Hub : Genes

GPRC5B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1070	0.0330	1.1e-05	0.047	0.042	0.031	0.042	0.043	2.1e-06	7.4e-06	9.4e-05	6.2e-06	5.2e-06
2	GTEx	Adipose Subcutaneous	0.0710	0.0300	2.3e-03	0.041	NA	0.001	NA	0.031	2.5e-04	NA	2.4e-01	NA	1.3e-03
3	GTEx	Lung	0.0848	0.0303	3.4e-04	0.053	NA	0.033	NA	0.059	6.6e-05	NA	1.4e-03	NA	2.4e-05
4	TCGA	Thyroid Carcinoma	0.0620	0.0370	3.3e-03	0.008	0.011	0.000	NA	0.007	5.2e-02	2.4e-02	2.8e-01	NA	5.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	0.4	0.5	0.6	0.5	-0.3
Bipolar Disorder or Schizophrenia	0.2	0.4	0.8	-0.6	-0.2	-0.6	0.9
Depressed Affect (Nagel 2018)	0.5	1.0	1.5	-0.2	-1.2	-1.0	1.1
Depression (Nagel 2018)	0.5	0.7	2.1	1.5	-0.2	0.8	0.3
Intelligence (Savage-Jansen 2018)	1.0	3.2	4.9	-2.0	-1.4	-2.2	1.3
Neuroticism (Nagel 2018)	1.0	2.3	3.7	-1.0	-1.9	-1.6	1.4
Schizophrenia (2018)	0.7	1.4	2.2	-1.2	-0.8	-1.2	1.5
Schizophrenia vs Biploar Disorder	1.0	1.3	3.3	-0.3	-1.8	-0.5	1.2
Worry (Nagel 2018)	3.8	7.9	11.3	-2.2	-3.4	-2.9	2.7
Alzheimer’s Disease (in mother)	1.0	1.2	2.3	0.1	-1.5	-0.6	1.5
Alzheimer’s Disease (in father)	0.0	0.0	0.1	-0.1	0.4	0.0	0.1
Alzheimer’s Disease (including proxy)	1.0	1.5	3.7	1.9	0.6	1.3	0.3
Crohns Disease (2017)	1.6	3.6	5.5	1.3	2.4	1.5	-2.3
Irritable Bowel Disease (IBD)	0.6	1.5	2.8	0.8	1.7	0.9	-1.3
Ulcerative Colitis (UC)	0.2	0.4	1.1	0.5	1.0	0.5	-0.1
Major Depression (MDD)	2.3	2.8	6.0	-0.9	-1.8	-1.0	2.4
Reaction Time	1.0	2.0	2.4	-1.5	-1.5	-1.5	1.0
Verbal and Numeric Reasoning (VNR)	0.9	2.1	2.8	-1.2	-1.2	-1.7	1.6
Breast Cancer	0.4	0.9	2.2	0.6	1.5	0.8	-0.5
Ovarian Cancer	1.5	2.0	3.9	-2.0	-1.7	-1.0	0.2
Prostate Cancer	0.4	0.5	1.5	-0.0	-1.2	-0.7	0.3
Age at First Birth	1.6	2.4	3.4	-1.8	-1.6	-1.9	0.6
Bipolar Disorder (2011)	0.2	0.1	0.3	-0.6	0.0	-0.5	0.0
Body Mass Index (BMI) (2010)	18.6	25.5	41.9	4.0	6.5	4.5	-4.9
Coronary Artery Disease (CAD)	0.2	0.2	0.4	-0.2	-0.6	-0.3	0.6
Crohns Disease (2012)	1.3	2.1	4.1	0.6	2.0	1.0	-1.7
Mean Putamen Volume	3.3	3.8	5.5	2.3	1.6	2.3	-1.5
Fasting Glucose	0.9	1.0	2.7	1.6	-0.9	0.7	-0.2
HbA1C	1.8	2.0	4.3	2.1	-1.7	0.8	-0.4
HDL Cholesterol	8.2	13.6	18.8	-3.3	-3.5	-4.3	3.5
LDL Cholesterol	0.2	0.3	0.7	0.8	0.3	0.4	0.7
Lupus	0.1	0.2	0.4	0.6	-0.1	-0.1	-0.4
Neuroticism (2016)	0.7	0.9	1.4	-0.9	-1.2	-1.0	0.8
Primary Biliary Cirrhosis	0.5	0.7	1.7	0.8	1.3	0.5	-0.5
Rheumatoid Arthritis	1.1	1.6	2.9	-1.4	-0.3	-1.7	1.2
Schizophrenia (2014)	0.5	1.2	1.8	-1.0	-1.1	-0.8	1.3
Triglycerides	1.2	2.0	2.3	1.5	1.4	1.5	-1.3
Type 2 Diabetes (T2D) (2012)	5.9	6.8	8.8	2.5	2.2	3.0	-2.7
Ulcerative Colitis	0.2	0.3	0.7	-0.3	0.4	-0.5	0.8
Blood Eosinophil Count	1.1	8.5	9.4	2.9	2.9	3.1	-2.8
