TWAS hub - REST

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1270	0.0410	0.00014	0.036	NA	0.035	NA	0.035	0.00110	NA	0.00110	NA	1.2e-03
2	GTEx	Colon Transverse	0.2590	0.0720	0.00015	0.045	NA	0.059	NA	0.099	0.00330	NA	0.00085	NA	1.9e-05
3	GTEx	Muscle Skeletal	0.0532	0.0236	0.00870	0.014	NA	0.020	NA	0.016	0.01400	NA	0.00390	NA	8.6e-03
4	GTEx	Testis	0.1530	0.0520	0.00054	0.082	NA	0.039	NA	0.031	0.00017	NA	0.00740	NA	1.5e-02
5	ROSMAP	Brain Pre-frontal Cortex	0.0443	0.0189	0.00880	0.016	0.015	0.011	0.016	0.014	0.00340	0.0043	0.01100	0.0034	5.3e-03
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0385	0.0220	0.00100	0.012	0.021	0.019	NA	0.025	0.01300	0.0019	0.00280	NA	7.8e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Ever smoked	9.7	17.1	24.7	-1.7	-3.1	-5.0	-4.9	-4.7	-4.4
Forced expiratory volume in 1-second (FEV1)	9.2	31.2	47.1	-3.6	-6.2	-6.7	-5.3	-4.0	-6.9
Past tobacco smoking	8.5	15.6	30.6	2.0	2.4	4.9	5.5	3.7	3.8
Forced expiratory volume in 1-second (FEV1), Best measure	7.6	24.2	34.6	-4.0	-5.3	-5.6	-5.1	-3.1	-5.9
Blood White Count	6.8	50.2	89.5	5.2	9.5	7.9	4.9	4.3	9.0
Peak expiratory flow (PEF)	6.8	15.7	25.4	-2.2	-4.4	-4.6	-3.6	-3.2	-5.0
Heel T-Score	6.6	52.8	79.9	4.6	6.4	8.5	7.2	7.2	8.9
Forced vital capacity (FVC)	6.3	24.2	37.7	-2.8	-5.4	-6.0	-4.7	-3.6	-6.1
Respiratory disease	6.2	13.7	22.4	4.0	3.6	4.7	4.0	1.8	3.5
Heel bone mineral density (BMD) T-score, automated (left)	6.2	14.1	23.7	2.1	2.5	4.6	3.8	3.8	4.9
Primary Biliary Cirrhosis	6.1	8.6	11.7	-2.1	-2.8	-3.3	-3.0	-2.9	-3.4
Headache pain in last month	6.1	10.5	17.8	4.2	2.8	4.1	2.6	2.3	2.9
Heel bone mineral density (BMD) T-score, automated (right)	6.0	13.7	22.4	2.2	2.5	4.7	4.1	3.5	4.5
Forced vital capacity (FVC), Best measure	5.8	21.1	31.1	-3.5	-5.1	-5.2	-4.7	-3.0	-5.6
Blood Platelet Count	5.6	64.8	127.7	4.9	10.4	8.2	4.2	6.7	11.3
Medication: Ibuprofen	5.5	6.5	10.4	2.3	2.6	3.2	2.0	2.7	2.3
Smoking status: Previous	5.5	8.2	18.9	-1.6	-1.7	-3.6	-4.3	-2.1	-2.7
Had other major operations	5.2	6.3	12.2	-1.0	-3.2	-2.3	-1.8	-2.4	-3.5
Tinnitus: Yes, now most or all of the time	5.2	6.0	11.8	-1.1	-2.7	-3.0	-3.4	0.1	-2.5
Alcohol intake frequency.	5.1	11.9	22.7	3.5	1.9	4.1	4.8	2.5	3.2
Blood Eosinophil Count	4.8	36.8	56.2	5.3	7.5	6.2	5.2	3.9	7.5
Hearing difficulty/problems with background noise	4.8	7.6	12.2	-1.2	-1.3	-3.2	-3.5	-3.3	-3.0
Father’s age at death	4.8	6.4	9.5	2.2	2.6	3.1	2.3	1.9	2.9
Hearing difficulty/problems: Yes	4.5	6.8	12.5	-2.4	-0.4	-3.2	-3.5	-2.5	-2.5
Trunk fat-free mass	4.4	25.1	43.4	-2.8	-4.7	-5.1	-4.6	-5.5	-6.6
Trunk predicted mass	4.3	24.3	41.9	-2.8	-4.7	-5.0	-4.4	-5.5	-6.5
Mean time to correctly identify matches	4.3	8.2	12.4	2.7	2.5	3.2	3.0	1.9	3.5
Arm fat-free mass (right)	4.2	21.4	33.0	-2.6	-4.3	-4.6	-4.2	-5.7	-5.6
Smoking Status	4.1	9.8	17.4	-1.5	-2.1	-4.1	-4.2	-3.0	-2.9
Arm predicted mass (right)	4.1	21.0	32.4	-2.4	-4.4	-4.5	-4.1	-5.7	-5.6
Reaction Time	4.0	7.6	11.3	2.4	2.5	3.3	3.2	1.1	3.4
Height	4.0	76.4	171.6	-4.4	-11.3	-8.8	-4.6	-6.5	-13.1
Medication: Ibuprofen (e.g. Nurofen)	3.9	4.9	8.5	2.4	2.2	2.9	1.8	2.1	1.7
