Best TWAS P=1.19e-13 · Best GWAS P=5.82e-16 conditioned to 0.000955
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | DNA2 | 0.32 | 0.18 | lasso | 9 | 0.20 | 1.9e-10 | -5.3 | 5.5 | 4.8e-08 | 0.34 | 1.00 | 0.00 | FALSE |
2 | GTEx | Artery Aorta | DNA2 | 0.22 | 0.17 | lasso | 6 | 0.16 | 5.1e-09 | -4.6 | 5.2 | 2.3e-07 | 0.32 | 1.00 | 0.00 | FALSE |
3 | GTEx | Artery Coronary | DNA2 | 0.12 | 0.12 | lasso | 5 | 0.12 | 5.3e-05 | -5.2 | 5.7 | 1.3e-08 | 0.35 | 0.31 | 0.19 | FALSE |
4 | GTEx | Brain Cerebellum | SLC25A16 | 0.22 | 0.15 | lasso | 9 | 0.19 | 2.2e-06 | -4.6 | -5.2 | 1.8e-07 | -0.33 | 0.32 | 0.04 | FALSE |
5 | GTEx | Brain Hypothalamus | SLC25A16 | 0.20 | 0.19 | lasso | 5 | 0.14 | 3.6e-04 | -5.3 | -5.3 | 1.1e-07 | -0.32 | 0.15 | 0.05 | FALSE |
6 | GTEx | Cells EBV-transformed lymphocytes | DNA2 | 0.32 | 0.14 | lasso | 2 | 0.10 | 2.9e-04 | -5.3 | 5.3 | 1.2e-07 | 0.33 | 0.46 | 0.03 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | SLC25A16 | 0.10 | 0.02 | enet | 25 | 0.01 | 2.5e-02 | -4.3 | -6.6 | 4.2e-11 | -0.54 | 0.70 | 0.20 | FALSE |
8 | GTEx | Heart Atrial Appendage | PBLD | 0.08 | 0.02 | lasso | 2 | 0.02 | 6.1e-02 | -6.4 | -6.9 | 6.7e-12 | -0.41 | 0.11 | 0.09 | FALSE |
9 | GTEx | Lung | DNA2 | 0.22 | 0.17 | enet | 12 | 0.24 | 3.9e-18 | -5.2 | 5.4 | 8.3e-08 | 0.35 | 1.00 | 0.00 | FALSE |
10 | GTEx | Ovary | DNA2 | 0.15 | 0.12 | lasso | 3 | 0.06 | 1.7e-02 | -5.2 | 5.3 | 9.0e-08 | 0.34 | 0.12 | 0.05 | FALSE |
11 | GTEx | Pancreas | DNA2 | 0.12 | 0.06 | enet | 9 | 0.08 | 4.1e-04 | -4.3 | 5.8 | 8.5e-09 | 0.40 | 0.36 | 0.32 | FALSE |
12 | GTEx | Skin Not Sun Exposed Suprapubic | DNA2 | 0.29 | 0.16 | lasso | 14 | 0.22 | 2.4e-12 | -4.6 | 5.4 | 6.6e-08 | 0.32 | 1.00 | 0.00 | FALSE |
13 | NTR | Blood | SLC25A16 | 0.03 | 0.02 | enet | 16 | 0.03 | 1.7e-09 | -5.2 | -5.6 | 2.1e-08 | -0.41 | 1.00 | 0.00 | FALSE |
14 | ROSMAP | Brain Pre-frontal Cortex | SLC25A16 | 0.17 | 0.11 | lasso | 6 | 0.15 | 2.9e-19 | -4.3 | -5.6 | 2.3e-08 | -0.33 | 1.00 | 0.00 | FALSE |
15 | YFS | Blood | SLC25A16 | 0.09 | 0.13 | lasso | 3 | 0.13 | 6.8e-39 | -5.2 | -5.6 | 2.4e-08 | -0.35 | 1.00 | 0.00 | TRUE |
16 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PBLD | 0.06 | 0.07 | lasso | 2 | 0.04 | 2.3e-04 | -6.0 | -6.0 | 2.5e-09 | -0.32 | 0.01 | 0.98 | FALSE |
17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SLC25A16 | 0.01 | 0.02 | lasso | 2 | 0.01 | 5.5e-04 | -5.3 | -5.3 | 1.3e-07 | -0.33 | 0.34 | 0.06 | FALSE |
18 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | DNA2 | 0.08 | 0.09 | lasso | 1 | 0.06 | 7.3e-04 | -6.5 | 6.5 | 9.2e-11 | 0.39 | 0.00 | 0.97 | FALSE |
19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ATOH7 | 0.05 | 0.01 | lasso | 3 | 0.02 | 2.6e-03 | -5.9 | 5.2 | 2.2e-07 | 0.26 | 0.01 | 0.81 | FALSE |
20 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PBLD | 0.03 | 0.03 | lasso | 9 | 0.02 | 1.6e-03 | -5.1 | -5.1 | 2.7e-07 | -0.26 | 0.04 | 0.66 | FALSE |
21 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PBLD | 0.10 | 0.03 | lasso | 3 | 0.04 | 2.2e-05 | -6.0 | -5.6 | 1.7e-08 | -0.31 | 0.02 | 0.98 | FALSE |
22 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | DNA2 | 0.05 | 0.00 | blup | 43 | 0.00 | 3.0e-01 | -5.4 | 5.9 | 3.6e-09 | 0.39 | 0.02 | 0.71 | FALSE |
23 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PBLD | 0.12 | 0.18 | enet | 10 | 0.18 | 6.7e-20 | -4.5 | -5.3 | 1.1e-07 | -0.35 | 0.39 | 0.61 | FALSE |
24 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SLC25A16 | 0.05 | 0.01 | blup | 42 | 0.02 | 2.9e-03 | -5.4 | -6.2 | 4.7e-10 | -0.51 | 0.11 | 0.71 | FALSE |
25 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SLC25A16 | 0.02 | 0.02 | enet | 8 | 0.02 | 7.7e-04 | -6.5 | -6.3 | 4.1e-10 | -0.38 | 0.09 | 0.03 | FALSE |
26 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PBLD | 0.03 | 0.01 | blup | 76 | 0.01 | 1.3e-02 | -5.0 | -5.2 | 1.6e-07 | -0.30 | 0.06 | 0.34 | FALSE |
27 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SLC25A16 | 0.07 | 0.03 | blup | 42 | 0.02 | 1.7e-02 | -6.5 | -7.4 | 1.2e-13 | -0.53 | 0.12 | 0.16 | TRUE |
28 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | DNA2 | 0.14 | 0.07 | blup | 43 | 0.08 | 8.6e-04 | -5.5 | -5.9 | 4.0e-09 | -0.39 | 0.07 | 0.51 | FALSE |
29 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC25A16 | 0.05 | 0.05 | lasso | 3 | 0.04 | 3.8e-05 | -5.2 | -5.5 | 4.5e-08 | -0.36 | 0.30 | 0.10 | FALSE |