TWAS hub - SLC25A16

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1700	0.0470	1.0e-07	0.036	0.070	0.085	0.094	0.094	3.2e-05	6.1e-09	1.4e-10	1.8e-11	1.5e-11
2	GTEx	Brain Cerebellar Hemisphere	0.2980	0.0990	1.1e-03	0.158	NA	0.054	NA	0.082	7.3e-05	NA	1.7e-02	NA	4.0e-03
3	GTEx	Brain Cerebellum	0.2160	0.0770	2.0e-03	0.153	NA	0.142	NA	0.194	2.8e-05	NA	5.7e-05	NA	2.1e-06
4	GTEx	Brain Hypothalamus	0.1980	0.0840	5.4e-03	0.186	NA	0.103	NA	0.140	3.9e-05	NA	2.2e-03	NA	3.6e-04
5	GTEx	Cells Transformed fibroblasts	0.1000	0.0380	6.9e-05	0.024	NA	0.015	NA	0.015	5.9e-03	NA	2.5e-02	NA	2.6e-02
6	GTEx	Esophagus Mucosa	0.1000	0.0490	5.3e-03	0.023	NA	0.039	NA	0.037	1.0e-02	NA	1.3e-03	NA	1.6e-03
7	GTEx	Esophagus Muscularis	0.0980	0.0470	3.3e-03	0.073	NA	0.059	NA	0.059	3.2e-05	NA	1.8e-04	NA	1.7e-04
8	GTEx	Testis	0.2410	0.0860	5.3e-05	0.233	NA	0.183	NA	0.191	1.1e-10	NA	1.5e-08	NA	7.3e-09
9	NTR	Blood	0.0265	0.0086	1.9e-08	0.019	0.026	0.028	0.024	0.024	5.4e-07	8.2e-09	1.7e-09	2.7e-08	1.9e-08
10	ROSMAP	Brain Pre-frontal Cortex	0.1674	0.0405	1.9e-13	0.106	0.119	0.145	0.143	0.154	1.6e-13	4.2e-15	3.3e-18	5.3e-18	2.9e-19
11	YFS	Blood	0.0895	0.0217	0.0e+00	0.127	0.113	0.123	0.125	0.126	2.4e-39	4.3e-35	3.4e-38	7.9e-39	6.8e-39
12	TCGA	Bladder Urothelial Carcinoma	0.0310	0.0170	3.2e-03	0.016	0.021	0.007	NA	0.013	1.6e-02	6.7e-03	7.6e-02	NA	2.7e-02
13	TCGA	Breast Invasive Carcinoma	0.0143	0.0085	1.8e-03	0.018	0.012	0.010	NA	0.014	9.0e-05	1.6e-03	3.1e-03	NA	5.5e-04
14	TCGA	Brain Lower Grade Glioma	0.0458	0.0257	2.4e-04	0.015	0.019	0.015	NA	0.014	7.2e-03	2.9e-03	6.4e-03	NA	9.4e-03
15	TCGA	Lung Adenocarcinoma	0.0296	0.0156	1.1e-03	0.029	0.021	0.015	NA	0.021	2.3e-04	1.5e-03	6.2e-03	NA	1.3e-03
16	TCGA	Lung Squamous Cell Carcinoma	0.0201	0.0120	7.0e-03	0.023	0.022	0.024	NA	0.024	1.1e-03	1.3e-03	7.8e-04	NA	9.2e-04
17	TCGA	Prostate Adenocarcinoma	0.0459	0.0204	1.5e-05	0.020	0.050	0.047	NA	0.042	3.0e-03	5.5e-06	1.2e-05	NA	3.3e-05
18	TCGA	Soft Tissue Sarcoma	0.0710	0.0410	1.8e-03	0.026	0.022	0.020	NA	0.011	1.1e-02	1.7e-02	2.2e-02	NA	6.8e-02
19	TCGA	Thyroid Carcinoma	0.0530	0.0300	4.8e-04	0.047	0.034	0.037	NA	0.044	2.0e-05	2.5e-04	1.6e-04	NA	3.8e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Suffer from ‘nerves’	11.0	17.2	22.4	4.2	3.8	3.7	4.5	3.1	3.1	3.6	4.0	3.8	4.3	4.6	4.5	4.7	4.6	4.7	4.1	4.1	4.2	4.7
Sitting height	9.3	66.4	100.0	-3.0	-8.8	-9.0	-9.0	-6.6	-6.7	-8.3	-9.0	-10.0	-9.7	-8.9	-6.7	-8.2	-7.2	-7.1	-9.5	-5.4	-9.9	-8.2
Had major operations	7.2	8.5	11.2	-2.1	-3.3	-3.1	-3.3	-2.7	-1.8	-3.1	-3.3	-3.1	-3.3	-3.1	-2.7	-3.1	-2.4	-3.0	-3.0	-1.9	-3.1	-3.1
Osteoporosis (self-reported)	6.9	8.6	13.0	1.2	2.6	3.1	3.2	2.9	2.3	2.4	2.6	3.3	3.5	3.5	2.7	3.2	3.0	2.7	3.6	2.1	3.5	3.2
Height	6.8	130.2	187.7	-6.8	-10.8	-11.5	-12.7	-9.3	-6.3	-10.6	-11.0	-13.5	-12.3	-12.5	-11.0	-12.1	-12.6	-11.3	-12.5	-10.9	-13.7	-12.3
Migraine (self-reported)	6.8	8.4	13.6	-2.2	-3.5	-3.6	-2.9	-3.7	-2.6	-3.3	-3.4	-2.8	-3.0	-2.8	-2.9	-2.8	-1.9	-2.8	-2.7	-2.1	-3.0	-2.8
Trunk fat-free mass	6.4	36.9	78.3	-1.4	-5.2	-5.8	-6.3	-6.5	-3.5	-4.7	-5.5	-6.6	-6.7	-6.7	-5.4	-6.3	-7.4	-5.3	-7.7	-5.5	-8.8	-6.5
Trunk predicted mass	6.4	36.5	78.0	-1.3	-5.2	-5.8	-6.3	-6.5	-3.5	-4.7	-5.5	-6.5	-6.6	-6.7	-5.4	-6.2	-7.3	-5.2	-7.6	-5.5	-8.8	-6.5
Arm fat-free mass (left)	5.9	30.0	56.7	-1.7	-5.0	-5.4	-5.6	-6.6	-3.6	-4.7	-5.2	-5.8	-5.9	-5.9	-4.8	-5.6	-6.3	-4.8	-6.5	-4.8	-7.5	-5.8
Arm predicted mass (right)	5.8	29.7	59.4	-1.6	-5.0	-5.5	-5.5	-6.8	-3.6	-4.6	-5.2	-5.8	-5.8	-5.8	-4.8	-5.5	-6.3	-4.7	-6.4	-4.8	-7.7	-5.7
Whole body fat-free mass	5.8	32.9	67.9	-1.6	-5.0	-5.5	-6.0	-6.2	-3.4	-4.5	-5.3	-6.1	-6.2	-6.3	-5.2	-5.9	-6.8	-5.0	-7.1	-5.2	-8.2	-6.1
Whole body water mass	5.5	31.7	66.1	-1.5	-4.9	-5.4	-5.8	-6.2	-3.4	-4.5	-5.2	-6.0	-6.1	-6.2	-5.0	-5.8	-6.7	-4.9	-7.0	-5.0	-8.1	-6.0
Arm fat-free mass (right)	5.4	27.8	55.0	-1.5	-4.8	-5.2	-5.3	-6.6	-3.6	-4.4	-4.9	-5.6	-5.6	-5.6	-4.6	-5.3	-6.2	-4.5	-6.3	-4.7	-7.4	-5.5
Arm predicted mass (left)	5.4	27.6	54.7	-1.2	-4.9	-5.2	-5.3	-6.3	-3.5	-4.5	-5.1	-5.6	-5.8	-5.7	-4.4	-5.3	-5.9	-4.4	-6.4	-4.3	-7.4	-5.5
Basal metabolic rate	5.3	29.3	55.5	-1.9	-5.1	-5.4	-5.7	-6.0	-3.6	-4.7	-5.3	-5.7	-6.0	-5.9	-4.8	-5.6	-6.2	-4.8	-6.5	-4.6	-7.5	-5.7
Worry (Nagel 2018)	5.2	10.9	15.5	3.9	3.4	3.2	3.6	2.9	3.3	3.3	3.4	3.0	3.1	3.3	3.2	3.6	3.6	3.9	2.7	2.9	2.5	3.5
Standing height	5.2	52.0	106.1	-1.5	-6.5	-7.0	-7.8	-6.0	-3.4	-6.1	-6.8	-8.8	-8.3	-8.1	-6.2	-7.4	-8.2	-6.1	-9.2	-6.3	-10.3	-7.6
Comparative height size at age 10	5.1	28.2	46.6	-1.6	-4.8	-5.3	-5.8	-3.9	-3.2	-4.5	-5.1	-6.8	-6.1	-6.1	-5.1	-5.7	-5.5	-4.8	-6.8	-4.7	-6.7	-5.6
Reaction Time	4.9	9.4	15.7	3.1	3.7	3.5	3.3	1.8	4.0	3.6	3.7	3.4	3.1	3.0	2.9	3.1	2.0	3.2	2.4	2.1	2.2	3.0
Mean time to correctly identify matches	4.8	9.1	12.8	3.6	3.3	3.2	3.3	1.6	3.5	3.1	3.4	3.3	2.9	3.0	3.1	3.1	2.4	3.4	2.2	2.6	2.2	3.1
Tense / ‘highly strung’	4.7	7.7	10.7	3.3	3.0	2.8	2.9	2.6	2.8	3.0	3.0	2.2	2.7	2.8	2.7	2.9	2.9	3.2	2.2	2.3	2.5	3.0
Leg predicted mass (right)	4.7	25.1	49.9	-1.8	-4.6	-5.0	-5.3	-5.2	-3.1	-4.1	-4.9	-5.2	-5.5	-5.4	-4.7	-5.2	-5.7	-4.5	-6.0	-4.5	-7.1	-5.3
Leg fat-free mass (right)	4.6	24.5	48.9	-1.8	-4.5	-4.9	-5.2	-5.2	-3.1	-4.0	-4.8	-5.1	-5.4	-5.4	-4.7	-5.1	-5.6	-4.5	-5.9	-4.4	-7.0	-5.3
Leg fat-free mass (left)	4.5	23.9	46.6	-1.8	-4.5	-4.8	-5.2	-5.2	-3.1	-4.0	-4.8	-5.0	-5.4	-5.3	-4.6	-5.1	-5.5	-4.4	-5.9	-4.3	-6.8	-5.2
Leg predicted mass (left)	4.5	24.0	46.0	-1.9	-4.6	-4.8	-5.2	-5.2	-3.2	-4.1	-4.8	-5.0	-5.4	-5.3	-4.6	-5.1	-5.5	-4.5	-5.9	-4.3	-6.8	-5.2
Nervous feelings	4.5	8.4	10.8	2.8	3.0	3.3	3.1	2.9	2.9	2.8	3.0	3.3	2.7	2.8	3.0	3.0	2.8	3.2	2.6	2.6	2.4	2.9
Medication: Ventolin 100micrograms inhaler	4.5	5.8	8.1	2.8	2.3	2.9	2.5	2.4	2.5	2.4	2.3	2.3	2.2	2.4	2.7	2.4	2.1	2.6	1.8	2.5	1.8	2.5
