Hub : Genes

IQCK

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0620 0.0230 5.5e-04 0.037 0.029 0.049 0.038 0.056 2.5e-05 1.8e-04 1.1e-06 1.6e-05 2.3e-07
2 YFS Blood 0.0158 0.0071 6.3e-03 0.013 0.003 0.005 0.003 0.007 3.3e-05 3.0e-02 8.6e-03 3.0e-02 2.0e-03
3 TCGA Bladder Urothelial Carcinoma 0.0460 0.0240 3.5e-04 0.016 0.031 0.021 NA 0.021 1.6e-02 1.0e-03 6.5e-03 NA 5.7e-03
4 TCGA Breast Invasive Carcinoma 0.0278 0.0110 8.7e-09 0.032 0.034 0.027 NA 0.028 3.4e-07 1.6e-07 2.2e-06 NA 1.6e-06
5 TCGA Head and Neck Squamous Cell Carcinoma 0.0422 0.0222 1.6e-04 0.033 0.024 0.022 NA 0.035 1.3e-04 8.1e-04 1.6e-03 NA 7.5e-05
6 TCGA Lung Adenocarcinoma 0.0855 0.0362 5.0e-08 0.043 0.032 0.024 NA 0.035 8.7e-06 1.2e-04 7.1e-04 NA 4.9e-05
7 TCGA Lung Squamous Cell Carcinoma 0.0343 0.0189 4.0e-04 0.028 0.019 0.017 NA 0.025 3.2e-04 2.8e-03 3.9e-03 NA 7.2e-04
8 TCGA Ovarian Serous Cystadenocarcinoma 0.0710 0.0420 2.6e-03 0.021 0.036 0.028 NA 0.017 1.3e-02 1.7e-03 5.1e-03 NA 2.4e-02
9 TCGA Prostate Adenocarcinoma 0.0423 0.0240 4.5e-04 0.012 0.012 0.003 NA 0.009 1.9e-02 1.8e-02 1.3e-01 NA 3.6e-02
10 TCGA Thyroid Carcinoma 0.0460 0.0230 1.7e-04 0.039 0.022 0.030 NA 0.032 9.5e-05 2.8e-03 5.6e-04 NA 4.3e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.3 0.4 2.4 0.6 -1.5 -0.1 0.3 -0.1 -0.1 0.0 -0.9 -0.7 -0.3
Bipolar Disorder or Schizophrenia 0.1 0.3 0.9 -0.3 -0.3 0.7 1.0 0.6 0.4 0.8 -0.6 0.3 0.5
Depressed Affect (Nagel 2018) 0.2 0.4 1.4 -0.3 0.8 0.7 0.6 0.0 -0.0 1.2 0.0 0.9 0.5
Depression (Nagel 2018) 1.1 1.7 5.3 1.2 0.1 -1.0 -0.9 -1.3 -1.8 -0.2 -2.3 -1.1 -1.6
Intelligence (Savage-Jansen 2018) 0.9 2.9 4.6 -1.2 1.7 1.6 1.5 1.8 1.7 1.0 2.1 2.1 1.8
Neuroticism (Nagel 2018) 0.7 1.6 3.2 -1.3 1.1 1.5 1.4 0.8 0.9 1.8 0.7 1.5 1.2
Schizophrenia (2018) 0.3 0.7 1.2 -0.8 0.9 0.9 1.0 0.8 0.5 1.1 0.0 0.9 0.9
Schizophrenia vs Biploar Disorder 0.6 0.8 3.9 0.2 -1.1 1.1 1.1 0.3 0.2 2.0 -0.5 0.5 0.1
Worry (Nagel 2018) 2.8 5.9 8.7 -2.1 1.5 2.8 2.9 2.6 2.3 3.0 1.7 2.8 2.2
Alzheimer’s Disease (in mother) 0.7 0.8 2.5 0.4 -1.1 0.9 0.8 1.0 0.7 1.6 0.7 0.7 0.3
Alzheimer’s Disease (in father) 0.2 0.2 1.3 -0.5 0.7 -0.1 0.2 0.1 -0.3 -0.4 -1.1 -0.2 0.1
Alzheimer’s Disease (including proxy) 0.7 1.0 2.2 1.4 -0.1 -1.1 -0.8 -0.2 -0.9 -0.6 -1.5 -1.3 -1.0
Crohns Disease (2017) 0.9 1.9 4.7 1.8 0.6 -1.4 -1.1 -1.2 -1.1 -2.2 -1.2 -1.5 -1.1
Irritable Bowel Disease (IBD) 0.8 1.9 4.0 1.2 1.1 -1.4 -1.1 -1.2 -1.4 -1.8 -2.0 -1.2 -1.2
Ulcerative Colitis (UC) 1.1 2.1 7.2 0.5 1.1 -1.4 -1.1 -1.3 -1.8 -1.3 -2.7 -1.0 -1.3
Major Depression (MDD) 0.9 1.0 2.8 -1.2 -0.1 1.2 1.4 0.7 -0.1 1.7 -0.8 1.2 0.5
Reaction Time 1.5 2.9 4.7 -1.7 0.2 1.8 1.8 1.5 2.0 1.8 2.2 1.5 1.8
Verbal and Numeric Reasoning (VNR) 0.8 1.9 3.9 -1.2 -0.1 1.4 1.4 2.0 1.5 1.4 1.5 1.5 1.1
Breast Cancer 0.2 0.5 1.4 0.8 -0.3 -0.9 -0.8 -0.1 -0.1 -1.2 0.0 -0.8 -0.5
Ovarian Cancer 2.4 3.2 5.2 -2.3 -1.4 2.1 1.9 1.0 1.8 2.1 1.6 1.6 1.8
Prostate Cancer 0.7 0.9 2.3 -0.2 -0.1 1.1 1.0 1.0 1.5 1.5 1.2 0.5 0.3
Age at First Birth 2.8 4.1 6.2 -2.0 -2.2 2.2 2.0 1.3 2.1 2.5 2.1 1.9 1.5
Bipolar Disorder (2011) 0.5 0.5 0.9 -1.0 0.6 0.6 0.6 0.8 0.8 0.2 0.7 0.7 0.8
Body Mass Index (BMI) (2010) 16.7 22.9 34.0 4.3 -0.4 -5.5 -5.4 -5.0 -5.1 -5.8 -4.3 -5.0 -4.7
Coronary Artery Disease (CAD) 0.2 0.2 1.1 0.4 0.6 0.3 0.4 -0.2 -0.3 0.6 -1.1 0.1 0.0
Crohns Disease (2012) 0.7 1.1 3.4 1.8 0.8 -0.9 -0.7 -0.7 -0.6 -1.9 -0.7 -1.0 -0.5
Mean Putamen Volume 3.5 3.9 5.2 2.2 -1.8 -1.9 -1.9 -2.3 -2.0 -1.3 -2.1 -2.2 -2.0
Fasting Glucose 1.3 1.6 2.7 1.4 -0.8 -1.2 -1.4 -1.4 -1.4 -0.3 -1.2 -1.2 -1.6
HbA1C 2.1 2.3 4.6 1.0 0.8 -1.5 -1.5 -1.4 -1.3 -1.4 -2.1 -1.6 -2.1
HDL Cholesterol 8.2 13.6 17.1 -3.2 2.2 4.0 4.0 3.9 4.0 3.8 3.5 4.1 3.6
LDL Cholesterol 0.3 0.4 1.4 1.2 -0.4 -0.6 -0.4 0.1 -0.6 -0.6 -0.9 -0.4 -0.7
Lupus 0.3 0.5 1.2 0.4 0.8 -0.6 -0.5 -0.5 -0.5 -0.5 -0.9 -0.5 -1.1
Neuroticism (2016) 0.7 1.1 3.2 -1.8 0.6 1.0 1.0 0.8 0.8 1.1 0.8 0.9 1.0