Blood Platelet Count	2.1	24.9	39.9	-4.4	-6.3	-4.6	4.4
Blood Red Count	0.3	2.5	3.5	1.9	1.6	1.4	-1.4
Blood White Count	0.6	4.2	10.0	-0.9	-3.2	-1.2	2.1
Heel T-Score	3.1	24.5	27.6	4.6	5.2	5.1	-4.8
BMI	16.7	96.6	151.3	7.9	12.3	9.0	-9.6
Height	1.2	22.6	39.1	-6.2	-4.6	-5.0	2.3
Waist Hip Ratio (WHR)	0.8	3.5	5.9	-1.4	-2.4	-1.5	2.0
Systolic Blood Pressure	0.2	1.1	1.7	-1.3	-1.3	-0.6	-0.8
Smoking Status	0.1	0.1	0.2	-0.2	0.5	0.4	-0.3
Allergy or Eczema	0.3	0.8	1.7	-0.2	1.3	0.7	-1.0
Cardiovascular Disease	0.3	1.1	2.0	0.8	1.4	0.9	-1.0
Hypothyroidism (self reported)	0.3	0.7	1.6	1.3	0.3	0.8	-0.6
Respiratory disease	0.0	0.1	0.3	-0.6	0.2	0.0	-0.2
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.2	0.6	1.2	1.0	-1.5
Lung FEV1/FVC ratio	2.3	11.7	18.0	-4.2	-2.5	-4.2	2.3
Lung FVC	0.6	3.1	7.4	0.2	2.7	1.1	-1.9
Neuroticism	1.4	3.5	6.1	-0.7	-2.5	-1.7	2.1
Chronotype (morning person)	0.6	1.4	2.4	-1.6	0.5	-1.4	1.0
Hair Pigment	0.1	2.0	4.9	-0.6	-1.1	-1.2	2.2
Tanning	0.0	0.6	1.9	-0.1	-0.6	0.2	-1.4
Hand grip strength (left)	7.4	19.5	25.8	4.2	5.1	4.2	-4.1
Number of treatments/medications taken	1.4	2.5	3.8	-1.9	-1.1	-1.7	1.5
Average weekly spirits intake	1.3	1.7	5.0	-0.7	2.2	-0.3	-1.0
Sensitivity / hurt feelings	0.3	0.6	0.9	-0.6	-0.6	-1.0	0.9
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.5	1.2	0.6	1.1	-0.4
Hearing difficulty/problems: Yes	0.0	0.0	0.1	0.2	-0.1	0.3	0.2
Relative age of first facial hair	1.5	3.2	8.3	-1.4	-2.9	-1.4	0.6
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.5	-0.1	0.7	0.1	-0.0
Ever used hormone-replacement therapy (HRT)	2.6	3.4	5.8	-0.5	-2.4	-1.4	2.3
Ever had hysterectomy (womb removed)	1.7	1.9	3.5	-1.5	-0.8	-1.9	1.1
Systolic blood pressure, automated reading	0.2	0.6	2.0	-0.5	0.0	0.1	-1.4
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	5.2	2.3	1.6	1.5	-1.7
Angina	1.8	2.4	4.5	-1.5	-2.1	-1.1	1.3
Medication for hormone replacement therapy	1.0	1.1	2.2	1.5	-0.3	1.4	0.2
Vitamin and mineral supplements	1.8	2.4	3.2	1.7	1.2	1.8	-1.5
Supplements: Zinc	0.3	0.4	0.5	-0.7	0.0	-0.7	0.7
Medication: Co-codamol	0.6	0.7	1.9	-0.2	-0.7	-0.5	1.4
Medication: Metformin	1.8	2.5	3.1	1.6	1.2	1.8	-1.7
Diabetes (father)	0.2	0.3	1.0	0.2	1.0	-0.2	0.2
Diabetes (mother)	2.6	3.4	4.8	2.2	1.8	2.0	-1.3
Severe depression (siblings)	1.8	2.0	3.7	1.9	0.1	1.8	-1.1
Pack years adult smoking proportion	0.5	0.8	3.0	0.1	-0.5	-0.2	1.7
Impedance of leg (right)	17.1	82.7	127.7	-7.3	-11.3	-8.2	9.1
Leg fat-free mass (left)	8.1	42.9	72.2	4.5	8.5	5.4	-7.0
Trunk fat percentage	0.5	1.8	5.9	0.3	2.4	0.1	-1.2
Hand grip strength (right)	3.5	9.6	16.6	2.2	4.1	2.7	-3.2