Had menopause	4.3	5.4	9.9	2.2	1.3	1.8	2.5	0.8	2.0	1.1	1.7	1.8	2.3	2.7	2.8	2.8	3.1	2.7	2.5	2.8	2.7	2.8
Chronic bronchitis/emphysema (father)	4.0	4.7	15.2	2.9	0.4	1.2	2.1	0.9	1.1	0.4	0.4	1.0	1.1	2.2	3.2	2.5	3.4	2.7	1.9	3.9	2.0	2.7
Lung FVC	3.9	19.6	30.3	3.3	4.4	4.1	5.5	1.7	4.0	4.1	4.6	4.4	4.8	5.0	4.9	5.0	4.0	4.7	5.0	3.7	4.8	4.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.8	4.4	10.3	-1.3	-3.2	-2.2	-2.2	-2.4	-2.8	-2.9	-3.2	-1.7	-2.5	-1.8	-0.9	-1.7	-1.0	-1.7	-1.6	0.0	-2.1	-1.6
Weight	3.6	17.5	24.8	-2.6	-4.9	-4.5	-4.4	-4.9	-3.7	-4.6	-5.0	-4.0	-4.7	-4.3	-3.4	-4.1	-3.8	-3.9	-4.3	-2.6	-4.7	-4.2
Medication: Atorvastatin	3.5	4.3	7.2	0.8	2.1	2.6	2.0	2.7	2.1	2.0	2.1	2.4	2.3	2.2	1.9	1.9	1.6	1.6	2.2	1.5	2.4	2.0
Medication: Lansoprazole	3.4	3.8	6.4	1.5	1.6	1.9	2.2	1.6	1.6	1.4	1.5	2.1	2.1	2.3	2.5	2.2	1.8	2.0	2.2	2.1	1.7	2.2
Age when periods started (menarche)	3.1	7.5	10.8	2.7	2.9	3.1	3.1	1.2	3.3	3.1	2.9	3.1	2.8	2.9	2.4	3.0	2.5	3.0	2.5	2.0	1.7	2.8
Father’s age at death	3.0	4.1	6.0	1.7	2.4	2.1	2.2	1.4	1.3	2.4	2.5	2.0	2.2	2.0	1.7	2.2	2.0	2.3	2.1	1.1	2.1	2.0
Crohns Disease (2012)	2.9	4.7	11.6	2.4	1.0	2.1	2.1	1.3	0.8	1.0	1.2	1.6	1.6	2.4	3.0	2.6	2.8	2.7	2.1	3.4	2.1	2.7
Taking other prescription medications	2.8	4.3	7.4	2.0	1.4	2.4	2.0	2.7	2.0	1.3	1.3	2.2	1.7	2.0	2.6	2.1	2.1	2.1	1.7	2.7	1.8	2.2
Time employed in main current job	2.8	3.3	6.5	1.1	2.6	2.3	1.8	2.0	2.1	2.5	2.5	1.9	2.3	1.8	1.2	1.5	0.7	1.4	1.4	0.3	1.6	1.5
Alcohol intake versus 10 years previously	2.8	4.2	7.3	-1.9	-1.9	-1.7	-2.3	-0.7	-1.5	-1.9	-2.1	-2.0	-2.2	-2.3	-1.8	-2.3	-2.7	-2.3	-2.1	-1.5	-2.4	-2.3
Leg pain on walking	2.8	3.5	8.0	-2.3	-2.7	-2.4	-1.9	-2.1	-1.9	-2.8	-2.6	-1.3	-1.7	-1.3	-1.5	-1.5	-0.9	-1.8	-0.8	-1.0	-1.6	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.8	3.3	10.2	1.8	0.0	0.4	1.9	0.8	-0.5	-0.1	0.0	1.5	1.0	2.0	2.6	2.2	3.0	2.2	1.8	3.2	2.0	2.3
Medication: Ibuprofen	2.7	3.2	6.6	-2.0	-1.0	-1.7	-1.8	-1.0	-2.3	-1.2	-1.1	-1.8	-1.2	-1.8	-2.1	-2.0	-2.6	-2.1	-1.5	-2.5	-1.3	-2.0
Diverticular disease/diverticulitis (self-reported)	2.6	3.1	6.6	-0.2	-2.5	-1.8	-1.7	-2.5	-2.1	-2.4	-2.6	-1.7	-2.2	-1.6	-0.7	-1.4	-0.7	-1.1	-1.8	0.1	-1.9	-1.3
Neuroticism score	2.6	5.4	8.3	2.9	2.1	2.4	2.5	2.0	1.6	2.1	2.1	2.4	2.1	2.3	2.6	2.5	2.5	2.8	2.0	2.5	1.7	2.4
Medication: Aspirin	2.6	3.4	4.9	2.0	1.6	1.6	1.9	2.1	1.8	1.5	1.5	1.6	1.4	1.8	2.2	1.9	2.2	2.0	1.5	2.2	1.8	2.0
Hip circumference	2.5	10.6	19.7	-2.6	-4.4	-3.2	-3.4	-3.0	-3.4	-4.2	-4.4	-2.9	-3.7	-3.2	-2.2	-3.2	-2.7	-3.2	-3.0	-1.2	-3.2	-3.1
Worrier / anxious feelings	2.5	4.7	8.0	2.3	2.2	2.3	2.2	2.1	2.8	2.2	2.2	2.6	2.2	2.1	2.1	2.1	2.0	2.3	1.8	1.8	1.3	2.1
Medication: Aspirin	2.5	3.2	4.4	2.0	1.6	1.7	1.8	1.9	2.0	1.6	1.5	1.6	1.5	1.8	2.0	1.9	2.1	1.9	1.4	1.9	1.6	1.9
Alzheimer’s Disease (in mother)	2.4	2.8	5.9	1.6	1.0	1.0	1.7	1.2	1.1	1.2	1.1	1.8	1.2	1.7	2.1	1.9	2.3	2.0	1.7	2.4	1.8	1.9
Hair/balding pattern: Pattern 3	2.4	3.6	5.9	-2.2	-1.4	-1.3	-2.1	-1.2	-2.1	-1.4	-1.4	-1.2	-1.8	-2.1	-2.2	-2.2	-2.4	-2.2	-1.7	-2.2	-2.1	-2.3
Fractured/broken bones in last 5 years	2.3	2.9	7.2	-0.3	-1.5	-1.5	-1.8	-2.7	-0.8	-1.4	-1.5	-1.7	-1.8	-1.8	-1.4	-1.8	-1.8	-1.5	-2.1	-1.3	-2.6	-1.8
Schizophrenia vs Biploar Disorder	2.2	2.9	4.0	-1.7	-1.5	-1.8	-1.8	-0.9	-1.1	-1.5	-1.7	-1.7	-1.9	-2.0	-1.9	-1.9	-1.6	-1.9	-1.7	-1.5	-1.6	-2.0
Alzheimer’s Disease (including proxy)	2.2	3.2	7.4	1.9	1.3	1.1	1.8	1.7	1.1	1.4	1.3	1.7	1.4	1.6	2.2	1.9	2.7	2.1	1.7	2.6	1.7	1.9
Ever used hormone-replacement therapy (HRT)	2.2	2.8	7.8	2.1	0.4	0.9	1.6	-0.0	1.4	0.2	0.6	1.0	1.1	1.8	2.6	2.0	2.2	2.2	1.6	2.8	1.6	2.1
Illnesses of siblings	2.2	3.1	4.5	-1.5	-1.4	-1.6	-1.8	-2.1	-1.8	-1.2	-1.4	-1.6	-1.8	-1.9	-1.9	-1.9	-2.0	-1.8	-1.7	-1.8	-2.0	-1.9
Illnesses of father: None of the above (group 1)	2.2	2.7	6.2	-2.5	-1.6	-2.0	-1.6	-1.8	-2.2	-1.5	-1.5	-1.6	-1.4	-1.4	-1.9	-1.4	-1.3	-1.6	-0.7	-2.0	-0.9	-1.5
Average weekly spirits intake	2.1	2.6	4.2	1.5	1.3	1.3	1.8	0.0	1.5	1.3	1.5	0.7	1.7	2.0	1.7	2.0	1.9	2.0	1.8	1.2	2.0	2.0
Pack years adult smoking proportion	2.1	3.2	6.0	0.9	1.8	1.9	1.9	1.1	2.5	1.9	1.8	2.2	1.8	1.8	1.5	1.8	2.0	1.6	2.0	1.3	1.8	1.8
Hand grip strength (right)	2.1	5.7	13.9	-2.4	-1.9	-2.3	-2.3	-3.7	-1.8	-1.6	-1.8	-2.2	-1.9	-2.2	-2.4	-2.3	-3.3	-2.4	-1.8	-3.1	-2.5	-2.5
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.4	8.7	-0.3	-1.9	-2.0	-2.2	-1.8	-1.4	-1.6	-2.0	-3.0	-2.4	-2.3	-1.8	-2.1	-2.5	-1.7	-2.7	-1.9	-2.9	-2.1
Asthma (self-reported)	2.1	4.1	13.3	1.4	2.5	2.7	1.9	3.6	2.4	2.4	2.3	1.8	2.0	1.6	1.6	1.6	1.1	1.7	1.5	1.1	1.8	1.7
Pack years of smoking	2.1	3.1	6.3	0.9	1.8	1.8	1.8	1.0	2.5	1.8	1.7	2.2	1.8	1.8	1.5	1.7	2.0	1.6	2.0	1.2	1.8	1.8
Exposure to tobacco smoke at home	2.0	2.3	3.9	1.5	1.1	1.5	1.7	0.4	1.0	1.1	1.0	1.8	1.3	1.8	2.0	1.8	1.7	1.7	1.6	1.8	1.1	1.8
Guilty feelings	2.0	3.1	5.0	1.5	1.4	0.9	1.9	0.3	1.0	1.5	1.4	2.1	1.9	2.1	1.7	2.1	2.2	2.0	2.1	1.8	1.7	2.1
Cholesterol lowering medication	2.0	3.0	7.1	1.4	0.9	1.4	1.6	1.2	1.1	0.7	0.9	2.1	1.3	1.8	2.0	1.9	2.7	1.8	1.9	2.6	2.0	1.9
Coronary Artery Disease (CAD)	1.9	2.3	6.8	2.1	0.1	0.8	1.5	0.1	0.4	0.3	0.2	1.5	0.9	1.6	2.1	1.7	2.2	1.7	1.5	2.6	1.5	1.8
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	5.8	-1.9	-0.8	-1.3	-1.5	-1.2	-2.2	-0.9	-0.8	-1.2	-0.8	-1.4	-1.8	-1.7	-2.4	-1.9	-1.1	-2.3	-1.1	-1.7
Health satisfaction	1.9	2.5	4.2	-1.1	-1.8	-1.8	-1.7	-2.1	-0.7	-1.9	-1.7	-1.7	-1.7	-1.7	-1.4	-1.5	-1.6	-1.4	-1.5	-1.2	-1.4	-1.6
Sensitivity / hurt feelings	1.8	3.2	5.9	1.5	2.3	2.4	1.8	1.4	1.8	2.3	2.2	2.4	2.1	1.7	1.4	1.7	1.1	1.7	1.6	0.7	1.0	1.5
Average weekly fortified wine intake	1.8	2.2	6.2	0.8	0.3	0.7	1.4	-0.3	0.4	0.6	0.5	1.7	1.2	1.7	1.6	1.8	2.5	1.5	2.0	2.1	1.8	1.8
Asthma	1.8	3.5	13.3	1.2	2.3	2.4	1.8	3.6	2.1	2.2	2.1	1.6	1.8	1.5	1.5	1.5	1.1	1.5	1.4	1.1	1.8	1.5