Had major operations	3.9	4.6	10.0	-3.2	-1.6	-2.6	-2.1	-1.0	-1.8
Arm predicted mass (left)	3.9	19.6	30.1	-2.5	-4.3	-4.4	-4.1	-5.1	-5.5
Medication: Paracetamol	3.8	6.3	10.3	2.6	2.1	3.2	2.6	1.2	2.8
Average weekly red wine intake	3.8	5.6	11.5	-2.6	-2.0	-2.4	-3.4	-1.1	-2.3
Lung FEV1/FVC ratio	3.7	18.6	25.7	-4.0	-4.0	-5.1	-4.5	-3.1	-4.8
Intelligence (Savage-Jansen 2018)	3.6	11.0	22.1	-1.3	-3.5	-3.3	-3.1	-3.0	-4.7
Whole body fat-free mass	3.6	20.8	34.9	-2.4	-4.5	-4.5	-3.9	-5.3	-5.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.6	7.7	14.7	-2.9	-1.2	-3.6	-3.8	-1.3	-2.7
Whole body water mass	3.6	20.4	34.5	-2.4	-4.4	-4.5	-3.9	-5.2	-5.9
Standing height	3.5	35.1	82.6	-2.2	-7.7	-5.8	-3.6	-4.2	-9.1
Osteoporosis (self-reported)	3.5	4.3	6.4	-1.7	-2.5	-2.2	-2.2	-1.9	-1.8
Lung FVC	3.4	17.1	29.5	-3.8	-3.5	-5.1	-5.4	-2.5	-3.8
Arm fat-free mass (left)	3.4	17.4	27.8	-2.3	-4.1	-4.1	-3.7	-4.9	-5.3
Basal metabolic rate	3.2	17.5	28.6	-2.3	-4.4	-4.2	-3.5	-4.7	-5.3
Number of operations (self-reported)	3.2	4.7	7.8	-2.0	-2.8	-2.3	-1.4	-1.1	-2.8
Heart attack	3.0	3.8	6.1	-1.1	-2.5	-1.9	-1.3	-2.2	-2.3
Medication: Blood pressure	3.0	5.8	7.7	-2.4	-1.3	-2.4	-2.7	-2.6	-2.8
Illnesses of father: Heart disease	2.9	4.0	6.5	-1.1	-2.1	-2.5	-1.3	-2.0	-2.5
Fractured/broken bones in last 5 years	2.9	3.8	6.8	-1.2	-2.6	-2.2	-1.9	-1.2	-2.2
Medication: Aspirin	2.8	3.6	6.7	-1.4	-0.9	-1.8	-1.6	-2.5	-2.6
Vascular/heart problems diagnosed by doctor	2.8	7.7	19.0	1.9	0.8	2.8	2.8	4.4	2.7
Risk taking	2.7	3.9	6.0	-2.1	-1.3	-2.0	-2.4	-2.3	-1.5
Unable to work because of sickness or disability	2.7	3.5	7.0	-1.2	-2.7	-1.8	-1.2	-1.7	-2.2
Heart attack/myocardial infarction (self-reported)	2.7	3.4	6.0	-1.2	-2.4	-1.7	-1.2	-2.0	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.3	5.3	-1.5	-1.6	-2.1	-2.3	-1.3	-1.9
Health satisfaction	2.6	3.4	4.2	1.6	2.0	2.0	1.4	1.9	2.1
Medication: Co-codamol	2.5	2.9	3.8	1.4	1.9	1.8	1.4	1.6	1.9
Financial difficulties in last 2 years	2.5	3.3	5.4	-0.8	-2.3	-2.3	-1.6	-0.9	-2.3
Asthma	2.5	5.0	9.1	1.9	2.4	3.0	2.3	1.3	2.1
Leg fat-free mass (right)	2.5	13.4	22.4	-1.9	-4.0	-3.4	-2.6	-4.5	-4.7
Eye problems/disorders: Cataract	2.5	2.9	4.3	-1.5	-2.0	-2.1	-1.9	-0.7	-1.6
Medication: Aspirin	2.5	3.3	6.0	-1.6	-0.8	-1.8	-1.8	-2.0	-2.4
Leg predicted mass (right)	2.5	13.3	21.7	-1.9	-4.0	-3.4	-2.5	-4.5	-4.7
Leg fat-free mass (left)	2.4	12.5	20.9	-1.9	-3.9	-3.4	-2.7	-4.1	-4.6
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.6	4.2	-1.2	-2.1	-1.8	-1.3	-1.4	-1.7
Asthma (self-reported)	2.4	4.8	8.7	2.0	2.5	3.0	2.0	1.3	2.1
Coronary Artery Disease (CAD)	2.3	2.7	5.9	-1.7	-1.7	-1.4	-1.1	-1.3	-2.4
Leg predicted mass (left)	2.3	12.1	20.0	-1.8	-3.8	-3.3	-2.6	-4.1	-4.5
High blood pressure (siblings)	2.3	3.2	6.1	-1.6	-1.3	-2.1	-2.5	-0.9	-1.9
Medication for pain relief, constipation, heartburn	2.3	3.9	8.1	-1.7	-2.2	-2.8	-2.1	-0.7	-1.8
Friendships satisfaction	2.3	2.8	6.5	-1.9	-0.9	-2.0	-2.5	-0.3	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	3.7	1.2	1.6	1.9	1.9	1.2	1.9
Commuting to job workplace: Cycle	2.3	2.8	9.7	-2.2	0.5	-1.2	-3.1	0.5	-0.8