Townsend deprivation index at recruitment	1.2	1.7	2.0	-1.4	-1.1	-1.4	1.2
Current tobacco smoking	2.0	3.3	4.9	1.1	1.8	2.2	-2.0
Average weekly fortified wine intake	0.2	0.2	0.5	-0.7	0.3	-0.4	-0.1
Maternal smoking around birth	0.3	0.5	0.7	-0.7	-0.4	-0.7	0.8
Fed-up feelings	0.6	1.1	2.3	-0.1	-1.1	-0.9	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.9	0.9	0.1	0.6	0.3
Relative age voice broke	2.0	3.0	4.3	-1.6	-2.1	-1.5	1.7
Taking other prescription medications	0.0	0.0	0.2	-0.0	-0.2	0.0	0.4
Age when periods started (menarche)	10.1	24.2	39.7	-3.8	-6.3	-4.2	5.0
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	1.2	0.2	0.6	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.8	0.4	1.7	0.8	-1.2
Tinnitus: Yes, but not now, but have in the past	1.6	1.8	3.1	0.7	1.8	1.1	-1.5
Qualifications: CSEs or equivalent	0.3	0.4	1.3	-0.2	-1.2	-0.2	0.2
Serious illness, injury or assault to yourself	3.5	4.2	5.9	-1.7	-1.7	-2.3	2.4
High blood pressure	1.1	3.1	5.2	1.1	1.8	1.6	-2.3
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.5	0.1	1.2	0.8	-0.9
Multivitamins +/- minerals	0.8	1.0	1.5	-0.7	-0.9	-1.0	1.2
Stomach or abdominal pain in last month	0.2	0.2	0.4	0.2	0.7	0.4	-0.5
Supplements: Glucosamine	3.5	4.6	7.2	2.7	1.6	1.8	-2.3
Diverticular disease/diverticulitis (self-reported)	5.9	7.0	8.9	-2.8	-3.0	-2.2	2.6
Medication: Atenolol	0.9	1.2	2.1	1.1	0.6	1.5	-1.0
Medication: Levothyroxine sodium	0.3	0.5	0.9	-0.7	-0.5	-0.9	0.7
Sitting height	0.2	1.5	3.2	-1.6	0.5	-0.5	-1.8
Chronic bronchitis/emphysema (father)	0.5	0.6	1.2	1.1	-0.0	1.0	-0.5
High blood pressure (mother)	6.5	9.1	10.7	2.6	3.1	3.0	-3.3
Body mass index (BMI)	9.1	38.7	66.0	5.1	8.1	5.3	-5.9
Impedance of leg (left)	18.3	89.0	139.2	-7.6	-11.8	-8.5	9.3
Leg predicted mass (left)	7.9	42.1	70.9	4.4	8.4	5.4	-7.0
Trunk fat mass	1.7	7.5	18.2	1.4	4.3	1.5	-2.8
Waist circumference	3.6	13.1	24.1	2.6	4.9	2.9	-3.6
Number of incorrect matches in round	0.3	0.4	1.5	0.3	1.2	0.3	0.2
Past tobacco smoking	1.5	2.7	3.9	2.0	1.5	1.8	-1.1
Alcohol usually taken with meals	1.0	1.6	3.6	0.3	1.9	0.5	-1.5
Nervous feelings	6.2	11.5	13.9	-3.6	-3.2	-3.7	3.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.3	0.2	-1.1	-0.0	0.4
Hearing difficulty/problems with background noise	0.0	0.1	0.1	0.2	0.2	0.3	-0.1
Hair/balding pattern: Pattern 2	1.5	1.9	3.0	-1.7	-0.9	-1.4	1.3
Had menopause	1.2	1.5	2.1	-0.7	-1.3	-1.3	1.5
Had other major operations	0.8	1.0	2.0	1.2	-0.4	0.6	1.4
Forced vital capacity (FVC)	0.2	0.9	2.3	-1.5	0.8	-0.7	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	2.8	0.3	1.7	0.9	-1.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.8	-0.5	-0.4	-0.3	0.9