Primary Biliary Cirrhosis 0.7 1.0 2.4 0.7 0.4 -1.0 -0.8 -0.9 -1.2 -0.9 -1.6 -1.0 -1.1
Rheumatoid Arthritis 1.0 1.4 1.9 -1.4 0.6 1.2 1.3 1.3 1.2 1.2 1.0 1.3 1.0
Schizophrenia (2014) 0.4 0.9 2.3 -0.6 -0.9 1.2 1.5 0.8 0.6 1.5 -0.5 0.7 0.8
Triglycerides 1.7 2.8 5.1 1.8 0.0 -1.6 -1.5 -1.9 -1.9 -1.6 -2.3 -1.6 -1.6
Type 2 Diabetes (T2D) (2012) 5.4 6.2 7.7 2.7 -1.1 -2.7 -2.6 -2.5 -2.6 -2.5 -2.6 -2.8 -2.6
Ulcerative Colitis 0.4 0.5 3.6 -0.2 0.6 -0.4 -0.0 -0.3 -0.8 -0.5 -1.9 0.0 -0.3
Blood Eosinophil Count 1.0 7.9 11.0 2.6 0.2 -3.0 -2.8 -3.1 -2.8 -3.3 -3.1 -3.3 -2.6
Blood Platelet Count 2.1 24.2 33.3 -4.8 -1.9 5.7 5.4 4.5 5.1 5.8 4.8 5.1 5.0
Blood Red Count 0.2 2.4 3.3 1.7 1.2 -1.8 -1.8 -1.5 -1.4 -1.8 -0.9 -1.5 -1.6
Blood White Count 0.3 1.9 3.7 -1.1 -0.4 1.7 1.6 1.4 1.3 1.9 1.3 1.5 1.2
Heel T-Score 3.1 24.8 33.4 5.8 -0.1 -5.2 -4.8 -4.8 -4.5 -5.7 -5.7 -5.3 -5.1
BMI 13.3 76.9 118.8 7.2 0.2 -10.1 -9.8 -9.5 -9.0 -10.9 -7.9 -9.7 -8.6
Height 1.6 30.9 48.2 -6.9 -0.4 6.1 5.6 4.6 6.1 5.5 6.3 5.6 5.7
Waist Hip Ratio (WHR) 0.2 1.1 3.7 -0.8 0.3 1.3 1.0 0.8 0.2 1.9 0.4 1.5 0.8
Systolic Blood Pressure 0.2 1.1 3.7 -1.9 0.2 0.9 0.2 -0.5 0.8 1.6 1.2 1.0 0.7
Smoking Status 0.1 0.2 1.1 -0.1 1.0 0.2 0.3 -0.1 -0.0 -0.4 -0.3 0.1 0.3
Allergy or Eczema 0.2 0.4 2.2 -0.5 0.7 -0.7 -0.5 -0.3 0.2 -1.5 0.1 -0.7 0.1
Cardiovascular Disease 0.4 1.3 2.3 0.4 -0.1 -1.3 -1.4 -1.5 -1.3 -1.3 -1.3 -1.1 -1.1
Hypothyroidism (self reported) 0.3 0.6 1.2 0.8 0.5 -0.9 -1.0 -0.8 -0.4 -0.6 -0.5 -1.0 -1.1
Respiratory disease 0.2 0.4 1.0 -0.8 -0.6 0.4 0.4 0.5 0.9 -0.2 1.0 0.3 0.7
Type 2 Diabetes (T2D) (2018) 0.5 1.0 1.9 1.3 -0.8 -0.9 -0.8 -1.4 -0.9 -1.0 -0.9 -1.0 -0.5
Lung FEV1/FVC ratio 2.5 12.6 18.6 -3.6 1.9 3.6 3.2 3.2 3.4 3.0 4.3 4.3 4.2
Lung FVC 0.2 1.2 6.5 0.1 1.9 -1.0 -0.9 0.3 -0.2 -2.5 0.1 -0.6 0.2
Neuroticism 0.7 1.7 3.7 -1.0 0.4 1.5 1.5 1.5 1.0 1.9 0.7 1.6 1.1
Chronotype (morning person) 0.6 1.4 2.5 -1.4 0.8 1.2 1.4 1.6 1.2 0.5 0.8 1.2 1.4
Hair Pigment 0.0 0.8 2.0 -0.4 0.7 0.9 1.1 1.4 0.7 0.9 0.2 1.2 0.9
Tanning 0.0 0.3 1.0 0.1 -1.0 0.1 -0.2 0.2 0.5 0.7 1.0 -0.2 0.2
Hand grip strength (left) 6.8 17.8 23.1 3.9 0.3 -4.8 -4.6 -4.4 -4.4 -4.5 -3.9 -4.8 -4.6
Number of treatments/medications taken 1.2 2.2 4.0 -2.0 0.5 1.6 1.9 1.5 1.7 1.3 0.7 1.4 1.5
Average weekly spirits intake 0.6 0.8 4.7 -0.2 2.2 -0.4 -0.6 -0.5 -0.3 -1.4 0.2 0.3 0.3
Sensitivity / hurt feelings 0.6 0.9 2.4 -0.7 1.5 1.0 1.1 1.0 0.8 1.0 0.6 0.9 0.7
Frequency of depressed mood in last 2 weeks 1.2 1.7 3.5 1.0 -0.4 -1.0 -1.1 -1.8 -1.9 -0.2 -1.8 -1.2 -1.6
Hearing difficulty/problems: Yes 0.1 0.2 0.4 0.4 0.6 -0.5 -0.3 0.2 -0.1 -0.6 0.0 -0.6 -0.3
Relative age of first facial hair 1.9 3.9 8.0 -1.6 -2.0 2.3 1.9 1.3 1.8 2.8 2.0 2.0 1.7
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 1.4 0.4 1.2 -0.1 0.1 0.3 0.0 -0.6 -0.3 0.1 0.1
Ever used hormone-replacement therapy (HRT) 0.9 1.1 3.4 -0.1 0.3 1.4 1.2 1.0 0.7 1.8 0.7 1.3 0.8
Ever had hysterectomy (womb removed) 2.1 2.4 4.0 -0.7 0.5 1.7 1.6 1.6 1.9 0.9 1.9 1.9 2.0
Systolic blood pressure, automated reading 0.1 0.3 1.0 -1.0 -0.3 0.2 -0.2 -1.0 0.3 0.5 0.5 0.2 0.0
Eye problems/disorders: Diabetes related eye disease 3.5 3.9 6.6 2.6 -0.4 -1.9 -1.9 -2.2 -2.2 -1.5 -2.2 -1.8 -2.1
Angina 1.6 2.1 5.7 -2.4 -0.2 1.6 1.5 0.8 1.2 1.8 1.2 1.4 1.3
Medication for hormone replacement therapy 1.2 1.3 4.5 2.1 0.2 -1.1 -1.0 -0.7 -1.0 -0.9 -1.0 -1.3 -1.1
Vitamin and mineral supplements 2.2 3.0 5.3 2.1 -0.2 -1.9 -2.3 -1.9 -2.1 -1.4 -0.8 -1.5 -1.8
Supplements: Zinc 0.2 0.2 1.3 -1.2 0.4 0.2 0.2 0.5 0.3 0.3 0.2 0.3 0.3
Medication: Co-codamol 0.3 0.4 1.2 0.2 0.9 0.5 0.8 1.1 0.5 0.2 0.0 0.4 0.3
Medication: Metformin 1.6 2.2 3.0 1.7 -1.2 -1.4 -1.3 -1.7 -1.4 -1.5 -1.5 -1.7 -1.4
Diabetes (father) 0.8 1.0 3.9 1.1 2.0 -0.6 -0.2 -0.3 -0.6 -1.4 -1.5 -0.4 -0.5
Diabetes (mother) 3.2 4.1 5.8 2.1 0.4 -2.2 -1.9 -1.7 -2.0 -2.2 -2.3 -2.2 -2.4