Pulse rate	2.2	3.6	6.4	1.8	0.9	2.2	2.4	0.8	2.5
Chronic bronchitis/emphysema (mother)	2.2	2.5	4.0	1.5	1.4	1.6	1.1	1.8	2.0
Mouth/teeth dental problems: Mouth ulcers	2.2	3.5	8.2	0.8	-2.9	-1.0	0.2	-2.3	-2.4
Alzheimer’s Disease (in mother)	2.1	2.5	5.5	-0.8	-0.4	-1.9	-2.4	-1.1	-1.9
Age when periods started (menarche)	2.1	5.0	7.3	-1.7	-1.9	-2.4	-2.4	-2.1	-2.7
Impedance of arm (right)	2.1	9.8	33.1	1.9	-0.3	2.4	3.6	5.8	1.8
Impedance of arm (left)	2.1	9.7	28.7	1.9	-0.1	2.7	3.8	5.4	2.0
Medication for cholesterol, blood pressure or diabetes	2.1	3.5	8.0	1.6	0.5	2.1	2.1	2.8	1.2
Pain all over the body in last month	2.0	2.2	4.4	2.1	0.7	1.4	2.1	-0.7	1.1
Alcohol drinker status: Never	2.0	2.4	4.3	1.4	-0.2	2.1	1.9	1.8	1.1
Verbal and Numeric Reasoning (VNR)	1.9	4.6	9.2	-1.2	-2.6	-1.7	-1.6	-2.2	-3.0
High blood pressure	1.9	5.2	12.7	-1.7	0.1	-2.5	-2.5	-3.6	-1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	5.9	-0.8	-1.7	-1.9	-1.7	-1.1	-2.4
Average weekly beer plus cider intake	1.9	2.7	4.3	-2.1	-1.4	-1.9	-2.1	-0.8	-1.2
Impedance of whole body	1.9	9.7	29.3	1.9	0.1	2.7	3.5	5.4	2.3
Allergy	1.8	4.1	9.7	-2.4	-1.4	-2.3	-3.1	-0.4	-1.2
Loud music exposure frequency	1.8	2.0	4.3	-1.2	0.7	-1.9	-2.1	-0.5	-1.2
Medication: Cholesterol lowering	1.7	2.7	4.2	-1.8	-0.9	-2.1	-1.4	-2.0	-1.3
Medication: Ventolin 100micrograms inhaler	1.7	2.2	4.2	2.1	0.7	1.8	1.8	1.1	1.1
Medication: Paracetamol	1.7	2.6	5.2	1.0	1.6	2.2	1.3	0.7	2.3
Schizophrenia vs Biploar Disorder	1.6	2.1	4.5	0.3	-1.5	-1.4	-0.9	-2.1	-1.7
Alzheimer’s Disease (including proxy)	1.6	2.4	6.2	-1.3	-0.3	-2.2	-2.5	0.1	-1.0
Mean Putamen Volume	1.6	1.8	3.0	-1.6	-0.5	-1.5	-1.7	-1.2	-1.1
Weight	1.6	7.8	14.6	-1.6	-3.8	-2.7	-2.2	-2.4	-3.4
Comparative height size at age 10	1.6	8.6	23.7	-0.8	-4.4	-2.6	-0.1	-1.3	-4.9
Hypertension (Self-reported)	1.6	4.6	11.0	-1.7	-0.1	-2.4	-2.4	-3.3	-1.5
Osteoarthritis (self-reported)	1.6	2.1	7.6	0.1	1.3	0.7	1.0	2.8	1.4
Sitting height	1.5	10.5	24.7	-0.3	-4.9	-2.5	-1.1	-2.6	-5.0
Medication: Ramipril	1.5	2.0	5.0	-1.1	-1.0	-1.1	-1.3	-2.2	-1.3
Time employed in main current job	1.5	1.8	3.1	1.5	1.2	1.6	1.8	0.4	1.0
Breastfed as a baby	1.5	1.8	4.2	-1.1	0.1	-2.1	-1.9	-0.8	-1.1
Worry too long after embarrassment	1.5	2.5	4.5	0.8	-0.4	-1.8	-1.5	-2.1	-2.0
Handedness (chirality/laterality): Left-handed	1.5	1.8	2.4	1.2	1.3	1.6	1.2	1.3	1.4
Alcohol drinker status: Previous	1.5	1.7	4.9	0.8	0.7	1.7	2.2	-0.3	1.1
Suffer from ‘nerves’	1.4	2.3	4.9	1.5	2.2	1.2	2.1	-0.2	0.8
Medication for cholesterol	1.4	2.1	4.0	1.4	0.1	1.4	2.0	1.5	1.5
Irritability	1.4	2.3	6.0	-1.2	-0.8	-1.6	-1.2	-2.5	-1.3
Myopia	1.4	2.0	3.9	1.8	0.7	1.7	2.0	1.0	0.8
Depression (Nagel 2018)	1.3	2.0	4.6	-0.8	-1.5	-1.6	-2.1	-0.6	-1.4
Frequency of depressed mood in last 2 weeks	1.3	1.8	2.9	-0.0	-0.9	-1.6	-1.6	-1.3	-1.7
Angina	1.3	1.7	3.8	0.6	-1.9	-0.8	0.5	-1.4	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	3.2	-0.6	-1.5	-1.6	-1.8	-0.7	-1.3
Exposure to tobacco smoke at home	1.3	1.5	2.7	-1.6	-0.5	-1.6	-1.2	-0.4	-1.3
Eye problems/disorders: None of the above	1.3	1.5	2.4	0.7	1.4	1.6	1.4	0.4	1.5
