	0.1	0.3	0.4	0.3	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.2	0.3	-0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.3	0.2	0.6
Pain all over the body in last month	0.1	0.2	0.2	-0.2	-0.5
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	-0.4	-0.2
Neuroticism score	0.1	0.2	0.3	0.6	0.1
Worrier / anxious feelings	0.1	0.1	0.1	0.4	-0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.2	-0.5	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.4	-0.2
Lung cancer (father)	0.1	0.1	0.1	0.0	-0.4
Pulse wave Arterial Stiffness index	0.1	0.1	0.1	0.4	-0.0
Glaucoma (self-reported)	0.1	0.1	0.1	0.2	0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	0.1	0.5
Birth weight	0.1	0.3	0.5	0.2	-0.7
Exposure to tobacco smoke outside home	0.1	0.2	0.3	-0.5	0.3
Age at first live birth	0.1	0.1	0.2	-0.4	0.2
Pulse wave peak to peak time	0.1	0.1	0.2	-0.1	-0.4
Neck or shoulder pain in last month	0.1	0.2	0.4	-0.6	0.1
Medication: Blood pressure	0.1	0.2	0.4	0.6	-0.4
Medication: Omeprazole	0.1	0.2	0.3	-0.2	0.6
Chest pain or discomfort	0.1	0.2	0.3	0.3	-0.6
Knee pain experienced in last month	0.1	0.2	0.2	-0.4	-0.4
Illnesses of father: Heart disease	0.1	0.1	0.2	0.5	-0.2
Average weekly red wine intake	0.1	0.1	0.1	0.3	-0.3
Mood swings	0.1	0.2	0.5	-0.7	0.0
Loneliness, isolation	0.1	0.1	0.3	0.1	0.5
Long-standing illness, disability or infirmity	0.1	0.2	0.4	0.0	-0.6
Medication: Gliclazide	0.1	0.1	0.1	0.4	0.1
Illnesses of father: None of the above (group 1)	0.1	0.1	0.1	0.3	0.4
Average weekly champagne plus white wine intake	0.1	0.1	0.1	-0.3	0.3
Financial situation satisfaction	0.1	0.2	0.3	-0.1	0.6
Alcohol drinker status: Never	0.1	0.1	0.2	0.5	0.1
Ever smoked	0.1	0.1	0.2	0.4	-0.0
Fractured/broken bones in last 5 years	0.1	0.2	0.2	-0.4	0.4
Neuroticism (Nagel 2018)	0.0	0.0	0.0	0.2	-0.2
Rheumatoid Arthritis	0.0	0.1	0.1	-0.3	0.2
Blood Eosinophil Count	0.0	0.3	0.5	0.7	0.4
Smoking Status	0.0	0.1	0.2	-0.2	-0.4
Hair Pigment	0.0	0.7	1.4	0.3	-1.2
Tanning	0.0	0.4	0.6	-0.8	0.5
Average weekly fortified wine intake	0.0	0.0	0.1	-0.3	-0.2
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	-0.4	-0.1
Medication: Levothyroxine sodium	0.0	0.1	0.1	0.3	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.0	-0.1	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.1	-0.3	0.1
Arm fat percentage (right)	0.0	0.1	0.3	-0.1	-0.5
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.0	0.1	-0.1
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.0	0.2	0.1
Leg fat percentage (right)	0.0	0.0	0.1	-0.0	-0.3
Migraine (self-reported)	0.0	0.0	0.1	0.1	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.1	-0.1	0.2
Illnesses of siblings: Diabetes	0.0	0.0	0.0	0.1	-0.0
Arm fat percentage (left)	0.0	0.1	0.2	-0.2	-0.4
Eye problems/disorders: Glaucoma	0.0	0.0	0.0	0.0	0.2
Irritability	0.0	0.0	0.0	-0.1	-0.0
Cholesterol lowering medication	0.0	0.1	0.1	-0.0	0.3
Heart disease (siblings)	0.0	0.1	0.1	-0.3	-0.1

Hub : Genes

COL14A1

Models

Trait associations