Severe depression (siblings) 1.9 2.2 3.8 1.6 -0.1 -1.3 -1.2 -1.5 -1.4 -1.2 -2.0 -1.7 -1.8
Pack years adult smoking proportion 0.2 0.3 0.7 -0.5 -0.7 0.4 0.6 0.8 0.1 0.7 -0.5 0.2 -0.3
Impedance of leg (right) 12.7 61.3 97.8 -6.7 -1.4 9.0 8.8 8.3 7.7 9.9 6.7 8.6 7.9
Leg fat-free mass (left) 4.9 26.1 49.1 3.7 1.4 -6.0 -5.9 -5.7 -4.7 -7.0 -3.7 -5.8 -4.9
Trunk fat percentage 0.1 0.6 1.3 -0.0 1.0 -0.7 -0.8 -1.1 -0.8 -1.1 -0.3 -0.5 -0.4
Hand grip strength (right) 2.2 6.0 10.3 2.3 0.0 -2.9 -2.8 -2.6 -2.2 -3.2 -1.9 -2.8 -2.3
Townsend deprivation index at recruitment 1.4 1.9 3.2 -0.7 0.7 1.8 1.8 1.3 1.5 1.3 1.0 1.5 1.7
Current tobacco smoking 0.9 1.5 3.1 1.0 -0.3 -1.3 -1.3 -1.5 -1.2 -1.8 -1.0 -1.4 -1.0
Average weekly fortified wine intake 0.4 0.5 1.2 0.5 0.9 0.5 0.5 0.8 0.8 -0.1 1.1 0.6 0.7
Maternal smoking around birth 0.5 0.7 4.7 -0.8 2.2 0.3 0.5 0.6 -0.0 -0.1 -0.2 0.5 0.4
Fed-up feelings 0.4 0.6 3.1 -0.0 1.7 0.6 0.6 0.5 -0.1 0.9 0.5 0.9 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.9 0.8 -0.7 -0.5 -0.4 -1.0 -1.3 0.6 -1.4 -0.9 -1.1
Relative age voice broke 1.7 2.5 3.8 -1.3 -1.6 1.8 1.6 1.6 1.2 1.9 1.1 1.9 1.7
Taking other prescription medications 0.1 0.2 0.4 0.6 -0.4 0.3 0.4 0.4 0.4 0.6 0.3 -0.0 -0.1
Age when periods started (menarche) 7.9 18.9 31.8 -4.5 0.2 5.1 5.1 4.5 4.2 5.6 3.3 4.5 4.0
Bilateral oophorectomy (both ovaries removed) 0.7 0.9 2.6 1.4 1.6 -0.8 -0.8 -0.2 -0.0 -1.5 -0.0 -0.5 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 2.4 1.1 -0.0 -0.7 -0.3 -0.7 -0.4 -1.1 -1.6 -0.8 -0.7
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 2.6 0.7 -1.2 -1.3 -1.6 -1.6 -1.2 -1.0 -0.1 -1.1 -1.0
Qualifications: CSEs or equivalent 0.2 0.3 0.9 -0.1 -0.8 0.5 0.5 0.5 0.4 1.0 0.1 0.3 0.3
Serious illness, injury or assault to yourself 3.1 3.7 6.2 -1.4 0.9 2.2 2.5 2.4 2.1 2.1 1.4 2.0 1.6
High blood pressure 1.1 3.1 6.3 0.8 0.1 -2.0 -2.1 -2.5 -2.0 -2.0 -1.6 -1.6 -1.5
Hayfever, allergic rhinitis or eczema 0.2 0.5 2.2 -0.4 0.8 -0.8 -0.5 -0.2 -0.0 -1.5 -0.1 -0.7 -0.2
Multivitamins +/- minerals 0.9 1.1 2.7 -1.0 -0.4 1.2 1.6 1.3 1.3 0.9 0.3 0.8 0.9
Stomach or abdominal pain in last month 0.2 0.3 1.5 1.2 0.2 -0.1 -0.0 0.2 0.4 -0.7 0.4 -0.2 0.2
Supplements: Glucosamine 3.7 4.8 7.4 2.5 -0.4 -2.2 -2.1 -2.3 -2.2 -1.9 -2.7 -2.2 -2.6
Diverticular disease/diverticulitis (self-reported) 5.2 6.1 8.4 -1.8 0.4 2.9 2.8 2.5 2.8 2.5 2.3 2.8 2.8
Medication: Atenolol 1.3 1.7 3.6 1.0 -0.6 -1.2 -0.9 -1.5 -1.3 -1.3 -1.9 -1.5 -1.2
Medication: Levothyroxine sodium 0.5 0.9 1.5 -0.9 1.0 0.9 0.9 0.9 1.2 0.7 1.1 0.8 0.8
Sitting height 0.2 1.7 5.2 -2.3 -0.1 1.0 0.7 0.2 1.6 0.6 2.1 0.8 1.3
Chronic bronchitis/emphysema (father) 0.7 0.9 1.4 1.0 0.3 -1.1 -1.1 -0.8 -1.0 -0.7 -0.6 -1.2 -1.2
High blood pressure (mother) 5.1 7.2 11.1 2.3 -0.4 -2.9 -2.8 -3.3 -2.8 -3.1 -2.7 -2.9 -2.5
Body mass index (BMI) 6.9 29.6 44.6 4.5 1.3 -6.2 -6.1 -6.0 -5.6 -6.7 -4.6 -6.0 -5.5
Impedance of leg (left) 13.2 64.1 108.2 -7.0 -1.1 9.3 9.0 8.3 7.7 10.4 6.7 8.9 7.9
Leg predicted mass (left) 4.8 25.4 48.2 3.6 1.5 -5.9 -5.8 -5.6 -4.6 -6.9 -3.7 -5.8 -4.8
Trunk fat mass 0.9 3.9 7.6 0.8 1.4 -2.2 -2.2 -2.5 -2.0 -2.8 -1.3 -2.0 -1.7
Waist circumference 2.6 9.5 14.6 1.9 0.7 -3.5 -3.5 -3.8 -3.4 -3.5 -2.5 -3.4 -3.2
Number of incorrect matches in round 0.8 1.2 3.7 1.0 1.3 -1.0 -0.6 -0.7 -1.2 -1.3 -1.9 -0.7 -0.9
Past tobacco smoking 2.6 4.8 7.7 1.8 -0.3 -2.6 -2.6 -2.3 -2.8 -1.9 -2.2 -2.2 -2.3
Alcohol usually taken with meals 0.2 0.4 1.4 0.4 0.7 -0.7 -0.8 -0.5 -0.2 -1.2 0.2 -0.5 -0.1
Nervous feelings 5.7 10.6 14.3 -3.1 2.4 3.6 3.6 3.3 3.1 3.3 2.8 3.8 3.4
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 1.5 -0.1 -0.5 0.4 0.3 -0.2 -0.1 1.2 -0.0 0.1 -0.3
Hearing difficulty/problems with background noise 0.1 0.1 0.4 0.4 0.6 -0.3 -0.1 -0.0 -0.2 -0.5 -0.1 -0.6 -0.2
Hair/balding pattern: Pattern 2 1.6 2.0 3.5 -1.4 0.9 1.5 1.8 1.4 1.5 0.8 0.9 1.6 1.9