Qualifications: None of the above	0.1	0.2	0.7	0.3	0.2	0.2	0.8
Financial difficulties in last 2 years	0.2	0.2	0.6	-0.0	-0.5	-0.0	0.8
Mouth/teeth dental problems	0.3	0.4	1.0	0.6	-0.4	0.3	-1.0
Heart attack	0.5	0.6	2.0	-0.6	-1.4	-0.3	0.2
Allergy	0.3	0.6	1.6	0.1	-1.3	-0.6	0.6
Pain all over the body in last month	0.3	0.3	0.5	-0.7	-0.5	-0.4	0.5
Diabetes (self-reported)	1.0	1.5	3.1	0.8	1.8	0.8	-1.3
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	1.6	-1.3	0.4	-1.2	1.2
Medication: Ramipril	0.3	0.4	1.0	-1.0	0.6	-0.4	-0.3
Medication: Simvastatin	0.1	0.1	0.4	0.0	0.6	-0.1	0.0
Fluid intelligence score	1.2	2.5	3.5	-1.9	-1.2	-1.7	1.4
Illnesses of siblings	0.3	0.4	0.8	-0.6	0.9	-0.6	-0.1
Neuroticism score	1.1	2.3	3.5	-0.9	-1.7	-1.5	1.9
Weight	5.4	26.5	48.2	3.3	6.9	4.0	-5.6
Impedance of arm (right)	11.1	51.9	66.9	-6.6	-8.2	-6.7	7.2
Arm fat percentage (right)	3.7	14.6	31.1	2.7	5.6	2.8	-3.4
Trunk fat-free mass	5.1	29.3	46.4	3.5	6.8	4.6	-6.1
Hip circumference	3.1	13.2	28.3	1.7	5.3	2.4	-4.0
Time employed in main current job	1.1	1.3	1.8	-1.2	-0.9	-1.0	1.4
Alcohol intake versus 10 years previously	0.4	0.7	2.6	-0.0	-1.6	0.2	0.2
Father’s age at death	2.1	2.8	3.9	1.3	1.7	2.0	-1.7
Worrier / anxious feelings	2.2	4.2	6.2	-1.6	-2.5	-2.0	2.1
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.9	7.1	-0.4	-2.7	-1.6	2.4
Falls in the last year	0.2	0.2	0.6	0.7	-0.0	0.5	-0.3
Hair/balding pattern: Pattern 3	2.1	3.2	4.6	1.3	1.9	1.6	-2.2
Number of live births	1.4	2.0	4.8	1.4	2.2	1.1	-0.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	4.3	-2.1	0.1	-1.4	-0.2
Pulse rate	5.3	8.9	12.9	-1.9	-3.6	-2.5	3.5
Happiness	1.4	1.7	3.4	1.4	0.9	1.8	-0.8
Noisy workplace	0.7	0.9	1.8	0.6	0.2	1.3	-1.2
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.1	0.7	1.0	1.0	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.9	-0.2	-1.0	-0.4	1.4
Mouth/teeth dental problems: Dentures	1.1	1.9	3.7	0.6	1.9	1.5	-1.2
Asthma	0.2	0.4	1.0	-1.0	-0.4	-0.5	0.2
Medication: Ibuprofen (e.g. Nurofen)	4.5	5.8	7.9	-2.2	-2.0	-2.5	2.8
Medication: Cholesterol lowering	0.6	0.9	1.4	-1.1	-0.6	-1.2	0.8
Depression (self-reported)	0.3	0.3	0.9	-0.5	0.1	-0.3	1.0
Medication: Lansoprazole	0.5	0.5	1.2	-0.5	-0.5	-0.6	1.1
Prospective memory result	0.2	0.2	0.7	-0.8	0.2	-0.5	-0.1
Lung cancer (father)	0.1	0.1	0.3	0.5	-0.5	-0.0	0.2
Illnesses of mother	2.5	3.1	3.6	-1.9	-1.8	-1.6	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.2	-1.5	-0.1	-1.2	0.3
Pulse wave Arterial Stiffness index	1.1	1.3	2.0	-1.4	-1.2	-1.1	0.6
Impedance of arm (left)	13.1	60.8	79.2	-7.0	-8.9	-7.4	7.8
Arm fat mass (right)	5.8	24.0	47.2	3.4	6.9	3.8	-4.8