Mouth/teeth dental problems: Loose teeth	1.3	1.6	3.0	0.4	1.1	1.3	1.0	1.7	1.6
Angina (self-reported)	1.3	1.7	4.0	0.7	-1.9	-0.9	0.4	-1.1	-2.0
Average weekly champagne plus white wine intake	1.3	1.8	3.8	-1.9	-0.2	-1.7	-1.7	-0.6	-1.0
Heart disease (siblings)	1.3	1.7	5.1	-0.4	-0.3	-1.5	-1.4	-0.6	-2.2
Major Depression (MDD)	1.2	1.4	3.9	-0.5	-2.0	-1.1	-0.6	-1.6	-0.5
Ovarian Cancer	1.2	1.5	3.1	-1.8	-0.7	-1.4	-1.3	-1.2	-0.8
Bipolar Disorder (2011)	1.2	1.2	5.0	-0.3	0.1	0.8	0.8	2.2	0.9
Hair/balding pattern: Pattern 2	1.2	1.5	2.9	-1.0	-1.5	-1.7	-1.0	-0.1	-1.3
Gout (self-reported)	1.2	1.6	4.0	-1.5	0.2	-1.3	-2.0	-0.5	-1.1
Medication: Blood pressure	1.2	2.1	5.0	-1.1	-0.1	-1.6	-1.7	-2.2	-0.9
Leg pain on walking	1.2	1.5	3.8	-0.0	1.9	0.4	0.4	1.0	2.0
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	6.8	-0.5	-2.6	-1.7	-1.3	0.1	-1.8
Neuroticism (2016)	1.1	1.6	4.8	0.0	-1.7	-0.9	0.1	-2.2	-1.2
Rheumatoid Arthritis	1.1	1.5	7.6	0.2	-2.8	-0.6	0.6	-0.3	-0.9
Waist Hip Ratio (WHR)	1.1	4.8	8.6	-1.6	-2.0	-2.5	-1.2	-2.5	-2.9
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	3.1	-1.1	-1.8	-0.8	-0.5	-0.8	-1.7
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	4.6	-0.8	-1.1	-0.8	-0.5	-2.2	-1.7
Medication: Allopurinol	1.1	1.4	2.8	-1.7	-0.5	-1.1	-1.2	-1.0	-1.3
Pulse rate, automated reading	1.1	3.4	7.7	1.6	1.5	2.3	1.5	0.1	2.8
Hand grip strength (left)	1.0	2.7	4.1	-0.4	-1.9	-2.0	-1.8	-1.4	-1.7
Chronic bronchitis/emphysema (father)	1.0	1.2	2.8	0.6	1.1	1.4	0.1	0.9	1.7
Medication: Simvastatin	1.0	1.4	2.9	-1.5	0.3	-1.7	-1.3	-1.1	-0.4
Fluid intelligence score	1.0	2.1	3.6	-1.2	-1.3	-0.9	-1.5	-1.9	-1.7
Illnesses of mother	1.0	1.2	3.2	0.7	-0.6	0.9	1.8	0.6	1.6
Pulse wave reflection index	1.0	1.2	3.7	1.4	1.9	1.1	0.4	0.5	0.4
Pulse wave peak to peak time	1.0	1.1	2.3	-1.0	-1.5	-1.1	-0.5	-0.3	-1.4
Ever had prostate specific antigen (PSA) test	1.0	1.1	1.7	-1.3	0.1	-1.2	-1.2	-1.0	-0.9
Relative age of first facial hair	0.9	1.9	5.4	-1.5	2.3	0.2	-1.3	0.3	1.5
Medication for hormone replacement therapy	0.9	1.0	2.8	0.4	1.7	1.4	0.6	-0.6	0.6
Hand grip strength (right)	0.9	2.3	4.5	0.3	-1.7	-1.7	-2.1	-1.1	-1.6
Average weekly fortified wine intake	0.9	1.0	2.2	-0.9	-1.5	-0.2	-1.2	-1.0	-0.8
Illnesses of siblings	0.9	1.3	2.0	1.1	0.8	1.4	1.3	0.6	1.4
Number of live births	0.9	1.3	2.3	0.4	-0.4	-1.4	-1.5	-1.2	-1.4
Neck or shoulder pain in last month	0.9	1.3	2.5	1.4	1.0	1.4	1.6	0.6	0.5
Commuting to job workplace: Car/motor vehicle	0.9	1.0	3.1	-1.1	-0.7	-0.9	-0.6	-0.2	-1.8
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.0	-0.4	0.8	1.3	0.8	0.8	1.7
Long-standing illness, disability or infirmity	0.9	1.4	3.2	1.4	0.7	1.3	1.8	0.1	1.1
Back pain experienced in last month	0.9	1.3	2.1	-0.6	-1.4	-1.2	-0.8	-1.1	-1.5
Alzheimer’s Disease (in father)	0.8	0.9	1.7	-1.2	0.2	-1.3	-1.3	0.5	-0.1
Crohns Disease (2017)	0.8	1.8	5.4	-0.3	-1.3	-1.5	-0.6	-1.0	-2.3
Breast Cancer	0.8	1.9	4.5	-0.4	1.6	-0.4	-1.7	2.1	1.1
Ulcerative Colitis	0.8	1.1	4.7	-0.0	-1.1	-0.0	0.3	-2.2	-0.9
Qualifications: CSEs or equivalent	0.8	1.0	3.4	-0.5	-0.0	1.2	1.8	-0.6	1.0