Had menopause 1.2 1.5 3.3 -0.6 -0.9 1.4 1.1 0.7 1.1 1.8 1.5 1.3 1.1
Had other major operations 0.9 1.1 2.7 1.6 -1.2 -0.8 -0.5 -0.1 -1.3 -0.2 -1.7 -0.9 -1.0
Forced vital capacity (FVC) 0.5 1.8 3.8 -1.5 1.5 0.8 0.8 1.2 1.6 -0.4 2.0 1.1 1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.3 1.0 -0.1 -0.6 -0.4 -0.6 -0.3 -1.1 -0.9 -0.8 -0.7
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.2 -0.3 0.2 0.3 0.2 0.3 -0.1 0.4 0.0 0.4 0.4
Qualifications: None of the above 0.1 0.3 1.1 0.6 0.6 -0.4 -0.0 -0.1 -0.4 -0.7 -1.1 -0.2 -0.3
Financial difficulties in last 2 years 0.2 0.3 0.7 -0.5 -0.4 0.5 0.4 0.6 0.5 0.8 0.8 0.4 0.2
Mouth/teeth dental problems 0.1 0.2 0.6 0.3 0.2 -0.3 -0.7 -0.8 -0.2 0.3 0.6 -0.2 -0.4
Heart attack 0.9 1.2 2.0 -1.0 -1.2 1.3 1.3 0.6 1.2 1.4 0.9 0.6 0.8
Allergy 0.3 0.6 2.7 0.3 -1.5 0.6 0.3 -0.1 -0.1 1.6 -0.1 0.5 -0.1
Pain all over the body in last month 0.6 0.7 1.4 -0.8 -0.6 1.0 1.2 0.8 1.0 0.6 0.4 0.7 0.8
Diabetes (self-reported) 0.8 1.3 2.3 1.5 0.5 -1.1 -1.1 -1.3 -1.2 -1.5 -1.1 -1.0 -0.7
Hayfever/allergic rhinitis (self-reported) 1.2 1.5 4.8 -0.8 2.2 0.7 1.2 1.8 1.3 -0.4 0.7 0.8 1.3
Medication: Ramipril 0.5 0.6 1.2 -1.1 -1.1 0.8 0.9 0.5 0.9 0.4 0.5 0.4 0.7
Medication: Simvastatin 0.0 0.1 0.2 0.5 0.2 -0.1 -0.1 -0.2 -0.2 -0.1 -0.4 0.1 -0.1
Fluid intelligence score 1.2 2.5 4.3 -2.0 0.7 1.3 1.2 1.9 1.6 0.8 2.1 1.8 1.7
Illnesses of siblings 0.2 0.3 0.6 -0.5 0.3 0.2 0.2 0.8 0.8 -0.4 0.7 0.5 0.7
Neuroticism score 0.8 1.6 2.6 -1.0 1.1 1.4 1.4 1.3 0.9 1.6 1.0 1.6 1.2
Weight 3.1 15.4 27.9 2.5 1.3 -4.5 -4.5 -4.6 -3.8 -5.3 -2.8 -4.5 -3.8
Impedance of arm (right) 9.2 42.9 55.4 -6.2 -1.4 7.3 7.1 7.1 6.4 7.4 6.0 7.4 7.0
Arm fat percentage (right) 2.7 10.6 18.3 2.4 0.9 -3.8 -3.8 -3.6 -3.5 -4.3 -2.5 -3.4 -3.0
Trunk fat-free mass 3.0 17.4 32.0 2.6 1.3 -4.8 -4.8 -4.8 -3.7 -5.7 -3.0 -5.0 -4.1
Hip circumference 1.2 5.3 11.3 1.2 0.7 -2.6 -2.7 -2.9 -1.9 -3.4 -1.1 -2.7 -2.1
Time employed in main current job 1.0 1.2 2.5 -1.6 -0.4 1.1 1.0 1.0 0.8 1.5 1.1 1.0 0.8
Alcohol intake versus 10 years previously 0.6 1.0 5.2 -0.3 -2.3 0.9 0.6 -0.0 0.7 1.3 0.6 0.5 0.3
Father’s age at death 1.8 2.4 3.6 1.1 -1.8 -1.5 -1.6 -1.9 -1.5 -0.9 -1.3 -1.8 -1.8
Worrier / anxious feelings 1.9 3.6 5.6 -1.5 1.0 2.1 2.1 2.2 1.9 2.4 1.9 1.9 1.6
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 7.9 -0.7 -0.4 1.5 1.7 0.9 0.3 2.8 -0.1 1.0 0.5
Falls in the last year 0.4 0.6 1.3 0.4 1.2 -0.8 -0.7 -0.7 -0.9 -0.5 -0.8 -0.7 -0.7
Hair/balding pattern: Pattern 3 1.8 2.7 4.4 0.7 -0.4 -1.9 -2.1 -2.0 -1.6 -1.9 -1.4 -1.7 -1.9
Number of live births 1.8 2.6 4.4 2.1 0.4 -1.6 -1.4 -1.4 -1.8 -1.8 -2.0 -1.5 -1.4
Forced expiratory volume in 1-second (FEV1) 0.9 3.0 6.1 -2.0 1.7 1.2 1.1 1.6 1.9 0.2 2.5 1.7 2.3
Pulse rate 3.3 5.5 10.1 -1.7 0.8 2.5 2.6 3.2 2.4 2.6 2.2 2.4 2.3
Happiness 1.8 2.2 3.3 1.2 -1.8 -1.5 -1.7 -1.7 -1.6 -1.1 -1.1 -1.5 -1.5
Noisy workplace 0.4 0.5 1.5 0.2 -0.7 -0.6 -0.7 -1.2 -0.7 -0.2 -0.6 -1.0 -0.8
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.2 0.6 -0.3 -0.9 -1.0 -0.1 -0.3 -1.1 0.0 -0.9 -0.6
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 1.0 -1.0 0.7 0.3 0.4 0.6 0.0 0.7 -0.3 0.3 -0.1
Mouth/teeth dental problems: Dentures 0.6 1.1 2.9 0.5 -0.6 -1.1 -1.2 -1.2 -0.8 -1.7 -0.8 -1.2 -0.8
Asthma 0.6 1.3 3.3 -1.1 0.1 1.0 1.0 1.1 1.5 0.5 1.8 0.9 1.2
Medication: Ibuprofen (e.g. Nurofen) 3.3 4.2 6.2 -1.4 1.6 2.2 2.2 2.5 2.0 2.2 1.9 2.3 2.1
Medication: Cholesterol lowering 0.6 0.9 1.4 -0.7 0.3 1.0 1.0 1.1 1.2 0.8 1.0 1.0 1.0
Depression (self-reported) 0.1 0.1 0.6 -0.7 -0.1 0.4 0.5 0.2 -0.1 0.4 -0.1 0.3 0.4
Medication: Lansoprazole 0.2 0.2 0.7 -0.3 0.5 0.3 0.3 0.8 0.0 0.4 0.5 0.4 0.2
Prospective memory result 0.2 0.3 1.0 -0.7 -1.0 0.5 0.5 0.2 0.4 0.5 0.2 0.4 0.5
Lung cancer (father) 0.3 0.3 0.7 0.7 0.7 -0.3 -0.5 -0.6 -0.8 0.4 -0.5 -0.2 -0.6
