Best TWAS P=1.67e-19 · Best GWAS P=6.32e-35 conditioned to 1.56e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | GTEx | Muscle Skeletal | C14orf39 | 0.06 | 0.05 | lasso | 3 | 0.05 | 2.7e-05 | 6.02 | -9.0 | 1.7e-19 | -0.67 | 0.13 | 0.86 | TRUE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | PCNXL4 | 0.15 | 0.05 | enet | 15 | 0.12 | 6.2e-07 | 2.19 | -8.5 | 1.6e-17 | -0.61 | 0.76 | 0.10 | TRUE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | C14orf39 | 0.02 | 0.02 | blup | 37 | 0.02 | 4.2e-03 | 5.86 | -8.1 | 3.9e-16 | -0.55 | 0.06 | 0.43 | FALSE |
| 7 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C14orf39 | 0.08 | 0.05 | blup | 37 | 0.05 | 4.2e-03 | 5.61 | -7.7 | 1.8e-14 | -0.51 | 0.09 | 0.37 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C14orf39 | 0.08 | 0.09 | blup | 37 | 0.11 | 1.8e-11 | 5.99 | -7.5 | 4.4e-14 | -0.51 | 0.99 | 0.01 | FALSE |
| 3 | GTEx | Liver | MNAT1 | 0.21 | 0.00 | lasso | 4 | -0.01 | 5.4e-01 | 0.17 | -6.5 | 6.6e-11 | -0.44 | 0.08 | 0.20 | FALSE |
| 1 | GTEx | Adipose Subcutaneous | C14orf39 | 0.08 | 0.05 | lasso | 8 | 0.06 | 2.1e-05 | 6.02 | -6.1 | 9.6e-10 | -0.41 | 0.92 | 0.02 | FALSE |
| 2 | GTEx | Esophagus Muscularis | C14orf39 | 0.10 | 0.02 | enet | 9 | 0.02 | 2.9e-02 | -0.39 | -5.2 | 1.7e-07 | -0.41 | 0.12 | 0.18 | FALSE |