Heart attack/myocardial infarction (self-reported)	1.8	2.3	5.5	-0.8	-2.2	-2.3	-1.5	-2.1	-2.2	-2.1	-2.1	-1.2	-1.8	-1.2	-0.9	-1.1	0.1	-1.0	-1.1	-0.1	-1.2	-1.0
Heel T-Score	1.7	13.1	17.9	-4.2	-3.5	-3.1	-3.9	-3.4	-1.6	-3.4	-3.4	-3.6	-3.6	-3.9	-3.8	-4.0	-4.2	-4.1	-3.3	-3.7	-3.4	-4.0
Hand grip strength (left)	1.7	4.5	8.2	-1.9	-1.6	-1.9	-2.2	-2.5	-2.2	-1.5	-1.7	-1.9	-2.0	-2.2	-2.1	-2.1	-2.9	-2.1	-1.9	-2.5	-2.3	-2.4
Intelligence (Savage-Jansen 2018)	1.5	4.6	11.3	-0.1	-0.8	-1.8	-2.0	-3.2	-0.3	-0.7	-1.0	-2.6	-1.9	-2.2	-2.3	-2.1	-2.9	-1.7	-2.7	-2.8	-3.4	-2.2
Alzheimer’s Disease (in father)	1.5	1.7	3.5	1.9	0.9	0.8	1.5	1.0	0.7	0.8	0.8	0.8	1.1	1.4	1.7	1.5	1.5	1.6	1.2	1.8	0.7	1.5
Neuroticism (2016)	1.5	2.1	3.6	0.8	1.5	1.6	1.2	1.3	1.6	1.4	1.6	1.6	1.9	1.6	1.3	1.4	1.3	1.3	1.8	0.9	1.6	1.4
Rheumatoid Arthritis	1.5	2.0	5.5	1.0	0.4	1.2	1.4	0.5	-0.5	0.5	0.7	1.4	1.1	1.6	1.7	1.8	2.3	1.8	1.7	2.0	1.4	1.7
Qualifications: None of the above	1.5	3.2	8.6	-0.3	0.3	1.1	1.6	1.6	1.4	0.3	0.5	2.2	1.4	2.0	1.8	1.9	2.9	1.4	2.5	2.6	2.8	2.0
Heart attack	1.5	1.9	4.8	-0.8	-2.1	-2.1	-1.3	-2.0	-2.2	-1.9	-2.0	-1.0	-1.6	-1.1	-0.7	-0.9	0.3	-0.8	-0.9	0.2	-0.9	-0.8
Mouth/teeth dental problems: Loose teeth	1.5	1.8	5.0	0.5	0.5	1.1	1.3	1.4	0.2	0.3	0.6	1.4	0.9	1.3	1.4	1.4	2.2	1.3	1.5	1.9	2.0	1.4
Eye problems/disorders: Cataract	1.5	1.7	3.9	0.2	-1.5	-1.6	-1.4	-0.0	-1.0	-1.4	-1.7	-1.3	-1.9	-1.6	-0.9	-1.2	-0.3	-0.9	-1.7	-0.2	-2.0	-1.2
Leg fat mass (left)	1.5	5.7	15.1	-2.5	-3.9	-2.8	-2.1	-3.5	-3.2	-3.7	-3.7	-1.6	-2.4	-1.7	-1.1	-1.7	-0.6	-2.0	-1.1	0.1	-1.0	-1.7
Neuroticism (Nagel 2018)	1.4	3.3	8.4	2.9	1.8	1.6	1.9	1.3	1.3	1.8	1.7	1.8	1.6	1.7	1.8	1.9	2.2	2.3	1.2	1.7	0.7	1.9
Lupus	1.4	2.1	4.5	0.5	2.0	1.5	1.3	1.7	1.9	2.1	1.9	1.7	1.8	1.5	0.6	1.2	0.8	0.9	1.4	-0.2	1.3	1.2
Blood Eosinophil Count	1.4	10.8	15.7	3.8	3.4	3.5	3.4	4.0	2.5	3.4	3.4	3.5	3.1	3.1	3.2	3.2	3.5	3.5	2.5	3.2	2.9	3.3
Waist circumference	1.4	5.1	12.7	-2.2	-3.6	-2.6	-2.1	-2.9	-3.0	-3.3	-3.5	-1.6	-2.4	-1.8	-1.2	-1.8	-0.8	-2.0	-1.4	-0.1	-1.2	-1.8
Medication: Simvastatin	1.4	2.1	4.9	1.4	0.6	0.9	1.3	0.2	1.3	0.4	0.7	1.9	1.0	1.5	1.8	1.6	2.2	1.6	1.4	2.2	1.5	1.6
Impedance of arm (left)	1.4	6.4	16.6	0.1	1.7	2.1	2.3	4.1	1.8	1.6	1.9	2.1	2.5	2.7	2.1	2.5	3.6	2.0	3.2	2.2	4.0	2.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	3.8	-1.4	-0.6	-0.9	-1.5	-0.7	-0.4	-0.7	-0.7	-1.2	-1.3	-1.6	-1.8	-1.7	-1.7	-1.6	-1.4	-1.9	-1.2	-1.7
Whole body fat mass	1.4	5.7	14.6	-2.5	-3.8	-2.9	-2.2	-3.2	-3.0	-3.6	-3.7	-1.8	-2.5	-1.8	-1.3	-1.8	-0.7	-2.1	-1.3	-0.2	-1.2	-1.8
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.6	-1.2	-1.5	-1.3	-1.4	-0.5	-1.9	-1.6	-1.6	-1.1	-1.4	-1.2	-1.0	-1.3	-1.2	-1.4	-1.1	-0.6	-1.3	-1.2
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	5.0	1.1	0.5	1.0	1.4	0.6	0.0	0.4	0.5	1.4	0.6	1.3	1.8	1.6	1.9	1.7	1.3	2.2	1.2	1.5
Multivitamins +/- minerals	1.3	1.7	7.9	-1.9	0.3	-0.6	-1.1	0.0	-0.2	0.4	0.3	-1.4	-0.3	-1.1	-1.8	-1.3	-2.2	-1.6	-0.8	-2.8	-0.1	-1.4
Trunk fat mass	1.3	5.8	15.0	-2.4	-3.9	-3.0	-2.2	-3.1	-2.8	-3.7	-3.7	-1.9	-2.6	-1.8	-1.4	-1.8	-0.7	-2.0	-1.4	-0.2	-1.2	-1.8
Alcohol usually taken with meals	1.3	2.1	5.1	1.2	2.2	1.3	1.4	1.1	1.3	2.1	2.2	1.6	1.6	1.2	0.9	1.3	0.6	1.4	1.2	0.4	1.3	1.3
Leg fat mass (right)	1.3	5.1	13.5	-2.2	-3.7	-2.7	-2.0	-3.4	-2.9	-3.5	-3.5	-1.6	-2.3	-1.7	-1.0	-1.6	-0.6	-1.8	-1.1	0.1	-0.9	-1.6
Ever had bowel cancer screening	1.3	1.6	3.0	-1.0	-1.6	-1.3	-1.4	-1.6	-1.0	-1.7	-1.5	-0.9	-1.4	-1.3	-1.1	-1.2	-0.9	-1.2	-1.1	-0.6	-1.0	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	5.4	0.7	1.2	1.3	2.1	-0.6	0.9	1.1	1.4	1.8	2.0	2.2	1.9	2.0	1.5	1.6	2.3	1.4	1.9	2.0
Medication: Lisinopril	1.3	1.7	6.2	2.5	0.6	1.2	1.2	0.2	0.7	0.6	0.7	1.2	0.6	1.0	2.2	1.4	1.2	1.8	0.5	2.3	0.5	1.4
Ever depressed for a whole week	1.3	1.6	3.5	1.3	0.9	1.0	1.3	1.1	0.5	0.7	1.0	0.9	1.0	1.3	1.5	1.4	1.9	1.5	1.2	1.8	1.5	1.4
Impedance of whole body	1.3	6.4	17.1	0.4	1.6	2.1	2.4	3.8	1.6	1.3	1.8	1.7	2.3	2.7	2.5	2.6	3.6	2.2	3.1	2.5	4.1	2.8
LDL Cholesterol	1.2	1.9	4.6	-1.9	-1.6	-1.1	-1.6	0.1	-2.2	-1.8	-1.6	-1.2	-1.1	-1.2	-1.3	-1.5	-0.9	-1.8	-0.6	-1.0	-0.0	-1.5
Type 2 Diabetes (T2D) (2018)	1.2	2.3	6.7	0.7	-0.0	0.7	1.3	0.2	-1.2	0.0	0.2	1.5	1.0	1.6	1.9	1.6	2.6	1.5	1.7	2.6	2.5	1.8
Maternal smoking around birth	1.2	1.7	5.4	1.4	0.2	0.4	1.2	0.7	0.2	0.2	0.3	0.9	0.7	1.4	1.7	1.5	2.3	1.5	1.3	2.2	1.4	1.7
Hearing difficulty/problems with background noise	1.2	1.9	4.9	0.6	1.6	1.7	1.3	2.2	0.4	1.5	1.6	1.2	1.4	1.2	1.2	1.3	1.0	1.2	1.4	0.9	1.9	1.2
Impedance of arm (right)	1.2	5.5	18.6	0.4	1.6	2.0	2.0	4.3	1.6	1.5	1.7	1.8	2.0	2.3	2.0	2.2	3.4	1.9	2.6	2.3	3.7	2.4
Medication: Cholesterol lowering	1.2	1.9	3.8	0.6	1.5	1.2	1.5	0.6	2.0	1.3	1.5	1.8	1.6	1.6	1.1	1.4	1.3	1.2	1.6	0.6	1.7	1.4
Arm fat mass (right)	1.2	5.0	11.6	-2.4	-3.4	-2.7	-2.1	-3.0	-2.8	-3.2	-3.3	-1.5	-2.3	-1.8	-1.5	-1.8	-0.9	-2.1	-1.4	-0.4	-1.3	-1.8
Gout (self-reported)	1.2	1.7	3.2	0.6	0.6	1.2	1.4	1.1	0.6	0.6	0.7	1.3	1.2	1.4	1.8	1.4	1.6	1.2	1.7	1.8	1.6	1.5
Shortness of breath walking on level ground	1.2	1.4	2.5	0.8	1.1	1.4	1.2	1.6	0.9	1.1	1.1	1.2	1.1	1.2	1.3	1.2	1.2	1.2	1.2	1.1	1.4	1.2
Arm fat mass (left)	1.2	5.0	11.9	-2.5	-3.5	-2.7	-2.1	-3.0	-2.7	-3.3	-3.4	-1.4	-2.3	-1.7	-1.4	-1.8	-0.8	-2.1	-1.3	-0.4	-1.3	-1.8
Breast Cancer	1.1	2.7	5.7	2.4	2.3	2.2	1.6	1.3	1.8	2.2	2.2	1.5	1.5	1.3	1.5	1.4	0.9	1.7	0.7	1.0	1.0	1.4
Neuroticism	1.1	2.6	6.8	2.6	1.2	1.3	1.7	0.7	0.6	1.2	1.2	1.6	1.3	1.6	1.9	1.9	2.2	2.2	1.2	2.1	0.8	1.8
Impedance of leg (right)	1.1	5.3	15.6	0.6	1.2	1.8	2.4	2.6	1.2	0.9	1.5	1.4	2.1	2.5	2.8	2.5	3.1	2.1	3.0	2.6	3.9	2.6
Impedance of leg (left)	1.1	5.2	16.4	0.3	1.0	1.6	2.3	2.5	1.0	0.6	1.2	1.3	2.0	2.5	2.7	2.5	3.2	2.1	3.1	2.7	4.1	2.7
Illnesses of mother	1.1	1.3	2.6	-0.5	-0.7	-0.9	-1.1	-1.3	-0.7	-0.5	-0.7	-1.4	-1.1	-1.2	-1.4	-1.2	-1.3	-1.1	-1.4	-1.6	-1.5	-1.3
Knee pain experienced in last month	1.1	1.7	6.2	-1.2	-2.3	-1.9	-1.0	-2.1	-1.1	-2.5	-2.1	-0.6	-1.2	-0.6	-0.3	-0.6	0.3	-0.7	-0.2	0.5	-0.6	-0.6