Illnesses of mother 2.1 2.6 3.7 -1.9 0.0 1.7 1.6 1.7 1.5 1.9 1.2 1.7 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.1 4.1 -1.3 1.3 1.1 1.2 1.6 1.6 0.2 1.9 1.4 2.0
Pulse wave Arterial Stiffness index 1.7 2.0 3.2 -1.8 1.1 1.6 1.5 0.9 1.4 1.2 1.3 1.3 1.7
Impedance of arm (left) 11.0 50.8 68.9 -6.4 -1.3 8.1 7.9 7.6 7.0 8.3 6.2 8.1 7.6
Arm fat mass (right) 4.0 16.3 28.1 2.9 1.3 -4.7 -4.6 -4.6 -4.1 -5.3 -3.2 -4.4 -3.9
Trunk predicted mass 2.9 16.8 31.4 2.6 1.3 -4.8 -4.7 -4.7 -3.6 -5.6 -3.0 -4.9 -4.0
Standing height 0.8 7.9 14.7 -3.8 -0.0 2.9 2.8 2.2 3.3 2.4 3.3 2.5 3.1
Length of working week for main job 0.3 0.4 1.9 0.4 0.5 -0.7 -0.6 -0.2 -0.4 -1.4 -0.1 -0.6 -0.1
Exposure to tobacco smoke at home 0.2 0.2 0.9 0.4 0.9 0.2 0.2 -0.1 0.5 -0.0 0.2 0.4 0.4
Breastfed as a baby 1.1 1.3 9.4 -0.4 3.1 0.4 0.5 1.0 0.9 0.2 1.0 0.5 0.7
Tense / ‘highly strung’ 2.1 3.5 6.4 -1.5 0.7 2.3 2.5 2.1 1.7 2.2 0.9 2.2 1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.4 -0.5 -0.2 -0.0 0.0 -0.2 -0.8 0.6 -1.2 -0.1 -0.5
Hair/balding pattern: Pattern 4 1.3 3.0 4.9 -0.5 1.1 2.0 1.9 1.9 1.9 2.2 1.8 1.9 1.6
Birth weight of first child 1.0 1.7 9.7 -0.8 3.1 0.6 0.8 1.2 1.2 -0.1 0.6 0.9 1.3
Peak expiratory flow (PEF) 3.1 7.2 11.7 -3.2 1.5 2.3 2.2 2.8 2.7 1.4 3.3 3.0 3.4
Pulse wave reflection index 0.1 0.2 0.4 -0.2 0.1 0.5 0.4 -0.2 0.4 0.2 0.4 0.4 0.6
Ever highly irritable/argumentative for 2 days 1.4 1.6 3.6 -1.9 -0.9 1.5 1.5 0.7 1.3 1.1 1.0 1.3 1.4
Loud music exposure frequency 0.7 0.7 1.2 1.0 -0.8 -0.6 -0.6 -0.9 -1.1 -0.1 -1.0 -1.0 -1.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 2.6 -0.9 -0.4 0.0 -0.2 0.8 0.6 0.1 1.6 0.3 0.4
Mouth/teeth dental problems: Bleeding gums 1.7 2.1 5.8 1.0 0.4 -1.4 -0.9 -1.3 -1.7 -1.9 -2.4 -1.4 -1.2
Blood clot in the leg (DVT) 1.9 2.4 5.0 1.5 0.2 -2.0 -1.9 -1.2 -1.5 -2.2 -1.1 -1.7 -1.3
Medication: Paracetamol 1.8 2.9 7.4 -0.8 -0.7 2.0 2.0 2.0 1.3 2.7 1.2 1.8 1.4
Headache pain in last month 1.1 1.9 2.7 -0.7 0.8 1.5 1.5 1.4 1.4 1.6 1.3 1.5 1.5
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 2.6 1.5 0.2 -1.4 -1.6 -1.3 -1.6 -1.1 -1.1 -1.3 -1.5
Glaucoma (self-reported) 0.3 0.4 1.3 -0.7 -1.1 0.7 0.7 0.2 0.7 0.4 0.1 0.4 0.4
Gout (self-reported) 0.1 0.1 0.2 0.4 -0.3 -0.5 -0.4 0.2 -0.2 0.1 -0.1 -0.5 -0.4
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.5 0.4 0.4 -0.4 -0.4 -0.5 -0.1 -0.1 -0.1 -0.7 -0.7
Medication: Amlodipine 1.2 1.7 2.6 -1.5 -0.8 1.5 1.6 1.3 1.3 1.3 0.9 1.3 1.3
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.9 -0.9 -0.2 0.7 0.5 0.0 0.6 0.1 0.7 0.6 0.9
Birth weight 0.8 1.7 5.9 -2.4 -0.9 1.4 1.5 0.8 1.0 1.3 0.6 1.1 1.1
Chronic bronchitis/emphysema (mother) 0.9 1.1 2.6 1.3 1.6 -1.0 -0.9 -0.4 -0.9 -1.6 -0.6 -0.8 -0.5
High blood pressure (siblings) 1.1 1.6 3.6 0.9 -1.9 -0.9 -1.1 -1.6 -1.4 -0.5 -1.1 -1.0 -1.4
Forced vital capacity (FVC), Best measure 0.3 1.3 2.6 -1.0 1.0 0.8 0.9 1.2 1.4 -0.2 1.5 0.8 1.6
Body fat percentage 0.6 2.4 4.0 0.8 1.0 -1.7 -1.7 -1.9 -1.7 -2.0 -1.1 -1.5 -1.4
Leg fat percentage (right) 1.0 3.8 5.5 1.5 1.1 -2.2 -2.1 -2.1 -2.2 -2.3 -1.6 -2.0 -1.9
Arm fat-free mass (right) 3.6 18.5 30.1 3.2 1.8 -4.8 -4.7 -5.0 -3.9 -5.5 -3.5 -5.0 -4.3
Exposure to tobacco smoke outside home 0.0 0.0 0.3 -0.1 0.3 0.1 0.1 -0.5 0.2 0.1 -0.1 -0.2 -0.1
Comparative body size at age 10 25.6 70.8 123.2 7.2 -0.5 -9.7 -9.4 -8.8 -8.3 -11.1 -7.5 -9.2 -7.8
Number of full brothers 0.3 0.4 1.7 0.7 0.6 0.2 0.7 0.7 -0.2 -0.3 -1.3 0.2 0.1
Worry too long after embarrassment 0.5 0.8 1.4 1.0 -0.9 -0.8 -0.9 -1.2 -0.8 -0.4 -0.4 -1.1 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.2 -0.9 -0.6 -0.6 -0.6 -0.8 -1.1 -0.2 -1.0 -0.6 -0.6
Wheeze or whistling in the chest in last year 0.1 0.2 0.6 0.0 -0.4 0.3 0.5 0.4 0.8 -0.8 0.4 -0.3 0.4
Number of children fathered 0.4 0.5 1.0 0.9 0.4 -0.6 -0.5 -0.8 -1.0 -0.6 -0.8 -0.7 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.7 3.8 1.4 1.4 -1.4 -1.1 -0.4 -1.1 -1.9 -1.4 -1.3 -1.1
