Hub : Genes

GPRC5B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1070 0.0330 1.1e-05 0.047 0.042 0.031 0.042 0.043 2.1e-06 7.4e-06 9.4e-05 6.2e-06 5.2e-06
2 GTEx Adipose Subcutaneous 0.0710 0.0300 2.3e-03 0.041 NA 0.001 NA 0.031 2.5e-04 NA 2.4e-01 NA 1.3e-03
3 GTEx Lung 0.0848 0.0303 3.4e-04 0.053 NA 0.033 NA 0.059 6.6e-05 NA 1.4e-03 NA 2.4e-05
4 TCGA Thyroid Carcinoma 0.0620 0.0370 3.3e-03 0.008 0.011 0.000 NA 0.007 5.2e-02 2.4e-02 2.8e-01 NA 5.8e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.2 0.3 0.4 0.5 0.6 0.5 -0.3
Bipolar Disorder or Schizophrenia 0.2 0.4 0.8 -0.6 -0.2 -0.6 0.9
Depressed Affect (Nagel 2018) 0.5 1.0 1.5 -0.2 -1.2 -1.0 1.1
Depression (Nagel 2018) 0.5 0.7 2.1 1.5 -0.2 0.8 0.3
Intelligence (Savage-Jansen 2018) 1.0 3.2 4.9 -2.0 -1.4 -2.2 1.3
Neuroticism (Nagel 2018) 1.0 2.3 3.7 -1.0 -1.9 -1.6 1.4
Schizophrenia (2018) 0.7 1.4 2.2 -1.2 -0.8 -1.2 1.5
Schizophrenia vs Biploar Disorder 1.0 1.3 3.3 -0.3 -1.8 -0.5 1.2
Worry (Nagel 2018) 3.8 7.9 11.3 -2.2 -3.4 -2.9 2.7
Alzheimer’s Disease (in mother) 1.0 1.2 2.3 0.1 -1.5 -0.6 1.5
Alzheimer’s Disease (in father) 0.0 0.0 0.1 -0.1 0.4 0.0 0.1
Alzheimer’s Disease (including proxy) 1.0 1.5 3.7 1.9 0.6 1.3 0.3
Crohns Disease (2017) 1.6 3.6 5.5 1.3 2.4 1.5 -2.3
Irritable Bowel Disease (IBD) 0.6 1.5 2.8 0.8 1.7 0.9 -1.3
Ulcerative Colitis (UC) 0.2 0.4 1.1 0.5 1.0 0.5 -0.1
Major Depression (MDD) 2.3 2.8 6.0 -0.9 -1.8 -1.0 2.4
Reaction Time 1.0 2.0 2.4 -1.5 -1.5 -1.5 1.0
Verbal and Numeric Reasoning (VNR) 0.9 2.1 2.8 -1.2 -1.2 -1.7 1.6
Breast Cancer 0.4 0.9 2.2 0.6 1.5 0.8 -0.5
Ovarian Cancer 1.5 2.0 3.9 -2.0 -1.7 -1.0 0.2
Prostate Cancer 0.4 0.5 1.5 -0.0 -1.2 -0.7 0.3
Age at First Birth 1.6 2.4 3.4 -1.8 -1.6 -1.9 0.6
Bipolar Disorder (2011) 0.2 0.1 0.3 -0.6 0.0 -0.5 0.0
Body Mass Index (BMI) (2010) 18.6 25.5 41.9 4.0 6.5 4.5 -4.9
Coronary Artery Disease (CAD) 0.2 0.2 0.4 -0.2 -0.6 -0.3 0.6
Crohns Disease (2012) 1.3 2.1 4.1 0.6 2.0 1.0 -1.7
Mean Putamen Volume 3.3 3.8 5.5 2.3 1.6 2.3 -1.5
Fasting Glucose 0.9 1.0 2.7 1.6 -0.9 0.7 -0.2
HbA1C 1.8 2.0 4.3 2.1 -1.7 0.8 -0.4
HDL Cholesterol 8.2 13.6 18.8 -3.3 -3.5 -4.3 3.5
LDL Cholesterol 0.2 0.3 0.7 0.8 0.3 0.4 0.7
Lupus 0.1 0.2 0.4 0.6 -0.1 -0.1 -0.4
Neuroticism (2016) 0.7 0.9 1.4 -0.9 -1.2 -1.0 0.8
Primary Biliary Cirrhosis 0.5 0.7 1.7 0.8 1.3 0.5 -0.5
Rheumatoid Arthritis 1.1 1.6 2.9 -1.4 -0.3 -1.7 1.2
Schizophrenia (2014) 0.5 1.2 1.8 -1.0 -1.1 -0.8 1.3
Triglycerides 1.2 2.0 2.3 1.5 1.4 1.5 -1.3
Type 2 Diabetes (T2D) (2012) 5.9 6.8 8.8 2.5 2.2 3.0 -2.7
Ulcerative Colitis 0.2 0.3 0.7 -0.3 0.4 -0.5 0.8
Blood Eosinophil Count 1.1 8.5 9.4 2.9 2.9 3.1 -2.8