Trunk predicted mass	5.0	28.4	45.4	3.4	6.7	4.5	-6.0
Standing height	0.4	4.4	10.3	-3.2	-1.6	-2.2	0.2
Length of working week for main job	0.4	0.5	1.1	0.3	1.1	0.4	-0.7
Exposure to tobacco smoke at home	0.0	0.1	0.1	-0.3	-0.2	-0.3	-0.1
Breastfed as a baby	0.4	0.4	1.4	-0.3	0.1	-1.2	0.6
Tense / ‘highly strung’	2.8	4.6	6.0	-1.6	-2.5	-2.1	2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.3	0.1	-1.1	0.1	1.2
Hair/balding pattern: Pattern 4	1.5	3.5	5.4	-1.5	-1.8	-2.3	1.8
Birth weight of first child	0.4	0.8	1.5	-1.1	0.7	-1.2	0.1
Peak expiratory flow (PEF)	2.4	5.5	11.2	-3.3	-1.3	-2.6	1.6
Pulse wave reflection index	0.1	0.1	0.4	-0.3	0.0	-0.2	-0.6
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.9	-1.7	-0.7	-0.7	0.2
Loud music exposure frequency	0.3	0.4	0.9	0.9	-0.1	0.8	0.2
Qualifications: O levels/GCSEs or equivalent	0.0	0.1	0.1	-0.3	0.2	-0.1	0.3
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	4.1	0.9	2.0	0.8	-1.1
Blood clot in the leg (DVT)	2.3	3.0	4.5	1.5	2.1	1.8	-1.3
Medication: Paracetamol	3.6	6.0	9.9	-1.4	-2.8	-2.1	3.1
Headache pain in last month	1.7	3.0	3.5	-1.4	-1.9	-1.7	1.9
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	2.6	1.6	0.8	1.2	-0.8
Glaucoma (self-reported)	0.0	0.1	0.1	-0.3	-0.3	0.0	-0.2
Gout (self-reported)	0.1	0.2	0.4	0.6	-0.3	0.2	0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.7	0.8	-0.1	0.6	-0.2
Medication: Amlodipine	1.0	1.4	1.7	-1.2	-1.1	-1.3	1.1
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.8	-0.9	0.5	-0.1	-0.5
Birth weight	0.5	1.0	1.9	-1.4	-0.4	-1.3	0.5
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.9	0.9	0.9	0.5	-0.4
High blood pressure (siblings)	0.7	1.0	2.1	1.2	0.1	1.5	-0.8
Forced vital capacity (FVC), Best measure	0.1	0.4	1.1	-1.1	0.2	-0.5	-0.2
Body fat percentage	0.9	3.7	9.7	1.2	3.1	1.0	-1.6
Leg fat percentage (right)	1.1	4.1	9.0	1.8	3.0	1.3	-1.6
Arm fat-free mass (right)	5.6	28.7	45.6	3.8	6.8	4.4	-5.9
Exposure to tobacco smoke outside home	0.3	0.4	0.9	0.4	-0.5	0.2	-1.0
Comparative body size at age 10	35.5	98.1	163.8	7.3	12.8	9.0	-9.7
Number of full brothers	0.5	0.6	2.0	-0.1	-0.4	-0.5	1.4
Worry too long after embarrassment	0.6	1.0	1.4	1.0	0.8	1.2	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.6	0.3	-0.2	0.8	-0.2
Wheeze or whistling in the chest in last year	0.2	0.4	1.2	-0.2	1.1	0.5	-0.5
Number of children fathered	0.5	0.5	1.2	0.6	1.1	0.2	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.2	1.2	1.8	0.8	-0.5
Age at first live birth	0.2	0.3	0.6	0.7	-0.3	0.7	-0.2
Pulse wave peak to peak time	0.9	1.0	1.6	1.1	1.3	1.0	-0.6
Health satisfaction	1.5	1.9	4.1	1.3	0.8	2.0	-1.1