Age at first live birth 0.3 0.6 3.4 0.4 -1.8 -0.4 -0.5 -0.6 -0.8 0.6 -0.5 -0.5 -0.7
Pulse wave peak to peak time 1.2 1.4 2.2 1.4 -0.8 -1.5 -1.4 -0.7 -1.1 -1.2 -1.0 -1.1 -1.4
Health satisfaction 1.7 2.2 5.5 1.4 -2.3 -1.3 -1.3 -1.5 -1.4 -0.9 -1.3 -1.6 -1.3
Shortness of breath walking on level ground 0.6 0.7 2.2 0.1 -1.5 0.8 0.6 -0.3 0.5 1.5 0.9 0.0 -0.0
Qualifications: College or University degree 0.9 2.8 4.6 0.9 -0.9 -2.0 -1.9 -1.7 -1.4 -2.1 -1.4 -2.1 -1.5
Eye problems/disorders: None of the above 0.5 0.5 1.2 0.5 -0.1 -1.0 -0.8 -0.3 -0.8 -1.1 -0.6 -0.8 -0.7
Mouth/teeth dental problems: Loose teeth 1.4 1.6 4.1 1.9 -0.1 -1.1 -0.7 -0.4 -1.8 -0.5 -2.0 -1.1 -1.4
Emphysema/chronic bronchitis 3.3 3.7 5.9 -1.6 0.7 2.3 2.4 2.0 1.9 2.4 1.2 2.1 1.9
Medication for pain relief, constipation, heartburn 2.3 4.0 6.2 1.8 0.1 -2.3 -2.5 -2.5 -1.9 -2.2 -1.4 -2.1 -2.1
Neck or shoulder pain in last month 3.1 4.4 9.7 -2.0 -0.3 2.6 2.4 1.9 2.1 3.1 2.0 1.9 1.6
Medication: Blood pressure 0.2 0.4 1.0 -0.8 0.1 0.8 1.0 0.6 0.7 0.9 -0.1 0.4 0.4
Angina (self-reported) 1.2 1.6 5.5 -2.4 -0.4 1.4 1.3 0.5 0.9 1.7 0.9 1.1 1.0
Migraine (self-reported) 0.8 1.0 2.2 -1.2 -0.6 0.9 0.7 0.6 1.2 0.7 1.5 0.9 1.3
Medication: Ibuprofen 3.2 3.8 5.7 -1.3 0.6 2.1 2.0 2.4 2.1 2.2 2.2 2.2 1.8
Medication: Allopurinol 0.9 1.3 3.1 1.1 -1.8 -1.1 -1.1 -0.7 -1.1 -0.1 -0.9 -1.2 -1.4
Medication: Omeprazole 1.4 1.6 4.6 0.8 -0.5 -1.4 -1.3 -1.6 -1.0 -2.1 -0.9 -1.4 -0.8
Medication: Seretide 50 evohaler 1.8 2.0 3.1 -1.8 -1.6 1.4 1.3 0.8 1.6 1.2 1.8 1.1 1.4
Mean time to correctly identify matches 1.1 2.1 3.6 -1.4 0.2 1.5 1.4 1.2 1.7 1.6 1.9 1.2 1.4
Heart disease (mother) 3.0 3.7 6.6 -1.2 1.6 2.0 2.0 2.6 1.8 1.4 1.8 2.4 2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.2 -1.5 1.0 1.0 1.0 1.1 0.7 1.0 0.5 1.3 0.8
Whole body fat mass 2.2 9.2 15.4 1.9 1.4 -3.5 -3.4 -3.6 -3.1 -3.9 -2.4 -3.3 -2.9
Leg fat mass (right) 2.4 9.5 17.1 2.1 1.5 -3.6 -3.5 -3.4 -3.0 -4.1 -2.3 -3.4 -3.0
Arm predicted mass (right) 3.7 18.8 30.7 3.2 1.6 -4.9 -4.8 -5.1 -3.9 -5.5 -3.4 -5.0 -4.4
Pulse rate, automated reading 2.4 7.6 15.2 -1.6 0.5 2.9 2.9 3.9 2.9 3.1 2.8 3.0 2.6
Alcohol intake frequency. 2.3 5.4 13.3 -0.7 0.5 2.9 3.2 2.7 1.8 3.7 0.8 2.5 2.0
Comparative height size at age 10 0.5 2.6 7.0 0.9 1.1 -1.9 -1.7 -1.6 -1.1 -2.6 -1.0 -1.9 -1.3
Number of full sisters 2.6 3.2 5.1 2.0 1.3 -2.0 -2.0 -1.8 -1.6 -2.3 -1.4 -1.7 -1.4
Suffer from ‘nerves’ 1.2 1.8 4.4 -0.6 0.1 1.7 1.7 1.3 1.4 2.1 0.9 1.5 1.0
Overall health rating 0.7 1.5 3.2 0.6 -1.4 -1.0 -0.8 -1.6 -1.5 -0.6 -1.8 -1.3 -1.0
Chest pain or discomfort 2.4 3.4 5.9 -1.4 0.2 2.3 2.4 2.2 2.4 1.6 1.8 1.7 1.5
Had major operations 4.4 5.2 7.2 -2.2 -0.8 2.7 2.6 2.1 2.2 2.6 1.8 2.6 2.5
Age at last live birth 0.5 0.7 2.4 1.5 -0.5 -0.6 -0.6 -0.9 -1.0 0.1 -0.8 -0.9 -0.9
Family relationship satisfaction 3.5 4.4 6.8 1.6 -0.2 -2.2 -2.0 -2.2 -2.5 -2.0 -2.6 -2.2 -2.3
Leg pain on walking 0.2 0.2 0.8 -0.2 -0.2 0.1 0.1 -0.8 -0.3 0.3 -0.9 -0.3 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 2.7 -1.6 -0.1 1.1 1.0 0.7 0.9 0.6 1.0 1.1 1.1
Commuting to job workplace: Car/motor vehicle 2.9 3.3 5.9 1.9 0.6 -1.8 -1.4 -1.7 -2.0 -1.9 -2.4 -2.0 -1.9
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.1 1.1 -0.9 -0.8 -0.8 -0.7 -0.9 -0.4 -0.6 -0.9 -0.7
Medication: Aspirin 0.9 1.2 4.0 -2.0 -0.3 1.1 1.1 0.9 1.1 0.8 0.8 0.9 1.3
Supplements: Vitamin C 2.7 3.1 7.2 -2.7 0.0 1.9 1.9 1.2 2.1 1.9 1.7 1.4 1.7
Knee pain experienced in last month 1.0 1.5 3.0 1.5 -0.2 -1.4 -1.3 -0.8 -1.1 -1.7 -1.1 -1.2 -1.3
Hypertension (Self-reported) 1.0 2.8 5.3 0.6 0.5 -1.9 -2.0 -2.3 -1.9 -2.1 -1.6 -1.5 -1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 2.0 -0.5 1.1 1.1 1.2 1.2 0.8 0.8 0.4 1.4 1.2
Illnesses of father: Heart disease 1.8 2.5 3.3 -1.5 -0.6 1.8 1.7 1.8 1.5 1.7 1.4 1.7 1.6
Illnesses of siblings: Diabetes 0.2 0.3 1.4 0.1 1.2 0.4 0.5 0.4 -0.0 0.1 -0.3 0.5 0.5
