[Hub]/) : Traits : Arm fat-free mass (right) : ← →

chr12:109,591,369-113,517,494

Best TWAS P=2.01e-15 · Best GWAS P=1.41e-22 conditioned to 0.497

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Artery Tibial	HECTD4	0.05	0.02	lasso	3	0.01	3.1e-02	-8.14	-7.9	2.0e-15	0.78	0.02	0.92	TRUE
6	GTEx	Breast Mammary Tissue (Female)	VPS29	0.10	-0.01	lasso	2	0.02	1.0e-01	-5.34	6.9	4.4e-12	-0.34	0.03	0.22	TRUE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	CUX2	0.08	0.01	blup	95	0.02	1.3e-03	4.58	6.2	5.6e-10	-0.15	0.17	0.03	TRUE
2	GTEx	Adrenal Gland	PPTC7	0.13	-0.01	lasso	6	0.00	3.4e-01	5.66	6.7	2.1e-11	-0.26	0.04	0.12	FALSE
30	NTR	Blood	GPN3	0.03	0.01	blup	236	0.02	2.7e-06	5.42	-6.5	9.9e-11	0.12	0.17	0.83	FALSE
3	GTEx	Artery Tibial	VPS29	0.05	0.03	lasso	3	0.02	5.9e-03	6.29	6.3	2.4e-10	-0.11	0.03	0.89	FALSE
1	GTEx	Adipose Subcutaneous	HECTD4	0.06	0.00	enet	15	0.02	1.0e-02	3.34	-6.3	2.7e-10	0.65	0.06	0.84	FALSE
19	GTEx	Skin Not Sun Exposed Suprapubic	VPS29	0.06	0.01	lasso	3	0.01	6.9e-02	5.61	6.3	2.8e-10	-0.07	0.07	0.46	FALSE
32	YFS	Blood	SH2B3	0.05	0.01	enet	22	0.02	3.3e-07	3.13	-6.2	4.2e-10	0.64	0.70	0.30	FALSE
14	GTEx	Muscle Skeletal	VPS29	0.06	0.06	lasso	3	0.05	4.3e-06	6.29	6.2	4.8e-10	-0.09	0.02	0.98	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	VPS29	0.02	0.02	lasso	5	0.03	4.6e-06	5.85	6.2	5.4e-10	-0.07	0.00	0.99	FALSE
9	GTEx	Colon Transverse	FAM109A	0.21	0.00	lasso	4	0.01	1.3e-01	5.41	-6.2	5.8e-10	0.41	0.06	0.06	FALSE
26	GTEx	Thyroid	VPS29	0.07	0.01	lasso	5	0.01	8.9e-02	5.85	6.2	6.6e-10	-0.11	0.03	0.72	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	VPS29	0.06	0.06	enet	7	0.06	2.1e-07	6.00	6.1	1.2e-09	-0.06	0.00	1.00	FALSE
8	GTEx	Cells Transformed fibroblasts	VPS29	0.09	0.13	lasso	3	0.13	9.8e-10	6.29	6.1	1.4e-09	-0.09	0.02	0.98	FALSE
22	GTEx	Skin Sun Exposed Lower leg	ALDH2	0.10	0.09	enet	13	0.13	6.7e-11	3.06	-6.1	1.4e-09	0.62	0.91	0.09	FALSE
27	GTEx	Whole Blood	GPN3	0.19	0.20	lasso	4	0.19	1.9e-17	5.85	-6.0	1.9e-09	0.10	0.06	0.94	FALSE
16	GTEx	Muscle Skeletal	ANAPC7	0.08	0.01	lasso	3	0.00	1.1e-01	5.42	6.0	2.0e-09	-0.07	0.03	0.77	FALSE
29	NTR	Blood	ALDH2	0.06	0.01	blup	222	0.02	4.3e-08	3.65	5.8	4.9e-09	-0.43	0.94	0.06	FALSE
31	YFS	Blood	GLTP	0.05	0.01	enet	14	0.04	1.5e-13	4.59	5.8	6.8e-09	-0.08	0.02	0.98	FALSE