High cholesterol (Self-reported)	1.1	2.0	4.8	0.3	0.9	1.1	1.4	1.0	2.2	0.8	1.0	2.2	1.6	1.7	1.2	1.4	1.4	1.1	1.7	1.1	1.9	1.5
Number of operations (self-reported)	1.1	1.6	3.4	-0.6	-1.8	-1.5	-1.3	-1.6	-1.7	-1.8	-1.7	-1.5	-1.2	-0.9	-0.7	-1.0	-0.9	-1.1	-1.0	-0.4	-1.2	-0.9
Allergy or Eczema	1.0	2.5	6.5	0.7	2.3	2.1	1.2	2.6	2.0	2.2	2.3	0.7	1.9	1.3	0.7	1.1	0.5	1.0	1.2	-0.3	2.1	1.2
Hearing difficulty/problems: Yes	1.0	1.6	3.5	-0.1	1.4	1.5	1.2	1.6	1.3	1.4	1.5	1.2	1.5	1.3	0.7	1.1	0.8	0.8	1.5	0.3	1.9	1.1
Mouth/teeth dental problems	1.0	1.6	4.5	-0.4	-0.1	-0.6	-1.3	-1.1	0.4	0.2	-0.1	-1.0	-0.9	-1.4	-1.6	-1.4	-2.1	-1.2	-1.5	-2.1	-2.0	-1.6
Worry too long after embarrassment	1.0	1.6	2.5	1.3	1.4	1.5	1.2	1.4	1.5	1.6	1.4	1.5	1.3	1.2	1.0	1.2	1.1	1.3	1.0	0.9	0.8	1.2
Medication for pain relief, constipation, heartburn	1.0	1.7	4.7	-0.8	-0.4	-0.5	-1.3	-0.9	0.2	-0.2	-0.5	-0.9	-0.8	-1.3	-1.9	-1.5	-2.0	-1.4	-1.6	-2.2	-2.0	-1.6
Diabetes diagnosed by doctor	1.0	1.7	5.2	0.3	-0.5	0.4	1.0	-0.1	-1.4	-0.4	-0.3	1.4	0.5	1.2	1.6	1.4	2.3	1.2	1.5	2.3	1.8	1.4
Medication for cholesterol	1.0	1.5	6.0	-1.7	0.1	-0.4	-1.1	0.0	-0.2	0.4	0.1	-1.5	-0.5	-1.2	-1.8	-1.4	-1.8	-1.5	-0.9	-2.5	-0.6	-1.4
Risk taking	1.0	1.5	2.9	0.1	1.1	1.1	1.3	1.1	1.0	1.2	1.1	1.5	1.5	1.5	1.1	1.3	1.0	1.0	1.7	0.6	1.5	1.4
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	5.0	1.2	-0.3	0.2	1.0	-0.2	0.0	-0.3	-0.3	1.0	0.3	1.1	1.6	1.3	2.1	1.3	1.1	2.2	0.5	1.4
Crohns Disease (2017)	0.9	2.0	5.2	1.7	0.4	1.4	1.4	0.1	0.4	0.4	0.7	0.6	1.1	1.6	2.1	1.7	1.9	1.8	1.4	2.3	1.5	1.8
Type 2 Diabetes (T2D) (2012)	0.9	1.0	4.8	-0.5	-1.1	-1.0	-0.9	-0.8	-2.2	-1.6	-1.3	-0.4	-0.9	-0.8	-0.6	-0.9	-0.7	-1.1	-0.6	-0.2	-0.6	-0.7
Respiratory disease	0.9	2.0	9.1	0.7	2.1	1.9	1.0	3.0	2.2	2.0	1.9	0.6	1.4	0.8	0.3	0.6	0.0	0.6	0.5	-0.5	1.3	0.7
Diabetes (mother)	0.9	1.2	2.7	-0.8	-1.5	-0.9	-1.0	-0.3	-0.9	-1.6	-1.6	-1.5	-1.2	-1.1	-0.5	-1.1	-1.0	-1.1	-1.0	0.0	-0.8	-1.0
Hayfever, allergic rhinitis or eczema	0.9	1.9	5.4	0.0	2.3	1.8	0.8	2.2	1.9	2.3	2.3	0.5	1.6	0.7	-0.1	0.4	-0.3	0.3	0.8	-1.2	1.4	0.4
Allergy	0.9	2.0	6.5	-0.6	-1.9	-1.8	-1.2	-2.6	-1.9	-1.8	-1.8	-0.9	-1.7	-1.2	-0.8	-1.0	-0.8	-0.9	-1.2	-0.2	-1.8	-1.1
Depression (self-reported)	0.9	1.1	2.6	1.3	0.6	1.1	1.0	0.3	0.4	0.5	0.6	1.1	0.8	1.0	1.4	1.1	1.4	1.3	0.8	1.6	1.0	1.1
Pulse wave reflection index	0.9	1.1	5.3	2.3	1.2	0.9	1.1	0.0	0.1	1.1	1.2	0.2	0.8	0.7	1.3	1.0	1.0	1.4	0.2	1.2	0.9	1.0
Emphysema/chronic bronchitis	0.9	1.0	3.1	1.3	0.5	0.8	0.9	0.6	1.8	0.6	0.6	0.6	0.7	1.0	1.3	1.1	1.0	1.2	0.8	1.0	0.6	1.1
Medication: Allopurinol	0.9	1.2	2.3	1.4	0.9	1.2	1.0	1.3	0.8	0.8	0.9	0.5	1.0	1.1	1.5	1.1	1.1	1.1	0.9	1.4	1.2	1.2
Mean Putamen Volume	0.8	1.0	2.3	-1.1	-1.4	-0.8	-0.8	-0.1	-1.5	-1.3	-1.4	-0.6	-1.2	-0.9	-0.4	-0.9	-0.9	-0.9	-0.7	-0.1	-1.0	-0.9
Number of live births	0.8	1.1	3.3	0.8	0.1	0.6	1.0	0.4	-0.3	0.1	0.0	1.6	0.5	1.1	1.4	1.2	1.6	1.2	1.2	1.8	0.4	1.2
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	3.2	0.3	-1.2	-1.0	-1.0	-1.4	-1.4	-1.1	-1.2	-1.3	-1.4	-1.1	-0.4	-0.8	-1.3	-0.5	-1.3	-0.5	-1.8	-1.0
Medication: Paracetamol	0.8	1.3	4.7	0.3	0.4	0.5	1.1	0.2	-0.1	0.2	0.7	0.7	0.9	1.2	1.4	1.3	1.8	1.2	1.6	1.6	2.2	1.4
Average weekly red wine intake	0.8	1.2	4.1	-0.0	0.4	-0.4	-0.8	0.3	0.8	0.4	0.1	-1.3	-0.6	-1.2	-1.5	-1.2	-1.7	-0.9	-1.6	-2.0	-1.4	-1.2
Mood swings	0.8	1.5	3.6	1.4	1.7	1.6	1.2	1.4	1.0	1.9	1.6	1.6	1.3	1.0	0.9	1.0	0.5	1.2	0.7	0.4	0.2	1.0
Qualifications: nursing, teaching	0.8	1.3	4.9	-0.4	0.6	-0.4	-1.0	0.1	0.8	0.7	0.4	-0.6	-0.4	-1.1	-1.7	-1.3	-1.9	-1.2	-1.5	-2.2	-1.2	-1.3
Commuting to job workplace: Walk	0.8	0.9	4.3	-0.6	1.1	0.4	0.8	1.0	2.1	1.1	1.1	0.8	1.2	0.8	-0.0	0.5	0.4	0.2	0.9	-0.5	1.4	0.6
Leg fat percentage (left)	0.8	2.9	8.4	-2.6	-2.8	-1.4	-0.3	-2.0	-2.5	-2.9	-2.5	0.3	-0.6	0.2	0.6	0.1	1.7	-0.6	1.3	2.0	2.0	0.2
Irritable Bowel Disease (IBD)	0.7	1.7	3.0	1.4	0.7	1.1	1.4	-0.5	0.5	0.7	1.0	0.7	1.3	1.6	1.6	1.6	1.7	1.6	1.4	1.5	1.2	1.7
BMI	0.7	4.1	10.0	-2.6	-3.0	-2.5	-1.8	-3.2	-3.1	-2.8	-2.9	-0.5	-1.8	-1.5	-1.5	-1.6	-0.3	-1.9	-0.8	-0.3	-0.7	-1.6
Lung FEV1/FVC ratio	0.7	3.5	10.0	-1.6	-2.4	-1.9	-1.8	-3.2	-2.4	-2.4	-2.3	-1.5	-1.7	-1.5	-1.3	-1.5	-1.3	-1.6	-1.1	-0.8	-2.0	-1.6
Ever had hysterectomy (womb removed)	0.7	0.8	3.0	1.4	-0.6	-0.9	-0.7	-0.5	-0.8	-0.9	-0.8	-0.9	-1.1	-1.0	-0.1	-0.7	-0.7	-0.3	-1.6	0.2	-1.7	-0.7
Angina	0.7	0.9	2.4	0.5	0.1	0.3	0.9	0.4	0.7	-0.2	0.0	1.1	0.5	1.1	1.4	1.1	1.3	0.9	1.3	1.6	1.0	1.1
Diabetes (father)	0.7	0.8	3.8	0.4	-0.8	-0.3	0.3	0.6	-1.1	-1.0	-0.7	0.2	0.1	0.6	1.0	0.5	1.9	0.4	0.5	1.9	1.4	0.8
Relative age voice broke	0.7	1.0	1.7	1.1	1.2	1.1	1.1	-0.2	1.0	1.1	1.3	0.8	1.0	1.1	0.9	1.2	1.0	1.3	1.0	0.6	0.8	1.1
Serious illness, injury or assault to yourself	0.7	0.8	4.0	0.2	-0.8	-1.1	-0.8	-2.0	-0.6	-0.9	-0.7	-1.0	-1.1	-1.0	-0.6	-0.8	-0.5	-0.4	-1.1	-0.5	-0.8	-0.9
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.3	-0.6	-0.8	-1.1	-0.9	-1.5	-0.6	-0.9	-0.8	-1.1	-0.9	-1.0	-0.9	-0.9	-1.0	-0.8	-0.8	-0.9	-1.2	-1.0
Noisy workplace	0.7	0.9	3.1	-0.0	-0.9	-0.1	0.7	0.2	-1.2	-1.2	-0.8	0.6	0.2	0.9	1.1	0.9	1.5	0.7	1.0	1.8	1.2	1.0
Qualifications: A levels/AS levels or equivalent	0.7	1.4	4.1	-0.3	-0.2	-0.7	-1.2	-0.6	-0.1	-0.0	-0.3	-1.6	-0.9	-1.5	-1.5	-1.4	-1.8	-1.1	-1.6	-2.0	-1.4	-1.5
High blood pressure (siblings)	0.7	1.0	2.9	0.9	1.5	1.3	0.9	1.7	1.5	1.4	1.3	1.0	1.0	0.6	0.7	0.6	-0.2	0.7	0.4	0.3	0.5	0.5
Leg fat percentage (right)	0.7	2.5	6.8	-2.2	-2.6	-1.1	-0.1	-1.9	-2.2	-2.6	-2.2	0.4	-0.4	0.4	0.8	0.3	1.8	-0.3	1.4	2.1	2.1	0.4
Number of full brothers	0.7	0.9	3.7	0.5	0.4	0.3	0.9	0.6	0.3	0.6	0.5	1.1	1.1	1.2	0.5	1.1	1.9	0.9	1.3	0.6	1.0	1.2
Wheeze or whistling in the chest in last year	0.7	1.2	4.4	1.0	0.3	1.3	1.0	1.5	-0.2	0.4	0.2	1.0	0.5	1.0	1.7	1.1	1.3	1.2	0.9	2.1	0.9	1.2
