Best TWAS P=1.48e-11 · Best GWAS P=8.85e-12 conditioned to 6.12e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | GPRC5B | 0.07 | 0.04 | lasso | 4 | 0.03 | 1.3e-03 | -6.1 | 6.8 | 1.5e-11 | 0.31 | 0.27 | 0.31 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | GPRC5B | 0.06 | 0.01 | blup | 38 | 0.01 | 2.4e-02 | -3.9 | -5.9 | 3.1e-09 | -0.43 | 0.01 | 0.09 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IQCK | 0.03 | 0.03 | lasso | 3 | 0.02 | 7.2e-04 | -5.2 | -5.5 | 4.0e-08 | -0.25 | 0.03 | 0.93 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | AC002550.5 | 0.62 | 0.54 | enet | 35 | 0.63 | 4.4e-29 | -4.0 | -5.4 | 8.1e-08 | -0.27 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Brain Putamen basal ganglia | AC002550.5 | 0.59 | 0.48 | enet | 23 | 0.58 | 1.2e-16 | -4.1 | -5.3 | 1.1e-07 | -0.19 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | KNOP1 | 0.51 | 0.44 | enet | 22 | 0.56 | 5.3e-24 | -4.7 | -5.2 | 2.2e-07 | -0.27 | 0.96 | 0.04 | FALSE |
| 5 | GTEx | Liver | KNOP1 | 0.23 | 0.21 | lasso | 7 | 0.25 | 1.4e-07 | -4.0 | -5.1 | 2.8e-07 | -0.27 | 0.84 | 0.01 | FALSE |