Blood Platelet Count 2.1 24.9 39.9 -4.4 -6.3 -4.6 4.4
Blood Red Count 0.3 2.5 3.5 1.9 1.6 1.4 -1.4
Blood White Count 0.6 4.2 10.0 -0.9 -3.2 -1.2 2.1
Heel T-Score 3.1 24.5 27.6 4.6 5.2 5.1 -4.8
BMI 16.7 96.6 151.3 7.9 12.3 9.0 -9.6
Height 1.2 22.6 39.1 -6.2 -4.6 -5.0 2.3
Waist Hip Ratio (WHR) 0.8 3.5 5.9 -1.4 -2.4 -1.5 2.0
Systolic Blood Pressure 0.2 1.1 1.7 -1.3 -1.3 -0.6 -0.8
Smoking Status 0.1 0.1 0.2 -0.2 0.5 0.4 -0.3
Allergy or Eczema 0.3 0.8 1.7 -0.2 1.3 0.7 -1.0
Cardiovascular Disease 0.3 1.1 2.0 0.8 1.4 0.9 -1.0
Hypothyroidism (self reported) 0.3 0.7 1.6 1.3 0.3 0.8 -0.6
Respiratory disease 0.0 0.1 0.3 -0.6 0.2 0.0 -0.2
Type 2 Diabetes (T2D) (2018) 0.7 1.3 2.2 0.6 1.2 1.0 -1.5
Lung FEV1/FVC ratio 2.3 11.7 18.0 -4.2 -2.5 -4.2 2.3
Lung FVC 0.6 3.1 7.4 0.2 2.7 1.1 -1.9
Neuroticism 1.4 3.5 6.1 -0.7 -2.5 -1.7 2.1
Chronotype (morning person) 0.6 1.4 2.4 -1.6 0.5 -1.4 1.0
Hair Pigment 0.1 2.0 4.9 -0.6 -1.1 -1.2 2.2
Tanning 0.0 0.6 1.9 -0.1 -0.6 0.2 -1.4
Hand grip strength (left) 7.4 19.5 25.8 4.2 5.1 4.2 -4.1
Number of treatments/medications taken 1.4 2.5 3.8 -1.9 -1.1 -1.7 1.5
Average weekly spirits intake 1.3 1.7 5.0 -0.7 2.2 -0.3 -1.0
Sensitivity / hurt feelings 0.3 0.6 0.9 -0.6 -0.6 -1.0 0.9
Frequency of depressed mood in last 2 weeks 0.6 0.8 1.5 1.2 0.6 1.1 -0.4
Hearing difficulty/problems: Yes 0.0 0.0 0.1 0.2 -0.1 0.3 0.2
Relative age of first facial hair 1.5 3.2 8.3 -1.4 -2.9 -1.4 0.6
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.5 -0.1 0.7 0.1 -0.0
Ever used hormone-replacement therapy (HRT) 2.6 3.4 5.8 -0.5 -2.4 -1.4 2.3
Ever had hysterectomy (womb removed) 1.7 1.9 3.5 -1.5 -0.8 -1.9 1.1
Systolic blood pressure, automated reading 0.2 0.6 2.0 -0.5 0.0 0.1 -1.4
Eye problems/disorders: Diabetes related eye disease 2.9 3.2 5.2 2.3 1.6 1.5 -1.7
Angina 1.8 2.4 4.5 -1.5 -2.1 -1.1 1.3
Medication for hormone replacement therapy 1.0 1.1 2.2 1.5 -0.3 1.4 0.2
Vitamin and mineral supplements 1.8 2.4 3.2 1.7 1.2 1.8 -1.5
Supplements: Zinc 0.3 0.4 0.5 -0.7 0.0 -0.7 0.7
Medication: Co-codamol 0.6 0.7 1.9 -0.2 -0.7 -0.5 1.4
Medication: Metformin 1.8 2.5 3.1 1.6 1.2 1.8 -1.7
Diabetes (father) 0.2 0.3 1.0 0.2 1.0 -0.2 0.2
Diabetes (mother) 2.6 3.4 4.8 2.2 1.8 2.0 -1.3
Severe depression (siblings) 1.8 2.0 3.7 1.9 0.1 1.8 -1.1
Pack years adult smoking proportion 0.5 0.8 3.0 0.1 -0.5 -0.2 1.7
Impedance of leg (right) 17.1 82.7 127.7 -7.3 -11.3 -8.2 9.1
Leg fat-free mass (left) 8.1 42.9 72.2 4.5 8.5 5.4 -7.0
Trunk fat percentage 0.5 1.8 5.9 0.3 2.4 0.1 -1.2
Hand grip strength (right) 3.5 9.6 16.6 2.2 4.1 2.7 -3.2