Family relationship satisfaction	0.7	0.8	3.7	-0.1	0.6	-0.0	-0.6	0.2	1.0	0.4	0.4	-0.8	-0.5	-1.0	-1.0	-1.0	-1.9	-0.8	-1.2	-1.5	-0.8	-1.0
Basal cell carcinoma (self-reported)	0.7	0.8	2.6	1.6	1.2	0.6	0.9	0.9	0.7	1.1	1.1	1.2	0.5	0.5	0.7	0.8	0.9	1.1	0.2	0.7	0.3	0.7
Bipolar Disorder (2011)	0.6	0.6	3.1	1.0	-0.6	-0.2	0.2	0.2	-0.8	-0.9	-0.7	-0.3	0.3	0.4	1.1	0.4	1.4	0.4	0.4	1.7	0.6	0.6
Primary Biliary Cirrhosis	0.6	0.8	2.3	-0.7	-1.5	-1.0	-0.8	-1.5	-0.9	-1.4	-1.3	-0.9	-0.7	-0.5	-0.2	-0.6	-0.2	-0.8	-0.5	0.4	-0.8	-0.5
Severe depression (siblings)	0.6	0.7	1.6	-1.1	-0.8	-0.8	-0.9	0.9	-0.6	-0.5	-0.9	-0.7	-0.8	-0.9	-1.3	-0.9	-0.3	-1.0	-0.7	-0.9	-0.3	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	3.2	-1.8	-0.9	-0.9	-1.1	-1.2	-0.8	-0.9	-0.8	-1.2	-0.7	-1.0	-1.4	-1.2	-1.4	-1.4	-0.7	-1.6	-0.7	-1.2
Had other major operations	0.6	0.8	3.4	0.9	-1.0	-0.1	0.3	-1.1	-1.3	-1.0	-0.9	0.3	-0.3	0.5	1.4	0.6	0.8	0.7	0.4	1.8	-0.3	0.6
Diabetes (self-reported)	0.6	0.9	3.3	-0.3	-0.9	-0.1	0.3	-0.7	-1.6	-0.9	-0.8	0.9	0.1	0.7	0.8	0.7	1.8	0.5	1.0	1.5	1.2	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.4	0.9	0.6	1.0	0.9	-0.3	0.2	0.6	0.7	0.8	0.8	1.0	1.2	1.1	1.2	1.1	1.0	1.1	1.0	1.1
Body fat percentage	0.6	2.5	7.6	-2.5	-2.8	-1.6	-0.5	-1.7	-2.1	-2.7	-2.5	0.0	-0.7	0.1	0.2	-0.1	1.5	-0.8	1.0	1.4	1.6	0.0
Qualifications: College or University degree	0.6	1.8	9.5	-0.3	1.1	-0.2	-0.8	-0.5	1.6	1.3	1.1	-0.6	0.1	-1.0	-2.2	-1.2	-2.1	-1.1	-1.3	-3.1	-1.4	-1.3
Loneliness, isolation	0.6	0.9	2.2	1.1	1.1	1.5	1.0	1.2	0.6	0.9	1.0	0.9	0.9	0.9	1.1	0.8	0.4	0.9	0.6	0.7	0.6	0.9
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	4.7	-0.1	-0.1	-0.1	1.1	0.5	-0.8	-0.2	-0.0	0.6	0.6	1.1	0.8	1.2	2.2	1.0	1.5	1.2	1.6	1.2
Medication: Bendroflumethiazide	0.6	0.9	2.4	0.5	-1.4	-0.7	-1.1	-1.1	-0.8	-1.5	-1.5	-0.5	-1.1	-0.7	0.2	-0.7	-0.5	-0.5	-1.2	0.8	-1.3	-0.5
Average weekly beer plus cider intake	0.6	0.9	4.2	0.6	-0.5	-0.1	0.8	-0.6	-0.0	-0.4	-0.4	0.9	0.3	0.9	1.2	1.0	2.1	1.0	1.0	1.8	1.1	1.0
Age at First Birth	0.5	0.7	4.8	-0.4	1.1	0.9	0.5	0.6	2.2	1.4	1.1	0.3	1.0	0.3	-0.2	0.1	-0.2	-0.1	0.4	-0.9	0.5	0.1
Fasting Glucose	0.5	0.6	1.7	0.5	-1.2	-1.1	-0.6	-1.3	-1.2	-1.1	-0.9	-1.3	-0.9	-0.5	0.2	-0.3	0.0	-0.2	-0.3	0.4	0.3	-0.4
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.9	0.4	-0.4	0.1	0.5	0.2	-0.5	-0.4	-0.4	0.8	0.3	0.8	1.0	0.8	1.4	0.8	0.8	1.4	0.9	0.9
Vitamin and mineral supplements	0.5	0.7	3.8	1.1	-0.5	0.2	0.7	-0.3	0.3	-0.5	-0.5	1.0	0.1	0.7	1.3	0.8	1.3	1.0	0.5	1.9	-0.0	0.9
Medication: Co-codamol	0.5	0.6	2.2	-1.0	-1.5	-1.0	-0.6	-0.7	-1.0	-1.5	-1.4	-0.2	-0.8	-0.3	0.2	-0.2	-0.1	-0.4	-0.1	0.6	-0.0	-0.2
Medication: Metformin	0.5	0.6	1.5	-0.6	-1.1	-0.5	-0.9	0.7	-1.1	-1.2	-1.2	-0.7	-1.0	-0.8	-0.5	-0.8	-0.4	-0.8	-0.9	-0.1	-0.3	-0.7
Trunk fat percentage	0.5	1.9	5.7	-2.1	-2.4	-1.3	-0.3	-1.3	-1.7	-2.4	-2.1	0.0	-0.5	0.3	0.3	0.1	1.7	-0.5	1.0	1.4	1.5	0.2
Supplements: Glucosamine	0.5	0.7	2.3	-1.5	-0.7	-1.0	-0.9	-0.1	-1.2	-0.7	-0.7	-0.8	-0.7	-0.8	-1.0	-0.8	-0.7	-1.0	-0.3	-1.0	0.1	-0.8
Number of incorrect matches in round	0.5	0.9	2.8	-1.0	-0.1	-0.7	-0.9	0.8	0.2	-0.2	-0.2	-0.7	-0.2	-0.8	-1.4	-1.2	-1.4	-1.4	-1.0	-1.7	-0.2	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.0	0.0	0.4	0.6	0.9	0.7	-0.7	0.4	0.4	1.2	0.6	0.9	0.9	1.0	1.4	0.9	1.3	1.2	1.4	1.1
Arm fat percentage (right)	0.5	1.8	5.6	-2.4	-2.3	-1.3	-0.5	-1.2	-1.9	-2.2	-2.1	0.4	-0.6	0.0	-0.0	-0.2	1.3	-0.8	0.8	1.2	1.4	-0.1
Happiness	0.5	0.6	1.2	-0.4	-0.7	-0.9	-0.8	-0.9	-0.1	-0.8	-0.8	-0.8	-1.1	-1.0	-0.6	-0.8	-1.1	-0.6	-0.9	-0.5	-0.8	-0.9
Mouth/teeth dental problems: Dentures	0.5	0.9	2.1	0.4	1.1	1.1	0.9	1.5	1.1	0.8	0.9	0.8	0.9	1.0	0.9	0.9	0.6	0.8	0.9	0.5	1.2	0.9
Peak expiratory flow (PEF)	0.5	1.1	4.9	-0.5	-1.6	-1.7	-0.5	-2.2	-1.7	-1.5	-1.4	-1.2	-0.8	-0.4	0.0	-0.3	-0.3	-0.3	-0.0	-0.0	-0.5	-0.3
Blood clot in the leg (DVT)	0.5	0.6	2.6	0.8	-0.6	-0.2	0.5	-0.4	-0.1	-0.6	-0.6	0.5	-0.1	0.7	1.0	0.8	1.6	0.8	0.7	1.6	0.0	0.9
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.3	1.0	0.6	0.5	0.8	0.3	0.3	0.6	0.6	0.9	0.6	0.8	1.1	1.0	0.8	1.1	0.9	1.0	0.3	0.9
Neck or shoulder pain in last month	0.5	0.7	3.0	0.6	-0.2	0.1	0.7	0.6	-0.6	-0.3	-0.2	0.4	0.2	0.8	1.3	0.9	1.2	0.9	0.8	1.7	1.0	1.0
Angina (self-reported)	0.5	0.7	1.9	0.4	-0.0	0.2	0.7	0.2	0.9	-0.3	-0.1	1.1	0.4	1.0	1.2	1.0	1.1	0.8	1.1	1.4	0.7	1.0
Medication: Omeprazole	0.5	0.6	2.3	0.6	0.0	0.4	0.8	0.8	-0.4	0.0	-0.0	0.5	0.1	0.6	1.1	0.9	1.3	1.0	0.7	1.5	0.9	0.9
Medication: Seretide 50 evohaler	0.5	0.6	1.6	0.1	0.6	0.5	-0.5	1.2	0.5	0.7	0.3	-0.3	-0.7	-1.0	-0.6	-0.8	-1.3	-0.4	-1.2	-0.8	-1.0	-0.9
Heart disease (mother)	0.5	0.6	1.8	-0.3	-0.0	0.3	0.7	-0.2	0.2	-0.1	0.1	1.2	0.7	1.0	0.8	0.9	1.1	0.6	1.4	0.9	1.1	0.9
Illnesses of father: Heart disease	0.5	0.8	2.0	1.0	1.0	1.1	0.7	1.2	1.4	1.0	0.9	1.3	0.9	0.7	0.8	0.6	0.2	0.6	0.3	0.6	0.2	0.7
Friendships satisfaction	0.5	0.6	1.6	0.7	0.6	0.9	0.7	1.2	1.3	0.6	0.6	0.6	0.4	0.5	0.9	0.7	0.7	0.8	0.6	1.0	0.6	0.7
Smoking status: Current	0.5	0.8	1.8	0.7	0.5	0.8	1.0	0.6	0.4	0.4	0.4	1.0	0.7	1.0	1.3	1.0	1.0	1.0	1.0	1.2	0.6	1.0
Miserableness	0.5	0.9	2.5	1.6	0.9	1.0	1.1	0.8	0.9	1.0	0.8	0.8	0.9	0.9	0.9	1.0	0.9	1.3	0.6	0.9	0.5	1.0
Ever taken oral contraceptive pill	0.5	0.6	2.0	0.8	0.0	0.0	0.7	0.3	-1.3	-0.1	0.1	0.6	0.1	0.5	0.9	0.8	1.4	0.9	0.7	1.4	0.9	0.8
Mother’s age at death	0.5	0.7	2.4	-0.2	1.0	0.4	-0.3	0.9	1.4	0.8	0.9	-0.5	0.2	-0.4	-0.9	-0.6	-1.5	-0.5	-0.6	-1.5	-0.3	-0.5
Prostate Cancer	0.4	0.6	3.0	-0.0	-1.2	-0.8	-0.5	0.4	-1.7	-0.9	-1.2	-0.2	-0.9	-0.4	0.0	-0.3	1.0	-0.2	-0.2	1.1	-0.3	-0.2
HDL Cholesterol	0.4	0.6	1.9	-0.7	1.2	0.8	0.4	1.1	1.1	1.4	1.1	1.0	0.4	0.1	-0.5	0.1	-0.8	0.0	0.3	-1.1	-0.2	-0.0
Triglycerides	0.4	0.6	2.5	1.0	-0.5	-0.1	0.4	0.2	-1.1	-0.6	-0.4	-0.0	0.1	0.5	1.3	0.6	1.1	0.7	0.4	1.6	1.0	0.7
Systolic Blood Pressure	0.4	1.9	4.2	1.1	1.2	1.8	1.5	2.0	1.4	0.9	1.1	1.0	1.1	1.3	1.4	1.4	1.4	1.4	1.3	1.5	1.5	1.4
