Hub : Genes

IQCK

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0620	0.0230	5.5e-04	0.037	0.029	0.049	0.038	0.056	2.5e-05	1.8e-04	1.1e-06	1.6e-05	2.3e-07
2	YFS	Blood	0.0158	0.0071	6.3e-03	0.013	0.003	0.005	0.003	0.007	3.3e-05	3.0e-02	8.6e-03	3.0e-02	2.0e-03
3	TCGA	Bladder Urothelial Carcinoma	0.0460	0.0240	3.5e-04	0.016	0.031	0.021	NA	0.021	1.6e-02	1.0e-03	6.5e-03	NA	5.7e-03
4	TCGA	Breast Invasive Carcinoma	0.0278	0.0110	8.7e-09	0.032	0.034	0.027	NA	0.028	3.4e-07	1.6e-07	2.2e-06	NA	1.6e-06
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0422	0.0222	1.6e-04	0.033	0.024	0.022	NA	0.035	1.3e-04	8.1e-04	1.6e-03	NA	7.5e-05
6	TCGA	Lung Adenocarcinoma	0.0855	0.0362	5.0e-08	0.043	0.032	0.024	NA	0.035	8.7e-06	1.2e-04	7.1e-04	NA	4.9e-05
7	TCGA	Lung Squamous Cell Carcinoma	0.0343	0.0189	4.0e-04	0.028	0.019	0.017	NA	0.025	3.2e-04	2.8e-03	3.9e-03	NA	7.2e-04
8	TCGA	Ovarian Serous Cystadenocarcinoma	0.0710	0.0420	2.6e-03	0.021	0.036	0.028	NA	0.017	1.3e-02	1.7e-03	5.1e-03	NA	2.4e-02
9	TCGA	Prostate Adenocarcinoma	0.0423	0.0240	4.5e-04	0.012	0.012	0.003	NA	0.009	1.9e-02	1.8e-02	1.3e-01	NA	3.6e-02
10	TCGA	Thyroid Carcinoma	0.0460	0.0230	1.7e-04	0.039	0.022	0.030	NA	0.032	9.5e-05	2.8e-03	5.6e-04	NA	4.3e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.3	0.4	2.4	0.6	-1.5	-0.1	0.3	-0.1	-0.1	0.0	-0.9	-0.7	-0.3
Bipolar Disorder or Schizophrenia	0.1	0.3	0.9	-0.3	-0.3	0.7	1.0	0.6	0.4	0.8	-0.6	0.3	0.5
Depressed Affect (Nagel 2018)	0.2	0.4	1.4	-0.3	0.8	0.7	0.6	0.0	-0.0	1.2	0.0	0.9	0.5
Depression (Nagel 2018)	1.1	1.7	5.3	1.2	0.1	-1.0	-0.9	-1.3	-1.8	-0.2	-2.3	-1.1	-1.6
Intelligence (Savage-Jansen 2018)	0.9	2.9	4.6	-1.2	1.7	1.6	1.5	1.8	1.7	1.0	2.1	2.1	1.8
Neuroticism (Nagel 2018)	0.7	1.6	3.2	-1.3	1.1	1.5	1.4	0.8	0.9	1.8	0.7	1.5	1.2
Schizophrenia (2018)	0.3	0.7	1.2	-0.8	0.9	0.9	1.0	0.8	0.5	1.1	0.0	0.9	0.9
Schizophrenia vs Biploar Disorder	0.6	0.8	3.9	0.2	-1.1	1.1	1.1	0.3	0.2	2.0	-0.5	0.5	0.1
Worry (Nagel 2018)	2.8	5.9	8.7	-2.1	1.5	2.8	2.9	2.6	2.3	3.0	1.7	2.8	2.2
Alzheimer’s Disease (in mother)	0.7	0.8	2.5	0.4	-1.1	0.9	0.8	1.0	0.7	1.6	0.7	0.7	0.3
Alzheimer’s Disease (in father)	0.2	0.2	1.3	-0.5	0.7	-0.1	0.2	0.1	-0.3	-0.4	-1.1	-0.2	0.1
Alzheimer’s Disease (including proxy)	0.7	1.0	2.2	1.4	-0.1	-1.1	-0.8	-0.2	-0.9	-0.6	-1.5	-1.3	-1.0
Crohns Disease (2017)	0.9	1.9	4.7	1.8	0.6	-1.4	-1.1	-1.2	-1.1	-2.2	-1.2	-1.5	-1.1
Irritable Bowel Disease (IBD)	0.8	1.9	4.0	1.2	1.1	-1.4	-1.1	-1.2	-1.4	-1.8	-2.0	-1.2	-1.2
Ulcerative Colitis (UC)	1.1	2.1	7.2	0.5	1.1	-1.4	-1.1	-1.3	-1.8	-1.3	-2.7	-1.0	-1.3
Major Depression (MDD)	0.9	1.0	2.8	-1.2	-0.1	1.2	1.4	0.7	-0.1	1.7	-0.8	1.2	0.5
Reaction Time	1.5	2.9	4.7	-1.7	0.2	1.8	1.8	1.5	2.0	1.8	2.2	1.5	1.8
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.9	-1.2	-0.1	1.4	1.4	2.0	1.5	1.4	1.5	1.5	1.1
Breast Cancer	0.2	0.5	1.4	0.8	-0.3	-0.9	-0.8	-0.1	-0.1	-1.2	0.0	-0.8	-0.5
Ovarian Cancer	2.4	3.2	5.2	-2.3	-1.4	2.1	1.9	1.0	1.8	2.1	1.6	1.6	1.8
Prostate Cancer	0.7	0.9	2.3	-0.2	-0.1	1.1	1.0	1.0	1.5	1.5	1.2	0.5	0.3
Age at First Birth	2.8	4.1	6.2	-2.0	-2.2	2.2	2.0	1.3	2.1	2.5	2.1	1.9	1.5
Bipolar Disorder (2011)	0.5	0.5	0.9	-1.0	0.6	0.6	0.6	0.8	0.8	0.2	0.7	0.7	0.8
Body Mass Index (BMI) (2010)	16.7	22.9	34.0	4.3	-0.4	-5.5	-5.4	-5.0	-5.1	-5.8	-4.3	-5.0	-4.7
Coronary Artery Disease (CAD)	0.2	0.2	1.1	0.4	0.6	0.3	0.4	-0.2	-0.3	0.6	-1.1	0.1	0.0
Crohns Disease (2012)	0.7	1.1	3.4	1.8	0.8	-0.9	-0.7	-0.7	-0.6	-1.9	-0.7	-1.0	-0.5
Mean Putamen Volume	3.5	3.9	5.2	2.2	-1.8	-1.9	-1.9	-2.3	-2.0	-1.3	-2.1	-2.2	-2.0
Fasting Glucose	1.3	1.6	2.7	1.4	-0.8	-1.2	-1.4	-1.4	-1.4	-0.3	-1.2	-1.2	-1.6
HbA1C	2.1	2.3	4.6	1.0	0.8	-1.5	-1.5	-1.4	-1.3	-1.4	-2.1	-1.6	-2.1
HDL Cholesterol	8.2	13.6	17.1	-3.2	2.2	4.0	4.0	3.9	4.0	3.8	3.5	4.1	3.6
LDL Cholesterol	0.3	0.4	1.4	1.2	-0.4	-0.6	-0.4	0.1	-0.6	-0.6	-0.9	-0.4	-0.7
Lupus	0.3	0.5	1.2	0.4	0.8	-0.6	-0.5	-0.5	-0.5	-0.5	-0.9	-0.5	-1.1
