Best TWAS P=1.13e-11 · Best GWAS P=7.42e-11 conditioned to 0.0278
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PTPN13 | 0.13 | 0.18 | bslmm | 418 | 0.18 | 6.8e-22 | 5.3 | -5.7 | 1.3e-08 | -0.44 | 0.79 | 0.21 | FALSE |
| 2 | GTEx | Artery Aorta | MAPK10 | 0.15 | 0.17 | enet | 16 | 0.17 | 1.4e-09 | 6.2 | -6.1 | 9.6e-10 | -0.81 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Colon Sigmoid | MAPK10 | 0.25 | 0.11 | lasso | 8 | 0.07 | 1.6e-03 | 6.2 | -6.8 | 1.1e-11 | -0.74 | 0.02 | 0.96 | TRUE |
| 4 | GTEx | Nerve Tibial | MAPK10 | 0.08 | 0.01 | enet | 17 | 0.03 | 1.7e-03 | 6.3 | -5.5 | 4.5e-08 | -0.63 | 0.01 | 0.96 | FALSE |
| 5 | GTEx | Thyroid | PTPN13 | 0.41 | 0.31 | lasso | 6 | 0.30 | 3.2e-23 | 6.4 | 6.2 | 4.7e-10 | 0.81 | 0.01 | 0.99 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | PTPN13 | 0.09 | 0.03 | blup | 409 | 0.07 | 4.7e-09 | 5.3 | -5.6 | 2.4e-08 | -0.45 | 0.77 | 0.23 | FALSE |