Smoking Status	0.4	1.0	3.9	0.6	0.9	0.9	0.9	2.0	0.1	0.6	0.8	1.0	0.9	0.9	1.2	0.9	1.0	0.8	0.9	1.2	1.3	0.9
Cardiovascular Disease	0.4	1.3	4.0	2.0	1.0	1.2	1.0	1.2	1.4	1.1	0.8	1.3	0.8	0.9	1.2	1.0	1.0	1.2	0.3	1.6	0.4	1.1
Number of treatments/medications taken	0.4	0.7	2.8	0.2	0.4	0.9	0.6	1.7	0.8	0.1	0.3	1.2	0.7	0.8	0.9	0.6	0.6	0.5	0.7	1.1	0.9	0.8
Current tobacco smoking	0.4	0.6	1.3	0.4	0.5	0.7	0.9	0.7	0.3	0.4	0.3	1.0	0.6	0.8	1.1	0.9	0.9	0.8	1.0	1.0	0.5	0.9
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.8	0.4	-0.7	-0.7	-0.5	0.5	-1.4	-1.0	-0.9	-0.5	-0.9	-0.7	-0.1	-0.5	-0.3	-0.3	-0.9	0.3	-0.8	-0.5
Medication: Levothyroxine sodium	0.4	0.6	2.5	-0.5	0.5	1.1	0.6	1.6	0.0	0.4	0.5	0.6	0.8	0.8	0.8	0.6	0.4	0.3	1.0	0.7	1.3	0.6
Body mass index (BMI)	0.4	1.7	5.3	-1.9	-2.1	-1.4	-0.8	-2.3	-2.1	-2.0	-1.9	0.1	-0.9	-0.5	-0.5	-0.7	0.0	-1.1	-0.0	0.3	-0.0	-0.7
Hair/balding pattern: Pattern 2	0.4	0.5	2.6	0.9	0.4	0.5	0.7	-0.2	1.6	0.3	0.5	0.2	0.6	0.7	0.7	0.7	0.6	0.8	0.5	0.6	0.3	0.7
Pain all over the body in last month	0.4	0.4	1.6	0.1	0.2	0.3	-0.5	0.6	1.3	0.3	-0.0	0.1	-0.4	-0.6	-0.6	-0.7	-0.7	-0.5	-0.9	-0.8	-0.8	-0.7
Fluid intelligence score	0.4	0.9	4.1	-0.1	0.3	-0.1	-0.6	-1.4	0.0	0.4	0.4	-1.3	0.0	-0.5	-1.1	-0.7	-1.7	-0.6	-0.7	-2.0	-1.1	-0.8
Pulse rate	0.4	0.6	2.2	-0.6	-0.8	-1.0	-0.6	-1.1	-0.4	-0.7	-0.9	-0.2	-0.4	-0.4	-0.8	-0.6	-0.9	-0.7	-0.4	-1.1	-1.5	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.1	-0.9	1.0	0.9	0.3	0.3	-0.2	1.0	1.0	0.7	0.9	0.4	-0.4	0.0	-0.7	-0.3	0.6	-1.0	0.4	-0.0
Length of working week for main job	0.4	0.4	1.1	1.1	0.8	0.9	0.7	-0.0	0.8	0.9	0.8	0.3	0.7	0.6	0.7	0.6	0.1	0.6	0.3	0.3	0.3	0.6
Breastfed as a baby	0.4	0.5	1.6	-0.3	-1.2	-1.0	-0.3	-0.9	-1.1	-1.3	-1.1	-0.4	-0.7	-0.2	0.2	-0.1	0.8	-0.1	0.0	0.6	0.1	0.0
Loud music exposure frequency	0.4	0.4	3.4	-1.8	-0.4	-0.1	-0.3	0.1	-0.5	-0.5	-0.4	0.5	0.5	0.3	-0.7	-0.2	-0.1	-0.8	0.7	-0.9	0.5	-0.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	2.3	0.5	0.4	1.1	0.8	1.2	0.2	0.2	0.4	0.4	0.5	0.9	1.5	1.0	1.0	0.9	1.0	1.5	1.3	1.0
Birth weight	0.4	1.0	5.6	-0.6	0.5	-0.6	-0.5	-0.3	0.2	0.7	0.5	-0.5	-0.0	-0.8	-1.7	-1.0	-1.5	-1.0	-0.9	-2.4	-0.8	-1.0
Pulse wave peak to peak time	0.4	0.5	1.4	-1.2	-0.3	-0.0	-0.9	0.5	-0.2	-0.2	-0.4	-0.4	-0.7	-0.8	-0.9	-0.8	-1.1	-0.9	-0.5	-0.9	-0.5	-0.9
Chest pain or discomfort	0.4	0.6	2.0	-0.1	-0.4	-0.0	0.6	0.6	-0.5	-0.3	-0.5	1.1	0.2	0.8	1.0	0.7	1.4	0.5	1.0	1.4	0.9	0.8
Commuting to job workplace: Car/motor vehicle	0.4	0.5	2.6	0.7	-0.9	-0.5	-0.1	-1.6	-0.3	-1.0	-0.8	-0.4	-0.5	-0.1	0.4	0.1	0.9	0.3	-0.2	1.1	-0.0	0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.2	-0.8	-1.0	-0.9	-0.8	0.6	-0.6	-0.9	-1.1	-0.8	-0.9	-0.7	-0.7	-0.7	-0.2	-0.7	-0.7	-0.1	-0.2	-0.6
Illnesses of siblings: Diabetes	0.4	0.5	1.7	0.5	-0.2	0.7	0.5	0.5	-0.3	-0.2	-0.0	0.4	0.4	0.7	0.9	0.8	1.3	0.8	0.8	1.3	0.9	0.8
Arm fat percentage (left)	0.4	1.7	6.1	-2.5	-2.1	-1.2	-0.4	-1.4	-1.8	-2.1	-2.0	0.5	-0.4	0.2	-0.0	-0.1	1.3	-0.7	1.0	1.1	1.5	0.0
Medication: Gliclazide	0.4	0.5	1.3	-0.1	-0.7	-0.6	-0.8	0.7	-0.7	-0.7	-0.8	-1.1	-0.9	-0.8	-0.4	-0.7	-0.7	-0.5	-1.1	-0.3	-0.5	-0.6
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.1	-1.1	-0.5	-0.2	-0.6	-0.3	-0.9	-0.7	-0.6	-0.3	-0.5	-0.5	-0.7	-0.7	-0.9	-0.9	-0.5	-0.8	-0.6	-0.7
Pain type(s) experienced in last month: Hip pain	0.4	0.5	3.6	-0.9	-0.9	-0.6	-0.4	0.3	-1.9	-1.4	-0.9	-0.3	-0.5	-0.2	-0.1	-0.3	-0.0	-0.5	0.1	0.2	0.4	-0.2
Illnesses of father: High blood pressure	0.4	0.6	1.6	0.7	0.9	1.2	0.6	1.3	0.5	0.7	1.0	1.2	1.0	0.7	0.5	0.4	-0.1	0.4	0.2	0.4	0.5	0.5
Ever smoked	0.4	0.6	3.2	0.7	-1.1	-0.7	-0.1	-0.1	-1.2	-1.2	-1.1	-0.0	-0.8	-0.1	0.9	0.2	0.9	0.3	-0.1	1.8	-0.2	0.2
Age started oral contraceptive pill	0.4	0.5	1.3	0.3	0.4	0.4	0.7	0.4	0.9	0.2	0.5	0.9	0.6	0.7	0.6	0.8	1.1	0.7	0.8	0.8	1.0	0.8
Commuting to job workplace: Cycle	0.4	0.5	2.1	-0.4	1.1	0.3	-0.1	1.2	-0.3	1.0	1.1	-0.3	0.7	0.1	-0.8	-0.2	-0.5	-0.3	-0.0	-1.5	0.6	-0.1
Supplements: Calcium	0.4	0.4	2.7	-0.7	0.5	0.2	0.4	1.1	-0.0	0.4	0.6	0.3	0.8	0.5	-0.2	0.3	0.5	-0.0	0.8	-0.5	1.7	0.4
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.9	1.0	1.0	0.0	0.1	-1.7	0.8	1.1	1.0	-0.9	0.3	0.0	-0.7	0.0	-0.7	0.2	-0.4	-1.6	-0.6	-0.1
Ulcerative Colitis	0.3	0.5	0.9	0.0	0.7	0.6	0.8	-0.1	-0.1	0.6	0.9	0.9	0.9	0.8	0.5	0.7	0.7	0.6	0.9	0.2	0.8	0.8
Waist Hip Ratio (WHR)	0.3	1.5	5.2	0.2	0.6	0.4	1.2	0.5	-0.0	0.8	0.8	1.3	1.2	1.4	0.8	1.3	2.3	1.0	1.7	1.2	2.3	1.4
Hypothyroidism (self reported)	0.3	0.8	2.3	0.0	0.6	1.3	0.7	1.5	0.3	0.4	0.6	0.5	0.8	0.9	1.2	0.8	0.5	0.6	1.1	1.1	1.4	0.9
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.2	0.8	0.7	1.1	0.6	1.1	-0.3	0.7	0.5	1.1	0.4	0.4	0.9	0.5	0.1	0.7	0.3	0.8	0.3	0.5
Medication for hormone replacement therapy	0.3	0.3	0.9	0.2	-0.9	-0.4	0.1	-0.4	-0.7	-0.8	-0.8	0.4	-0.0	0.4	0.6	0.4	0.8	0.4	0.4	0.9	-0.1	0.5
Supplements: Zinc	0.3	0.3	2.1	0.0	0.7	-0.1	0.0	-0.6	0.4	0.8	0.9	-0.4	0.4	-0.1	-0.8	-0.2	-0.3	-0.1	-0.2	-1.5	0.4	-0.2
Medication: Atenolol	0.3	0.4	1.6	1.2	-0.5	0.3	-0.0	-0.6	-0.9	-0.3	-0.6	0.7	-0.3	0.1	0.8	0.2	0.2	0.4	-0.5	1.3	-0.8	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.7	-1.0	-0.6	-0.5	-0.7	-1.3	-0.1	-0.5	-0.4	-1.2	-0.5	-0.7	-0.9	-0.8	-1.2	-0.9	-0.5	-1.3	-0.5	-0.9
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.7	-0.9	0.3	0.1	-0.6	0.2	0.4	0.2	0.4	-0.3	0.1	-0.5	-1.0	-0.8	-0.9	-0.8	-0.5	-1.3	0.3	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.9	-1.1	0.0	0.3	-0.6	0.1	-0.4	0.2	-0.2	0.3	-0.4	-0.6	-0.7	-0.7	-1.4	-0.8	-0.5	-1.1	-0.8	-0.8
Prospective memory result	0.3	0.4	1.1	-0.6	0.9	0.4	0.3	0.5	0.1	0.9	1.0	0.6	0.8	0.3	-0.4	0.1	-0.3	-0.0	0.4	-1.0	0.8	0.1
Birth weight of first child	0.3	0.5	3.8	1.9	0.5	-0.4	0.2	-0.6	-0.0	0.6	0.3	0.6	-0.4	-0.4	-0.0	-0.0	-0.2	0.6	-1.1	-0.1	-1.5	-0.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.9	0.1	-0.7	-0.2	0.3	-0.5	-0.8	-0.6	-0.6	0.2	-0.1	0.3	0.8	0.5	1.0	0.4	0.5	1.4	0.9	0.5