Neuroticism (2016)	0.7	1.1	3.2	-1.8	0.6	1.0	1.0	0.8	0.8	1.1	0.8	0.9	1.0
Primary Biliary Cirrhosis	0.7	1.0	2.4	0.7	0.4	-1.0	-0.8	-0.9	-1.2	-0.9	-1.6	-1.0	-1.1
Rheumatoid Arthritis	1.0	1.4	1.9	-1.4	0.6	1.2	1.3	1.3	1.2	1.2	1.0	1.3	1.0
Schizophrenia (2014)	0.4	0.9	2.3	-0.6	-0.9	1.2	1.5	0.8	0.6	1.5	-0.5	0.7	0.8
Triglycerides	1.7	2.8	5.1	1.8	0.0	-1.6	-1.5	-1.9	-1.9	-1.6	-2.3	-1.6	-1.6
Type 2 Diabetes (T2D) (2012)	5.4	6.2	7.7	2.7	-1.1	-2.7	-2.6	-2.5	-2.6	-2.5	-2.6	-2.8	-2.6
Ulcerative Colitis	0.4	0.5	3.6	-0.2	0.6	-0.4	-0.0	-0.3	-0.8	-0.5	-1.9	0.0	-0.3
Blood Eosinophil Count	1.0	7.9	11.0	2.6	0.2	-3.0	-2.8	-3.1	-2.8	-3.3	-3.1	-3.3	-2.6
Blood Platelet Count	2.1	24.2	33.3	-4.8	-1.9	5.7	5.4	4.5	5.1	5.8	4.8	5.1	5.0
Blood Red Count	0.2	2.4	3.3	1.7	1.2	-1.8	-1.8	-1.5	-1.4	-1.8	-0.9	-1.5	-1.6
Blood White Count	0.3	1.9	3.7	-1.1	-0.4	1.7	1.6	1.4	1.3	1.9	1.3	1.5	1.2
Heel T-Score	3.1	24.8	33.4	5.8	-0.1	-5.2	-4.8	-4.8	-4.5	-5.7	-5.7	-5.3	-5.1
BMI	13.3	76.9	118.8	7.2	0.2	-10.1	-9.8	-9.5	-9.0	-10.9	-7.9	-9.7	-8.6
Height	1.6	30.9	48.2	-6.9	-0.4	6.1	5.6	4.6	6.1	5.5	6.3	5.6	5.7
Waist Hip Ratio (WHR)	0.2	1.1	3.7	-0.8	0.3	1.3	1.0	0.8	0.2	1.9	0.4	1.5	0.8
Systolic Blood Pressure	0.2	1.1	3.7	-1.9	0.2	0.9	0.2	-0.5	0.8	1.6	1.2	1.0	0.7
Smoking Status	0.1	0.2	1.1	-0.1	1.0	0.2	0.3	-0.1	-0.0	-0.4	-0.3	0.1	0.3
Allergy or Eczema	0.2	0.4	2.2	-0.5	0.7	-0.7	-0.5	-0.3	0.2	-1.5	0.1	-0.7	0.1
Cardiovascular Disease	0.4	1.3	2.3	0.4	-0.1	-1.3	-1.4	-1.5	-1.3	-1.3	-1.3	-1.1	-1.1
Hypothyroidism (self reported)	0.3	0.6	1.2	0.8	0.5	-0.9	-1.0	-0.8	-0.4	-0.6	-0.5	-1.0	-1.1
Respiratory disease	0.2	0.4	1.0	-0.8	-0.6	0.4	0.4	0.5	0.9	-0.2	1.0	0.3	0.7
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.9	1.3	-0.8	-0.9	-0.8	-1.4	-0.9	-1.0	-0.9	-1.0	-0.5
Lung FEV1/FVC ratio	2.5	12.6	18.6	-3.6	1.9	3.6	3.2	3.2	3.4	3.0	4.3	4.3	4.2
Lung FVC	0.2	1.2	6.5	0.1	1.9	-1.0	-0.9	0.3	-0.2	-2.5	0.1	-0.6	0.2
Neuroticism	0.7	1.7	3.7	-1.0	0.4	1.5	1.5	1.5	1.0	1.9	0.7	1.6	1.1
Chronotype (morning person)	0.6	1.4	2.5	-1.4	0.8	1.2	1.4	1.6	1.2	0.5	0.8	1.2	1.4
Hair Pigment	0.0	0.8	2.0	-0.4	0.7	0.9	1.1	1.4	0.7	0.9	0.2	1.2	0.9
Tanning	0.0	0.3	1.0	0.1	-1.0	0.1	-0.2	0.2	0.5	0.7	1.0	-0.2	0.2
Hand grip strength (left)	6.8	17.8	23.1	3.9	0.3	-4.8	-4.6	-4.4	-4.4	-4.5	-3.9	-4.8	-4.6
Number of treatments/medications taken	1.2	2.2	4.0	-2.0	0.5	1.6	1.9	1.5	1.7	1.3	0.7	1.4	1.5
Average weekly spirits intake	0.6	0.8	4.7	-0.2	2.2	-0.4	-0.6	-0.5	-0.3	-1.4	0.2	0.3	0.3
Sensitivity / hurt feelings	0.6	0.9	2.4	-0.7	1.5	1.0	1.1	1.0	0.8	1.0	0.6	0.9	0.7
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.5	1.0	-0.4	-1.0	-1.1	-1.8	-1.9	-0.2	-1.8	-1.2	-1.6
Hearing difficulty/problems: Yes	0.1	0.2	0.4	0.4	0.6	-0.5	-0.3	0.2	-0.1	-0.6	0.0	-0.6	-0.3
Relative age of first facial hair	1.9	3.9	8.0	-1.6	-2.0	2.3	1.9	1.3	1.8	2.8	2.0	2.0	1.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	1.4	0.4	1.2	-0.1	0.1	0.3	0.0	-0.6	-0.3	0.1	0.1
Ever used hormone-replacement therapy (HRT)	0.9	1.1	3.4	-0.1	0.3	1.4	1.2	1.0	0.7	1.8	0.7	1.3	0.8
Ever had hysterectomy (womb removed)	2.1	2.4	4.0	-0.7	0.5	1.7	1.6	1.6	1.9	0.9	1.9	1.9	2.0
Systolic blood pressure, automated reading	0.1	0.3	1.0	-1.0	-0.3	0.2	-0.2	-1.0	0.3	0.5	0.5	0.2	0.0
Eye problems/disorders: Diabetes related eye disease	3.5	3.9	6.6	2.6	-0.4	-1.9	-1.9	-2.2	-2.2	-1.5	-2.2	-1.8	-2.1
Angina	1.6	2.1	5.7	-2.4	-0.2	1.6	1.5	0.8	1.2	1.8	1.2	1.4	1.3
Medication for hormone replacement therapy	1.2	1.3	4.5	2.1	0.2	-1.1	-1.0	-0.7	-1.0	-0.9	-1.0	-1.3	-1.1
Vitamin and mineral supplements	2.2	3.0	5.3	2.1	-0.2	-1.9	-2.3	-1.9	-2.1	-1.4	-0.8	-1.5	-1.8
Supplements: Zinc	0.2	0.2	1.3	-1.2	0.4	0.2	0.2	0.5	0.3	0.3	0.2	0.3	0.3
Medication: Co-codamol	0.3	0.4	1.2	0.2	0.9	0.5	0.8	1.1	0.5	0.2	0.0	0.4	0.3
Medication: Metformin	1.6	2.2	3.0	1.7	-1.2	-1.4	-1.3	-1.7	-1.4	-1.5	-1.5	-1.7	-1.4
Diabetes (father)	0.8	1.0	3.9	1.1	2.0	-0.6	-0.2	-0.3	-0.6	-1.4	-1.5	-0.4	-0.5