Shortness of breath walking on level ground	0.4	0.4	1.4	0.5	-1.2	0.2	-0.1
Qualifications: College or University degree	1.0	3.3	4.8	1.1	1.7	2.0	-2.2
Eye problems/disorders: None of the above	0.3	0.4	0.6	0.8	0.6	0.5	0.5
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.0	1.4	0.1	0.7	0.9
Emphysema/chronic bronchitis	4.6	5.2	8.2	-1.8	-2.9	-2.0	2.3
Medication for pain relief, constipation, heartburn	3.1	5.3	7.3	2.3	2.2	2.0	-2.7
Neck or shoulder pain in last month	3.3	4.6	8.9	-1.4	-3.0	-1.8	2.1
Medication: Blood pressure	0.2	0.4	0.5	-0.7	-0.7	-0.6	0.5
Angina (self-reported)	1.4	1.8	4.1	-1.2	-2.0	-0.8	1.0
Migraine (self-reported)	0.4	0.5	1.5	-1.2	-0.6	-0.3	-0.3
Medication: Ibuprofen	3.7	4.4	5.0	-1.9	-2.0	-2.2	2.2
Medication: Allopurinol	0.7	0.9	2.5	1.6	-0.4	1.0	-0.0
Medication: Omeprazole	2.7	3.3	5.3	1.0	2.3	1.7	-2.0
Medication: Seretide 50 evohaler	0.3	0.4	0.8	-0.9	-0.5	-0.6	0.5
Mean time to correctly identify matches	0.7	1.3	1.7	-1.2	-1.1	-1.3	0.9
Heart disease (mother)	4.2	5.2	6.6	-2.3	-1.5	-2.5	2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	2.3	-1.4	-1.5	-1.4	1.4
Whole body fat mass	3.3	13.9	28.5	2.5	5.3	2.6	-3.7
Leg fat mass (right)	3.6	14.1	28.7	2.7	5.4	2.8	-3.6
Arm predicted mass (right)	5.8	29.5	44.9	4.0	6.7	4.6	-6.0
Pulse rate, automated reading	4.0	13.1	21.2	-2.2	-4.3	-2.8	4.6
Alcohol intake frequency.	5.0	11.5	22.1	-1.5	-3.7	-2.9	4.7
Comparative height size at age 10	0.9	5.0	8.2	1.3	2.9	1.7	-2.7
Number of full sisters	1.8	2.2	3.0	1.5	1.1	1.7	-1.6
Suffer from ‘nerves’	1.4	2.2	5.1	-0.8	-2.2	-1.3	1.3
Overall health rating	0.4	0.8	2.2	0.9	0.1	1.5	-0.4
Chest pain or discomfort	1.5	2.2	3.0	-1.4	-1.2	-1.5	1.7
Had major operations	4.9	5.7	6.4	-2.5	-2.3	-2.5	2.3
Age at last live birth	0.4	0.5	1.1	1.0	-0.0	1.1	-0.2
Family relationship satisfaction	2.2	2.8	3.5	1.9	1.7	1.8	-1.3
Leg pain on walking	0.1	0.1	0.1	0.3	-0.2	0.4	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.6	-1.3	0.1	-1.3	0.2
Commuting to job workplace: Car/motor vehicle	2.8	3.2	5.6	1.7	2.4	1.6	-1.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.8	0.9	0.0	0.6	-0.5
Medication: Aspirin	0.7	0.9	2.4	-1.6	-0.6	-0.8	0.6
Supplements: Vitamin C	1.5	1.8	3.3	-1.8	-1.1	-1.5	0.4
Knee pain experienced in last month	1.1	1.7	2.5	1.6	1.4	1.3	-0.7
Hypertension (Self-reported)	0.9	2.6	4.1	0.9	1.8	1.4	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	2.1	-1.3	-0.7	-1.4	1.2
Illnesses of father: Heart disease	2.0	2.8	3.5	-1.6	-1.7	-1.5	1.9
Illnesses of siblings: Diabetes	0.4	0.5	0.8	-0.8	-0.4	-0.8	0.9
Smoking status: Previous	2.6	3.8	5.4	-1.9	-1.9	-2.3	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	0.3	-0.1	-0.0	0.4