Smoking status: Previous 3.5 5.3 8.1 -1.7 0.3 2.8 2.9 2.5 2.8 2.3 2.0 2.3 2.2
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 1.0 -0.2 0.9 -0.4 -0.1 -0.2 -0.7 -0.5 -1.0 -0.4 -0.3
Whole body fat-free mass 4.0 23.0 41.3 3.3 1.4 -5.5 -5.5 -5.5 -4.3 -6.4 -3.6 -5.6 -4.7
Leg fat-free mass (right) 4.9 26.3 47.3 3.6 1.4 -6.0 -5.9 -5.8 -4.8 -6.9 -3.9 -5.8 -5.0
Arm fat percentage (left) 2.6 10.2 17.9 2.4 1.0 -3.7 -3.6 -3.5 -3.4 -4.2 -2.6 -3.3 -3.0
Average weekly red wine intake 0.5 0.7 3.1 -0.1 0.7 -0.9 -1.0 -0.8 -0.6 -1.7 -0.1 -0.5 -0.3
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.9 -1.2 -1.0 0.7 0.7 -0.2 -0.3 1.4 -1.0 0.3 0.1
Mood swings 0.7 1.3 2.7 -1.0 0.7 1.4 1.4 1.0 0.7 1.6 0.5 1.4 1.0
Loneliness, isolation 2.8 3.9 5.6 1.8 -1.1 -2.1 -2.0 -2.2 -2.3 -1.3 -1.8 -2.3 -2.4
Long-standing illness, disability or infirmity 0.2 0.4 3.2 -0.3 -1.8 0.0 -0.1 -0.1 0.1 0.3 0.2 -0.2 -0.1
Ever had bowel cancer screening 0.2 0.2 0.5 -0.0 0.4 -0.6 -0.5 -0.5 -0.4 -0.7 -0.3 -0.6 -0.6
Diabetes diagnosed by doctor 0.1 0.1 0.4 0.1 0.4 0.1 0.2 -0.1 0.2 -0.6 0.1 0.2 0.6
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 3.3 0.5 1.1 -1.5 -1.2 -0.9 -1.2 -1.8 -1.6 -1.4 -1.3
Friendships satisfaction 2.9 3.5 5.7 1.5 -0.7 -2.0 -2.0 -2.2 -2.4 -1.5 -2.1 -2.0 -1.9
Qualifications: nursing, teaching 0.5 0.8 1.8 0.5 -1.0 -1.1 -1.3 -0.8 -0.8 -0.8 0.1 -0.9 -0.9
Commuting to job workplace: Walk 0.1 0.1 0.5 -0.7 -0.2 0.2 0.1 0.4 0.3 0.4 0.4 0.1 -0.0
Eye problems/disorders: Cataract 1.3 1.5 2.7 -1.5 0.1 1.3 0.8 0.7 1.1 1.6 1.7 1.4 1.3
Mouth/teeth dental problems: Mouth ulcers 3.0 4.7 6.8 -1.8 0.1 2.5 2.6 2.5 2.3 2.1 1.9 2.3 2.4
Medication for cholesterol 0.6 0.9 1.4 -1.2 0.1 1.0 1.0 1.1 1.2 0.7 1.1 0.9 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 5.2 6.2 12.2 2.1 -0.1 -3.0 -2.8 -2.2 -2.5 -3.5 -2.1 -2.7 -2.3
Back pain experienced in last month 0.1 0.2 0.7 0.3 -0.9 0.3 0.3 0.7 0.5 0.2 0.5 0.3 -0.0
Mineral and other dietary supplements 0.4 0.5 1.5 -0.4 -0.7 0.7 0.6 0.7 0.7 0.6 1.2 0.6 0.8
Breast cancer (self-reported) 0.5 0.6 1.2 0.8 -0.2 -1.1 -0.9 -0.3 -0.4 -1.1 -0.7 -1.0 -0.9
Asthma (self-reported) 0.5 1.1 2.8 -1.1 -0.5 0.9 0.9 0.9 1.5 0.4 1.7 0.7 1.1
Osteoporosis (self-reported) 0.4 0.5 3.1 0.4 1.8 -0.5 -0.5 -0.0 0.2 -0.8 0.6 -0.2 0.1
Osteoarthritis (self-reported) 1.0 1.3 2.9 0.8 -0.1 -1.2 -1.0 -1.1 -1.3 -1.1 -1.7 -1.1 -1.2
Medication: Aspirin 0.5 0.7 2.8 -1.7 -0.2 0.7 0.8 0.6 0.8 0.6 0.6 0.6 0.9
Medication: Gliclazide 0.2 0.2 0.5 -0.7 0.6 0.2 0.2 0.2 0.5 -0.2 0.6 0.3 0.7
Illnesses of father: None of the above (group 1) 0.1 0.2 0.7 -0.8 -0.2 0.2 0.1 -0.1 0.2 0.5 0.3 0.4 0.4
Smoking status: Current 0.8 1.3 2.5 1.1 -0.2 -1.1 -1.2 -1.4 -1.1 -1.6 -0.9 -1.3 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.4 2.9 7.6 -0.9 2.8 1.1 1.1 1.9 1.5 0.1 2.1 1.8 2.1
Whole body water mass 4.1 23.2 41.1 3.3 1.4 -5.6 -5.5 -5.5 -4.4 -6.4 -3.6 -5.6 -4.8
Leg predicted mass (right) 4.9 25.9 46.6 3.6 1.4 -5.9 -5.8 -5.8 -4.7 -6.8 -3.8 -5.8 -5.0
Arm fat mass (left) 4.1 16.8 28.6 3.0 1.2 -4.7 -4.6 -4.7 -4.2 -5.3 -3.2 -4.5 -4.0
Number of self-reported non-cancer illnesses 0.0 0.1 0.4 -0.2 -0.6 0.1 0.2 -0.2 0.2 -0.0 -0.3 -0.2 -0.0
Average weekly champagne plus white wine intake 0.2 0.3 0.7 0.2 0.2 -0.6 -0.6 -0.5 -0.6 -0.8 -0.6 -0.1 -0.3
Miserableness 0.2 0.4 1.1 -1.0 0.3 0.7 0.4 -0.3 0.0 1.1 0.6 0.9 0.6
Guilty feelings 0.2 0.3 0.9 -0.7 0.3 0.5 0.5 0.4 0.2 0.9 0.4 0.5 0.4
Wears glasses or contact lenses 1.5 1.7 2.4 -1.4 0.1 1.6 1.5 1.2 1.3 1.3 1.0 1.4 1.5
Ever taken oral contraceptive pill 0.3 0.3 0.9 0.0 0.5 -0.7 -1.0 -0.5 -0.4 -0.7 0.2 -0.2 -0.4
Hearing aid user 0.6 0.7 2.3 0.9 -1.5 -0.6 -1.1 -0.9 -0.4 -0.1 0.5 -0.5 -0.7
Mother’s age at death 0.2 0.3 0.5 -0.5 0.4 0.6 0.7 0.5 0.2 0.5 0.1 0.7 0.6
Financial situation satisfaction 2.0 2.5 3.7 1.1 -0.5 -1.7 -1.7 -1.9 -1.9 -1.5 -1.7 -1.8 -1.4