Diabetes (mother)	3.2	4.1	5.8	2.1	0.4	-2.2	-1.9	-1.7	-2.0	-2.2	-2.3	-2.2	-2.4
Severe depression (siblings)	1.9	2.2	3.8	1.6	-0.1	-1.3	-1.2	-1.5	-1.4	-1.2	-2.0	-1.7	-1.8
Pack years adult smoking proportion	0.2	0.3	0.7	-0.5	-0.7	0.4	0.6	0.8	0.1	0.7	-0.5	0.2	-0.3
Impedance of leg (right)	12.7	61.3	97.8	-6.7	-1.4	9.0	8.8	8.3	7.7	9.9	6.7	8.6	7.9
Leg fat-free mass (left)	4.9	26.1	49.1	3.7	1.4	-6.0	-5.9	-5.7	-4.7	-7.0	-3.7	-5.8	-4.9
Trunk fat percentage	0.1	0.6	1.3	-0.0	1.0	-0.7	-0.8	-1.1	-0.8	-1.1	-0.3	-0.5	-0.4
Hand grip strength (right)	2.2	6.0	10.3	2.3	0.0	-2.9	-2.8	-2.6	-2.2	-3.2	-1.9	-2.8	-2.3
Townsend deprivation index at recruitment	1.4	1.9	3.2	-0.7	0.7	1.8	1.8	1.3	1.5	1.3	1.0	1.5	1.7
Current tobacco smoking	0.9	1.5	3.1	1.0	-0.3	-1.3	-1.3	-1.5	-1.2	-1.8	-1.0	-1.4	-1.0
Average weekly fortified wine intake	0.4	0.5	1.2	0.5	0.9	0.5	0.5	0.8	0.8	-0.1	1.1	0.6	0.7
Maternal smoking around birth	0.5	0.7	4.7	-0.8	2.2	0.3	0.5	0.6	-0.0	-0.1	-0.2	0.5	0.4
Fed-up feelings	0.4	0.6	3.1	-0.0	1.7	0.6	0.6	0.5	-0.1	0.9	0.5	0.9	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.9	0.8	-0.7	-0.5	-0.4	-1.0	-1.3	0.6	-1.4	-0.9	-1.1
Relative age voice broke	1.7	2.5	3.8	-1.3	-1.6	1.8	1.6	1.6	1.2	1.9	1.1	1.9	1.7
Taking other prescription medications	0.1	0.2	0.4	0.6	-0.4	0.3	0.4	0.4	0.4	0.6	0.3	-0.0	-0.1
Age when periods started (menarche)	7.9	18.9	31.8	-4.5	0.2	5.1	5.1	4.5	4.2	5.6	3.3	4.5	4.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	2.6	1.4	1.6	-0.8	-0.8	-0.2	-0.0	-1.5	-0.0	-0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.4	1.1	-0.0	-0.7	-0.3	-0.7	-0.4	-1.1	-1.6	-0.8	-0.7
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.6	0.7	-1.2	-1.3	-1.6	-1.6	-1.2	-1.0	-0.1	-1.1	-1.0
Qualifications: CSEs or equivalent	0.2	0.3	0.9	-0.1	-0.8	0.5	0.5	0.5	0.4	1.0	0.1	0.3	0.3
Serious illness, injury or assault to yourself	3.1	3.7	6.2	-1.4	0.9	2.2	2.5	2.4	2.1	2.1	1.4	2.0	1.6
High blood pressure	1.1	3.1	6.3	0.8	0.1	-2.0	-2.1	-2.5	-2.0	-2.0	-1.6	-1.6	-1.5
Hayfever, allergic rhinitis or eczema	0.2	0.5	2.2	-0.4	0.8	-0.8	-0.5	-0.2	-0.0	-1.5	-0.1	-0.7	-0.2
Multivitamins +/- minerals	0.9	1.1	2.7	-1.0	-0.4	1.2	1.6	1.3	1.3	0.9	0.3	0.8	0.9
Stomach or abdominal pain in last month	0.2	0.3	1.5	1.2	0.2	-0.1	-0.0	0.2	0.4	-0.7	0.4	-0.2	0.2
Supplements: Glucosamine	3.7	4.8	7.4	2.5	-0.4	-2.2	-2.1	-2.3	-2.2	-1.9	-2.7	-2.2	-2.6
Diverticular disease/diverticulitis (self-reported)	5.2	6.1	8.4	-1.8	0.4	2.9	2.8	2.5	2.8	2.5	2.3	2.8	2.8
Medication: Atenolol	1.3	1.7	3.6	1.0	-0.6	-1.2	-0.9	-1.5	-1.3	-1.3	-1.9	-1.5	-1.2
Medication: Levothyroxine sodium	0.5	0.9	1.5	-0.9	1.0	0.9	0.9	0.9	1.2	0.7	1.1	0.8	0.8
Sitting height	0.2	1.7	5.2	-2.3	-0.1	1.0	0.7	0.2	1.6	0.6	2.1	0.8	1.3
Chronic bronchitis/emphysema (father)	0.7	0.9	1.4	1.0	0.3	-1.1	-1.1	-0.8	-1.0	-0.7	-0.6	-1.2	-1.2
High blood pressure (mother)	5.1	7.2	11.1	2.3	-0.4	-2.9	-2.8	-3.3	-2.8	-3.1	-2.7	-2.9	-2.5
Body mass index (BMI)	6.9	29.6	44.6	4.5	1.3	-6.2	-6.1	-6.0	-5.6	-6.7	-4.6	-6.0	-5.5
Impedance of leg (left)	13.2	64.1	108.2	-7.0	-1.1	9.3	9.0	8.3	7.7	10.4	6.7	8.9	7.9
Leg predicted mass (left)	4.8	25.4	48.2	3.6	1.5	-5.9	-5.8	-5.6	-4.6	-6.9	-3.7	-5.8	-4.8
Trunk fat mass	0.9	3.9	7.6	0.8	1.4	-2.2	-2.2	-2.5	-2.0	-2.8	-1.3	-2.0	-1.7
Waist circumference	2.6	9.5	14.6	1.9	0.7	-3.5	-3.5	-3.8	-3.4	-3.5	-2.5	-3.4	-3.2
Number of incorrect matches in round	0.8	1.2	3.7	1.0	1.3	-1.0	-0.6	-0.7	-1.2	-1.3	-1.9	-0.7	-0.9
Past tobacco smoking	2.6	4.8	7.7	1.8	-0.3	-2.6	-2.6	-2.3	-2.8	-1.9	-2.2	-2.2	-2.3
Alcohol usually taken with meals	0.2	0.4	1.4	0.4	0.7	-0.7	-0.8	-0.5	-0.2	-1.2	0.2	-0.5	-0.1
Nervous feelings	5.7	10.6	14.3	-3.1	2.4	3.6	3.6	3.3	3.1	3.3	2.8	3.8	3.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	1.5	-0.1	-0.5	0.4	0.3	-0.2	-0.1	1.2	-0.0	0.1	-0.3
Hearing difficulty/problems with background noise	0.1	0.1	0.4	0.4	0.6	-0.3	-0.1	-0.0	-0.2	-0.5	-0.1	-0.6	-0.2