33	YFS	Blood	TRAFD1	0.04	0.02	lasso	2	0.01	2.9e-05	-4.67	-5.8	6.9e-09	0.55	0.09	0.85	FALSE
10	GTEx	Esophagus Mucosa	VPS29	0.14	0.13	lasso	6	0.13	3.0e-09	5.51	5.8	7.5e-09	-0.07	0.05	0.95	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	VPS29	0.08	0.06	lasso	5	0.07	2.0e-08	5.85	5.7	9.6e-09	-0.10	0.00	1.00	FALSE
15	GTEx	Muscle Skeletal	IFT81	0.08	0.08	lasso	5	0.07	1.7e-07	5.63	5.7	1.0e-08	-0.04	0.12	0.88	FALSE
21	GTEx	Skin Sun Exposed Lower leg	VPS29	0.05	0.04	lasso	6	0.03	1.0e-03	5.03	5.7	1.2e-08	-0.10	0.06	0.84	FALSE
20	GTEx	Skin Sun Exposed Lower leg	ARPC3	0.13	0.15	lasso	3	0.15	1.9e-12	5.64	-5.6	1.7e-08	0.05	0.30	0.70	FALSE
24	GTEx	Testis	ARPC3	0.16	0.16	lasso	3	0.14	7.5e-07	5.63	-5.6	1.7e-08	0.05	0.29	0.70	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	RAD9B	0.10	0.06	enet	5	0.06	1.2e-06	5.64	5.6	1.7e-08	-0.05	0.06	0.94	FALSE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACAD10	0.02	0.02	lasso	3	0.01	7.0e-03	5.65	5.6	1.8e-08	-0.50	0.00	0.91	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	ARPC3	0.13	0.09	lasso	4	0.04	2.0e-02	5.60	-5.6	2.5e-08	0.04	0.12	0.26	FALSE
11	GTEx	Esophagus Muscularis	VPS29	0.08	0.04	lasso	4	0.03	9.0e-03	5.52	5.5	3.3e-08	-0.07	0.06	0.80	FALSE
18	GTEx	Nerve Tibial	HECTD4	0.05	0.01	enet	6	0.01	3.6e-02	5.36	-5.5	4.3e-08	0.41	0.22	0.46	FALSE
28	METSIM	Adipose	GPN3	0.05	0.04	enet	17	0.04	1.1e-06	5.79	-5.5	4.4e-08	0.01	0.09	0.91	FALSE
13	GTEx	Lung	GPN3	0.08	0.08	enet	8	0.07	1.0e-05	4.94	-5.3	9.3e-08	0.06	0.51	0.48	FALSE
17	GTEx	Nerve Tibial	VPS29	0.05	0.01	lasso	4	0.00	2.5e-01	5.85	5.3	1.2e-07	-0.04	0.05	0.55	FALSE
25	GTEx	Thyroid	BRAP	0.07	0.02	lasso	7	0.03	1.1e-03	3.13	5.3	1.4e-07	-0.54	0.36	0.42	FALSE
12	GTEx	Heart Left Ventricle	ADAM1A	0.20	0.07	enet	22	0.10	4.3e-06	0.72	5.2	1.7e-07	-0.34	0.35	0.15	FALSE
23	GTEx	Spleen	VPS29	0.24	0.01	enet	14	0.04	2.9e-02	4.86	5.2	1.7e-07	-0.02	0.07	0.22	FALSE
39	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ERP29	0.11	0.03	blup	25	0.05	5.0e-03	3.33	5.2	2.4e-07	-0.60	0.01	0.75	FALSE
35	The Cancer Genome Atlas	Colon Adenocarcinoma	ALDH2	0.07	0.03	lasso	4	0.06	3.9e-04	3.13	-5.2	2.5e-07	0.44	0.02	0.90	FALSE
5	GTEx	Brain Cerebellum	HECTD4	0.25	-0.01	enet	24	0.06	7.7e-03	1.90	-5.1	2.8e-07	0.42	0.06	0.72	FALSE