Whole body fat-free mass	6.6	37.6	60.5	4.1	7.8	5.2	-6.8
Leg fat-free mass (right)	8.0	42.8	70.9	4.5	8.4	5.5	-7.1
Arm fat percentage (left)	3.6	14.2	31.0	2.7	5.6	2.7	-3.3
Average weekly red wine intake	1.8	2.6	5.7	0.1	2.4	0.9	-1.9
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.9	-0.3	-1.4	-0.4	0.3
Mood swings	1.2	2.2	3.6	-0.7	-1.9	-1.3	1.7
Loneliness, isolation	2.7	3.7	6.2	2.5	1.3	2.3	-1.4
Long-standing illness, disability or infirmity	0.1	0.1	0.2	0.1	-0.5	0.3	0.2
Ever had bowel cancer screening	0.1	0.1	0.2	0.4	0.1	0.3	-0.4
Diabetes diagnosed by doctor	0.3	0.4	1.0	-0.5	1.0	-0.2	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.5	0.9	1.6	1.2	-0.6
Friendships satisfaction	2.3	2.8	4.1	1.7	1.6	2.0	-1.2
Qualifications: nursing, teaching	0.5	0.7	1.0	0.9	0.6	1.0	-0.8
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.1	-0.4	0.0	0.1
Eye problems/disorders: Cataract	1.0	1.2	2.6	-1.6	-0.9	-1.0	0.4
Mouth/teeth dental problems: Mouth ulcers	3.0	4.8	5.9	-2.4	-1.9	-2.4	2.1
Medication for cholesterol	0.3	0.4	0.9	-0.9	0.2	-0.8	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	6.2	7.3	11.0	2.3	3.3	2.9	-2.2
Back pain experienced in last month	0.1	0.2	0.4	0.3	-0.3	-0.2	0.6
Mineral and other dietary supplements	0.1	0.2	0.3	-0.5	-0.4	-0.1	0.6
Breast cancer (self-reported)	0.5	0.5	1.0	0.7	0.7	1.0	-0.4
Asthma (self-reported)	0.1	0.2	0.8	-0.9	-0.1	-0.2	-0.1
Osteoporosis (self-reported)	0.4	0.5	1.1	-0.4	1.0	-0.4	-0.9
Osteoarthritis (self-reported)	1.0	1.2	2.4	1.4	1.6	0.8	-0.2
Medication: Aspirin	0.4	0.5	1.2	-1.1	-0.6	-0.5	0.4
Medication: Gliclazide	0.4	0.4	1.0	-0.7	1.0	-0.3	-0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	-0.2	-0.5	-0.5	-0.1
Smoking status: Current	1.8	2.8	4.6	1.0	1.5	2.1	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	3.5	-1.7	0.2	-1.9	1.0
Whole body water mass	6.6	37.9	61.0	4.2	7.8	5.2	-6.8
Leg predicted mass (right)	7.9	42.2	70.6	4.4	8.4	5.4	-7.0
Arm fat mass (left)	6.2	25.3	49.1	3.6	7.0	3.9	-4.9
Number of self-reported non-cancer illnesses	0.0	0.0	0.1	-0.1	0.1	0.3	-0.2
Average weekly champagne plus white wine intake	0.3	0.5	1.5	0.2	1.2	0.4	-0.5
Miserableness	0.2	0.4	0.5	-0.7	-0.7	-0.7	0.5
Guilty feelings	0.3	0.4	0.8	-0.3	-0.5	-0.7	0.9
Wears glasses or contact lenses	1.3	1.5	2.1	-1.5	-0.7	-1.3	1.2
Ever taken oral contraceptive pill	0.2	0.2	0.5	0.3	0.5	0.2	-0.7
Hearing aid user	0.4	0.5	0.7	0.8	0.5	0.8	-0.6
Mother’s age at death	0.4	0.5	1.1	-0.8	-0.2	-1.0	0.5
Financial situation satisfaction	1.8	2.2	3.9	1.5	1.2	2.0	-1.2
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.4	-0.8	-0.8	-1.1	1.2