Hair/balding pattern: Pattern 2	1.6	2.0	3.5	-1.4	0.9	1.5	1.8	1.4	1.5	0.8	0.9	1.6	1.9
Had menopause	1.2	1.5	3.3	-0.6	-0.9	1.4	1.1	0.7	1.1	1.8	1.5	1.3	1.1
Had other major operations	0.9	1.1	2.7	1.6	-1.2	-0.8	-0.5	-0.1	-1.3	-0.2	-1.7	-0.9	-1.0
Forced vital capacity (FVC)	0.5	1.8	3.8	-1.5	1.5	0.8	0.8	1.2	1.6	-0.4	2.0	1.1	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.3	1.0	-0.1	-0.6	-0.4	-0.6	-0.3	-1.1	-0.9	-0.8	-0.7
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	-0.3	0.2	0.3	0.2	0.3	-0.1	0.4	0.0	0.4	0.4
Qualifications: None of the above	0.1	0.3	1.1	0.6	0.6	-0.4	-0.0	-0.1	-0.4	-0.7	-1.1	-0.2	-0.3
Financial difficulties in last 2 years	0.2	0.3	0.7	-0.5	-0.4	0.5	0.4	0.6	0.5	0.8	0.8	0.4	0.2
Mouth/teeth dental problems	0.1	0.2	0.6	0.3	0.2	-0.3	-0.7	-0.8	-0.2	0.3	0.6	-0.2	-0.4
Heart attack	0.9	1.2	2.0	-1.0	-1.2	1.3	1.3	0.6	1.2	1.4	0.9	0.6	0.8
Allergy	0.3	0.6	2.7	0.3	-1.5	0.6	0.3	-0.1	-0.1	1.6	-0.1	0.5	-0.1
Pain all over the body in last month	0.6	0.7	1.4	-0.8	-0.6	1.0	1.2	0.8	1.0	0.6	0.4	0.7	0.8
Diabetes (self-reported)	0.8	1.3	2.3	1.5	0.5	-1.1	-1.1	-1.3	-1.2	-1.5	-1.1	-1.0	-0.7
Hayfever/allergic rhinitis (self-reported)	1.2	1.5	4.8	-0.8	2.2	0.7	1.2	1.8	1.3	-0.4	0.7	0.8	1.3
Medication: Ramipril	0.5	0.6	1.2	-1.1	-1.1	0.8	0.9	0.5	0.9	0.4	0.5	0.4	0.7
Medication: Simvastatin	0.0	0.1	0.2	0.5	0.2	-0.1	-0.1	-0.2	-0.2	-0.1	-0.4	0.1	-0.1
Fluid intelligence score	1.2	2.5	4.3	-2.0	0.7	1.3	1.2	1.9	1.6	0.8	2.1	1.8	1.7
Illnesses of siblings	0.2	0.3	0.6	-0.5	0.3	0.2	0.2	0.8	0.8	-0.4	0.7	0.5	0.7
Neuroticism score	0.8	1.6	2.6	-1.0	1.1	1.4	1.4	1.3	0.9	1.6	1.0	1.6	1.2
Weight	3.1	15.4	27.9	2.5	1.3	-4.5	-4.5	-4.6	-3.8	-5.3	-2.8	-4.5	-3.8
Impedance of arm (right)	9.2	42.9	55.4	-6.2	-1.4	7.3	7.1	7.1	6.4	7.4	6.0	7.4	7.0
Arm fat percentage (right)	2.7	10.6	18.3	2.4	0.9	-3.8	-3.8	-3.6	-3.5	-4.3	-2.5	-3.4	-3.0
Trunk fat-free mass	3.0	17.4	32.0	2.6	1.3	-4.8	-4.8	-4.8	-3.7	-5.7	-3.0	-5.0	-4.1
Hip circumference	1.2	5.3	11.3	1.2	0.7	-2.6	-2.7	-2.9	-1.9	-3.4	-1.1	-2.7	-2.1
Time employed in main current job	1.0	1.2	2.5	-1.6	-0.4	1.1	1.0	1.0	0.8	1.5	1.1	1.0	0.8
Alcohol intake versus 10 years previously	0.6	1.0	5.2	-0.3	-2.3	0.9	0.6	-0.0	0.7	1.3	0.6	0.5	0.3
Father’s age at death	1.8	2.4	3.6	1.1	-1.8	-1.5	-1.6	-1.9	-1.5	-0.9	-1.3	-1.8	-1.8
Worrier / anxious feelings	1.9	3.6	5.6	-1.5	1.0	2.1	2.1	2.2	1.9	2.4	1.9	1.9	1.6
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	7.9	-0.7	-0.4	1.5	1.7	0.9	0.3	2.8	-0.1	1.0	0.5
Falls in the last year	0.4	0.6	1.3	0.4	1.2	-0.8	-0.7	-0.7	-0.9	-0.5	-0.8	-0.7	-0.7
Hair/balding pattern: Pattern 3	1.8	2.7	4.4	0.7	-0.4	-1.9	-2.1	-2.0	-1.6	-1.9	-1.4	-1.7	-1.9
Number of live births	1.8	2.6	4.4	2.1	0.4	-1.6	-1.4	-1.4	-1.8	-1.8	-2.0	-1.5	-1.4
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	6.1	-2.0	1.7	1.2	1.1	1.6	1.9	0.2	2.5	1.7	2.3
Pulse rate	3.3	5.5	10.1	-1.7	0.8	2.5	2.6	3.2	2.4	2.6	2.2	2.4	2.3
Happiness	1.8	2.2	3.3	1.2	-1.8	-1.5	-1.7	-1.7	-1.6	-1.1	-1.1	-1.5	-1.5
Noisy workplace	0.4	0.5	1.5	0.2	-0.7	-0.6	-0.7	-1.2	-0.7	-0.2	-0.6	-1.0	-0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.2	0.6	-0.3	-0.9	-1.0	-0.1	-0.3	-1.1	0.0	-0.9	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.0	-1.0	0.7	0.3	0.4	0.6	0.0	0.7	-0.3	0.3	-0.1
Mouth/teeth dental problems: Dentures	0.6	1.1	2.9	0.5	-0.6	-1.1	-1.2	-1.2	-0.8	-1.7	-0.8	-1.2	-0.8
Asthma	0.6	1.3	3.3	-1.1	0.1	1.0	1.0	1.1	1.5	0.5	1.8	0.9	1.2
Medication: Ibuprofen (e.g. Nurofen)	3.3	4.2	6.2	-1.4	1.6	2.2	2.2	2.5	2.0	2.2	1.9	2.3	2.1
Medication: Cholesterol lowering	0.6	0.9	1.4	-0.7	0.3	1.0	1.0	1.1	1.2	0.8	1.0	1.0	1.0
Depression (self-reported)	0.1	0.1	0.6	-0.7	-0.1	0.4	0.5	0.2	-0.1	0.4	-0.1	0.3	0.4
Medication: Lansoprazole	0.2	0.2	0.7	-0.3	0.5	0.3	0.3	0.8	0.0	0.4	0.5	0.4	0.2
Prospective memory result	0.2	0.3	1.0	-0.7	-1.0	0.5	0.5	0.2	0.4	0.5	0.2	0.4	0.5
Lung cancer (father)	0.3	0.3	0.7	0.7	0.7	-0.3	-0.5	-0.6	-0.8	0.4	-0.5	-0.2	-0.6