Townsend deprivation index at recruitment 1.2 1.7 2.0 -1.4 -1.1 -1.4 1.2
Current tobacco smoking 2.0 3.3 4.9 1.1 1.8 2.2 -2.0
Average weekly fortified wine intake 0.2 0.2 0.5 -0.7 0.3 -0.4 -0.1
Maternal smoking around birth 0.3 0.5 0.7 -0.7 -0.4 -0.7 0.8
Fed-up feelings 0.6 1.1 2.3 -0.1 -1.1 -0.9 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.9 0.9 0.1 0.6 0.3
Relative age voice broke 2.0 3.0 4.3 -1.6 -2.1 -1.5 1.7
Taking other prescription medications 0.0 0.0 0.2 -0.0 -0.2 0.0 0.4
Age when periods started (menarche) 10.1 24.2 39.7 -3.8 -6.3 -4.2 5.0
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.3 1.2 0.2 0.6 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 2.8 0.4 1.7 0.8 -1.2
Tinnitus: Yes, but not now, but have in the past 1.6 1.8 3.1 0.7 1.8 1.1 -1.5
Qualifications: CSEs or equivalent 0.3 0.4 1.3 -0.2 -1.2 -0.2 0.2
Serious illness, injury or assault to yourself 3.5 4.2 5.9 -1.7 -1.7 -2.3 2.4
High blood pressure 1.1 3.1 5.2 1.1 1.8 1.6 -2.3
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.5 0.1 1.2 0.8 -0.9
Multivitamins +/- minerals 0.8 1.0 1.5 -0.7 -0.9 -1.0 1.2
Stomach or abdominal pain in last month 0.2 0.2 0.4 0.2 0.7 0.4 -0.5
Supplements: Glucosamine 3.5 4.6 7.2 2.7 1.6 1.8 -2.3
Diverticular disease/diverticulitis (self-reported) 5.9 7.0 8.9 -2.8 -3.0 -2.2 2.6
Medication: Atenolol 0.9 1.2 2.1 1.1 0.6 1.5 -1.0
Medication: Levothyroxine sodium 0.3 0.5 0.9 -0.7 -0.5 -0.9 0.7
Sitting height 0.2 1.5 3.2 -1.6 0.5 -0.5 -1.8
Chronic bronchitis/emphysema (father) 0.5 0.6 1.2 1.1 -0.0 1.0 -0.5
High blood pressure (mother) 6.5 9.1 10.7 2.6 3.1 3.0 -3.3
Body mass index (BMI) 9.1 38.7 66.0 5.1 8.1 5.3 -5.9
Impedance of leg (left) 18.3 89.0 139.2 -7.6 -11.8 -8.5 9.3
Leg predicted mass (left) 7.9 42.1 70.9 4.4 8.4 5.4 -7.0
Trunk fat mass 1.7 7.5 18.2 1.4 4.3 1.5 -2.8
Waist circumference 3.6 13.1 24.1 2.6 4.9 2.9 -3.6
Number of incorrect matches in round 0.3 0.4 1.5 0.3 1.2 0.3 0.2
Past tobacco smoking 1.5 2.7 3.9 2.0 1.5 1.8 -1.1
Alcohol usually taken with meals 1.0 1.6 3.6 0.3 1.9 0.5 -1.5
Nervous feelings 6.2 11.5 13.9 -3.6 -3.2 -3.7 3.1
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 1.3 0.2 -1.1 -0.0 0.4
Hearing difficulty/problems with background noise 0.0 0.1 0.1 0.2 0.2 0.3 -0.1
Hair/balding pattern: Pattern 2 1.5 1.9 3.0 -1.7 -0.9 -1.4 1.3
Had menopause 1.2 1.5 2.1 -0.7 -1.3 -1.3 1.5
Had other major operations 0.8 1.0 2.0 1.2 -0.4 0.6 1.4
Forced vital capacity (FVC) 0.2 0.9 2.3 -1.5 0.8 -0.7 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.5 2.8 0.3 1.7 0.9 -1.6
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.8 -0.5 -0.4 -0.3 0.9