Commuting to job workplace: Public transport	1.6	1.9	3.8	-2.0	-1.4	-1.2	0.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	-0.7	-0.1	0.0	-0.5
Medication: Blood pressure	0.1	0.2	0.6	0.1	0.2	0.5	-0.8
Pain type(s) experienced in last month: Hip pain	0.9	1.2	2.9	1.7	0.6	1.1	0.0
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	-0.1	-0.4	-0.6	0.5
High cholesterol (Self-reported)	0.4	0.7	1.3	-0.6	-0.3	-1.0	1.1
Medication: Bendroflumethiazide	0.4	0.7	1.2	0.8	0.6	1.1	-0.6
Medication: Paracetamol	1.7	2.7	5.5	-0.7	-1.9	-1.1	2.4
Medication: Lisinopril	0.1	0.2	0.4	0.6	-0.0	0.5	0.0
Medication: Atorvastatin	0.7	0.9	3.3	0.2	-1.8	0.1	0.2
Illnesses of father: High blood pressure	1.2	1.5	2.1	1.1	1.5	1.3	-1.0
Alcohol drinker status: Never	5.0	5.9	8.2	-1.8	-2.4	-2.6	2.9
Ever smoked	0.5	0.8	1.8	-1.3	-0.9	-0.9	0.1
Basal metabolic rate	6.4	35.5	59.8	4.0	7.7	4.9	-6.5
Leg fat percentage (left)	1.2	4.2	9.1	1.9	3.0	1.3	-1.6
Arm fat-free mass (left)	5.6	28.5	45.6	3.6	6.8	4.4	-6.0
Number of operations (self-reported)	0.7	1.0	2.4	-0.4	-0.9	-0.9	1.6
Average weekly beer plus cider intake	1.2	1.7	3.8	-0.5	-1.9	-0.6	1.5
Irritability	0.2	0.4	0.6	-0.8	-0.2	-0.5	0.7
Risk taking	0.3	0.5	0.9	0.9	-0.3	0.7	-0.8
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.4	-0.0	0.6	-0.2	0.1
Fractured/broken bones in last 5 years	0.0	0.1	0.2	0.2	-0.4	-0.0	0.0
Age started oral contraceptive pill	0.6	0.8	1.2	-0.9	-1.1	-1.0	0.3
Diastolic blood pressure, automated reading	1.7	5.3	8.4	2.1	1.7	2.3	-2.9
Ever depressed for a whole week	0.2	0.2	0.5	-0.0	-0.7	-0.2	0.6
Unable to work because of sickness or disability	1.4	1.9	4.7	-0.5	-1.5	-0.6	2.2
Commuting to job workplace: Cycle	0.5	0.6	1.7	-1.3	0.2	-0.8	0.2
Myopia	1.5	2.2	3.2	-1.4	-1.8	-1.6	1.2
Vascular/heart problems diagnosed by doctor	0.7	1.9	3.8	-0.7	-1.2	-1.3	1.9
Cholesterol lowering medication	0.3	0.4	1.0	1.0	-0.3	0.7	0.2
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	2.8	0.5	1.7	0.9	-1.3
Pain experienced in last month	0.6	1.1	1.9	0.6	1.1	0.8	-1.4
Supplements: Calcium	0.9	1.0	2.1	-1.0	-0.1	-1.4	0.9
Basal cell carcinoma (self-reported)	0.5	0.6	1.4	1.2	0.6	0.8	0.1
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.2	-0.5	-1.5	-0.2	0.2
Deep venous thrombosis (DVT) (self-reported)	3.0	3.9	5.7	1.6	2.4	2.1	-1.7
Heart disease (siblings)	0.4	0.5	1.3	0.4	-1.1	-0.1	0.8
Alcohol drinker status: Previous	0.1	0.1	0.4	0.1	-0.3	-0.0	0.6
Pack years of smoking	0.4	0.6	2.1	0.2	-0.4	-0.0	1.4
Impedance of whole body	17.0	86.6	123.2	-7.9	-11.1	-8.7	9.2
Leg fat mass (left)	3.6	14.2	28.1	2.8	5.3	2.8	-3.6
Arm predicted mass (left)	5.9	30.1	47.5	3.8	6.9	4.6	-6.1