Illnesses of mother	2.1	2.6	3.7	-1.9	0.0	1.7	1.6	1.7	1.5	1.9	1.2	1.7	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	4.1	-1.3	1.3	1.1	1.2	1.6	1.6	0.2	1.9	1.4	2.0
Pulse wave Arterial Stiffness index	1.7	2.0	3.2	-1.8	1.1	1.6	1.5	0.9	1.4	1.2	1.3	1.3	1.7
Impedance of arm (left)	11.0	50.8	68.9	-6.4	-1.3	8.1	7.9	7.6	7.0	8.3	6.2	8.1	7.6
Arm fat mass (right)	4.0	16.3	28.1	2.9	1.3	-4.7	-4.6	-4.6	-4.1	-5.3	-3.2	-4.4	-3.9
Trunk predicted mass	2.9	16.8	31.4	2.6	1.3	-4.8	-4.7	-4.7	-3.6	-5.6	-3.0	-4.9	-4.0
Standing height	0.8	7.9	14.7	-3.8	-0.0	2.9	2.8	2.2	3.3	2.4	3.3	2.5	3.1
Length of working week for main job	0.3	0.4	1.9	0.4	0.5	-0.7	-0.6	-0.2	-0.4	-1.4	-0.1	-0.6	-0.1
Exposure to tobacco smoke at home	0.2	0.2	0.9	0.4	0.9	0.2	0.2	-0.1	0.5	-0.0	0.2	0.4	0.4
Breastfed as a baby	1.1	1.3	9.4	-0.4	3.1	0.4	0.5	1.0	0.9	0.2	1.0	0.5	0.7
Tense / ‘highly strung’	2.1	3.5	6.4	-1.5	0.7	2.3	2.5	2.1	1.7	2.2	0.9	2.2	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.4	-0.5	-0.2	-0.0	0.0	-0.2	-0.8	0.6	-1.2	-0.1	-0.5
Hair/balding pattern: Pattern 4	1.3	3.0	4.9	-0.5	1.1	2.0	1.9	1.9	1.9	2.2	1.8	1.9	1.6
Birth weight of first child	1.0	1.7	9.7	-0.8	3.1	0.6	0.8	1.2	1.2	-0.1	0.6	0.9	1.3
Peak expiratory flow (PEF)	3.1	7.2	11.7	-3.2	1.5	2.3	2.2	2.8	2.7	1.4	3.3	3.0	3.4
Pulse wave reflection index	0.1	0.2	0.4	-0.2	0.1	0.5	0.4	-0.2	0.4	0.2	0.4	0.4	0.6
Ever highly irritable/argumentative for 2 days	1.4	1.6	3.6	-1.9	-0.9	1.5	1.5	0.7	1.3	1.1	1.0	1.3	1.4
Loud music exposure frequency	0.7	0.7	1.2	1.0	-0.8	-0.6	-0.6	-0.9	-1.1	-0.1	-1.0	-1.0	-1.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	2.6	-0.9	-0.4	0.0	-0.2	0.8	0.6	0.1	1.6	0.3	0.4
Mouth/teeth dental problems: Bleeding gums	1.7	2.1	5.8	1.0	0.4	-1.4	-0.9	-1.3	-1.7	-1.9	-2.4	-1.4	-1.2
Blood clot in the leg (DVT)	1.9	2.4	5.0	1.5	0.2	-2.0	-1.9	-1.2	-1.5	-2.2	-1.1	-1.7	-1.3
Medication: Paracetamol	1.8	2.9	7.4	-0.8	-0.7	2.0	2.0	2.0	1.3	2.7	1.2	1.8	1.4
Headache pain in last month	1.1	1.9	2.7	-0.7	0.8	1.5	1.5	1.4	1.4	1.6	1.3	1.5	1.5
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	2.6	1.5	0.2	-1.4	-1.6	-1.3	-1.6	-1.1	-1.1	-1.3	-1.5
Glaucoma (self-reported)	0.3	0.4	1.3	-0.7	-1.1	0.7	0.7	0.2	0.7	0.4	0.1	0.4	0.4
Gout (self-reported)	0.1	0.1	0.2	0.4	-0.3	-0.5	-0.4	0.2	-0.2	0.1	-0.1	-0.5	-0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	0.4	0.4	-0.4	-0.4	-0.5	-0.1	-0.1	-0.1	-0.7	-0.7
Medication: Amlodipine	1.2	1.7	2.6	-1.5	-0.8	1.5	1.6	1.3	1.3	1.3	0.9	1.3	1.3
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	-0.9	-0.2	0.7	0.5	0.0	0.6	0.1	0.7	0.6	0.9
Birth weight	0.8	1.7	5.9	-2.4	-0.9	1.4	1.5	0.8	1.0	1.3	0.6	1.1	1.1
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.6	1.3	1.6	-1.0	-0.9	-0.4	-0.9	-1.6	-0.6	-0.8	-0.5
High blood pressure (siblings)	1.1	1.6	3.6	0.9	-1.9	-0.9	-1.1	-1.6	-1.4	-0.5	-1.1	-1.0	-1.4
Forced vital capacity (FVC), Best measure	0.3	1.3	2.6	-1.0	1.0	0.8	0.9	1.2	1.4	-0.2	1.5	0.8	1.6
Body fat percentage	0.6	2.4	4.0	0.8	1.0	-1.7	-1.7	-1.9	-1.7	-2.0	-1.1	-1.5	-1.4
Leg fat percentage (right)	1.0	3.8	5.5	1.5	1.1	-2.2	-2.1	-2.1	-2.2	-2.3	-1.6	-2.0	-1.9
Arm fat-free mass (right)	3.6	18.5	30.1	3.2	1.8	-4.8	-4.7	-5.0	-3.9	-5.5	-3.5	-5.0	-4.3
Exposure to tobacco smoke outside home	0.0	0.0	0.3	-0.1	0.3	0.1	0.1	-0.5	0.2	0.1	-0.1	-0.2	-0.1
Comparative body size at age 10	25.6	70.8	123.2	7.2	-0.5	-9.7	-9.4	-8.8	-8.3	-11.1	-7.5	-9.2	-7.8
Number of full brothers	0.3	0.4	1.7	0.7	0.6	0.2	0.7	0.7	-0.2	-0.3	-1.3	0.2	0.1
Worry too long after embarrassment	0.5	0.8	1.4	1.0	-0.9	-0.8	-0.9	-1.2	-0.8	-0.4	-0.4	-1.1	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.2	-0.9	-0.6	-0.6	-0.6	-0.8	-1.1	-0.2	-1.0	-0.6	-0.6
Wheeze or whistling in the chest in last year	0.1	0.2	0.6	0.0	-0.4	0.3	0.5	0.4	0.8	-0.8	0.4	-0.3	0.4
Number of children fathered	0.4	0.5	1.0	0.9	0.4	-0.6	-0.5	-0.8	-1.0	-0.6	-0.8	-0.7	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	3.8	1.4	1.4	-1.4	-1.1	-0.4	-1.1	-1.9	-1.4	-1.3	-1.1