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	1.6	0.9	-0.9	-1.3	-1.1	0.0	-1.1
Diabetes (self-reported)	0.8	1.3	3.2	-1.0	1.2	0.7	0.3	1.2	1.8
Emphysema/chronic bronchitis	0.8	0.9	2.5	0.4	1.0	1.6	0.6	0.6	1.0
Family relationship satisfaction	0.8	0.9	2.6	-0.9	-1.6	-0.6	-0.7	-0.9	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.9	-0.0	-1.7	-1.1	-1.2	0.3	-0.3
Commuting to job workplace: Walk	0.8	0.9	1.5	-0.5	-1.1	-1.0	-1.2	-1.1	-0.0
Medication: Gliclazide	0.8	0.9	1.6	-0.6	1.3	0.6	1.0	-0.6	1.3
Hearing aid user	0.8	0.9	2.4	-1.2	-0.9	-1.5	-0.8	0.2	-0.4
Commuting to job workplace: Public transport	0.8	0.9	1.6	0.8	0.9	1.1	1.3	0.1	1.1
Irritable Bowel Disease (IBD)	0.7	1.7	4.5	0.6	-1.4	-0.6	0.3	-1.7	-2.1
Ulcerative Colitis (UC)	0.7	1.3	2.2	1.5	-0.7	0.8	1.4	-1.3	-0.8
HbA1C	0.7	0.8	2.8	0.1	-1.7	-0.2	0.4	-0.5	-1.3
Type 2 Diabetes (T2D) (2018)	0.7	1.2	3.0	-1.5	-0.4	-1.4	-1.7	0.4	-0.2
Chronotype (morning person)	0.7	1.7	3.8	0.0	1.9	1.3	0.8	1.6	1.1
Hair Pigment	0.7	20.7	33.2	-3.9	-3.7	-5.5	-4.8	-3.2	-5.8
Supplements: Glucosamine	0.7	0.9	1.8	-0.4	-0.1	-1.2	-1.4	-0.3	-1.3
Impedance of leg (left)	0.7	3.2	11.5	1.3	-0.4	1.2	1.6	3.4	1.2
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	3.6	0.3	-0.8	1.0	1.9	-0.3	-0.2
Qualifications: A levels/AS levels or equivalent	0.7	1.5	5.3	-1.1	-2.3	-0.6	-1.1	-0.3	-0.9
Medication: Lansoprazole	0.7	0.9	2.1	-0.4	-1.4	-0.9	-0.6	-1.0	-0.8
Pulse wave Arterial Stiffness index	0.7	0.8	1.6	0.9	1.3	1.0	0.4	0.1	0.9
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	3.5	-0.3	-0.6	-0.6	-0.7	-1.9	-1.5
Wheeze or whistling in the chest in last year	0.7	1.2	2.5	1.6	0.7	1.2	1.6	0.2	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.9	0.8	0.4	1.0	0.7	1.4	0.8
Diabetes diagnosed by doctor	0.7	1.1	2.4	-0.5	1.3	0.4	-0.1	1.5	1.5
Illnesses of father: None of the above (group 1)	0.7	0.8	1.4	0.3	-0.9	1.1	1.2	1.1	0.6
Number of self-reported non-cancer illnesses	0.7	1.2	2.8	-0.1	-0.9	-0.6	-0.6	-1.7	-1.6
Supplements: Calcium	0.7	0.8	1.7	0.1	-0.9	-0.8	-0.7	-0.9	-1.3
Crohns Disease (2012)	0.6	1.0	2.6	-0.4	-0.8	-1.1	-0.0	-1.1	-1.6
Fasting Glucose	0.6	0.7	1.5	-1.2	-1.1	-0.1	-0.8	-0.4	-0.9
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.4	-0.1	-1.2	-0.9	-1.1	-0.0	-0.8
Neuroticism	0.6	1.4	3.1	0.3	-0.0	-1.6	-1.0	-1.8	-1.3
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.8	0.8	-0.3	-0.9	-1.3	-0.1	-1.2
Impedance of leg (right)	0.6	3.0	12.9	1.3	-0.4	1.0	1.3	3.6	0.9
Trunk fat percentage	0.6	2.5	6.7	0.8	-0.8	1.2	1.6	2.6	1.7
Taking other prescription medications	0.6	0.9	1.7	-0.9	-1.2	-1.1	-0.7	-0.3	-1.3
Medication: Levothyroxine sodium	0.6	1.0	1.8	1.3	1.2	1.0	0.5	-1.1	0.7
Worrier / anxious feelings	0.6	1.2	3.1	1.2	1.1	0.8	1.8	-0.8	0.4
Birth weight of first child	0.6	1.2	2.0	1.0	1.2	1.4	1.4	0.1	0.8
Body fat percentage	0.6	2.2	5.1	0.8	-0.4	1.1	1.4	2.2	2.0
Qualifications: College or University degree	0.6	1.9	3.6	-1.5	-1.4	-1.2	-1.9	-0.9	-1.0
Migraine (self-reported)	0.6	0.8	2.9	1.7	1.0	0.6	-0.4	0.0	-0.2
Illnesses of siblings: Diabetes	0.6	0.7	1.2	0.1	0.7	1.0	1.1	0.8	0.9
Breast cancer (self-reported)	0.6	0.7	1.5	-0.8	-1.2	-0.7	-0.4	-0.7	-0.8
