TWAS
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Traits
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Traits
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Arm fat-free mass (right)
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chr4:57,080,198-58,522,810
Best TWAS P=7.69e-09 · Best GWAS P=2.56e-08 conditioned to 1
57M
57.2M
57.4M
57.6M
57.8M
58M
58.2M
58.4M
58.6M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
METSIM
Adipose
RP11-738E22.3
0.07
0.04
lasso
6
0.05
7.7e-08
-5.6
5.8
7.7e-09
-0.98
0.01
0.99
TRUE
2
ROSMAP
Brain Pre-frontal Cortex
REST
0.04
0.02
bslmm
536
0.02
3.4e-03
-5.4
-5.7
9.2e-09
0.58
0.02
0.94
FALSE
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
REST
0.04
0.01
lasso
5
0.02
7.8e-04
-5.6
-5.6
1.8e-08
0.86
0.01
0.96
FALSE