Age at first live birth	0.3	0.6	3.4	0.4	-1.8	-0.4	-0.5	-0.6	-0.8	0.6	-0.5	-0.5	-0.7
Pulse wave peak to peak time	1.2	1.4	2.2	1.4	-0.8	-1.5	-1.4	-0.7	-1.1	-1.2	-1.0	-1.1	-1.4
Health satisfaction	1.7	2.2	5.5	1.4	-2.3	-1.3	-1.3	-1.5	-1.4	-0.9	-1.3	-1.6	-1.3
Shortness of breath walking on level ground	0.6	0.7	2.2	0.1	-1.5	0.8	0.6	-0.3	0.5	1.5	0.9	0.0	-0.0
Qualifications: College or University degree	0.9	2.8	4.6	0.9	-0.9	-2.0	-1.9	-1.7	-1.4	-2.1	-1.4	-2.1	-1.5
Eye problems/disorders: None of the above	0.5	0.5	1.2	0.5	-0.1	-1.0	-0.8	-0.3	-0.8	-1.1	-0.6	-0.8	-0.7
Mouth/teeth dental problems: Loose teeth	1.4	1.6	4.1	1.9	-0.1	-1.1	-0.7	-0.4	-1.8	-0.5	-2.0	-1.1	-1.4
Emphysema/chronic bronchitis	3.3	3.7	5.9	-1.6	0.7	2.3	2.4	2.0	1.9	2.4	1.2	2.1	1.9
Medication for pain relief, constipation, heartburn	2.3	4.0	6.2	1.8	0.1	-2.3	-2.5	-2.5	-1.9	-2.2	-1.4	-2.1	-2.1
Neck or shoulder pain in last month	3.1	4.4	9.7	-2.0	-0.3	2.6	2.4	1.9	2.1	3.1	2.0	1.9	1.6
Medication: Blood pressure	0.2	0.4	1.0	-0.8	0.1	0.8	1.0	0.6	0.7	0.9	-0.1	0.4	0.4
Angina (self-reported)	1.2	1.6	5.5	-2.4	-0.4	1.4	1.3	0.5	0.9	1.7	0.9	1.1	1.0
Migraine (self-reported)	0.8	1.0	2.2	-1.2	-0.6	0.9	0.7	0.6	1.2	0.7	1.5	0.9	1.3
Medication: Ibuprofen	3.2	3.8	5.7	-1.3	0.6	2.1	2.0	2.4	2.1	2.2	2.2	2.2	1.8
Medication: Allopurinol	0.9	1.3	3.1	1.1	-1.8	-1.1	-1.1	-0.7	-1.1	-0.1	-0.9	-1.2	-1.4
Medication: Omeprazole	1.4	1.6	4.6	0.8	-0.5	-1.4	-1.3	-1.6	-1.0	-2.1	-0.9	-1.4	-0.8
Medication: Seretide 50 evohaler	1.8	2.0	3.1	-1.8	-1.6	1.4	1.3	0.8	1.6	1.2	1.8	1.1	1.4
Mean time to correctly identify matches	1.1	2.1	3.6	-1.4	0.2	1.5	1.4	1.2	1.7	1.6	1.9	1.2	1.4
Heart disease (mother)	3.0	3.7	6.6	-1.2	1.6	2.0	2.0	2.6	1.8	1.4	1.8	2.4	2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.2	-1.5	1.0	1.0	1.0	1.1	0.7	1.0	0.5	1.3	0.8
Whole body fat mass	2.2	9.2	15.4	1.9	1.4	-3.5	-3.4	-3.6	-3.1	-3.9	-2.4	-3.3	-2.9
Leg fat mass (right)	2.4	9.5	17.1	2.1	1.5	-3.6	-3.5	-3.4	-3.0	-4.1	-2.3	-3.4	-3.0
Arm predicted mass (right)	3.7	18.8	30.7	3.2	1.6	-4.9	-4.8	-5.1	-3.9	-5.5	-3.4	-5.0	-4.4
Pulse rate, automated reading	2.4	7.6	15.2	-1.6	0.5	2.9	2.9	3.9	2.9	3.1	2.8	3.0	2.6
Alcohol intake frequency.	2.3	5.4	13.3	-0.7	0.5	2.9	3.2	2.7	1.8	3.7	0.8	2.5	2.0
Comparative height size at age 10	0.5	2.6	7.0	0.9	1.1	-1.9	-1.7	-1.6	-1.1	-2.6	-1.0	-1.9	-1.3
Number of full sisters	2.6	3.2	5.1	2.0	1.3	-2.0	-2.0	-1.8	-1.6	-2.3	-1.4	-1.7	-1.4
Suffer from ‘nerves’	1.2	1.8	4.4	-0.6	0.1	1.7	1.7	1.3	1.4	2.1	0.9	1.5	1.0
Overall health rating	0.7	1.5	3.2	0.6	-1.4	-1.0	-0.8	-1.6	-1.5	-0.6	-1.8	-1.3	-1.0
Chest pain or discomfort	2.4	3.4	5.9	-1.4	0.2	2.3	2.4	2.2	2.4	1.6	1.8	1.7	1.5
Had major operations	4.4	5.2	7.2	-2.2	-0.8	2.7	2.6	2.1	2.2	2.6	1.8	2.6	2.5
Age at last live birth	0.5	0.7	2.4	1.5	-0.5	-0.6	-0.6	-0.9	-1.0	0.1	-0.8	-0.9	-0.9
Family relationship satisfaction	3.5	4.4	6.8	1.6	-0.2	-2.2	-2.0	-2.2	-2.5	-2.0	-2.6	-2.2	-2.3
Leg pain on walking	0.2	0.2	0.8	-0.2	-0.2	0.1	0.1	-0.8	-0.3	0.3	-0.9	-0.3	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.7	-1.6	-0.1	1.1	1.0	0.7	0.9	0.6	1.0	1.1	1.1
Commuting to job workplace: Car/motor vehicle	2.9	3.3	5.9	1.9	0.6	-1.8	-1.4	-1.7	-2.0	-1.9	-2.4	-2.0	-1.9
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.1	1.1	-0.9	-0.8	-0.8	-0.7	-0.9	-0.4	-0.6	-0.9	-0.7
Medication: Aspirin	0.9	1.2	4.0	-2.0	-0.3	1.1	1.1	0.9	1.1	0.8	0.8	0.9	1.3
Supplements: Vitamin C	2.7	3.1	7.2	-2.7	0.0	1.9	1.9	1.2	2.1	1.9	1.7	1.4	1.7
Knee pain experienced in last month	1.0	1.5	3.0	1.5	-0.2	-1.4	-1.3	-0.8	-1.1	-1.7	-1.1	-1.2	-1.3
Hypertension (Self-reported)	1.0	2.8	5.3	0.6	0.5	-1.9	-2.0	-2.3	-1.9	-2.1	-1.6	-1.5	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.0	-0.5	1.1	1.1	1.2	1.2	0.8	0.8	0.4	1.4	1.2
Illnesses of father: Heart disease	1.8	2.5	3.3	-1.5	-0.6	1.8	1.7	1.8	1.5	1.7	1.4	1.7	1.6