Headache pain in last month	0.3	0.5	1.5	-0.5	-0.1	-0.4	-0.5	-1.0	-1.2	-0.1	-0.2	0.2	-0.2	-0.5	-0.9	-0.6	-1.1	-0.6	-0.5	-0.8	-1.2	-0.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	4.6	-1.1	-0.7	-0.5	-0.4	0.3	-2.1	-0.7	-0.7	-0.5	-0.2	-0.2	-0.3	-0.3	0.1	-0.5	0.3	0.0	0.4	-0.3
Glaucoma (self-reported)	0.3	0.3	0.7	-0.2	0.7	0.8	0.7	0.0	0.7	0.7	0.8	0.8	0.7	0.7	-0.0	0.5	0.6	0.3	0.7	-0.2	0.2	0.5
Medication: Amlodipine	0.3	0.5	2.1	1.2	-0.2	0.1	0.3	-0.4	-1.0	-0.4	-0.2	0.4	-0.3	0.2	0.8	0.6	1.3	0.9	0.0	1.4	-0.1	0.6
Exposure to tobacco smoke outside home	0.3	0.4	2.2	-0.1	-0.5	-0.8	-0.6	-1.5	-0.4	-0.5	-0.5	-0.6	-0.5	-0.5	-0.7	-0.6	-0.2	-0.6	-0.6	-0.6	-0.8	-0.6
Medication: Blood pressure	0.3	0.6	3.5	1.9	0.7	0.8	0.5	-0.4	1.4	0.6	0.6	0.3	0.1	0.2	0.8	0.4	0.1	0.9	-0.4	0.5	-0.7	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.8	-0.2	0.5	0.3	0.4	1.3	-0.5	0.5	0.6	0.5	0.8	0.6	0.2	0.5	0.5	0.3	0.8	0.0	1.4	0.6
Medication: Blood pressure	0.3	0.5	2.0	1.0	0.2	0.5	0.6	0.2	-0.1	0.1	0.2	1.4	0.5	0.7	0.9	0.6	0.7	0.6	0.4	1.4	0.2	0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.3	2.2	-0.8	-0.8	-0.6	-0.4	0.1	-1.5	-1.0	-0.8	-0.3	-0.4	-0.3	-0.1	-0.3	0.0	-0.4	0.0	0.2	0.1	-0.3
Pain experienced in last month	0.3	0.6	1.5	-0.2	-0.1	-0.4	-0.7	-0.4	0.4	0.1	-0.1	-1.2	-0.6	-0.9	-1.1	-0.9	-0.7	-0.8	-1.0	-1.2	-0.8	-0.9
Ovarian Cancer	0.2	0.3	1.1	-0.1	0.0	-0.2	-0.5	-0.8	-0.8	-0.1	-0.1	-0.1	-0.5	-0.5	-0.4	-0.5	-0.7	-0.5	-0.5	-0.6	-1.1	-0.6
Chronotype (morning person)	0.2	0.5	2.3	0.3	0.6	-0.3	0.2	-1.5	1.0	0.9	0.6	0.9	0.5	0.2	-0.1	0.1	-0.9	0.1	0.1	-0.8	-0.9	-0.0
Townsend deprivation index at recruitment	0.2	0.2	1.4	-0.6	-0.4	-0.1	0.2	-0.8	-1.2	-0.4	-0.3	0.5	0.2	0.4	0.2	0.3	0.3	-0.0	0.6	0.2	0.4	0.4
High blood pressure	0.2	0.4	2.8	1.7	0.5	0.6	0.5	0.3	0.0	0.4	0.3	1.1	0.0	0.3	0.7	0.4	0.4	0.8	-0.3	1.0	-0.4	0.4
Stomach or abdominal pain in last month	0.2	0.2	1.7	-0.5	-0.6	-0.3	-0.2	-0.4	-1.3	-0.6	-0.6	0.3	-0.5	-0.2	-0.0	-0.1	0.2	-0.1	0.1	0.5	0.0	-0.1
High blood pressure (mother)	0.2	0.3	0.9	-0.1	0.3	0.7	0.5	0.6	-0.1	0.1	0.5	0.9	1.0	0.7	0.5	0.5	0.4	0.4	0.7	0.5	1.0	0.6
Past tobacco smoking	0.2	0.4	2.0	-0.7	0.7	0.6	0.1	-0.3	1.2	0.9	0.7	0.0	0.5	0.1	-0.7	-0.1	-0.9	-0.3	0.2	-1.4	-0.2	-0.2
Financial difficulties in last 2 years	0.2	0.3	1.4	-1.0	-0.5	-0.4	-0.5	-1.2	-0.9	-0.6	-0.5	-0.3	-0.3	-0.4	-0.5	-0.4	-0.2	-0.6	0.0	-0.6	-0.2	-0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	5.7	0.3	-1.1	-1.1	-0.2	-2.4	-1.1	-1.0	-1.0	-1.1	-0.8	-0.4	0.2	-0.2	-0.8	-0.0	-0.4	-0.1	-1.2	-0.3
Number of children fathered	0.2	0.2	0.5	0.6	0.1	-0.0	0.6	-0.3	0.2	-0.1	0.1	0.5	0.5	0.6	0.5	0.7	0.7	0.6	0.6	0.6	0.3	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	-0.1	-0.4	-0.5	-0.6	-0.4	0.4	-0.3	-0.4	-0.4	-0.6	-0.7	-0.2	-0.5	-0.8	-0.4	-0.6	-0.3	-0.7	-0.6
Eye problems/disorders: None of the above	0.2	0.2	1.1	0.1	0.4	0.3	0.5	-0.6	0.3	0.3	0.6	0.2	0.6	0.5	0.6	0.5	0.0	0.4	0.6	0.3	1.0	0.4
Pulse rate, automated reading	0.2	0.7	3.0	-0.2	-0.0	0.9	0.6	0.0	0.8	-0.0	-0.0	1.7	1.0	1.2	1.1	0.9	0.1	0.6	1.4	0.9	-0.7	0.8
Number of full sisters	0.2	0.2	2.0	-0.1	-0.1	-0.2	-0.4	1.4	-1.1	-0.1	-0.3	0.4	-0.5	-0.3	-0.1	-0.3	0.2	-0.2	-0.2	0.4	-0.3	-0.3
Overall health rating	0.2	0.4	1.2	-0.7	-1.1	-0.6	-0.1	-0.6	-1.0	-1.1	-1.1	0.4	-0.5	0.0	0.4	0.1	0.2	-0.1	0.4	0.6	-0.3	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	1.9	-0.6	-0.5	0.0	-0.1	0.7	-1.4	-0.6	-0.6	-0.4	-0.4	-0.3	0.2	-0.3	-0.5	-0.3	-0.1	0.2	0.0	-0.2
Back pain experienced in last month	0.2	0.3	1.6	-0.6	0.2	-0.2	-0.3	1.3	0.5	-0.0	0.0	-0.4	-0.0	-0.3	-0.4	-0.4	-0.8	-0.5	-0.3	-0.9	0.0	-0.4
Breast cancer (self-reported)	0.2	0.3	1.5	0.8	-0.6	-0.2	-0.3	-1.2	-0.3	-0.5	-0.6	-0.2	-0.3	-0.2	0.5	-0.3	-0.5	-0.1	-0.7	0.5	-0.8	-0.2
Number of self-reported non-cancer illnesses	0.2	0.3	1.8	0.8	-0.6	0.1	-0.0	0.6	0.3	-0.7	-0.8	0.3	-0.6	-0.0	0.7	0.0	0.4	0.2	-0.5	1.3	-0.4	0.2
Average weekly champagne plus white wine intake	0.2	0.3	0.9	-0.9	-0.2	-0.5	-0.5	-0.8	0.2	0.0	-0.1	-0.6	-0.1	-0.3	-0.5	-0.4	-0.8	-0.5	-0.1	-1.0	0.1	-0.4
Wears glasses or contact lenses	0.2	0.3	3.7	-0.3	0.4	0.3	0.1	0.4	1.9	0.4	0.3	0.2	0.2	0.3	-0.2	0.2	0.0	-0.0	0.3	-0.3	-0.3	0.1
Medication: Paracetamol	0.2	0.4	1.2	-0.4	-0.7	-0.6	-0.1	-0.4	-1.1	-0.9	-0.6	-0.3	-0.3	0.1	0.5	0.2	0.7	0.1	0.5	1.1	1.0	0.3
Unable to work because of sickness or disability	0.2	0.2	1.0	-1.0	-0.7	-0.5	-0.3	0.1	-0.7	-0.7	-0.8	0.1	-0.2	-0.0	-0.2	-0.2	0.2	-0.5	0.2	0.1	0.1	-0.1
Myopia	0.2	0.2	0.8	0.3	-0.4	-0.5	-0.4	-0.9	-0.7	-0.2	-0.4	-0.4	-0.9	-0.6	-0.0	-0.3	-0.3	-0.0	-0.7	0.2	-0.5	-0.4
Heart disease (siblings)	0.2	0.2	0.7	0.2	-0.4	-0.3	0.1	-0.7	0.6	-0.7	-0.3	-0.3	0.3	0.5	0.4	0.3	0.8	0.1	0.4	0.6	0.9	0.5
Alcohol drinker status: Previous	0.2	0.2	0.9	-0.3	0.3	0.3	-0.2	-0.7	0.1	0.4	0.2	0.1	0.1	-0.2	-0.6	-0.4	-0.9	-0.4	-0.5	-0.9	-0.5	-0.4
Bipolar Disorder (2018)	0.1	0.1	1.2	0.5	-0.2	-0.3	0.1	-1.1	-0.4	-0.1	0.1	0.2	0.2	0.3	-0.1	0.2	0.6	0.1	0.1	-0.1	0.1	0.3
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	0.7	0.4	-0.1	-0.1	0.2	-0.4	0.6	0.4	0.5	-0.0	-0.2	-0.6	-0.2	0.0	-0.0	-0.6	-0.5	-0.5	-0.2
Depressed Affect (Nagel 2018)	0.1	0.3	1.4	1.0	-0.4	-0.3	-0.3	-0.3	-0.5	-0.4	-0.5	-0.1	-0.5	-0.4	0.0	-0.2	0.1	0.1	-0.8	0.3	-1.2	-0.3
Depression (Nagel 2018)	0.1	0.2	1.4	-0.0	0.5	0.7	0.1	1.2	0.0	0.4	0.4	0.7	0.3	0.1	0.3	0.1	-0.3	0.1	0.2	0.1	0.0	0.0
Schizophrenia (2018)	0.1	0.3	1.4	0.5	0.7	0.1	-0.2	1.2	0.1	0.8	0.4	0.5	-0.1	-0.5	-0.6	-0.4	-0.4	-0.1	-0.8	-0.6	-0.7	-0.5
Major Depression (MDD)	0.1	0.1	0.3	0.1	-0.4	-0.1	-0.3	0.1	0.4	-0.6	-0.3	-0.4	-0.5	-0.3	-0.3	-0.2	0.3	-0.1	-0.4	0.2	-0.2	-0.2
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	0.2	-0.0	-0.4	0.3	-0.5	0.3	0.0	0.0	0.0	0.3	0.4	0.1	0.4	0.6	0.4	0.2	0.2	0.1	0.4