Medication: Bendroflumethiazide	0.6	0.9	3.0	-0.7	0.4	-0.8	-0.8	-1.7	-0.6
Diastolic blood pressure, automated reading	0.6	1.8	3.5	-1.5	-0.7	-1.2	-1.7	-1.9	0.4
Pain experienced in last month	0.6	1.0	3.5	-1.9	-0.9	-0.5	-1.1	0.0	0.0
Worry (Nagel 2018)	0.5	1.1	2.6	1.6	1.0	0.5	1.5	-0.2	0.4
Body Mass Index (BMI) (2010)	0.5	0.7	1.3	-0.8	-0.5	-0.9	-1.1	-0.7	-0.9
Blood Red Count	0.5	4.9	8.1	2.4	2.3	2.8	2.2	-0.6	2.3
Average weekly spirits intake	0.5	0.6	1.6	-1.1	1.3	-0.2	-0.4	-0.7	0.2
Ever had hysterectomy (womb removed)	0.5	0.6	2.0	0.1	1.4	-0.4	-0.9	0.5	-0.3
Diabetes (father)	0.5	0.6	1.2	-0.3	0.5	1.1	0.9	0.6	0.9
Current tobacco smoking	0.5	0.8	3.2	0.7	-0.6	-0.6	0.5	-1.8	0.2
Fed-up feelings	0.5	1.0	4.2	1.1	2.0	0.3	-0.1	-0.3	0.6
Relative age voice broke	0.5	0.8	2.5	-0.8	1.6	0.0	-0.8	-0.6	0.5
Hayfever, allergic rhinitis or eczema	0.5	1.1	3.6	1.3	0.4	0.8	1.9	-0.5	-0.1
High blood pressure (mother)	0.5	0.7	2.1	-0.5	1.4	-0.2	-1.0	-0.8	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.0	0.4	-1.0	-0.7	-0.7	-0.3	-0.9
Hair/balding pattern: Pattern 4	0.5	1.1	4.5	-0.7	-0.6	-0.8	-0.7	-0.4	-2.1
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.7	-0.1	-1.2	-0.7	0.5	-1.3	0.1
Blood clot in the leg (DVT)	0.5	0.7	2.0	0.8	-0.4	0.6	1.4	0.9	-0.1
Leg fat percentage (right)	0.5	1.7	5.0	0.7	0.1	1.0	0.5	2.0	2.2
Arm fat percentage (left)	0.5	1.8	4.2	0.3	-0.3	1.0	1.1	2.1	2.0
Ever taken oral contraceptive pill	0.5	0.6	1.7	-0.1	0.2	-1.3	-1.2	-0.6	-0.3
Eye problems/disorders: Glaucoma	0.5	0.6	1.3	-1.1	0.1	-1.1	-0.9	0.1	-0.2
Medication: Atorvastatin	0.5	0.7	2.5	0.1	-0.2	1.1	1.6	0.1	0.5
Leg fat percentage (left)	0.5	1.7	5.4	0.6	0.0	1.1	0.6	1.7	2.3
Ever depressed for a whole week	0.5	0.6	1.5	0.1	-0.3	-1.2	-1.0	-0.2	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.0	-0.5	1.4	0.3	0.2	0.9	0.8
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.8	0.7	-0.1	0.7	1.7	0.7	-0.1
Depressed Affect (Nagel 2018)	0.4	0.8	1.9	-0.1	0.1	-1.2	-1.4	-0.8	-1.0
Neuroticism (Nagel 2018)	0.4	0.9	1.9	0.5	-0.2	-1.0	-0.5	-1.3	-1.4
HDL Cholesterol	0.4	0.6	1.8	0.8	-0.2	0.6	0.3	1.3	0.8
Systolic Blood Pressure	0.4	2.1	9.2	-1.0	-0.9	-0.9	-0.8	-3.0	-0.4
Allergy or Eczema	0.4	0.9	2.8	1.7	0.5	1.0	1.2	-0.2	0.2
Cardiovascular Disease	0.4	1.3	5.4	-0.7	0.6	-0.7	-1.0	-2.3	-0.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.9	-0.9	0.4	-0.5	-0.5	-0.6	0.7
Diabetes (mother)	0.4	0.5	1.8	-0.2	0.7	-0.2	-0.1	1.3	0.8
Maternal smoking around birth	0.4	0.6	1.7	-0.2	-0.2	-1.3	-1.3	-0.4	0.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	2.5	-1.6	0.3	-0.3	-0.0	-0.1	0.1
Serious illness, injury or assault to yourself	0.4	0.4	1.0	-0.1	-0.9	-0.7	-0.4	-0.5	-1.0
Medication: Atenolol	0.4	0.5	2.3	1.5	0.5	0.2	0.7	0.5	-0.1
Had menopause	0.4	0.5	1.4	0.9	1.2	0.0	-0.7	0.2	-0.4
Qualifications: None of the above	0.4	0.8	2.2	0.7	1.5	0.6	1.0	0.1	0.8
Arm fat percentage (right)	0.4	1.8	5.1	0.2	-0.3	0.8	1.0	2.3	1.9
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.2	1.3	-0.4	-0.3	-0.2	-1.5	-0.7
Medication: Amlodipine	0.4	0.6	1.8	-0.8	0.3	-0.9	-0.3	-1.4	-0.3