Illnesses of siblings: Diabetes	0.2	0.3	1.4	0.1	1.2	0.4	0.5	0.4	-0.0	0.1	-0.3	0.5	0.5
Smoking status: Previous	3.5	5.3	8.1	-1.7	0.3	2.8	2.9	2.5	2.8	2.3	2.0	2.3	2.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	1.0	-0.2	0.9	-0.4	-0.1	-0.2	-0.7	-0.5	-1.0	-0.4	-0.3
Whole body fat-free mass	4.0	23.0	41.3	3.3	1.4	-5.5	-5.5	-5.5	-4.3	-6.4	-3.6	-5.6	-4.7
Leg fat-free mass (right)	4.9	26.3	47.3	3.6	1.4	-6.0	-5.9	-5.8	-4.8	-6.9	-3.9	-5.8	-5.0
Arm fat percentage (left)	2.6	10.2	17.9	2.4	1.0	-3.7	-3.6	-3.5	-3.4	-4.2	-2.6	-3.3	-3.0
Average weekly red wine intake	0.5	0.7	3.1	-0.1	0.7	-0.9	-1.0	-0.8	-0.6	-1.7	-0.1	-0.5	-0.3
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.9	-1.2	-1.0	0.7	0.7	-0.2	-0.3	1.4	-1.0	0.3	0.1
Mood swings	0.7	1.3	2.7	-1.0	0.7	1.4	1.4	1.0	0.7	1.6	0.5	1.4	1.0
Loneliness, isolation	2.8	3.9	5.6	1.8	-1.1	-2.1	-2.0	-2.2	-2.3	-1.3	-1.8	-2.3	-2.4
Long-standing illness, disability or infirmity	0.2	0.4	3.2	-0.3	-1.8	0.0	-0.1	-0.1	0.1	0.3	0.2	-0.2	-0.1
Ever had bowel cancer screening	0.2	0.2	0.5	-0.0	0.4	-0.6	-0.5	-0.5	-0.4	-0.7	-0.3	-0.6	-0.6
Diabetes diagnosed by doctor	0.1	0.1	0.4	0.1	0.4	0.1	0.2	-0.1	0.2	-0.6	0.1	0.2	0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	3.3	0.5	1.1	-1.5	-1.2	-0.9	-1.2	-1.8	-1.6	-1.4	-1.3
Friendships satisfaction	2.9	3.5	5.7	1.5	-0.7	-2.0	-2.0	-2.2	-2.4	-1.5	-2.1	-2.0	-1.9
Qualifications: nursing, teaching	0.5	0.8	1.8	0.5	-1.0	-1.1	-1.3	-0.8	-0.8	-0.8	0.1	-0.9	-0.9
Commuting to job workplace: Walk	0.1	0.1	0.5	-0.7	-0.2	0.2	0.1	0.4	0.3	0.4	0.4	0.1	-0.0
Eye problems/disorders: Cataract	1.3	1.5	2.7	-1.5	0.1	1.3	0.8	0.7	1.1	1.6	1.7	1.4	1.3
Mouth/teeth dental problems: Mouth ulcers	3.0	4.7	6.8	-1.8	0.1	2.5	2.6	2.5	2.3	2.1	1.9	2.3	2.4
Medication for cholesterol	0.6	0.9	1.4	-1.2	0.1	1.0	1.0	1.1	1.2	0.7	1.1	0.9	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	5.2	6.2	12.2	2.1	-0.1	-3.0	-2.8	-2.2	-2.5	-3.5	-2.1	-2.7	-2.3
Back pain experienced in last month	0.1	0.2	0.7	0.3	-0.9	0.3	0.3	0.7	0.5	0.2	0.5	0.3	-0.0
Mineral and other dietary supplements	0.4	0.5	1.5	-0.4	-0.7	0.7	0.6	0.7	0.7	0.6	1.2	0.6	0.8
Breast cancer (self-reported)	0.5	0.6	1.2	0.8	-0.2	-1.1	-0.9	-0.3	-0.4	-1.1	-0.7	-1.0	-0.9
Asthma (self-reported)	0.5	1.1	2.8	-1.1	-0.5	0.9	0.9	0.9	1.5	0.4	1.7	0.7	1.1
Osteoporosis (self-reported)	0.4	0.5	3.1	0.4	1.8	-0.5	-0.5	-0.0	0.2	-0.8	0.6	-0.2	0.1
Osteoarthritis (self-reported)	1.0	1.3	2.9	0.8	-0.1	-1.2	-1.0	-1.1	-1.3	-1.1	-1.7	-1.1	-1.2
Medication: Aspirin	0.5	0.7	2.8	-1.7	-0.2	0.7	0.8	0.6	0.8	0.6	0.6	0.6	0.9
Medication: Gliclazide	0.2	0.2	0.5	-0.7	0.6	0.2	0.2	0.2	0.5	-0.2	0.6	0.3	0.7
Illnesses of father: None of the above (group 1)	0.1	0.2	0.7	-0.8	-0.2	0.2	0.1	-0.1	0.2	0.5	0.3	0.4	0.4
Smoking status: Current	0.8	1.3	2.5	1.1	-0.2	-1.1	-1.2	-1.4	-1.1	-1.6	-0.9	-1.3	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	7.6	-0.9	2.8	1.1	1.1	1.9	1.5	0.1	2.1	1.8	2.1
Whole body water mass	4.1	23.2	41.1	3.3	1.4	-5.6	-5.5	-5.5	-4.4	-6.4	-3.6	-5.6	-4.8
Leg predicted mass (right)	4.9	25.9	46.6	3.6	1.4	-5.9	-5.8	-5.8	-4.7	-6.8	-3.8	-5.8	-5.0
Arm fat mass (left)	4.1	16.8	28.6	3.0	1.2	-4.7	-4.6	-4.7	-4.2	-5.3	-3.2	-4.5	-4.0
Number of self-reported non-cancer illnesses	0.0	0.1	0.4	-0.2	-0.6	0.1	0.2	-0.2	0.2	-0.0	-0.3	-0.2	-0.0
Average weekly champagne plus white wine intake	0.2	0.3	0.7	0.2	0.2	-0.6	-0.6	-0.5	-0.6	-0.8	-0.6	-0.1	-0.3
Miserableness	0.2	0.4	1.1	-1.0	0.3	0.7	0.4	-0.3	0.0	1.1	0.6	0.9	0.6
Guilty feelings	0.2	0.3	0.9	-0.7	0.3	0.5	0.5	0.4	0.2	0.9	0.4	0.5	0.4
Wears glasses or contact lenses	1.5	1.7	2.4	-1.4	0.1	1.6	1.5	1.2	1.3	1.3	1.0	1.4	1.5
Ever taken oral contraceptive pill	0.3	0.3	0.9	0.0	0.5	-0.7	-1.0	-0.5	-0.4	-0.7	0.2	-0.2	-0.4
Hearing aid user	0.6	0.7	2.3	0.9	-1.5	-0.6	-1.1	-0.9	-0.4	-0.1	0.5	-0.5	-0.7
Mother’s age at death	0.2	0.3	0.5	-0.5	0.4	0.6	0.7	0.5	0.2	0.5	0.1	0.7	0.6
Financial situation satisfaction	2.0	2.5	3.7	1.1	-0.5	-1.7	-1.7	-1.9	-1.9	-1.5	-1.7	-1.8	-1.4