HbA1C	0.1	0.1	1.1	-0.6	-0.0	-0.0	-0.1	0.5	-0.4	-0.0	0.0	-0.1	0.4	0.3	0.4	0.3	0.2	0.2	0.3	0.4	1.0	0.2
Schizophrenia (2014)	0.1	0.3	0.9	-0.0	-0.4	-0.6	-0.4	0.4	-0.8	-0.3	-0.5	0.4	-0.5	-0.6	-0.7	-0.6	-0.2	-0.5	-0.8	-0.3	-0.9	-0.6
Blood Platelet Count	0.1	0.9	6.0	-2.5	-0.9	-0.6	-0.5	1.4	-1.4	-0.7	-0.9	-0.4	0.1	-0.2	-0.8	-0.5	0.4	-1.1	0.5	-0.4	0.9	-0.4
Blood Red Count	0.1	1.0	4.4	0.2	-1.6	-1.8	-0.7	-2.1	-0.3	-1.5	-1.5	-0.8	-1.0	-0.5	0.1	-0.3	0.5	-0.2	-0.5	0.6	-0.7	-0.3
Hair Pigment	0.1	1.6	3.5	0.2	0.7	1.3	1.3	0.9	0.2	0.6	0.7	1.8	1.3	1.5	1.7	1.4	1.3	1.1	1.9	1.6	1.3	1.4
Tanning	0.1	1.6	3.0	0.0	1.2	1.5	1.3	1.3	1.4	1.0	1.2	1.7	1.5	1.4	0.9	1.3	1.2	1.0	1.7	0.7	1.5	1.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.9	-0.8	0.2	0.3	-0.2	0.7	0.9	0.1	0.1	0.3	0.1	-0.1	-0.5	-0.3	-0.0	-0.4	0.1	-0.7	-0.1	-0.3
Systolic blood pressure, automated reading	0.1	0.2	0.9	-0.8	-0.1	0.2	-0.1	0.7	0.4	-0.4	-0.1	-0.1	-0.1	-0.1	-0.3	-0.2	0.3	-0.4	0.1	0.1	0.9	-0.1
Fed-up feelings	0.1	0.2	0.9	0.1	-0.7	-0.5	-0.3	-0.8	-0.9	-0.7	-0.7	-0.0	-0.5	-0.3	-0.2	-0.2	0.0	-0.1	-0.3	-0.1	-0.6	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	1.1	0.0	0.6	0.6	0.3	1.1	-0.1	0.6	0.5	0.7	0.3	0.1	0.2	0.2	-0.2	0.2	0.1	0.0	0.2	0.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	-0.6	0.0	0.1	0.2	-0.1	0.4	-0.1	0.1	0.4	0.5	0.4	-0.2	0.2	0.6	-0.1	0.6	-0.2	0.6	0.2
Qualifications: CSEs or equivalent	0.1	0.1	0.4	-0.2	-0.0	0.2	0.2	-0.2	-0.2	-0.2	0.1	0.1	0.3	0.2	0.5	0.2	-0.2	0.1	0.4	0.4	0.6	0.2
Forced vital capacity (FVC)	0.1	0.4	1.7	1.2	-0.4	-0.4	0.3	-1.3	-0.3	-0.4	-0.4	-0.9	-0.5	-0.0	0.9	0.2	-0.5	0.5	-0.3	0.4	-1.0	0.1
Medication: Ramipril	0.1	0.2	0.6	0.7	0.1	0.5	0.3	0.2	0.4	0.4	0.1	0.6	0.3	0.5	0.8	0.4	0.2	0.4	0.2	0.6	0.0	0.5
Falls in the last year	0.1	0.1	0.3	-0.4	-0.3	-0.1	0.1	-0.5	0.2	-0.2	-0.2	0.5	0.4	0.5	0.1	0.2	0.3	-0.1	0.5	-0.0	-0.1	0.2
Lung cancer (father)	0.1	0.2	0.4	-0.1	-0.4	-0.1	-0.5	0.6	-0.6	-0.5	-0.5	-0.3	-0.6	-0.5	0.0	-0.4	-0.2	-0.4	-0.4	0.4	-0.1	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	3.1	0.5	-0.1	0.0	0.6	-1.8	-0.2	-0.1	-0.1	0.1	0.2	0.6	0.9	0.6	-0.3	0.6	0.5	0.4	-0.3	0.5
Pulse wave Arterial Stiffness index	0.1	0.2	1.0	1.0	-0.1	-0.4	0.2	-0.9	0.2	-0.2	-0.1	-0.3	0.0	0.1	0.3	0.1	0.2	0.3	-0.3	0.2	-0.4	0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	1.4	-0.1	-0.0	0.0	0.1	0.7	-1.2	-0.2	-0.1	0.1	0.1	0.0	0.2	0.1	0.4	0.1	0.2	0.4	0.6	0.1
Forced vital capacity (FVC), Best measure	0.1	0.3	0.9	0.9	0.3	0.3	0.5	-0.9	0.8	0.3	0.2	-0.4	0.1	0.3	0.8	0.4	-0.9	0.5	0.0	-0.0	-0.6	0.3
Comparative body size at age 10	0.1	0.2	0.7	-0.7	-0.0	-0.6	-0.3	-0.8	-0.5	-0.1	0.1	-0.7	-0.1	-0.3	-0.5	-0.3	-0.3	-0.5	-0.1	-0.5	0.6	-0.3
Age at first live birth	0.1	0.2	0.6	-0.6	-0.0	-0.3	-0.4	-0.2	0.6	-0.0	-0.0	-0.2	-0.2	-0.5	-0.7	-0.4	-0.3	-0.4	-0.2	-0.8	-0.6	-0.6
Age at last live birth	0.1	0.1	0.4	-0.1	0.3	0.2	0.1	-0.5	0.3	0.3	0.3	0.2	0.3	0.0	-0.4	0.0	-0.1	0.0	0.1	-0.6	-0.5	-0.1
Supplements: Vitamin C	0.1	0.1	0.4	0.5	0.5	0.4	0.0	0.7	0.1	0.5	0.5	0.1	-0.1	-0.3	-0.2	-0.2	-0.2	-0.0	-0.5	-0.1	-0.1	-0.1
Hypertension (Self-reported)	0.1	0.3	2.5	1.6	0.5	0.5	0.2	-0.0	0.2	0.5	0.3	0.9	-0.1	-0.0	0.3	0.1	0.1	0.5	-0.7	0.5	-0.8	0.1
Smoking status: Previous	0.1	0.2	0.6	0.1	-0.0	-0.1	0.1	0.8	-0.8	-0.2	-0.0	0.2	-0.0	0.1	0.3	0.2	0.7	0.2	0.2	0.7	0.7	0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.5	0.1	-0.6	-0.2	-0.2	-0.1	-0.1	-0.7	-0.7	0.0	-0.5	-0.2	0.2	-0.1	0.1	-0.0	-0.2	0.6	-0.7	-0.2
Long-standing illness, disability or infirmity	0.1	0.2	1.0	0.1	0.0	0.5	0.3	1.0	0.5	0.0	-0.1	0.4	0.1	0.4	0.6	0.3	0.5	0.2	0.3	0.6	0.5	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.5	0.5	0.4	0.2	0.2	-0.4	-0.1	0.7	0.4	0.2	0.3	0.1	-0.2	-0.0	-0.3	0.1	-0.2	-0.7	-0.6	0.0
Mineral and other dietary supplements	0.1	0.1	0.8	0.6	0.1	0.2	0.2	-0.0	0.9	0.2	0.0	0.4	-0.0	0.1	0.2	0.1	0.2	0.2	-0.2	0.5	-0.3	0.2
Hearing aid user	0.1	0.1	0.3	0.5	0.5	0.5	0.4	0.3	-0.3	0.2	0.5	0.4	0.5	0.5	0.2	0.3	0.4	0.3	0.2	0.2	0.3	0.4
Financial situation satisfaction	0.1	0.1	0.3	0.4	-0.0	0.2	0.1	-0.5	-0.4	-0.1	-0.0	-0.4	-0.0	0.1	0.3	0.1	-0.5	0.2	-0.2	0.0	-0.5	0.1
Commuting to job workplace: Public transport	0.1	0.1	0.3	0.6	0.2	0.1	-0.1	0.2	0.4	0.3	0.1	-0.4	-0.0	-0.1	0.0	-0.0	-0.4	0.1	-0.3	-0.3	-0.5	-0.1
Eye problems/disorders: Glaucoma	0.1	0.1	0.5	-0.4	0.1	0.3	-0.0	-0.1	0.5	0.1	0.2	0.1	0.1	0.0	-0.6	-0.1	0.1	-0.3	0.1	-0.7	-0.4	-0.1
Alcohol drinker status: Never	0.1	0.1	0.6	0.4	-0.3	-0.0	-0.3	-0.4	0.8	-0.5	-0.3	-0.4	-0.4	-0.4	0.3	-0.2	-0.3	0.0	-0.4	0.3	-0.6	-0.2
Diastolic blood pressure, automated reading	0.1	0.2	0.9	0.7	-0.4	0.3	-0.1	-0.4	0.4	-0.6	-0.4	0.4	-0.3	-0.1	0.5	-0.1	-0.3	0.1	-0.4	0.9	-0.6	-0.0
Vascular/heart problems diagnosed by doctor	0.1	0.4	2.2	-1.5	-0.0	-0.3	-0.4	-0.2	-0.0	-0.0	0.1	-1.0	0.1	-0.3	-0.8	-0.5	-0.8	-0.7	0.2	-1.3	0.3	-0.5
Ulcerative Colitis (UC)	0.0	0.1	0.4	-0.1	0.2	0.2	0.3	-0.7	0.1	0.3	0.4	0.2	0.3	0.3	0.0	0.2	0.1	0.1	0.4	-0.2	-0.0	0.3
Blood White Count	0.0	0.3	2.2	-1.5	-0.8	-0.2	-0.6	-0.3	-0.2	-0.6	-0.8	0.5	-0.3	-0.4	-0.3	-0.5	-0.2	-0.8	0.2	0.2	-0.2	-0.5
Relative age of first facial hair	0.0	0.1	1.2	-0.0	0.2	0.2	0.1	-0.5	1.1	0.3	0.3	0.1	0.1	0.1	-0.1	0.1	0.2	0.1	0.1	-0.2	0.1	0.1
Hair/balding pattern: Pattern 4	0.0	0.1	0.4	-0.2	-0.3	-0.4	-0.1	-0.2	-0.6	-0.4	-0.3	-0.6	-0.3	-0.0	-0.2	0.0	0.6	0.0	0.0	-0.0	0.6	0.1
Alcohol intake frequency.	0.0	0.1	0.4	-0.4	-0.2	0.5	-0.1	-0.5	-0.6	-0.2	-0.1	0.3	0.1	0.1	0.3	0.0	-0.5	-0.1	0.2	0.4	-0.3	-0.0
Osteoarthritis (self-reported)	0.0	0.1	0.2	0.3	0.0	-0.1	0.2	0.4	-0.1	-0.2	-0.1	0.1	-0.1	0.2	0.3	0.3	0.3	0.4	0.1	0.2	-0.2	0.2
Irritability	0.0	0.1	0.2	0.3	0.1	-0.3	-0.1	0.3	-0.4	0.4	0.1	-0.3	-0.2	-0.3	-0.3	-0.1	0.4	0.0	-0.3	-0.1	0.2	-0.1

Hub : Genes

SLC25A16

Models

Trait associations