Qualifications: None of the above 0.1 0.2 0.7 0.3 0.2 0.2 0.8
Financial difficulties in last 2 years 0.2 0.2 0.6 -0.0 -0.5 -0.0 0.8
Mouth/teeth dental problems 0.3 0.4 1.0 0.6 -0.4 0.3 -1.0
Heart attack 0.5 0.6 2.0 -0.6 -1.4 -0.3 0.2
Allergy 0.3 0.6 1.6 0.1 -1.3 -0.6 0.6
Pain all over the body in last month 0.3 0.3 0.5 -0.7 -0.5 -0.4 0.5
Diabetes (self-reported) 1.0 1.5 3.1 0.8 1.8 0.8 -1.3
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 1.6 -1.3 0.4 -1.2 1.2
Medication: Ramipril 0.3 0.4 1.0 -1.0 0.6 -0.4 -0.3
Medication: Simvastatin 0.1 0.1 0.4 0.0 0.6 -0.1 0.0
Fluid intelligence score 1.2 2.5 3.5 -1.9 -1.2 -1.7 1.4
Illnesses of siblings 0.3 0.4 0.8 -0.6 0.9 -0.6 -0.1
Neuroticism score 1.1 2.3 3.5 -0.9 -1.7 -1.5 1.9
Weight 5.4 26.5 48.2 3.3 6.9 4.0 -5.6
Impedance of arm (right) 11.1 51.9 66.9 -6.6 -8.2 -6.7 7.2
Arm fat percentage (right) 3.7 14.6 31.1 2.7 5.6 2.8 -3.4
Trunk fat-free mass 5.1 29.3 46.4 3.5 6.8 4.6 -6.1
Hip circumference 3.1 13.2 28.3 1.7 5.3 2.4 -4.0
Time employed in main current job 1.1 1.3 1.8 -1.2 -0.9 -1.0 1.4
Alcohol intake versus 10 years previously 0.4 0.7 2.6 -0.0 -1.6 0.2 0.2
Father’s age at death 2.1 2.8 3.9 1.3 1.7 2.0 -1.7
Worrier / anxious feelings 2.2 4.2 6.2 -1.6 -2.5 -2.0 2.1
Frequency of tiredness / lethargy in last 2 weeks 2.4 3.9 7.1 -0.4 -2.7 -1.6 2.4
Falls in the last year 0.2 0.2 0.6 0.7 -0.0 0.5 -0.3
Hair/balding pattern: Pattern 3 2.1 3.2 4.6 1.3 1.9 1.6 -2.2
Number of live births 1.4 2.0 4.8 1.4 2.2 1.1 -0.3
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 4.3 -2.1 0.1 -1.4 -0.2
Pulse rate 5.3 8.9 12.9 -1.9 -3.6 -2.5 3.5
Happiness 1.4 1.7 3.4 1.4 0.9 1.8 -0.8
Noisy workplace 0.7 0.9 1.8 0.6 0.2 1.3 -1.2
Qualifications: A levels/AS levels or equivalent 0.4 0.8 1.1 0.7 1.0 1.0 -0.9
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.9 -0.2 -1.0 -0.4 1.4
Mouth/teeth dental problems: Dentures 1.1 1.9 3.7 0.6 1.9 1.5 -1.2
Asthma 0.2 0.4 1.0 -1.0 -0.4 -0.5 0.2
Medication: Ibuprofen (e.g. Nurofen) 4.5 5.8 7.9 -2.2 -2.0 -2.5 2.8
Medication: Cholesterol lowering 0.6 0.9 1.4 -1.1 -0.6 -1.2 0.8
Depression (self-reported) 0.3 0.3 0.9 -0.5 0.1 -0.3 1.0
Medication: Lansoprazole 0.5 0.5 1.2 -0.5 -0.5 -0.6 1.1
Prospective memory result 0.2 0.2 0.7 -0.8 0.2 -0.5 -0.1
Lung cancer (father) 0.1 0.1 0.3 0.5 -0.5 -0.0 0.2
Illnesses of mother 2.5 3.1 3.6 -1.9 -1.8 -1.6 1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 2.2 -1.5 -0.1 -1.2 0.3
Pulse wave Arterial Stiffness index 1.1 1.3 2.0 -1.4 -1.2 -1.1 0.6
Impedance of arm (left) 13.1 60.8 79.2 -7.0 -8.9 -7.4 7.8
Arm fat mass (right) 5.8 24.0 47.2 3.4 6.9 3.8 -4.8