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.9	-0.5	0.5	0.8	0.9	1.7	1.2	0.6	1.3	0.8	1.0
Commuting to job workplace: Public transport	2.6	3.1	7.8	-1.9	-1.2	1.5	1.1	1.3	2.0	1.6	2.8	1.7	1.9
Eye problems/disorders: Glaucoma	0.5	0.6	1.1	-0.5	-0.7	0.9	0.8	0.5	1.1	0.5	0.8	0.7	0.9
Medication: Blood pressure	0.2	0.4	1.0	-0.0	-0.2	-0.8	-0.9	-1.0	-0.6	-0.8	-0.2	-0.6	-0.4
Pain type(s) experienced in last month: Hip pain	1.4	1.7	2.8	1.6	-1.3	-1.2	-1.1	-1.0	-1.4	-0.8	-1.7	-1.2	-1.6
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.4	-0.1	-0.0	0.2	0.3	-0.1	-0.1	0.5	-0.6	0.1	-0.1
High cholesterol (Self-reported)	0.4	0.6	1.2	0.3	-0.7	1.0	1.1	1.0	0.7	1.0	0.2	0.9	0.6
Medication: Bendroflumethiazide	0.7	1.1	2.0	0.4	0.3	-1.4	-1.2	-0.9	-0.9	-1.4	-0.8	-1.3	-1.1
Medication: Paracetamol	0.7	1.1	3.5	-0.3	-1.2	1.2	1.2	1.2	0.5	1.9	0.4	1.1	0.7
Medication: Lisinopril	0.6	0.8	3.1	0.6	1.8	-0.9	-1.2	-0.6	-1.1	-0.7	-0.3	-0.4	-0.4
Medication: Atorvastatin	0.1	0.1	0.7	0.4	-0.1	0.2	0.2	-0.3	-0.1	0.8	-0.4	-0.2	-0.4
Illnesses of father: High blood pressure	1.0	1.2	1.8	0.9	-0.7	-1.1	-1.2	-1.4	-1.2	-0.9	-1.0	-1.1	-1.3
Alcohol drinker status: Never	3.3	3.9	6.6	-1.4	1.4	2.1	2.3	2.6	1.8	2.4	1.6	2.2	1.8
Ever smoked	1.4	2.4	4.3	-1.4	-0.8	1.8	1.6	1.3	2.1	1.4	1.9	1.4	1.5
Basal metabolic rate	3.9	21.6	39.1	3.1	1.5	-5.4	-5.3	-5.3	-4.3	-6.2	-3.5	-5.4	-4.5
Leg fat percentage (left)	1.2	4.4	6.1	1.4	1.5	-2.3	-2.3	-2.4	-2.5	-2.3	-1.9	-2.1	-2.2
Arm fat-free mass (left)	3.4	17.4	30.7	2.8	1.6	-4.8	-4.8	-4.8	-3.7	-5.5	-2.9	-4.9	-4.2
Number of operations (self-reported)	0.2	0.4	0.9	-0.0	-0.6	0.6	0.9	0.9	0.2	0.6	-0.4	0.5	0.5
Average weekly beer plus cider intake	0.4	0.6	1.6	-1.3	-0.1	0.7	0.9	1.0	0.6	1.0	0.3	0.4	0.3
Irritability	0.1	0.2	0.6	-0.2	0.5	0.3	0.2	0.4	0.1	0.1	0.8	0.7	0.5
Risk taking	0.5	0.7	2.1	0.4	-1.0	-0.3	-0.2	-1.0	-1.0	0.3	-1.5	-0.9	-0.8
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	-0.2	-0.1	0.0	0.2	0.3	0.2	-0.1	0.0	-0.2	-0.1
Fractured/broken bones in last 5 years	0.1	0.2	0.5	-0.4	-0.6	0.1	0.1	-0.7	-0.4	0.6	-0.5	-0.0	-0.2
Age started oral contraceptive pill	0.9	1.1	3.5	-1.4	-0.4	1.0	0.6	0.4	1.1	1.3	1.9	0.9	0.9
Diastolic blood pressure, automated reading	1.5	4.7	9.6	1.2	-0.5	-2.5	-3.0	-3.1	-2.4	-1.6	-1.3	-2.3	-2.4
Ever depressed for a whole week	0.2	0.2	1.1	-0.0	1.1	0.5	0.5	0.0	0.1	0.6	-0.2	0.3	0.3
Unable to work because of sickness or disability	0.7	0.9	3.5	-0.6	-1.9	0.8	0.8	1.0	0.3	1.5	0.4	0.6	0.5
Commuting to job workplace: Cycle	1.0	1.2	2.2	-1.5	1.4	0.7	0.8	1.2	1.3	-0.2	1.0	1.1	1.4
Myopia	1.0	1.4	3.0	-1.3	0.4	1.3	1.1	0.6	0.9	1.7	1.2	1.4	1.3
Vascular/heart problems diagnosed by doctor	0.7	1.8	4.9	-0.1	0.3	1.3	1.5	2.2	1.6	1.4	1.4	1.2	1.1
Cholesterol lowering medication	0.4	0.5	1.2	1.1	-0.6	-0.5	-0.4	-0.5	-0.8	-0.2	-1.1	-0.7	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	3.0	0.4	0.6	-0.9	-0.7	-0.8	-0.4	-1.7	-0.6	-0.8	-0.3
Pain experienced in last month	0.7	1.1	2.0	0.9	0.7	-1.1	-1.3	-1.4	-1.2	-0.9	-0.8	-1.1	-0.8
Supplements: Calcium	0.9	0.9	5.7	-1.1	2.4	0.6	0.8	0.4	0.3	0.3	-0.2	0.7	0.9
Basal cell carcinoma (self-reported)	1.1	1.3	1.8	1.3	1.1	-1.3	-1.3	-1.1	-1.3	-1.0	-0.9	-0.9	-1.1
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.0	-1.0	-1.2	1.3	1.3	0.7	1.2	1.4	0.9	0.6	0.9
Deep venous thrombosis (DVT) (self-reported)	2.2	2.9	6.0	1.6	0.0	-2.1	-2.0	-1.4	-1.6	-2.4	-1.3	-1.9	-1.5
Heart disease (siblings)	0.1	0.2	0.8	0.1	0.9	0.0	0.2	0.3	-0.2	0.5	-0.4	-0.2	-0.4
Alcohol drinker status: Previous	0.4	0.5	1.8	0.9	1.2	-0.1	0.1	-0.3	-0.7	-0.1	-1.3	0.1	-0.1
Pack years of smoking	0.2	0.3	0.9	-0.6	-0.9	0.3	0.5	0.6	-0.0	0.7	-0.4	0.2	-0.4
Impedance of whole body	13.1	66.8	100.0	-7.2	-1.2	9.4	9.2	8.6	7.9	10.0	7.0	9.2	8.4
Leg fat mass (left)	2.6	10.0	16.2	2.1	1.4	-3.6	-3.6	-3.6	-3.2	-4.0	-2.4	-3.5	-3.2
Arm predicted mass (left)	3.6	18.2	31.0	2.9	1.3	-4.9	-4.8	-5.0	-3.9	-5.6	-3.2	-5.0	-4.3