[Hub]/) : Traits : Arm fat-free mass (right) :

chr16:52,772,129-54,846,383

Best TWAS P=3.31e-31 · Best GWAS P=1.43e-111 conditioned to 5.09e-51

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FTO 0.11 0.00 bslmm 739 0.02 1.6e-03 0.35 11.6 3.3e-31 0.38 0.09 0.55 TRUE
2 CommonMind Brain Pre-frontal Cortex RBL2 0.22 0.24 enet 15 0.26 1.8e-31 4.49 -5.9 3.7e-09 0.02 1.00 0.00 FALSE
3 GTEx Adipose Subcutaneous RBL2 0.34 0.28 enet 18 0.30 1.0e-24 4.60 -5.4 6.9e-08 0.02 1.00 0.00 FALSE
4 GTEx Artery Tibial RBL2 0.16 0.17 enet 11 0.20 2.1e-15 4.63 -5.8 6.7e-09 0.02 1.00 0.00 FALSE
5 GTEx Brain Cortex RBL2 0.51 0.45 enet 12 0.46 3.5e-14 4.03 -5.9 4.5e-09 0.02 1.00 0.00 FALSE
6 GTEx Colon Sigmoid RBL2 0.38 0.37 lasso 12 0.29 8.4e-11 4.60 -5.4 7.8e-08 0.03 1.00 0.00 FALSE
7 GTEx Esophagus Mucosa RBL2 0.36 0.36 enet 37 0.37 2.9e-26 4.60 -5.4 8.4e-08 0.00 1.00 0.00 FALSE
8 GTEx Muscle Skeletal RBL2 0.11 0.00 lasso 5 0.00 2.9e-01 6.57 -9.0 1.8e-19 -0.10 0.28 0.23 FALSE
9 GTEx Spleen RBL2 0.59 0.47 enet 51 0.46 3.2e-13 4.64 -6.1 1.3e-09 -0.06 1.00 0.00 FALSE
10 GTEx Testis AKTIP 0.19 0.00 enet 26 0.00 1.9e-01 4.03 11.3 1.2e-29 0.51 0.03 0.40 TRUE
11 GTEx Vagina RBL2 0.41 0.37 enet 13 0.34 1.6e-08 4.93 -5.2 2.4e-07 0.03 0.89 0.01 FALSE
12 YFS Blood AKTIP 0.19 0.27 lasso 13 0.30 3.3e-99 7.44 6.5 8.3e-11 -0.01 1.00 0.00 FALSE
13 The Cancer Genome Atlas Esophageal Carcinoma RBL2 0.08 0.04 lasso 3 0.03 4.4e-02 7.44 5.7 1.6e-08 0.00 0.01 0.82 FALSE
14 The Cancer Genome Atlas Glioblastoma Multiforme FTO 0.27 0.16 enet 13 0.14 6.7e-05 -2.63 9.0 2.6e-19 0.33 0.11 0.32 TRUE
15 The Cancer Genome Atlas Brain Lower Grade Glioma RBL2 0.03 0.06 enet 5 0.05 8.2e-07 4.03 -5.2 2.2e-07 0.04 0.83 0.17 FALSE
16 The Cancer Genome Atlas Pancreatic Adenocarcinoma RBL2 0.11 0.08 blup 44 0.06 1.5e-03 6.59 -6.5 1.1e-10 -0.03 0.01 0.78 FALSE