Trunk predicted mass 5.0 28.4 45.4 3.4 6.7 4.5 -6.0
Standing height 0.4 4.4 10.3 -3.2 -1.6 -2.2 0.2
Length of working week for main job 0.4 0.5 1.1 0.3 1.1 0.4 -0.7
Exposure to tobacco smoke at home 0.0 0.1 0.1 -0.3 -0.2 -0.3 -0.1
Breastfed as a baby 0.4 0.4 1.4 -0.3 0.1 -1.2 0.6
Tense / ‘highly strung’ 2.8 4.6 6.0 -1.6 -2.5 -2.1 2.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 1.3 0.1 -1.1 0.1 1.2
Hair/balding pattern: Pattern 4 1.5 3.5 5.4 -1.5 -1.8 -2.3 1.8
Birth weight of first child 0.4 0.8 1.5 -1.1 0.7 -1.2 0.1
Peak expiratory flow (PEF) 2.4 5.5 11.2 -3.3 -1.3 -2.6 1.6
Pulse wave reflection index 0.1 0.1 0.4 -0.3 0.0 -0.2 -0.6
Ever highly irritable/argumentative for 2 days 0.8 1.0 2.9 -1.7 -0.7 -0.7 0.2
Loud music exposure frequency 0.3 0.4 0.9 0.9 -0.1 0.8 0.2
Qualifications: O levels/GCSEs or equivalent 0.0 0.1 0.1 -0.3 0.2 -0.1 0.3
Mouth/teeth dental problems: Bleeding gums 1.3 1.7 4.1 0.9 2.0 0.8 -1.1
Blood clot in the leg (DVT) 2.3 3.0 4.5 1.5 2.1 1.8 -1.3
Medication: Paracetamol 3.6 6.0 9.9 -1.4 -2.8 -2.1 3.1
Headache pain in last month 1.7 3.0 3.5 -1.4 -1.9 -1.7 1.9
Medication for cholesterol, blood pressure or diabetes 0.8 1.4 2.6 1.6 0.8 1.2 -0.8
Glaucoma (self-reported) 0.0 0.1 0.1 -0.3 -0.3 0.0 -0.2
Gout (self-reported) 0.1 0.2 0.4 0.6 -0.3 0.2 0.5
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.7 0.8 -0.1 0.6 -0.2
Medication: Amlodipine 1.0 1.4 1.7 -1.2 -1.1 -1.3 1.1
Medication: Ventolin 100micrograms inhaler 0.3 0.3 0.8 -0.9 0.5 -0.1 -0.5
Birth weight 0.5 1.0 1.9 -1.4 -0.4 -1.3 0.5
Chronic bronchitis/emphysema (mother) 0.4 0.5 0.9 0.9 0.9 0.5 -0.4
High blood pressure (siblings) 0.7 1.0 2.1 1.2 0.1 1.5 -0.8
Forced vital capacity (FVC), Best measure 0.1 0.4 1.1 -1.1 0.2 -0.5 -0.2
Body fat percentage 0.9 3.7 9.7 1.2 3.1 1.0 -1.6
Leg fat percentage (right) 1.1 4.1 9.0 1.8 3.0 1.3 -1.6
Arm fat-free mass (right) 5.6 28.7 45.6 3.8 6.8 4.4 -5.9
Exposure to tobacco smoke outside home 0.3 0.4 0.9 0.4 -0.5 0.2 -1.0
Comparative body size at age 10 35.5 98.1 163.8 7.3 12.8 9.0 -9.7
Number of full brothers 0.5 0.6 2.0 -0.1 -0.4 -0.5 1.4
Worry too long after embarrassment 0.6 1.0 1.4 1.0 0.8 1.2 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.6 0.3 -0.2 0.8 -0.2
Wheeze or whistling in the chest in last year 0.2 0.4 1.2 -0.2 1.1 0.5 -0.5
Number of children fathered 0.5 0.5 1.2 0.6 1.1 0.2 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 3.2 1.2 1.8 0.8 -0.5
Age at first live birth 0.2 0.3 0.6 0.7 -0.3 0.7 -0.2
Pulse wave peak to peak time 0.9 1.0 1.6 1.1 1.3 1.0 -0.6
Health satisfaction 1.5 1.9 4.1 1.3 0.8 2.0 -1.1