Tinnitus: Yes, now most or all of the time 0.8 1.0 2.9 -0.5 0.5 0.8 0.9 1.7 1.2 0.6 1.3 0.8 1.0
Commuting to job workplace: Public transport 2.6 3.1 7.8 -1.9 -1.2 1.5 1.1 1.3 2.0 1.6 2.8 1.7 1.9
Eye problems/disorders: Glaucoma 0.5 0.6 1.1 -0.5 -0.7 0.9 0.8 0.5 1.1 0.5 0.8 0.7 0.9
Medication: Blood pressure 0.2 0.4 1.0 -0.0 -0.2 -0.8 -0.9 -1.0 -0.6 -0.8 -0.2 -0.6 -0.4
Pain type(s) experienced in last month: Hip pain 1.4 1.7 2.8 1.6 -1.3 -1.2 -1.1 -1.0 -1.4 -0.8 -1.7 -1.2 -1.6
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.4 -0.1 -0.0 0.2 0.3 -0.1 -0.1 0.5 -0.6 0.1 -0.1
High cholesterol (Self-reported) 0.4 0.6 1.2 0.3 -0.7 1.0 1.1 1.0 0.7 1.0 0.2 0.9 0.6
Medication: Bendroflumethiazide 0.7 1.1 2.0 0.4 0.3 -1.4 -1.2 -0.9 -0.9 -1.4 -0.8 -1.3 -1.1
Medication: Paracetamol 0.7 1.1 3.5 -0.3 -1.2 1.2 1.2 1.2 0.5 1.9 0.4 1.1 0.7
Medication: Lisinopril 0.6 0.8 3.1 0.6 1.8 -0.9 -1.2 -0.6 -1.1 -0.7 -0.3 -0.4 -0.4
Medication: Atorvastatin 0.1 0.1 0.7 0.4 -0.1 0.2 0.2 -0.3 -0.1 0.8 -0.4 -0.2 -0.4
Illnesses of father: High blood pressure 1.0 1.2 1.8 0.9 -0.7 -1.1 -1.2 -1.4 -1.2 -0.9 -1.0 -1.1 -1.3
Alcohol drinker status: Never 3.3 3.9 6.6 -1.4 1.4 2.1 2.3 2.6 1.8 2.4 1.6 2.2 1.8
Ever smoked 1.4 2.4 4.3 -1.4 -0.8 1.8 1.6 1.3 2.1 1.4 1.9 1.4 1.5
Basal metabolic rate 3.9 21.6 39.1 3.1 1.5 -5.4 -5.3 -5.3 -4.3 -6.2 -3.5 -5.4 -4.5
Leg fat percentage (left) 1.2 4.4 6.1 1.4 1.5 -2.3 -2.3 -2.4 -2.5 -2.3 -1.9 -2.1 -2.2
Arm fat-free mass (left) 3.4 17.4 30.7 2.8 1.6 -4.8 -4.8 -4.8 -3.7 -5.5 -2.9 -4.9 -4.2
Number of operations (self-reported) 0.2 0.4 0.9 -0.0 -0.6 0.6 0.9 0.9 0.2 0.6 -0.4 0.5 0.5
Average weekly beer plus cider intake 0.4 0.6 1.6 -1.3 -0.1 0.7 0.9 1.0 0.6 1.0 0.3 0.4 0.3
Irritability 0.1 0.2 0.6 -0.2 0.5 0.3 0.2 0.4 0.1 0.1 0.8 0.7 0.5
Risk taking 0.5 0.7 2.1 0.4 -1.0 -0.3 -0.2 -1.0 -1.0 0.3 -1.5 -0.9 -0.8
Ever had prostate specific antigen (PSA) test 0.0 0.0 0.1 -0.2 -0.1 0.0 0.2 0.3 0.2 -0.1 0.0 -0.2 -0.1
Fractured/broken bones in last 5 years 0.1 0.2 0.5 -0.4 -0.6 0.1 0.1 -0.7 -0.4 0.6 -0.5 -0.0 -0.2
Age started oral contraceptive pill 0.9 1.1 3.5 -1.4 -0.4 1.0 0.6 0.4 1.1 1.3 1.9 0.9 0.9
Diastolic blood pressure, automated reading 1.5 4.7 9.6 1.2 -0.5 -2.5 -3.0 -3.1 -2.4 -1.6 -1.3 -2.3 -2.4
Ever depressed for a whole week 0.2 0.2 1.1 -0.0 1.1 0.5 0.5 0.0 0.1 0.6 -0.2 0.3 0.3
Unable to work because of sickness or disability 0.7 0.9 3.5 -0.6 -1.9 0.8 0.8 1.0 0.3 1.5 0.4 0.6 0.5
Commuting to job workplace: Cycle 1.0 1.2 2.2 -1.5 1.4 0.7 0.8 1.2 1.3 -0.2 1.0 1.1 1.4
Myopia 1.0 1.4 3.0 -1.3 0.4 1.3 1.1 0.6 0.9 1.7 1.2 1.4 1.3
Vascular/heart problems diagnosed by doctor 0.7 1.8 4.9 -0.1 0.3 1.3 1.5 2.2 1.6 1.4 1.4 1.2 1.1
Cholesterol lowering medication 0.4 0.5 1.2 1.1 -0.6 -0.5 -0.4 -0.5 -0.8 -0.2 -1.1 -0.7 -0.8
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 3.0 0.4 0.6 -0.9 -0.7 -0.8 -0.4 -1.7 -0.6 -0.8 -0.3
Pain experienced in last month 0.7 1.1 2.0 0.9 0.7 -1.1 -1.3 -1.4 -1.2 -0.9 -0.8 -1.1 -0.8
Supplements: Calcium 0.9 0.9 5.7 -1.1 2.4 0.6 0.8 0.4 0.3 0.3 -0.2 0.7 0.9
Basal cell carcinoma (self-reported) 1.1 1.3 1.8 1.3 1.1 -1.3 -1.3 -1.1 -1.3 -1.0 -0.9 -0.9 -1.1
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.0 -1.0 -1.2 1.3 1.3 0.7 1.2 1.4 0.9 0.6 0.9
Deep venous thrombosis (DVT) (self-reported) 2.2 2.9 6.0 1.6 0.0 -2.1 -2.0 -1.4 -1.6 -2.4 -1.3 -1.9 -1.5
Heart disease (siblings) 0.1 0.2 0.8 0.1 0.9 0.0 0.2 0.3 -0.2 0.5 -0.4 -0.2 -0.4
Alcohol drinker status: Previous 0.4 0.5 1.8 0.9 1.2 -0.1 0.1 -0.3 -0.7 -0.1 -1.3 0.1 -0.1
Pack years of smoking 0.2 0.3 0.9 -0.6 -0.9 0.3 0.5 0.6 -0.0 0.7 -0.4 0.2 -0.4
Impedance of whole body 13.1 66.8 100.0 -7.2 -1.2 9.4 9.2 8.6 7.9 10.0 7.0 9.2 8.4
Leg fat mass (left) 2.6 10.0 16.2 2.1 1.4 -3.6 -3.6 -3.6 -3.2 -4.0 -2.4 -3.5 -3.2
Arm predicted mass (left) 3.6 18.2 31.0 2.9 1.3 -4.9 -4.8 -5.0 -3.9 -5.6 -3.2 -5.0 -4.3