[Hub]/) : Traits : Arm fat-free mass (right) :

chr12:116,650,803-118,234,710

Best TWAS P=2.75e-10 · Best GWAS P=4.18e-10 conditioned to 0.171

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous TESC 0.09 0.04 lasso 2 0.01 2.1e-02 -5.0 -5.7 1.3e-08 0.87 0.11 0.77 FALSE
2 GTEx Adipose Subcutaneous FBXW8 0.12 0.04 lasso 6 0.02 1.2e-02 -5.1 -5.5 3.7e-08 0.81 0.08 0.73 FALSE
3 GTEx Cells Transformed fibroblasts FBXW8 0.25 0.24 lasso 4 0.25 5.0e-19 -5.9 5.7 9.3e-09 -0.88 0.06 0.94 FALSE
4 GTEx Cells Transformed fibroblasts RP11-231I16.1 0.16 0.18 lasso 2 0.16 2.5e-12 -5.9 6.0 1.6e-09 -0.94 0.04 0.96 FALSE
5 GTEx Nerve Tibial FBXW8 0.17 0.17 lasso 3 0.19 2.5e-13 -5.9 -5.3 1.2e-07 0.78 0.05 0.95 FALSE
6 GTEx Spleen FBXW8 0.36 0.16 lasso 2 0.12 5.8e-04 -5.9 -5.8 5.3e-09 0.90 0.03 0.84 FALSE
7 GTEx Testis FBXW8 0.27 0.10 lasso 4 0.06 1.9e-03 -5.8 -5.5 5.0e-08 0.83 0.06 0.90 FALSE
8 GTEx Thyroid FBXW8 0.14 0.08 lasso 3 0.07 2.3e-06 -5.2 -5.6 2.1e-08 0.93 0.09 0.91 FALSE
9 The Cancer Genome Atlas Bladder Urothelial Carcinoma FBXW8 0.14 0.09 lasso 8 0.08 1.8e-07 -5.8 5.8 5.0e-09 -0.90 0.03 0.97 FALSE
10 The Cancer Genome Atlas Breast Invasive Carcinoma FBXW8 0.16 0.17 blup 83 0.17 3.9e-34 -5.9 6.1 9.9e-10 -0.88 0.05 0.95 FALSE
11 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma FBXW8 0.09 0.04 blup 81 0.04 3.0e-03 -5.1 5.9 3.5e-09 -0.91 0.02 0.88 FALSE
12 The Cancer Genome Atlas Colon Adenocarcinoma FBXW8 0.25 0.18 blup 83 0.20 4.9e-12 -5.9 5.4 7.1e-08 -0.66 0.04 0.96 FALSE
13 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma FBXW8 0.20 0.22 enet 18 0.24 4.5e-26 -5.9 5.6 2.6e-08 -0.81 0.04 0.96 FALSE
14 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma FBXW8 0.12 0.17 enet 12 0.20 1.2e-21 -5.9 6.1 1.1e-09 -0.90 0.10 0.90 FALSE
15 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FBXW8 0.10 0.10 lasso 7 0.09 7.5e-06 -6.1 6.2 5.2e-10 -0.99 0.02 0.98 FALSE
16 The Cancer Genome Atlas Brain Lower Grade Glioma FBXW8 0.17 0.02 blup 83 0.03 7.0e-05 3.4 6.1 1.3e-09 -0.70 0.04 0.73 FALSE
17 The Cancer Genome Atlas Liver Hepatocellular Carcinoma FBXW8 0.11 0.15 blup 75 0.12 2.4e-06 -5.1 5.3 1.2e-07 -0.94 0.06 0.94 FALSE
18 The Cancer Genome Atlas Lung Adenocarcinoma FBXW8 0.10 0.08 enet 15 0.08 1.2e-09 -5.8 6.3 2.7e-10 -0.89 0.04 0.96 TRUE
19 The Cancer Genome Atlas Lung Squamous Cell Carcinoma FBXW8 0.11 0.12 lasso 6 0.12 3.1e-13 -5.1 5.7 1.5e-08 -0.91 0.06 0.94 FALSE
20 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma FBXW8 0.15 0.11 blup 79 0.13 7.7e-09 -5.1 5.4 5.2e-08 -0.89 0.12 0.88 FALSE
21 The Cancer Genome Atlas Pancreatic Adenocarcinoma FBXW8 0.14 0.16 lasso 3 0.17 1.3e-07 -5.0 5.4 5.2e-08 -0.79 0.26 0.63 FALSE
22 The Cancer Genome Atlas Prostate Adenocarcinoma FBXW8 0.20 0.29 lasso 9 0.29 1.2e-30 -5.8 5.7 1.4e-08 -0.91 0.06 0.94 FALSE
23 The Cancer Genome Atlas Rectum Adenocarcinoma FBXW8 0.13 0.17 lasso 7 0.10 2.0e-03 -5.9 5.8 6.0e-09 -0.91 0.03 0.69 FALSE
24 The Cancer Genome Atlas Soft Tissue Sarcoma FBXW8 0.13 0.11 enet 18 0.12 7.0e-08 -5.8 5.4 8.8e-08 -0.78 0.05 0.95 FALSE
25 The Cancer Genome Atlas Stomach Adenocarcinoma FBXW8 0.09 0.12 lasso 3 0.12 9.1e-09 -5.0 5.5 4.7e-08 -0.88 0.07 0.93 FALSE
26 The Cancer Genome Atlas Thyroid Carcinoma FBXW8 0.22 0.16 blup 83 0.17 2.1e-16 -5.8 5.8 7.2e-09 -0.82 0.06 0.94 FALSE