Number of children fathered	0.4	0.5	1.0	0.5	0.1	-1.0	-1.0	-0.3	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.5	0.3	1.2	0.5	0.6	0.0	0.9
Smoking status: Current	0.4	0.7	2.9	0.4	-0.5	-0.8	0.0	-1.7	0.1
Miserableness	0.4	0.7	2.8	0.2	1.7	-0.5	-1.1	0.2	-0.1
Mother’s age at death	0.4	0.5	1.4	0.1	0.3	-1.0	-1.2	-0.4	-0.3
Age started oral contraceptive pill	0.4	0.5	1.7	0.3	1.3	0.5	0.2	0.6	0.6
Bipolar Disorder (2018)	0.3	0.4	1.1	0.1	-0.9	0.5	1.0	-0.6	-0.2
Bipolar Disorder or Schizophrenia	0.3	0.7	1.6	-0.1	-0.6	0.6	1.2	-1.0	0.8
Hypothyroidism (self reported)	0.3	0.7	1.1	1.1	-0.9	-0.9	-0.8	-0.2	-0.9
Sensitivity / hurt feelings	0.3	0.6	1.3	0.7	0.0	-1.0	-0.1	-0.8	-1.1
Systolic blood pressure, automated reading	0.3	0.8	2.2	-0.9	0.4	-0.8	-0.7	-1.5	0.6
Medication: Metformin	0.3	0.4	1.5	-1.2	-0.7	-0.4	-0.6	0.1	0.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.7	-0.3	0.8	0.8	0.6	-0.1	0.3
Multivitamins +/- minerals	0.3	0.4	1.9	1.4	0.5	0.1	-0.1	-0.4	-0.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.7	-1.3	0.0	0.6	0.2	0.3	0.3
Alcohol usually taken with meals	0.3	0.5	1.3	0.9	0.7	0.7	1.1	-0.3	-0.1
Nervous feelings	0.3	0.6	2.1	1.2	1.4	0.1	0.4	-0.0	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	0.5	0.3	-1.0	-0.4	-1.1	-0.6
Hair/balding pattern: Pattern 3	0.3	0.4	1.4	-0.3	1.2	0.3	-0.2	0.1	1.0
Noisy workplace	0.3	0.4	1.3	0.4	-0.4	-1.1	-0.6	0.3	-0.7
Mouth/teeth dental problems: Dentures	0.3	0.5	2.1	0.1	1.5	-0.0	-0.7	-0.6	0.4
Birth weight	0.3	0.5	1.6	-1.0	0.3	0.0	0.1	-1.3	-0.7
Exposure to tobacco smoke outside home	0.3	0.4	1.5	-0.0	0.6	-0.5	0.0	-1.2	-0.5
Number of full brothers	0.3	0.3	1.0	-0.2	0.4	-0.2	0.5	-1.0	-0.7
Shortness of breath walking on level ground	0.3	0.4	1.8	0.0	-0.4	0.1	-0.2	-1.4	0.5
Medication: Omeprazole	0.3	0.4	1.1	-0.8	1.1	-0.3	-0.4	0.0	0.4
Number of full sisters	0.3	0.4	1.8	0.1	-1.4	-0.7	0.3	-0.1	-0.0
Chest pain or discomfort	0.3	0.4	1.4	0.3	-1.2	0.0	0.6	-0.4	-0.6
Mood swings	0.3	0.6	2.6	0.6	-0.2	-0.4	0.3	-1.6	-0.6
Ever had bowel cancer screening	0.3	0.3	0.6	0.1	0.8	0.6	0.5	0.8	0.2
Medication: Lisinopril	0.3	0.4	1.2	0.7	0.3	-0.5	-1.1	0.7	-0.2
Basal cell carcinoma (self-reported)	0.3	0.4	1.1	1.0	-0.3	0.1	0.3	0.3	-1.1
Leg fat mass (left)	0.3	1.0	3.3	-0.7	-1.8	-1.0	-0.9	-0.6	-0.2
Schizophrenia (2018)	0.2	0.5	1.5	-0.2	-0.0	0.4	0.8	-0.8	1.2
Prostate Cancer	0.2	0.3	0.6	-0.0	0.8	0.7	-0.2	0.6	0.4
Age at First Birth	0.2	0.2	0.4	0.6	-0.2	-0.4	-0.7	0.5	0.2
LDL Cholesterol	0.2	0.3	0.5	0.7	0.3	0.7	0.6	0.4	-0.5
Schizophrenia (2014)	0.2	0.4	1.0	0.2	-0.5	0.5	0.6	-0.8	1.0
Tanning	0.2	2.2	6.3	-2.0	0.4	-1.5	-2.5	-0.6	-0.6
Supplements: Zinc	0.2	0.2	0.4	-0.2	0.6	0.6	-0.2	0.4	0.1
Trunk fat mass	0.2	0.9	4.5	-0.3	-2.1	-0.5	0.2	0.7	-0.2
Number of incorrect matches in round	0.2	0.4	1.0	0.1	-0.3	0.5	1.0	0.9	0.5
Neuroticism score	0.2	0.4	0.8	0.4	0.7	-0.8	-0.1	-0.9	-0.6
Hip circumference	0.2	0.7	2.1	1.4	-0.5	0.9	0.6	0.6	0.5
Falls in the last year	0.2	0.2	0.9	0.4	-0.5	0.2	0.9	0.1	-0.2
Happiness	0.2	0.2	1.4	0.2	-0.0	0.1	0.0	1.2	0.0
Depression (self-reported)	0.2	0.2	0.5	0.2	-0.1	-0.6	-0.7	-0.2	-0.4