Shortness of breath walking on level ground 0.4 0.4 1.4 0.5 -1.2 0.2 -0.1
Qualifications: College or University degree 1.0 3.3 4.8 1.1 1.7 2.0 -2.2
Eye problems/disorders: None of the above 0.3 0.4 0.6 0.8 0.6 0.5 0.5
Mouth/teeth dental problems: Loose teeth 0.7 0.8 2.0 1.4 0.1 0.7 0.9
Emphysema/chronic bronchitis 4.6 5.2 8.2 -1.8 -2.9 -2.0 2.3
Medication for pain relief, constipation, heartburn 3.1 5.3 7.3 2.3 2.2 2.0 -2.7
Neck or shoulder pain in last month 3.3 4.6 8.9 -1.4 -3.0 -1.8 2.1
Medication: Blood pressure 0.2 0.4 0.5 -0.7 -0.7 -0.6 0.5
Angina (self-reported) 1.4 1.8 4.1 -1.2 -2.0 -0.8 1.0
Migraine (self-reported) 0.4 0.5 1.5 -1.2 -0.6 -0.3 -0.3
Medication: Ibuprofen 3.7 4.4 5.0 -1.9 -2.0 -2.2 2.2
Medication: Allopurinol 0.7 0.9 2.5 1.6 -0.4 1.0 -0.0
Medication: Omeprazole 2.7 3.3 5.3 1.0 2.3 1.7 -2.0
Medication: Seretide 50 evohaler 0.3 0.4 0.8 -0.9 -0.5 -0.6 0.5
Mean time to correctly identify matches 0.7 1.3 1.7 -1.2 -1.1 -1.3 0.9
Heart disease (mother) 4.2 5.2 6.6 -2.3 -1.5 -2.5 2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.7 2.0 2.3 -1.4 -1.5 -1.4 1.4
Whole body fat mass 3.3 13.9 28.5 2.5 5.3 2.6 -3.7
Leg fat mass (right) 3.6 14.1 28.7 2.7 5.4 2.8 -3.6
Arm predicted mass (right) 5.8 29.5 44.9 4.0 6.7 4.6 -6.0
Pulse rate, automated reading 4.0 13.1 21.2 -2.2 -4.3 -2.8 4.6
Alcohol intake frequency. 5.0 11.5 22.1 -1.5 -3.7 -2.9 4.7
Comparative height size at age 10 0.9 5.0 8.2 1.3 2.9 1.7 -2.7
Number of full sisters 1.8 2.2 3.0 1.5 1.1 1.7 -1.6
Suffer from ‘nerves’ 1.4 2.2 5.1 -0.8 -2.2 -1.3 1.3
Overall health rating 0.4 0.8 2.2 0.9 0.1 1.5 -0.4
Chest pain or discomfort 1.5 2.2 3.0 -1.4 -1.2 -1.5 1.7
Had major operations 4.9 5.7 6.4 -2.5 -2.3 -2.5 2.3
Age at last live birth 0.4 0.5 1.1 1.0 -0.0 1.1 -0.2
Family relationship satisfaction 2.2 2.8 3.5 1.9 1.7 1.8 -1.3
Leg pain on walking 0.1 0.1 0.1 0.3 -0.2 0.4 -0.0
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 1.6 -1.3 0.1 -1.3 0.2
Commuting to job workplace: Car/motor vehicle 2.8 3.2 5.6 1.7 2.4 1.6 -1.3
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 0.8 0.9 0.0 0.6 -0.5
Medication: Aspirin 0.7 0.9 2.4 -1.6 -0.6 -0.8 0.6
Supplements: Vitamin C 1.5 1.8 3.3 -1.8 -1.1 -1.5 0.4
Knee pain experienced in last month 1.1 1.7 2.5 1.6 1.4 1.3 -0.7
Hypertension (Self-reported) 0.9 2.6 4.1 0.9 1.8 1.4 -2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 2.1 -1.3 -0.7 -1.4 1.2
Illnesses of father: Heart disease 2.0 2.8 3.5 -1.6 -1.7 -1.5 1.9
Illnesses of siblings: Diabetes 0.4 0.5 0.8 -0.8 -0.4 -0.8 0.9
Smoking status: Previous 2.6 3.8 5.4 -1.9 -1.9 -2.3 1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.1 0.1 0.3 -0.1 -0.0 0.4
