Best TWAS P=5.65e-20 · Best GWAS P=2.04e-21 conditioned to 0.0157
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ECE2 | 0.24 | 0.20 | bslmm | 542 | 0.19 | 1.6e-22 | 7.1 | 6.7 | 1.6e-11 | -0.37 | 1.00 | 0.00 | FALSE |
2 | GTEx | Artery Tibial | PSMD2 | 0.13 | 0.09 | lasso | 5 | 0.08 | 1.3e-06 | -5.6 | 5.8 | 6.5e-09 | -0.42 | 0.88 | 0.02 | FALSE |
3 | GTEx | Brain Putamen basal ganglia | ECE2 | 0.38 | 0.03 | enet | 22 | 0.11 | 1.4e-03 | 7.1 | 5.8 | 7.0e-09 | -0.28 | 0.08 | 0.16 | FALSE |
4 | GTEx | Pituitary | ECE2 | 0.52 | 0.30 | lasso | 7 | 0.23 | 1.5e-06 | 7.1 | 6.1 | 9.6e-10 | -0.31 | 0.39 | 0.23 | FALSE |
5 | GTEx | Skin Sun Exposed Lower leg | ABCF3 | 0.13 | 0.08 | lasso | 4 | 0.11 | 1.6e-09 | 5.2 | 6.2 | 4.9e-10 | -0.36 | 0.98 | 0.01 | FALSE |
6 | GTEx | Skin Sun Exposed Lower leg | PSMD2 | 0.13 | 0.14 | lasso | 4 | 0.15 | 1.4e-12 | -5.6 | 5.8 | 8.8e-09 | -0.39 | 1.00 | 0.00 | FALSE |
7 | YFS | Blood | PSMD2 | 0.26 | 0.22 | lasso | 5 | 0.24 | 2.4e-77 | -5.5 | 5.2 | 1.9e-07 | -0.39 | 1.00 | 0.00 | FALSE |
8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PSMD2 | 0.03 | 0.03 | blup | 50 | 0.03 | 4.8e-06 | -5.6 | 5.4 | 8.1e-08 | -0.48 | 0.66 | 0.27 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ECE2 | 0.04 | 0.02 | blup | 61 | 0.03 | 3.5e-04 | 7.1 | 6.6 | 3.7e-11 | -0.24 | 0.54 | 0.02 | FALSE |
10 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ABCF3 | 0.08 | 0.03 | blup | 51 | 0.06 | 6.1e-04 | 2.7 | 5.1 | 2.7e-07 | -0.25 | 0.02 | 0.64 | TRUE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | PSMD2 | 0.09 | 0.02 | blup | 50 | 0.05 | 1.2e-06 | -8.6 | 9.2 | 5.6e-20 | -0.73 | 0.03 | 0.84 | TRUE |
12 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PSMD2 | 0.05 | 0.00 | enet | 10 | 0.01 | 3.6e-02 | 7.1 | 6.1 | 1.1e-09 | -0.49 | 0.01 | 0.10 | FALSE |
13 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | VWA5B2 | 0.10 | 0.04 | blup | 51 | 0.04 | 1.8e-02 | 5.2 | -7.5 | 5.2e-14 | 0.43 | 0.03 | 0.33 | FALSE |