Prospective memory result	0.2	0.2	0.8	0.1	-0.6	-0.3	0.2	-0.9	0.2
Arm fat mass (right)	0.2	0.7	2.6	-0.8	-1.6	-0.9	-0.6	0.0	-0.4
Tense / ‘highly strung’	0.2	0.3	1.1	-0.5	0.3	-1.1	-0.1	-0.4	0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.0	-1.0	0.3	-0.0	-0.0	-0.8	-0.1
Glaucoma (self-reported)	0.2	0.3	0.8	-0.1	0.2	-0.6	-0.9	0.6	-0.2
Heart disease (mother)	0.2	0.2	0.6	-0.1	0.2	0.5	0.6	-0.1	-0.7
Whole body fat mass	0.2	0.9	4.1	-0.5	-2.0	-1.0	-0.4	0.1	-0.4
Leg fat mass (right)	0.2	0.9	3.1	-0.6	-1.8	-1.0	-0.8	-0.4	-0.2
Overall health rating	0.2	0.4	1.0	0.5	0.2	0.6	1.0	-0.9	0.1
Supplements: Vitamin C	0.2	0.3	0.9	0.7	0.3	-0.3	-0.3	1.0	-0.1
Loneliness, isolation	0.2	0.3	1.2	-1.1	-0.4	-0.2	-0.3	-0.5	-0.6
Qualifications: nursing, teaching	0.2	0.3	0.7	-0.8	-0.1	0.8	-0.2	0.0	0.6
Arm fat mass (left)	0.2	0.7	2.8	-0.7	-1.7	-0.8	-0.6	-0.1	-0.3
Guilty feelings	0.2	0.3	0.6	0.8	0.3	-0.5	-0.4	-0.1	-0.8
Financial situation satisfaction	0.2	0.2	0.6	0.4	0.2	-0.4	-0.5	0.8	-0.3
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.1	-0.4	0.1	-0.3	-0.4	1.1	0.3
Illnesses of father: High blood pressure	0.2	0.2	0.7	-0.2	0.6	-0.9	0.1	-0.5	-0.4
Lupus	0.1	0.1	0.3	-0.1	0.6	0.2	0.3	-0.2	0.3
BMI	0.1	0.4	0.9	-0.8	0.1	-0.5	-1.0	0.1	0.7
Number of treatments/medications taken	0.1	0.1	0.4	-0.3	0.6	0.4	-0.4	-0.2	-0.1
Vitamin and mineral supplements	0.1	0.2	0.6	-0.8	0.4	0.2	0.1	0.1	0.6
Severe depression (siblings)	0.1	0.1	0.2	0.0	-0.2	-0.4	-0.5	0.2	0.2
Pack years adult smoking proportion	0.1	0.2	0.5	0.6	0.3	0.5	-0.2	-0.1	0.7
Townsend deprivation index at recruitment	0.1	0.1	0.4	-0.0	0.1	0.3	0.1	0.6	0.6
Stomach or abdominal pain in last month	0.1	0.1	0.3	0.5	0.1	-0.2	-0.2	0.2	-0.5
Body mass index (BMI)	0.1	0.3	0.5	-0.7	-0.3	-0.3	-0.7	-0.6	0.7
Waist circumference	0.1	0.4	1.4	0.1	-1.2	-0.4	-0.3	-0.8	-0.5
Mouth/teeth dental problems	0.1	0.1	0.4	-0.2	-0.1	0.2	0.1	0.7	0.6
Alcohol intake versus 10 years previously	0.1	0.2	0.7	0.0	0.8	0.1	0.4	0.2	0.4
Lung cancer (father)	0.1	0.2	0.3	-0.6	0.1	-0.1	-0.5	-0.2	-0.6
Comparative body size at age 10	0.1	0.3	0.6	0.5	0.7	0.3	0.3	0.4	0.8
Age at first live birth	0.1	0.2	0.5	-0.3	-0.1	-0.5	-0.1	-0.4	-0.7
Medication: Seretide 50 evohaler	0.1	0.2	0.4	-0.2	0.1	0.6	0.2	0.5	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.5	0.3	0.7	0.2	-0.1	-0.1	-0.1
Age at last live birth	0.1	0.2	0.9	-0.1	-0.3	-0.0	0.1	-0.9	-0.6
Knee pain experienced in last month	0.1	0.1	0.3	-0.4	-0.5	-0.5	0.1	0.0	0.1
Mineral and other dietary supplements	0.1	0.1	0.3	-0.2	0.1	0.4	0.1	-0.6	0.5
Wears glasses or contact lenses	0.1	0.1	0.5	0.7	-0.2	-0.1	0.1	0.1	-0.2
High cholesterol (Self-reported)	0.1	0.2	0.5	-0.2	0.4	-0.5	-0.7	-0.0	-0.2
Cholesterol lowering medication	0.1	0.1	0.3	-0.2	-0.1	-0.6	-0.3	-0.2	-0.5
Pack years of smoking	0.1	0.2	0.4	0.5	0.4	0.3	-0.5	0.2	0.6
Triglycerides	0.0	0.0	0.1	0.3	-0.1	-0.1	0.1	-0.3	-0.1
Length of working week for main job	0.0	0.1	0.2	0.0	0.4	0.1	-0.1	-0.4	0.1
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.2	-0.1	-0.3	-0.1	-0.2	-0.1	-0.4

Hub : Genes

REST

Models

Trait associations