Whole body fat-free mass 6.6 37.6 60.5 4.1 7.8 5.2 -6.8
Leg fat-free mass (right) 8.0 42.8 70.9 4.5 8.4 5.5 -7.1
Arm fat percentage (left) 3.6 14.2 31.0 2.7 5.6 2.7 -3.3
Average weekly red wine intake 1.8 2.6 5.7 0.1 2.4 0.9 -1.9
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.9 -0.3 -1.4 -0.4 0.3
Mood swings 1.2 2.2 3.6 -0.7 -1.9 -1.3 1.7
Loneliness, isolation 2.7 3.7 6.2 2.5 1.3 2.3 -1.4
Long-standing illness, disability or infirmity 0.1 0.1 0.2 0.1 -0.5 0.3 0.2
Ever had bowel cancer screening 0.1 0.1 0.2 0.4 0.1 0.3 -0.4
Diabetes diagnosed by doctor 0.3 0.4 1.0 -0.5 1.0 -0.2 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 2.5 0.9 1.6 1.2 -0.6
Friendships satisfaction 2.3 2.8 4.1 1.7 1.6 2.0 -1.2
Qualifications: nursing, teaching 0.5 0.7 1.0 0.9 0.6 1.0 -0.8
Commuting to job workplace: Walk 0.1 0.1 0.2 -0.1 -0.4 0.0 0.1
Eye problems/disorders: Cataract 1.0 1.2 2.6 -1.6 -0.9 -1.0 0.4
Mouth/teeth dental problems: Mouth ulcers 3.0 4.8 5.9 -2.4 -1.9 -2.4 2.1
Medication for cholesterol 0.3 0.4 0.9 -0.9 0.2 -0.8 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 6.2 7.3 11.0 2.3 3.3 2.9 -2.2
Back pain experienced in last month 0.1 0.2 0.4 0.3 -0.3 -0.2 0.6
Mineral and other dietary supplements 0.1 0.2 0.3 -0.5 -0.4 -0.1 0.6
Breast cancer (self-reported) 0.5 0.5 1.0 0.7 0.7 1.0 -0.4
Asthma (self-reported) 0.1 0.2 0.8 -0.9 -0.1 -0.2 -0.1
Osteoporosis (self-reported) 0.4 0.5 1.1 -0.4 1.0 -0.4 -0.9
Osteoarthritis (self-reported) 1.0 1.2 2.4 1.4 1.6 0.8 -0.2
Medication: Aspirin 0.4 0.5 1.2 -1.1 -0.6 -0.5 0.4
Medication: Gliclazide 0.4 0.4 1.0 -0.7 1.0 -0.3 -0.3
Illnesses of father: None of the above (group 1) 0.1 0.1 0.3 -0.2 -0.5 -0.5 -0.1
Smoking status: Current 1.8 2.8 4.6 1.0 1.5 2.1 -1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.8 3.5 -1.7 0.2 -1.9 1.0
Whole body water mass 6.6 37.9 61.0 4.2 7.8 5.2 -6.8
Leg predicted mass (right) 7.9 42.2 70.6 4.4 8.4 5.4 -7.0
Arm fat mass (left) 6.2 25.3 49.1 3.6 7.0 3.9 -4.9
Number of self-reported non-cancer illnesses 0.0 0.0 0.1 -0.1 0.1 0.3 -0.2
Average weekly champagne plus white wine intake 0.3 0.5 1.5 0.2 1.2 0.4 -0.5
Miserableness 0.2 0.4 0.5 -0.7 -0.7 -0.7 0.5
Guilty feelings 0.3 0.4 0.8 -0.3 -0.5 -0.7 0.9
Wears glasses or contact lenses 1.3 1.5 2.1 -1.5 -0.7 -1.3 1.2
Ever taken oral contraceptive pill 0.2 0.2 0.5 0.3 0.5 0.2 -0.7
Hearing aid user 0.4 0.5 0.7 0.8 0.5 0.8 -0.6
Mother’s age at death 0.4 0.5 1.1 -0.8 -0.2 -1.0 0.5
Financial situation satisfaction 1.8 2.2 3.9 1.5 1.2 2.0 -1.2
Tinnitus: Yes, now most or all of the time 0.8 0.9 1.4 -0.8 -0.8 -1.1 1.2
Commuting to job workplace: Public transport 1.6 1.9 3.8 -2.0 -1.4 -1.2 0.6
Eye problems/disorders: Glaucoma 0.2 0.2 0.4 -0.7 -0.1 0.0 -0.5
Medication: Blood pressure 0.1 0.2 0.6 0.1 0.2 0.5 -0.8
Pain type(s) experienced in last month: Hip pain 0.9 1.2 2.9 1.7 0.6 1.1 0.0
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.4 -0.1 -0.4 -0.6 0.5
High cholesterol (Self-reported) 0.4 0.7 1.3 -0.6 -0.3 -1.0 1.1
Medication: Bendroflumethiazide 0.4 0.7 1.2 0.8 0.6 1.1 -0.6
Medication: Paracetamol 1.7 2.7 5.5 -0.7 -1.9 -1.1 2.4
Medication: Lisinopril 0.1 0.2 0.4 0.6 -0.0 0.5 0.0
Medication: Atorvastatin 0.7 0.9 3.3 0.2 -1.8 0.1 0.2
Illnesses of father: High blood pressure 1.2 1.5 2.1 1.1 1.5 1.3 -1.0
Alcohol drinker status: Never 5.0 5.9 8.2 -1.8 -2.4 -2.6 2.9
Ever smoked 0.5 0.8 1.8 -1.3 -0.9 -0.9 0.1
Basal metabolic rate 6.4 35.5 59.8 4.0 7.7 4.9 -6.5
Leg fat percentage (left) 1.2 4.2 9.1 1.9 3.0 1.3 -1.6
Arm fat-free mass (left) 5.6 28.5 45.6 3.6 6.8 4.4 -6.0
Number of operations (self-reported) 0.7 1.0 2.4 -0.4 -0.9 -0.9 1.6
Average weekly beer plus cider intake 1.2 1.7 3.8 -0.5 -1.9 -0.6 1.5
Irritability 0.2 0.4 0.6 -0.8 -0.2 -0.5 0.7
Risk taking 0.3 0.5 0.9 0.9 -0.3 0.7 -0.8
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.4 -0.0 0.6 -0.2 0.1
Fractured/broken bones in last 5 years 0.0 0.1 0.2 0.2 -0.4 -0.0 0.0
Age started oral contraceptive pill 0.6 0.8 1.2 -0.9 -1.1 -1.0 0.3
Diastolic blood pressure, automated reading 1.7 5.3 8.4 2.1 1.7 2.3 -2.9
Ever depressed for a whole week 0.2 0.2 0.5 -0.0 -0.7 -0.2 0.6
Unable to work because of sickness or disability 1.4 1.9 4.7 -0.5 -1.5 -0.6 2.2
Commuting to job workplace: Cycle 0.5 0.6 1.7 -1.3 0.2 -0.8 0.2
Myopia 1.5 2.2 3.2 -1.4 -1.8 -1.6 1.2
Vascular/heart problems diagnosed by doctor 0.7 1.9 3.8 -0.7 -1.2 -1.3 1.9
Cholesterol lowering medication 0.3 0.4 1.0 1.0 -0.3 0.7 0.2
Medication: Omeprazole (e.g. Zanprol) 1.1 1.4 2.8 0.5 1.7 0.9 -1.3
Pain experienced in last month 0.6 1.1 1.9 0.6 1.1 0.8 -1.4
Supplements: Calcium 0.9 1.0 2.1 -1.0 -0.1 -1.4 0.9
Basal cell carcinoma (self-reported) 0.5 0.6 1.4 1.2 0.6 0.8 0.1
Heart attack/myocardial infarction (self-reported) 0.5 0.6 2.2 -0.5 -1.5 -0.2 0.2
Deep venous thrombosis (DVT) (self-reported) 3.0 3.9 5.7 1.6 2.4 2.1 -1.7
Heart disease (siblings) 0.4 0.5 1.3 0.4 -1.1 -0.1 0.8
Alcohol drinker status: Previous 0.1 0.1 0.4 0.1 -0.3 -0.0 0.6
Pack years of smoking 0.4 0.6 2.1 0.2 -0.4 -0.0 1.4
Impedance of whole body 17.0 86.6 123.2 -7.9 -11.1 -8.7 9.2
Leg fat mass (left) 3.6 14.2 28.1 2.8 5.3 2.8 -3.6
Arm predicted mass (left) 5.9 30.1 47.5 3.8 6.9 4.6 -6.1